Article
Engineering, Environmental
Yiping Feng, Jiayong Lao, Jiale Zou, Zhiyu Zhu, Daguang Li, Guoguang Liu, Liang Mao
Summary: Understanding the interactions between nanomaterials and cell membranes is important for ecotoxicology and human health. In this study, the interaction between graphitic carbon nitride (CN) and red blood cells was investigated. It was found that CN causes rapid cell membrane rupture through a physical interaction mechanism rather than chemical oxidation. Additionally, CN was found to extract phospholipids, particularly phosphatidylcholine, from cell membranes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Physics, Multidisciplinary
N. Maridi, M. Benhamou, D. Khalil
Summary: This work investigates the structure and thermodynamic properties of a bilayer membrane composed of peptide molecules forming nanopores. The study reveals the existence of both repulsive and attractive forces between the nanopores. It is found that there is a critical nanopore density below which the nanopores do not coagulate.
CHINESE JOURNAL OF PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Yusuke Shimizu, Kohei Sato, Kazushi Kinbara
Summary: Inspired by natural calcium-induced reversible assembly and disassembly of membrane proteins, a phosphorylated amphiphile (PA) containing an oligo(phenylene-ethynylene) unit as a hydrophobic unit and a phosphate ester group as a hydrophilic calcium-binding unit was developed. The study demonstrated that PA can reversibly assemble and disassemble within lipid bilayer membranes in response to the sequential addition of calcium chloride and ethylene-diaminetetraacetic acid as a synthetic molecule for the first time.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tanaz Islam, Olga N. Chesnokov, Andrew V. Oleinikov, Peng Yi
Summary: The interactions between nanoparticles and red blood cell membranes were investigated using characterization methods and techniques. The results showed that the surface charge of the nanoparticles played an important role in their attachment to the red blood cell membranes.
Article
Electrochemistry
Masaru Kato, Yuya Masuda, Narumi Yoshida, Takehiko Tosha, Yoshitsugu Shiro, Ichizo Yagi
Summary: The reconstitution of protein tethered bilayer lipid membranes in protein film electrochemistry has a significant impact on functionality and stability at electrolyte/electrode interfaces. Protein-lipid interactions affect the formation kinetics of phospholipid bilayers and the electrocatalytic stability of protein-modified electrodes, but not the fluidity of the phospholipid bilayer.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Physical
Elisa Aranda, Jose A. Teruel, Antonio Ortiz, Maria Dolores Perez-Carceles, Jose N. Rodriguez-Lopez, Francisco J. Aranda
Summary: The anticarcinogenic properties of catechins, their interaction with lipids, and their potential site of action in membranes were studied. Experimental and computational research showed that catechins can modify lipid polymorphism and membrane structure and dynamics. These findings provide insights into the molecular effects of catechins and their potential impact on membrane function.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
Tomas Sabirovas, Ausra Valiuniene, Gintaras Valincius
Summary: In this study, biomimetic electrodes suitable for probing protein/phospholipid interactions were created on metallurgically polished aluminum surfaces. The fusion of multilamellar vesicles on the aluminum surface formed a hybrid bilayer lipid membrane (hBLM), with its complex capacitance being typical for intact phospholipid bilayers. The presence of cholesterol in hBLMs inhibited membrane damage caused by the peptide melittin, which showed a concentration-dependent interaction with the hBLMs.
SCIENTIFIC REPORTS
(2021)
Article
Biophysics
Rafael G. Oliveira, Mariana Paolorossi, Leide Passos Cavalcanti, Antonio Malfatti-Gasperini, Guillermo G. Montich
Summary: The study found that when beta 2GPI binds with anionic phospholipids, it forms a lamellar stacking with a periodicity, and the interactions between membranes mediated by beta 2GPI are favored when the membranes are in the liquid crystalline state.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Multidisciplinary Sciences
Kyle I. P. Le Huray, He Wang, Frank Sobott, Antreas C. Kalli
Summary: This study systematically simulated the interactions between 100 mammalian PH domains and PIP-containing membranes. The observed PIP interaction hotspots recapitulate crystallographic binding sites and provide insights into the mechanisms of PH domain/membrane association. The study offers a comprehensive view of the binding of PH domains to membranes.
Article
Nanoscience & Nanotechnology
Alice Spadea, Mark Jackman, Lili Cui, Sara Pereira, M. Jayne Lawrence, Richard A. Campbell, Marianne Ashford
Summary: This study investigates the mechanism of interaction between nucleic acid-loaded LNPs and endosomal membranes using different reflectometry techniques. The insertion of lipids from LNPs into the model membrane is found to be greatest at pH 6.5 and 5.5, while at higher pH, lipid insertion is suppressed and intact LNPs are bound instead. The stage of the endosome has minimal effect on the extent of LNP interaction. The nature of the nucleic acid cargo can be tuned to optimize the interaction and improve nucleic acid delivery by LNPs.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Surajit Ghosh, Zeinab Mohamed, Jung-Ho Shin, Samavi Farnush Bint E. Naser, Karan Bali, Tobias Dorr, Roisin M. Owens, Alberto Salleo, Susan Daniel
Summary: Antibiotic resistance is a global health concern due to the decreasing number of available antibiotics and the development of drug-resistant bacteria. Understanding the interactions between the bacterial membrane and antibiotics is crucial for designing novel antimicrobial drugs. By creating a surface-supported planar bacterial outer membrane model, researchers can study these interactions and gain insights into membrane properties for drug design.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Shuai Zhang, Jeevapani J. J. Hettige, Yuhao Li, Tengyue Jian, Wenchao Yang, Yun-Chiao Yao, Renyu Zheng, Zhixing Lin, Jinhui Tao, James J. J. De Yoreo, Marcel Baer, Aleksandr Noy, Chun-Long Chen
Summary: Finding a stable and highly selective artificial membrane is crucial for solving global crises such as water scarcity. The co-assembly of carbon nanotube porins (CNTPs) and peptoids into 2D membrane nanosheets offers a promising solution with superior crystallinity and robustness.
Article
Biophysics
L. Bar, F. Perissinotto, L. Redondo-Morata, M. Giannotti, J. Goole, P. Losada-Perez
Summary: This study investigates the effect of topographical homogeneity of supported lipid bilayers (SLBs) on the adsorption of hydrophilic Quantum dots (QDs). It reveals significant differences in the interactions of QDs onto homogeneous and inhomogeneous SLBs, with QDs preferentially targeting membrane defects in inhomogeneous layers. The adsorption of QDs onto homogeneous SLBs is mainly driven by electrostatic interactions, while in inhomogeneous SLBs it is influenced by a subtle interplay of electrostatic and entropic effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemical Research Methods
Rananjaya S. Gamage, Jordan L. Chasteen, Bradley D. Smith
Summary: This article summarizes the different ways that proteins are anchored in cell membranes and the strategies used to label membrane proteins in living cells. It also describes the methods used to produce lipidated proteins. A three-component synthetic construct composed of a lipophilic membrane anchor, hydrophilic linker, and exposed functional component is used to anchor the payload on the cell surface. Hydrocarbon chains are commonly used as the membrane anchor and amphiphilic fluorescent dyes with a zwitterionic linker have high persistence in living cell membranes. A new advance is the development of switchable membrane anchors for fundamental studies and applied biomaterials.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Halina Grushevskaya, Andrey Timoshchenko, Ihor Lipnevich
Summary: This paper studies the origin and nature of defects induced by gamma radiation in graphene rolled-up planes. A novel graphene-based nanocomposite material was synthesized to reduce environmental influence and reveal the small effects of gamma rays. It was found that the interaction between the samples and gamma quanta results in the appearance of three characteristic photon escape peaks in the radiation spectra.