Article
Agriculture, Multidisciplinary
Junfan Niu, Gang Tang, Jingyue Tang, Jiale Yang, Zhiyuan Zhou, Yunhao Gao, Xi Chen, Yuyang Tian, Yan Li, Jianqiang Li, Yongsong Cao
Summary: Silver nanoparticles (AgNPs) have broad-spectrum antibacterial activities against both Gram-positive and Gram-negative bacteria, but their negative surface potential limits their effectiveness. By loading AgNPs into mesoporous silica nanoparticles and modifying them with the cationic antibacterial polymer QPEI, the resulting Ag@MSN-QPEI showed significantly enhanced antibacterial activities through improved surface potential and bacterial cell-targeting effect.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hongcai Zhang, Tingting Qiu, Yifei Bai, Bin Chen, Juan Yan, Jianxiong Xu
Summary: In this study, cellulose nanocrystals were used to stabilize Lysozyme encapsulated in quaternary ammonium chitosan nanoparticles. The CNC stabilized Lys loaded QC NPs showed potential implications in the food industry for food preservation and packaging, as well as demonstrated good antibacterial activity against Staphylococcus aureus and Vibrio parahaemolyticus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Joanna Fedorowicz, Cristina D. Cruz, Malgorzata Morawska, Krzesimir Ciura, Shella Gilbert-Girard, Liliana Mazur, Heidi Makkyla, Polina Ilina, Kirsi Savijoki, Adyary Fallarero, Paivi Tammela, Jaroslaw Saczewski
Summary: A series of quaternary ammonium fluoroquinolones were synthesized by methylation of the amine groups at the 7-position of fluoroquinolones. These compounds exhibited potent antibacterial activity and low cytotoxicity in vitro. Further experiments confirmed their ability to bind to DNA gyrase and topoisomerase IV active sites, as well as disrupt bacterial cell membranes. The most active compounds had moderate lipophilicity and contained a cyclopropyl group at the N1 nitrogen atom in the fluoroquinolone core.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Yalan Wang, Juan Du, Haiyong Guo, Renming Liu, Zhiyi Li, Tingyu Yang, Junzhe Ai, Chunbo Liu
Summary: An antibacterial PU coating with QAS was developed and characterized by XPS, FT-IR, and SEM, showing significant antimicrobial activity against both S. aureus and E. coli. Different theoretical molar fractions of DMAPD in chain extenders resulted in varying antibacterial effectiveness, with PU-4 showing the best activity against S. aureus and PU-5 against E. coli.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Engineering, Biomedical
Lidia Fanfoni, Eleonora Marsich, Gianluca Turco, Lorenzo Breschi, Milena Cadenaro
Summary: Nine antibacterial di-methacrylate monomers based on bis-quaternary ammonium salts were synthesized and showed promising results against different bacterial strains, with two structures outperforming a commercial monomer. The analysis revealed a correlation between the structure and antibacterial activity of the monomers, aiding in the design of new active structures.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Medicinal
Sergey Sapozhnikov, Alina E. Sabirova, Nikita Shtyrlin, Anastasia Y. Druk, Mariya N. Agafonova, Milana N. Chirkova, Renata R. Kazakova, Denis Y. Grishaev, Tatyana Nikishova, Elena S. Krylova, Elena Nikitina, Airat R. Kayumov, Yurii G. Shtyrlin
Summary: A series of novel soft antimicrobials based on quaternary ammonium pyridoxine derivatives were designed, with nine compounds exhibiting promising in vitro antibacterial activity. Lead compounds 6i and 12a showed comparable antibacterial activity with benzalkonium chloride and were non-toxic.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Songtai Gao, Yujun Sun, Zhong Lu, Nan Jiang, Huaiying Yao
Summary: Antibiotics overuse and misuse contribute to the emergence of multidrug-resistant bacterial strains and biofilm formation. This study screened out a combination of quaternary ammonium compound PDDA and Cu2+ as a promising antibacterial agent against Staphylococcus aureus. The combination showed strong synergistic antibacterial activity by disrupting membrane function, generating intracellular reactive oxygen, promoting Cu2+ uptake, and reducing biofilm extracellular matrix. In vitro biocompatibility studies demonstrated low cytotoxicity and hemolysis ratio. This work provides a novel and efficient strategy to combat planktonic and biofilm S. aureus infections.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Michal Dekel-Steinkeller, Ervin I. Weiss, Trudi Lev-Dor Samovici, Itzhak Abramovitz
Summary: This study tests the antibacterial properties of a novel composite material containing quaternary ammonium silica particles (QASi). The results demonstrate that QASi effectively kills E. faecalis bacteria and has comparable antibacterial activity to previously described quaternary ammonium polyethyleneimine particles.
JOURNAL OF DENTISTRY
(2022)
Article
Multidisciplinary Sciences
Li Chang, Wenjie Duan, Siqi Huang, Anguo Chen, Jianjun Li, Huijuan Tang, Gen Pan, Yong Deng, Lining Zhao, Defang Li
Summary: A novel antibacterial hemp fibre grafted with quaternary ammonium groups (HF-GTA) was prepared through multistage reactions, showing good antibacterial activity against Escherichia coli and Staphylococcus aureus. The grafting primarily occurred on the hydroxyl groups of cellulose and hemicellulose, retaining good fibrous morphology, thermal stability, and hygroscopicity. The antibacterial activity was attributed to electrostatic reactions reducing the electrochemical potential on cell membranes.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Materials Science, Paper & Wood
Xin Tang, Zaixing Zhang, Lingxiao Jing, Kun Luan, Sha Zhou, Tonghua Zhang
Summary: A novel antimicrobial compound was synthesized and successfully grafted onto cotton fabric, enhancing its antibacterial function. Chlorination treatment significantly improved the antibacterial activity of the fabric, which showed good antimicrobial durability. This study provides a new approach to enhance the antimicrobial performance of textiles.
Article
Biochemistry & Molecular Biology
Hongguang Zhang, Lijia Liu, Peng Hou, Jun Liu, Shuang Fu
Summary: The study designed and synthesized a series of linear polyisocyanide quaternary ammonium salts (L-PQASs) and evaluated their antibacterial activity against Escherichia coli and Staphylococcus aureus. The results demonstrated that the antibacterial activity of L-PQASs was dependent on the structure of the main chain and the length of the side chain, and decreased with an increase in the molecular weight of the main chain when having the same side chain.
Review
Chemistry, Medicinal
Mallikarjuna N. Nadagouda, Pooja Vijayasarathy, Aebin Sin, Heeyeon Nam, Sanaullah Khan, Javad B. M. Parambath, Ahmed A. Mohamed, Changseok Han
Summary: Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that have gained much attention in research. They have various applications such as disinfectants, inhibitors of biofilm growth, and antibacterials.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Physical
Ming-Ming Zhu, Yu Fang, Yan-Chen Chen, Yu-Qing Lei, Li-Feng Fang, Bao-Ku Zhu, Hideto Matsuyama
Summary: A dual-functional ultrafiltration membrane containing quaternary ammonium and zwitterionic polymers was designed to overcome organic/bio-fouling, with improved hydrophilicity and antibacterial properties. The membrane showed higher flux recovery, lower protein adhesion, and efficient broad-spectrum antibacterial performance against S. aureus and E. coli. It effectively inhibited bacterial adhesion for long-term antibacterial properties, demonstrating potential for microbiologically contaminated water filtration processes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Chemistry, Medicinal
Wenjia Dan, Jixiang Gao, Xiaohui Qi, Junru Wang, Jiangkun Dai
Summary: This review summarizes the chemical diversity, structure-activity relationships, and antibacterial mechanisms of quaternary ammonium compounds (QACs) reported over the past decade. The review aims to provide sufficient information for medicinal chemists to discover new generation antibacterial agents based on QACs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Dhruval K. Joshi, Frank Betancourt, Alyssa McAdorey, Ravi Shekar Yalagala, Andy Poupon, Hongbin Yan
Summary: N,N,N-trimethyl-2(4,4-difluoro-4-bora-3a,4a-diaza-s-indacen-8-yl)ethylammonium iodide (BODIPY quaternary ammonium 17) was successfully synthesized using 4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene as starting material. Although less stable than Rose Bengal, this BODIPY ammonium showed superior photosensitizing efficiency and faster photodegradation rate. It also exhibited antibacterial activity against Bacillus subtilis when exposed to light.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Polymer Science
Yuvaraj Arun, Mahran Daifa, Abraham J. Domb
Summary: Hydroxamic acid-containing organic polymeric flocculants were synthesized from three different commercially available polymeric flocculants and showed improved chelation with Fe3+ and Cu2+. The conversion of the amide groups to hydroxamic acid groups in the polymers enhanced their flocculation effect on tested wastewater.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Review
Chemistry, Multidisciplinary
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: Biodegradable, hydrophobic, and injectable liquid polymers are able to achieve sustained, local drug release, with potential applications in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Eliel Ben-David, Abraham J. Domb, Haixing Liao, Awanish Kumar, Issac Nissenbaum, Matthias Stechele, Peter Siman, Natalie Greenbaum, Naama Lev Cohain, S. Nahum Goldberg
Summary: The study evaluated the degradation rate and imaging effects of three biodegradable polymer markers in a mouse model, with significant differences observed in their visibility and absorption rate on CT and MRI.
Article
Biochemistry & Molecular Biology
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: The alternating structure and hydrophobic side chains of polyanhydrides contribute to their stability. The addition of phenyl moieties and tuning their distance from anhydride bonds significantly improves the stability of polyanhydrides.
Article
Pharmacology & Pharmacy
Radhakanta Ghosh, Yuvaraj Arun, Peter Siman, Abraham J. Domb
Summary: Polyanhydrides are synthesized by melt-polycondensation of diacid monomers and excess acetic anhydride to form stable polymers with controlled molecular weight. The synthesized aliphatic polyanhydrides have controllable molecular weight and low polydispersity, making them suitable for potential use as drug carriers. In vitro drug release studies show promising results for poly(sebacic acid) as a candidate for controlled drug delivery applications.
Review
Biochemistry & Molecular Biology
Pulikanti Guruprasad Reddy, Abraham J. Domb
Summary: Polyanhydrides (PAs) are synthetic biodegradable polymers used as controlled drug delivery vehicles. They are biocompatible, biodegradable, and generate nontoxic metabolites upon degradation. PAs have surface-eroding characteristics and have been developed into various drug delivery carriers. The rate of drug delivery is controlled by the polymer erosion rate, which is influenced by the polymer structure and composition, hydrophobicity, pH of the release medium, and device size.
Article
Chemistry, Medicinal
Pulikanti Guruprasad Reddy, Abraham J. Domb
Summary: This work presents the formation and characterization of thymol phenolate salts, which are representatives of phenol-containing bioactive molecules. Various thymol salts were synthesized and investigated for their physicochemical properties. It was found that the thymol salts exhibited improved solubility, thermal stability, and evaporation rate compared to thymol.
Article
Virology
Eyal Klein, Elisheva Smith, Chen Klap, Elena Bakelman, Arie Ophir, Aviad Sela, Elena Poverenov, Dmitry Rein, Yachin Cohen, Dan Eliahu, Shai Shahal, Guy Mechrez, Karthik Ananth Mani, Pulikanti Guruprasad Reddy, Abraham J. Domb, Nadav Pass, Aviv Dombrovsky
Summary: This study tested four root-coating technologies to mitigate soil-mediated Tomato brown rugose fruit virus (ToBRFV) infection. The formulations based on methylcellulose (MC), polyvinyl alcohol (PVA), silica Pickering emulsion, and super-absorbent polymer (SAP) with chlorinated-trisodium phosphate (Cl-TSP) disinfectant showed low percentages of soil-mediated ToBRFV infection and had no adverse effect on plant growth.
Review
Polymer Science
Elif Yuce-Erarslan, Abraham (Avi) J. Domb, Haytam Kasem, Vladimir N. Uversky, Orkid Coskuner-Weber
Summary: In biology and medicine, intrinsically disordered synthetic polymers, which mimic the characteristics of disordered proteins, are highly flexible and self-organizing, making them useful in various biomedical applications, such as drug delivery and organ design. The development of new synthesis and characterization methods is important for providing these polymers for medical use. This study presents strategies for designing intrinsically disordered synthetic polymers for biomedical applications based on mimicking intrinsically disordered proteins.
Review
Pharmacology & Pharmacy
Hossein Hosseinkhani, Abraham J. Domb, Ghorbanali Sharifzadeh, Victoria Nahum
Summary: The development of biological methods has generated interest in the possibility to regenerate human tissues. Stem cell research, gene therapy, and tissue engineering have advanced tissue and organ regeneration technology. Technical issues still remain in gene therapy, especially in the clinical use of viral vectors. Non-viral gene transfection agents are emerging as potentially safe and effective alternatives for treating genetic and acquired diseases.
Article
Biochemistry & Molecular Biology
Muhammad AbdEl-haq, Awanish Kumar, Fatima-ezzahra Ait Mohand, Nataly Kravchenko-Balasha, Yakir Rottenberg, Abraham J. Domb
Summary: The study investigated the development of paclitaxel-loaded polymeric nanoparticles for brain tumor treatment. Poly(lactide-glycolide) (PLGA) nanoparticles with a size of 216 nm and containing 10% w/w paclitaxel were administered through intranasal and intravenous routes to rats. Both routes of administration resulted in significant accumulation of paclitaxel in brain tissue, liver, and kidney, with no observed toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was similar to that of free paclitaxel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Pulikanti Guruprasad Reddy, Tan Hu, Meital Reches, Abraham J. Domb
Summary: This study developed a series of chlorine-rich transition metal complexes/TBA salts of Na-DCC for extended chlorine release studies. These DCC-salts exhibited poor water solubility and slow decomposition chlorine release compared to Na-DCC. Moreover, the DCC-salts demonstrated excellent antiviral and antibacterial properties.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tovi Shapira-Furman, Abraham J. Domb
Summary: This report introduces a novel approach of nano formulation using stereo-interaction mechanism with poly(D-lactide)-polyethylene glycol (D-PLA-PEG) to address the challenges of controlled drug delivery for peptide and protein therapeutics. The study demonstrates that nano particles formed by the interaction between water-soluble D-PLA-PEG and insulin can achieve sustained release of insulin, showing potential application in diabetes treatment.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Awanish Kumar, Yifat Lamberti, Rafael Y. Lewis, Eyal Marco, Abraham J. Domb
Summary: The aim of this study was to determine the type of material in the unknown fabrics excavated from archaeological sites in Israel using advanced material technology. Using various analytical methods, it was confirmed that these fabrics are composed of synthetic materials such as nylon 6, polyester, and polyacrylonitrile (PAN). The developed method offers a rapid and effective means of identifying archaeological fabrics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Pulikanti Guruprasad Reddy, Ayala Bar-Hai, Amnon Hoffman, Sir Marc Feldmann, Abraham J. Domb
Summary: This study explores the synthesis and characterization of metal and ammonium phenolate salts using CBD as an example. The conversion of CBD into salts significantly enhances its water solubility, thus improving its therapeutic effectiveness. The findings provide valuable insights into the potential use of CBD salts in medicine.
BIOORGANIC CHEMISTRY
(2023)