A study of tropomyosin’s role in cardiac function and disease using thin-filament reconstituted myocardium

Analysis of the Molecular Pathogenesis of Cardiomyopathy-Causing cTnT Mutants I79N, ΔE96, and ΔK210

(2013) Fan Bai et al.   BIOPHYSICAL JOURNAL

Long-Range Effects of Familial Hypertrophic Cardiomyopathy Mutations E180G and D175N on the Properties of Tropomyosin

(2012) Socheata Ly et al.   BIOCHEMISTRY

Tropomyosin: Double helix from the protein world

(2012) I. A. Nevzorov et al.   BIOCHEMISTRY-MOSCOW

DCM-Linked D230N Tropomyosin Mutation Results in Early Dilatation and Systolic Dysfunction in Mice

(2012) Lauren Tal et al.   BIOPHYSICAL JOURNAL

The N-Terminal Extension of Cardiac Troponin T Stabilizes the Blocked State of Cardiac Thin Filament

(2012) Sampath K. Gollapudi et al.   BIOPHYSICAL JOURNAL

Structure of the Rigor Actin-Tropomyosin-Myosin Complex

(2012) Elmar Behrmann et al.   CELL

Tropomyosin Dephosphorylation Results in Compensated Cardiac Hypertrophy

(2012) Emily M. Schulz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DCM-Related Tropomyosin Mutants E40K/E54K Over-Inhibit the Actomyosin Interaction and Lead to a Decrease in the Number of Cycling Cross-Bridges

(2012) Fan Bai et al.   PLoS One

Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin

(2012) B. Barua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle

(2011) Yurii S. Borovikov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin

(2011) Mohit C. Mathur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced Active Cross-Bridges during Diastole: Molecular Pathogenesis of Tropomyosin's HCM Mutations

(2011) Fan Bai et al.   BIOPHYSICAL JOURNAL

Thin Filament Mutations

(2011) Jil C. Tardiff   CIRCULATION RESEARCH

Sarcomere Gene Mutations in Isolated Left Ventricular Noncompaction Cardiomyopathy Do Not Predict Clinical Phenotype

(2011) Susanne Probst et al.   Circulation-Cardiovascular Genetics

Protein Phosphorylation and Signal Transduction in Cardiac Thin Filaments

(2011) R. John Solaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Three-Dimensional FRET Analysis to Construct an Atomic Model of the Actin–Tropomyosin Complex on a Reconstituted Thin Filament

(2011) Masao Miki et al.   JOURNAL OF MOLECULAR BIOLOGY

The Role of Tropomyosin Domains in Cooperative Activation of the Actin–Myosin Interaction

(2011) Yusuke Oguchi et al.   JOURNAL OF MOLECULAR BIOLOGY

Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation

(2011) Chehade N. Karam et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin

(2011) B. Barua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Espectro mutacional de los genes sarcoméricos MYH7, MYBPC3, TNNT2, TNNI3 y TPM1 en pacientes con miocardiopatía hipertrófica

(2011) Mónica García-Castro et al.   REVISTA ESPANOLA DE CARDIOLOGIA

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform

(2010) Sudarsan Rajan et al.   CIRCULATION

Increased Ca2+ sensitivity of myofibrillar tension in ischaemic vs dilated cardiomyopathy

(2010) Samuel Lee et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

A novel custom resequencing array for dilated cardiomyopathy

(2010) Rebekah S Zimmerman et al.   GENETICS IN MEDICINE

Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins

(2010) Liliana Sfichi-Duke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of tropomyosin isoforms and phosphorylation in force generation in thin-filament reconstituted bovine cardiac muscle fibres

(2010) Xiaoying Lu et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation

(2010) Neal K. Lakdawala et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of a novel TPM1 mutation in a family with left ventricular noncompaction and sudden death

(2010) Bo Chang et al.   MOLECULAR GENETICS AND METABOLISM

Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies

(2010) Bianca C. Bernardo et al.   PHARMACOLOGY & THERAPEUTICS

Left Ventricular Noncompaction

(2010) Radha J. Sarma et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Sudden cardiac death risk in hypertrophic cardiomyopathy

(2009) Steve R. Ommen et al.   EUROPEAN HEART JOURNAL

Genetic Evaluation of Cardiomyopathy—A Heart Failure Society of America Practice Guideline

(2009) Ray E. Hershberger et al.   JOURNAL OF CARDIAC FAILURE

Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?

(2009) Ruth H. Willott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Investigations into tropomyosin function using mouse models

(2009) Ganapathy Jagatheesan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural Basis for the Activation of Muscle Contraction by Troponin and Tropomyosin

(2009) William Lehman et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts

(2008) Chao Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diagnostic yield, interpretation, and clinical utility of mutation screening of sarcomere encoding genes in Danish hypertrophic cardiomyopathy patients and relatives

(2008) Paal Skytt Andersen et al.   HUMAN MUTATION

Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle

(2008) Adam M. Jacques et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Shared Genetic Causes of Cardiac Hypertrophy in Children and Adults

(2008) Hiroyuki Morita et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiac thin filament regulation

(2008) Tomoyoshi Kobayashi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Phosphorylation of tropomyosin extends cooperative binding of myosin beyond a single regulatory unit

(2008) Vijay S. Rao et al.   CELL MOTILITY AND THE CYTOSKELETON