Article
Cardiac & Cardiovascular Systems
Ming Dong, Dishen Chen, Yanxia Zhu, Shu Yang, Santosh Kumar, Rui Zhang, Yin Zhou, Ziyi Yang, Na Zheng, Ting Zhu, Jiaqing Xiang, Yun Liu, Lin Kang, Jie Liu
Summary: This study found that aging increases the size of myocardial infarction and impairs cardiac contractile function. The expression of MLCK3 and the activity of MLC2 do not increase in the aging hearts after myocardial infarction. miR-146a-5p down-regulates MMP2/16 expression, which in turn increases MLCK3 expression and MLC2 activity. However, this regulatory mechanism is compromised in senescent cardiomyocytes or in hearts lacking miR-146a.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Peng-Fei Zheng, Xiu-Qin Hong, Zheng-Yu Liu, Zhao-Fen Zheng, Peng Liu, Lu-Zhu Chen
Summary: This study explores the role of RNA N6-methyladenosine (m6A) modification in the regulation of the immune microenvironment in ischaemic cardiomyopathy (ICM). It identifies seven key m6A regulators and develops a diagnostic nomogram based on these regulators for distinguishing ICM patients from healthy individuals. The study also reveals the relationship between m6A modification patterns and the characteristics of the immune microenvironment in ICM.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Aimi Yokoi, Toru Kawada, Shohei Yokota, Midori Kakuuchi, Hiroki Matsushita, Akitsugu Nishiura, Meihua Li, Kazunori Uemura, Joe Alexander Jr, Ryou Tanaka, Keita Saku
Summary: This study compared the effects of vericiguat, an sGC stimulator, and sodium nitroprusside, an NO donor, on autonomic cardiovascular regulation. The results showed that vericiguat did not significantly affect sympathetic nerve activity and arterial pressure, but mainly decreased arterial pressure through peripheral effects. On the other hand, sodium nitroprusside had a more uniform vasodilative effect over the range of sympathetic nerve activity.
Review
Pharmacology & Pharmacy
Celine Bassand, Alessia Villois, Lucas Gianola, Grit Laue, Farshad Ramazani, Bernd Riebesehl, Manuel Sanchez-Felix, Kurt Sedo, Thomas Ullrich, Marieta Duvnjak Romic
Summary: This review evaluates the characteristics of long-acting products on the market/pipeline, focusing on patient centricity, adherence impact, health outcomes, and market trends. The emerging trends in the field of long-acting products include increased capability in engineered molecules, direct development of long-acting oral/injectable drug products, increased proportion of products for local drug delivery, and a shift towards subcutaneous, self-administered products. Nanosuspensions show superiority in dose per administration and dosing interval among long-acting injectable products.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Lara T. Hartmayer, Falk Hoffmann, Christian J. Bachmann, Kathrin Jobski
Summary: Methylphenidate (MPH) is commonly used in ADHD and narcolepsy treatment, but its rising prescription volume has led to concerns about potential misuse. An analysis of data from the EudraVigilance database revealed that narcolepsy patients using MPH were older, took more co-medications, and were more likely to administer it intravenously. Fatal cases had higher rates of substance abuse, dependence, or withdrawal compared to nonfatal cases. Minors receiving MPH for ADHD treatment had fewer serious outcomes. Prescribers should exercise caution in adult MPH users and consider co-medication assessments. Further research on substance abuse in narcolepsy patients is needed.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Enoch S. Kwon, Ahmad A. Kittaneh, Gina M. Gerardo, Julian Koenig, Julian F. Thayer, DeWayne P. Williams
Summary: Individual differences in drug use are associated with difficulties in emotion regulation, resting heart rate variability, and gender. Women may be more likely to engage in drug use to reduce stress, while men may do so to enhance positive feelings.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Julia Wicherski, Katharina Schneider, Joerg Zinserling, Steffen Hess, Britta Haenisch, Karl Broich
Summary: This review provides an overview of the current status, development potential, and initiatives to increase the use of real-world evidence (RWE) in European and international drug regulation. RWE is primarily used for supportive evidence in regulatory decision-making, and efforts are being made to establish a health data infrastructure to enhance the use of real-world data (RWD). However, accessing and analyzing RWD pose challenges due to their variability and heterogeneity.
PRAVENTION UND GESUNDHEITSFORDERUNG
(2023)
Article
Psychology, Clinical
Sara Scrimin, Marta Peruzza, Libera Ylenia Mastromatteo, Elisabetta Patron
Summary: The study found a positive link between classroom climate and physical well-being, and a negative association between emotional well-being and BMI. Additionally, there was an inverted U-shaped effect of cardiac vagal withdrawal on emotional well-being.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2021)
Article
Clinical Neurology
Richard Kasch, Julia Truthmann, Mark J. Hancock, Christopher G. Maher, Markus Otto, Christopher Nell, Niklas Reichwein, Robin Bulow, Jean-Francois Chenot, Andre Hofer, Georgi Wassilew, Carsten Oliver Schmidt
Summary: This population-based cohort study examined the associations between common lumbar degenerative changes observed on magnetic resonance imaging (MRI) and low back pain (LBP). The study found that there is no clinically important association between these degenerative findings and LBP, with most effects less than one unit on a 0 to 10 pain scale. Longitudinal studies on this topic are limited.
Article
Medicine, General & Internal
Carsten Oliver Schmidt, Elizabeth Sierocinski, Sebastian Baumeister, Katrin Hegenscheid, Henry Voelzke, J-F Chenot
Summary: Whole-body MRI (wb-MRI) may lead to increased outpatient healthcare costs, particularly due to incidental findings; the long-term cost increase is mainly driven by imaging and specialist care services.
Article
Urology & Nephrology
Simone Kiel, Gesine Weckmann, Jean-Francois Chenot, Sylvia Stracke, Jacob Spallek, Aniela Angelow
Summary: This study assessed the referral rates and healthcare expenditure based on different referral criteria. The results showed that different criteria resulted in different referral rates and costs, with referral rates exceeding the actually observed consultation rates.
Article
Health Care Sciences & Services
Gesine Weckmann, Janine Wirkner, Elisa Kasbohm, Carolin Zimak, Annekathrin Haase, Jean-Francois Chenot, Carsten Oliver Schmidt, Sylvia Stracke
Summary: This study aimed to evaluate the management and quality of care for chronic kidney disease (CKD) in ambulatory care. The results showed that patient diagnosis awareness was low, monitoring frequency did not fully meet recommendations, and adherence to referral criteria varied.
BMC HEALTH SERVICES RESEARCH
(2022)
Letter
Clinical Neurology
Julia Truthmann, Richard Kasch, Mark J. Hancock, Christopher G. Maher, Jean-Francois Chenot, Carsten O. Schmidt
Article
Medicine, General & Internal
Gesine Weckmann, Simone Kiel, Jean-Francois Chenot, Aniela Angelow
Summary: This study investigated the association between symptoms commonly attributed to anemia, such as fatigue, dyspnea, lack of energy, and concentration, and the actual presence of anemia. The results showed that although these symptoms were more prevalent in anemic individuals, they were also common in non-anemic individuals. Therefore, other diagnoses should be considered when evaluating these symptoms, such as depression, heart failure, asthma, and COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Martin Junge, Markus Krueger, Dietlind L. Wahner-Roedler, Brent A. Bauer, Marcus Doerr, Martin Bahls, Jean-Francois Chenot, Reiner Biffar, Carsten O. Schmidt
Summary: The studies aimed to evaluate the reliability and measurement agreement of a preventive medical device, the Preventiometer, for cardiovascular outcomes. The results showed high retest-reliability of the clinical examinations in the Preventiometer, but there were some differences in measurement agreement compared to other methods.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Elizabeth Sierocinski, Lina Droege, Jean-Francois Chenot, Natalie Ebert, Elke Schaeffner, Tim Bothe, Nina Mielke, Sylvia Stracke, Simone Kiel
Summary: Quality indicators (QIs) were developed to assess the quality of outpatient care for patients with CKD over the age of 70. These QIs were based on the German national guideline and international QIs, and were evaluated and selected by a panel of experts. The QIs will be used to evaluate and improve the quality of outpatient care for CKD patients.
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ
(2023)
Article
Health Care Sciences & Services
Ana S. Oliveira Goncalves, Imke Mayer, Ricarda S. Schulz, Agnes Floeel, Felix von Podewils, Anselm Angermaier, Kerstin Wainwright, Tobias Kurth, NeTKoH Consortium
Summary: Tele-neurology has the potential to improve access to healthcare services and quality of care in rural and underserved areas. The NeTKoH trial aims to evaluate the cost-effectiveness and policy implications of a tele-neurological intervention in primary care in Germany. The economic evaluation will provide high-quality evidence for the effectiveness and potential application of tele-neurological programs.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Kerstin Wainwright, Imke S. Mayer, Ana S. Oliveira S. Goncalves, Ricarda Schulz, Simone Kiel, Jean-Francois Chenot, Agnes Floeel, Felix von Podewils, Anselm Angermaier, Tobias Kurth, NeTKoH Consortium
Summary: This study aims to evaluate the effects of a tele-neurologic intervention in primary care in a rural area in Germany. It uses a cluster-randomized controlled trial design and involves 33 outpatient general practitioner's offices. The intervention group receives tele-neurologic consultations while the control group receives usual care. The study is rated with an importance score of 8.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Medicine, Research & Experimental
Julia Truthmann, Julia Freyer Martins Pereira, Adrian Richter, Franziska Schuster, Amelie Witte, Susanne Boehm, Alexandra Greser, Petra Kamin, Sylvia Stracke, Marcus Doerr, Robin Buelow, Stefan Engeli, Ildiko Gagyor, Eva Hummers, Jean-Francois Chenot
Summary: This study aims to investigate whether prednisolone is non-inferior to colchicine in the treatment of acute gout. The study is a pragmatic, prospective, double-blind, parallel-group, randomized trial conducted in 60 primary care practices. The primary outcome is the level of severe pain on day 3 measured using a numerical rating scale. Secondary outcomes include response to treatment, joint swelling and tenderness, global assessment of treatment success, use of additional pain medication, and safety assessment.
Review
Education, Scientific Disciplines
Elizabeth Sierocinski, Leonard Mathias, Julia Freyer Martins Pereira, Jean-Francois Chenot
Summary: The structure and content of postgraduate medical training in Germany are regulated by the state medical boards and lack formal educational programs. The training primarily relies on rotations and is hindered by limited funding and the organizational responsibility of junior doctors, leading to extended training times and dissatisfaction. Structured training programs prioritizing skill-building and formal education are needed to support junior doctors and ensure their competence in primary and specialty care.
GMS JOURNAL FOR MEDICAL EDUCATION
(2022)
Article
Anesthesiology
Simone Kiel, Elizabeth Sierocinski, Christina Raus, Peggy Knauthe, Jean-Francois Chenot
Summary: This study examined the alignment between patient views on psychosocial factors and the German national guideline for nonspecific low back pain (LBP). The results showed that pain severity, health status, level of education, and previous treatment experience influenced patient views. These findings highlight the importance of counseling patients on psychosocial factors and screening for psychosocial problems in LBP. Educational initiatives may help align patient expectations with recommendations.
Article
Health Care Sciences & Services
Norbert Hosten, Robin Buelow, Henry Voelzke, Martin Domin, Carsten Oliver Schmidt, Alexander Teumer, Till Ittermann, Matthias Nauck, Stephan Felix, Marcus Doerr, Marcello Ricardo Paulista Markus, Uwe Voelker, Amro Daboul, Christian Schwahn, Birte Holtfreter, Torsten Mundt, Karl-Friedrich Krey, Stefan Kindler, Maria Mksoud, Stefanie Samietz, Reiner Biffar, Wolfgang Hoffmann, Thomas Kocher, Jean-Francois Chenot, Andreas Stahl, Frank Tost, Nele Friedrich, Stephanie Zylla, Anke Hannemann, Martin Lotze, Jens-Peter Kuehn, Katrin Hegenscheid, Christian Rosenberg, Georgi Wassilew, Stefan Frenzel, Katharina Wittfeld, Hans J. Grabe, Marie-Luise Kromrey
Summary: The Study of Health in Pomerania conducted a population-based study using whole-body MR imaging in a rural area. Through analyzing the imaging sequences used and their citation frequency, fruitful sequences and focused body parts were identified. The study suggests that more precise goals should be defined when allocating imaging time and proposes recording the number and impact of published work for quality control.