期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1075, 期 -, 页码 49-52出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2014.06.091
关键词
Quadruplex; Cation; Strand polarity; NMR spectroscopy
资金
- Slovenian Research Agency (ARRS) [P1-0242, J1-4020]
- Bio-NMR FP7 project [261863]
- European Cooperation in Science and Technology (COST) [MP0802]
Stability, dynamics and function of nucleic acids are affected by nature of cations that are involved in interaction with specific functionalities. Introduction of inversion of polarity sites represents a very useful and chemically accessible backbone modification, which can alter the binding affinity of cations. NMR study on cation binding between G-quartets in tetramolecular G-quadruplex adopted by d(5'TGG3'-3'GGT5') with 3'-3' inversion of polarity sites in the middle of G-tract showed existence of two different G-quadruplex forms with all strands in parallel orientation, where all guanine residues adopt anti conformation around glycosidic bonds in the presence of (NH4+)-N-15 ions. In one of the forms all three binding sites are equally populated, while in the second form the binding site next to the inversion of polarity site is not fully populated by (NH4+)-N-15 ions. (C) 2014 Elsevier B.V. All rights reserved.
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