期刊
JOURNAL OF MOLECULAR RECOGNITION
卷 24, 期 3, 页码 414-421出版社
WILEY-BLACKWELL
DOI: 10.1002/jmr.1120
关键词
herpes simplex virus type 1 (HSV-1); viral capsid; viral genome; nuclear delivery of viral genome; nuclear pore complex
资金
- Innovative Medizinische Forschung [SH-110315, SH-520404, SH-120613]
- Deutsche Forschungsgemeinschaft [SFB629]
- International graduate school' [GRK1409, OB 63/16-1, SH167/4-1]
Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen infecting more than 80% of the population worldwide. Its replication involves an essential, poorly understood multistep process, referred to as uncoating. Uncoating steps are as follows: (1) The incoming capsid pinpoints the nuclear pore complex (NPC). (2) It opens up at the NPC and releases the highly pressurized viral genome. (3) The viral genome translocates through the NPC. In the present review, we highlight recent advances in this field and propose mechanisms underlying the individual steps of uncoating. We presume that the incoming HSV-1 capsid pinpoints the NPC by hydrophobic interactions and opens up upon binding to NPC proteins. Genome translocation is initially pressure-driven. Copyright (C) 2011 John Wiley & Sons, Ltd.
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