Article
Biochemistry & Molecular Biology
Victor Silva da Fonseca, Valeria de Cassia Goncalves, Mario Augusto Izidoro, Antonio-Carlos Guimaraes de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza
Summary: Parkinson's disease is an incurable neurodegenerative disease with an increasing global disability and mortality rate. Non-motor symptoms are the main cause of disability and decreased quality of life. This study used metabolomics to assess changes in cardiac metabolism in a PD model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ying Lyu, Yiying Huang, Guiying Shi, Xuepei Lei, Keya Li, Ran Zhou, Lin Bai, Chuan Qin
Summary: This study revealed gene expression changes in the five brain regions following exposure to 6-hydroxydopamine in PD rats, identifying key pathways and cascade involved in synaptic damage. The dopaminergic synapse, retrograde endocannabinoid signaling, and Gi/o-GIRK were highlighted as potential key pathways. Potential candidate genes such as Ephx2, Fam111a, and Gng2 were identified for further studies on the pathogenesis of PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Environmental Sciences
Camila G. Dantas, Ailma O. da Paixao, Tassia L. G. M. Nunes, Italo J. F. Silva, Bruno dos S. Lima, Adriano A. S. Araujo, Ricardo L. C. de Albuquerque-Junior, Katia P. Gramacho, Francine F. Padilha, Luiz P. da Costa, Patricia Severino, Juliana C. Cardoso, Eliana B. Souto, Margarete Z. Gomes
Summary: This study evaluated the neuroprotective effects of Africanized bee venom (BV) on a mice model of Parkinson's disease induced by 6-hydroxydopamine (6-OHDA). The results showed that BV could counteract the symptoms caused by 6-OHDA, reduce cell death, and protect the striatum from damage. These findings suggest that Africanized bee venom may have potential as a novel therapeutic approach for Parkinson's disease.
Review
Cell Biology
Pauline Mencke, Ibrahim Boussaad, Chiara D. Romano, Toshimori Kitami, Carole L. Linster, Rejko Kruger
Summary: DJ-1 is a multifunctional protein associated with pathomechanisms of various chronic diseases, with increasing evidence suggesting its potential role in regulating cellular metabolism. Despite the incomplete understanding of its physiological functions, DJ-1 has been implicated in modulating metabolic pathways. In the context of neurodegenerative diseases like Parkinson's, the metabolic effects of DJ-1 may have significant pathophysiological implications.
Article
Cell Biology
Cristina Solana-Manrique, Francisco Jose Sanz, Isabel Torregrosa, Martina Palomino-Schatzlein, Carolina Hernandez-Oliver, Antonio Pineda-Lucena, Nuria Paricio
Summary: The study investigates metabolic disturbances underlying the pathogenesis of Parkinson's disease (PD) using a Drosophila PD model. Through metabolomic analysis, the study finds that metabolic alterations are associated with PD and could potentially serve as therapeutic targets and biomarkers for the disease.
Article
Biochemistry & Molecular Biology
Bira Arumndari Nurrahma, Tu-Hsueh Yeh, Rong-Hong Hsieh, Shu-Ping Tsao, Chia-Wen Chen, Yen-Peng Lee, Chun-Hsu Pan, Hui-Yu Huang
Summary: The study suggests that mangosteen pericarp extract may delay the progression of Parkinson's disease by counteracting oxidative stress and improving gut microbiota composition.
Review
Immunology
Frida Lind-Holm Mogensen, Andrea Scafidi, Aurelie Poli, Alessandro Michelucci
Summary: Microglia are immune cells in the brain that play important roles in immune surveillance and neuroprotection. However, they can also contribute to neuroinflammation and neurotoxicity in neurodegenerative diseases like Parkinson's disease. This review focuses on the role of DJ-1, a protein encoded by the PARK7 gene, in microglia genetic programs and immunological traits. It also discusses the potential of targeting dysregulated pathways in microglia under DJ-1 deficiency as therapeutic approaches for PD, and proposes considering DJ-1 as a biomarker and using DJ-1-enhancing compounds to reduce oxidative stress and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Geriatrics & Gerontology
Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li, Zengfu Liu, Jiayun Zheng, Yunxin Wang, Hanqun Liu, Lijian Wei, Yilin Su, Yuwan Lin, Wei Dai, Zhiling Zhang, Xiang Chen, Liuyan Ding, Wenyuan Guo, Xiaoqin Zhu, Pingyi Xu, Mingshu Mo
Summary: This study established a rat model of Parkinson's disease (PD) using 6-hydroxydopamine (6-OHDA) and analyzed the lipid profile in cerebrospinal fluid (CSF) using lipidomic approaches. The results showed significant effects of 6-OHDA on behavior, dopaminergic neurons, and lipid composition in CSF. Specific lipid families and species exhibited fluctuations during the progression of Parkinson's disease and were correlated with behavioral and pathological changes in the midbrain.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Letter
Clinical Neurology
Suleyman Guler, Tugce Gul, Sukran Guler, Maja C. Haerle, A. Nazli Basak
Summary: A Turkish family was identified with a large deletion in the DJ-1 and TNFRSF9 genes, raising the possibility of TNFRSF9 being a disease modifier in Parkinson's disease patients with DJ-1 mutations.
MOVEMENT DISORDERS
(2021)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The article by Lei Jiang et al. titled "PKM2 overexpression protects against 6-hydroxydopamine-induced cell injury in the PC12 cell model of Parkinson's disease via regulation of the brahma-related gene 1/STAT3 pathway" has been retracted. The study focused on the protective effects of PKM2 against cell injury induced by 6-hydroxydopamine, through regulation of the brahma-related gene 1/STAT3 pathway.
Article
Biochemistry & Molecular Biology
Esha Sircar, Sristi Raj Rai, Mark A. Wilson, Michael G. Schlossmacher, Rajib Sengupta
Summary: Parkinson's disease is a rapidly growing neurodegenerative disorder with a strong genetic component. Aberrant S-nitrosylation of proteins like Parkin, DJ-1, and PINK1 may contribute to the pathogenesis of PD, emphasizing the importance of this post-translational modification in neuronal health.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Pharmacology & Pharmacy
Ana Carolina D. Noseda, Lais S. Rodrigues, Adriano D. S. Targa, Jessica L. Ilkiw, Juliane Fagotti, Patricia D. dos Santos, Erika Cecon, Regina P. Markus, Michele Solimena, Ralf Jockers, Marcelo M. S. Lima
Summary: Melatonin MT2 receptors in the glomerular layer are implicated in depressive-like behaviors and olfactory function impairment associated with Parkinson's disease, as demonstrated in a rat model using 6-OHDA-induced lesions. The activation of these receptors by melatonin and specific drugs shows potential for treating non-motor symptoms in PD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Suwei Chen, Sarah J. Annesley, Rasha A. F. Jasim, Paul R. Fisher
Summary: Studies have shown that oxidative stress and DJ-1 loss are AMPK-dependent and affect mitochondrial respiration and phagocytosis in Dictyostelium cells, ultimately impacting phototaxis, morphogenesis, and growth.
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Behavioral Sciences
Bita Firouzan, Farideh Iravanpour, Fatemeh Abbaszadeh, Valery Akparov, Jalal Zaringhalam, Rasoul Ghasemi, Nader Maghsoudi
Summary: This study investigated the effect of BHME on 6-OHDA-induced motor anomalies. Results showed that BHME prevented motor dysfunction and DA cell death following 6-OHDA injection, which was accompanied by an enhancement in Akt activity, decrement of P38 phosphorylation, and reduction in Bax/Bcl-2 ratio.
BEHAVIOURAL BRAIN RESEARCH
(2023)