Article
Neurosciences
Xuhui Ge, Wu Ye, Yufeng Zhu, Min Cui, Jiawen Zhou, Chenyu Xiao, Dongdong Jiang, Pengyu Tang, Jiaxing Wang, Zhuanghui Wang, Chengyue Ji, Xuhui Zhou, Xiaojian Cao, Wei Liu, Weihua Cai
Summary: RNA N6-methyladenosine (m6A) modification plays an important role in spinal cord injury (SCI). Increased m6A level and upregulated METTL3 in reactive astrocytes are observed after SCI. The USP1/UAF1 complex stabilizes METTL3 by removing its K48-linked ubiquitination. Conditional knockout of astrocytic METTL3 suppresses reactive astrogliosis after SCI, leading to detrimental effects on functional recovery. METTL3 selectively methylates the YAP1 transcript and maintains its stability in an IGF2BP2-dependent manner. Overexpression of YAP1 partly reverses the effects of METTL3 knockout on functional recovery after SCI. Additionally, METTL3's methyltransferase activity is essential for reactive astrogliosis and motor repair.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Adnan Hassan Tahir, Jia-Jia Li, Yong Tang
Summary: Visceral hypersensitivity (VH) is a significant characteristic feature of gastrointestinal disorders, and treatment efficacy is limited. Electro-acupuncture (EA) is a popular secondary therapy with fewer side effects for managing VH, but the underlying mechanisms still require further exploration.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Jacek M. Kwiecien, Wojciech Dabrowski, Jordan R. Yaron, Liqiang Zhang, Kathleen H. Delaney, Alexandra R. Lucas
Summary: Massive spinal cord trauma leads to complex pathological events, forming a spinal cord cavity and causing persistent inflammatory response, ultimately resulting in neurological deficits.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Cell Biology
Ciro De Luca, Assunta Virtuoso, Sohaib Ali Korai, Raffaella Cirillo, Francesca Gargano, Michele Papa, Giovanni Cirillo
Summary: The maladaptive response of the central nervous system following nerve injury is primarily linked to the activation of glial cells that produce an inflammatory reaction and remodeling. Glial acidic fibrillary protein (GFAP) is significantly upregulated in the spinal cord after nerve injury and may play a crucial role in neuroinflammation and morpho-functional-metabolic rewiring. Understanding the maladaptive changes in glial cells could open up new avenues for studying CNS diseases.
Article
Neurosciences
Yin Hongna, Tian Hongzhao, Li Quan, Feng Delin, Liu Guijun, Lv Xiaolin, Guan Fulin, Sun Zhongren
Summary: The study demonstrated that Jia-Ji electro-acupuncture treatment could improve hind limb motor function in SCI rats by enhancing autophagy flux and inhibiting necroptosis, providing potential therapeutic targets for spinal cord injury.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Kunpeng Jiang, Yulin Sun, Xinle Chen
Summary: Spinal cord injury (SCI) is a common cause of disability and death worldwide, causing severe physical and mental injury to patients. Acupuncture, as a traditional therapy, has a positive effect on promoting the recovery of SCI. It can provide neuroprotection through multiple mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Yi Huang, Kelin He, Dandan Fang, Fengjia Ni, Bei Qiu, Kang Liang, Ruijie Ma
Summary: This study analyzed the quantity and quality of publications related to acupuncture for spinal cord injury (SCI). The findings suggest that research on acupuncture for SCI is still flourishing, especially in the area of electroacupuncture for promoting nerve repair and regeneration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tim Vangansewinkel, Stefanie Lemmens, Assia Tiane, Nathalie Geurts, Dearbhaile Dooley, Tim Vanmierlo, Gunnar Pejler, Sven Hendrix
Summary: In this study, researchers investigated the therapeutic potential of recombinant mMCP6 in improving functional outcomes after spinal cord injury. The findings suggest that mMCP6 can enhance recovery by reducing astrogliosis and promoting (re)myelination in the injured spinal cord.
Review
Neurosciences
Yuan-Shan Zeng, Ying Ding, Hao-Yu Xu, Xiang Zeng, Bi-Qin Lai, Ge Li, Yuan-Huan Ma
Summary: The incidence and disability rate of spinal cord injury (SCI) are high worldwide. Traditional Chinese medicine technique Governor Vessel electro-acupuncture (GV-EA) has been found to improve the microenvironment of injured spinal cord, and adult stem cell transplantation has potential for reconnecting severed spinal cord tissue and restoring motor and sensory functions. However, no single treatment approach has proven satisfactory, and combining different treatments may be more promising.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Lucia Machova Urdzikova, Veronika Cimermanova, Kristyna Karova, Jose Dominguez, Katerina Stepankova, Michaela Petrovicova, Katerina Havelikova, Chirag D. Gandhi, Meena Jhanwar-Uniyal, Pavla Jendelova
Summary: Spinal cord injury (SCI) is a devastating condition with physical and psychological consequences. The study found that both EGCG and PP242 significantly improved sensory/motor functions in SCI, with EGCG appearing to be more effective. The results demonstrate the effectiveness of EGCG and PP242 in suppressing mTOR pathways and promoting recovery from SCI in rats.
Article
Immunology
Fei Yao, Yang Luo, Yan-Chang Liu, Yi-Hao Chen, Yi-Teng Li, Xu-Yang Hu, Xing-Yu You, Shui-Sheng Yu, Zi-Yu Li, Lei Chen, Da-Sheng Tian, Mei-Ge Zheng, Li Cheng, Jue-Hua Jing
Summary: The study reveals that the crosstalk between microvascular endothelial cells and pericytes promotes the transition of pericytes into fibroblasts through the PDGF-BB/PDGFR beta signaling pathway. Blocking the PDGF-BB/PDGFR beta pathway contributes to functional recovery, fibrotic scar formation, and inflammatory attenuation after SCI, providing a potential target for SCI treatment.
INFLAMMATION AND REGENERATION
(2022)
Article
Oncology
Xinyi Zhang, Hailiang Xu, Lei Zhu, Dageng Huang, Lingbo Kong, Zhiyuan Wang, Fang Tian, Botao Lu, Weidong Wu, Chao Jiang, Youjun Liu, Chengwen Wang, Shuaijun Jia, Yongliang Li, Minyi Yang, Xifang Liu, Dingjun Hao
Summary: Electro-acupuncture (EA) stimulation can protect the motor endplate, reduce muscle atrophy, improve electrophysiological function, and promote axon regeneration in rats with spinal cord injury (SCI).
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Neurosciences
Wei Liu, Xuhui Ge, Zheng Zhou, Dongdong Jiang, Yuluo Rong, Jiaxing Wang, Chengyue Ji, Jin Fan, Guoyong Yin, Weihua Cai
Summary: Reactive astrogliosis is a pathological feature of spinal cord injury, and USP18 plays a crucial role in this process by stabilizing SOX9. Activation of the Hedgehog signaling pathway induces USP18 expression, further impacting reactive astrogliosis.
Article
Biochemistry & Molecular Biology
Purva P. Nagarajan, Muhibullah S. Tora, Stewart G. Neill, Thais Federici, Pavlos Texakalidis, Anthony Donsante, Peter Canoll, Kecheng Lei, Nicholas M. Boulis
Summary: Intramedullary spinal cord tumors are rare and difficult to study, but using a combination of gene knockdowns, researchers were able to induce high-grade glioma development in spinal cords in minipigs. This study evaluated the efficiency of different lentiviral vector combinations in producing high-grade spinal cord gliomas in rats. Different vector combinations resulted in varying tumor growth rates and characteristics, with the triple cocktail of PDGF-B, HRAS, and sh-p53 showing the most significant tumor growth and proliferation. These findings suggest that the rat model of spinal cord glioma could be a valuable tool for evaluating therapeutic strategies in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Hongfeng Hu, Hui Wang, Wei Liu
Summary: The combination of ganglioside and Jiaji electroacupuncture has been shown to improve nerve function recovery in SCI rats, possibly through inhibiting the expression of proinflammatory cytokines and the Nogo-NgR signal pathway.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)