Article
Peripheral Vascular Disease
Wei Ying, Kechun Tang, Ennio Avolio, Jan M. Schilling, Teresa Pasqua, Matthew A. Liu, Hongqiang Cheng, Hong Gao, Jing Zhang, Sumana Mahata, Myung S. Ko, Gautam Bandyopadhyay, Soumita Das, David M. Roth, Debashis Sahoo, Nicholas J. G. Webster, Farah Sheikh, Gourisankar Ghosh, Hemal H. Patel, Pradipta Ghosh, Geert van den Bogaart, Sushil K. Mahata
Summary: The study demonstrates that CST plays a key role in attenuating cardiac inflammation in hypertension by reducing macrophage inflammation to alleviate disease symptoms.
Article
Biochemistry & Molecular Biology
Marko Kumric, Josip Vrdoljak, Goran Dujic, Daniela Supe-Domic, Tina Ticinovic Kurir, Zeljko Dujic, Josko Bozic
Summary: This study found that serum catestatin levels were higher in patients with primary hypertension (PH), especially in the untreated subgroup. Serum catestatin levels were associated with ambulatory blood pressure and arterial stiffness, suggesting a role for this peptide in PH.
Review
Medicine, Research & Experimental
Yasmina Bourebaba, Malwina Mularczyk, Krzyzstof Marycz, Lynda Bourebaba
Summary: Metabolic Syndrome consists of obesity, lipodystrophy, diabetes, and hypertension, which can lead to cardiovascular disease development. Catestatin, a bioactive peptide, plays a significant role in regulating insulin and lipid levels, blood pressure, and cardiac function.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ran Wei, Qiushuang Wu, Nana Ai, Lei Wang, Mei Zhou, Chris Shaw, Tianbao Chen, Richard Dequan Ye, Wei Ge, Shirley W. I. Siu, Hang Fai Kwok
Summary: A novel Vasostatin-1-derived peptide (V1DP) was synthesized with inhibitory effects on cancer cell proliferation, cell migration, and angiogenesis. The peptide acts by inhibiting the VEGFR signaling pathway, as confirmed through docking simulations and free energy calculations.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Suborno Jati, Sumana Mahata, Soumita Das, Saurabh Chatterjee, Sushil K. Mahata
Summary: The increase in drug-resistant and multidrug-resistant infections is a global health crisis. Antimicrobial peptides (AMPs) have the potential to be alternatives for antibiotic-resistant superbugs. In particular, Catestatin (CST) and its derivatives, such as bCST(1-15) and D-bCST(1-15), have shown effective antimicrobial effects without triggering resistance or eliciting cytokine release. This review highlights their antimicrobial effects, evolutionary conservation, and potential as therapies for antibiotic-resistant superbugs.
Article
Biochemistry & Molecular Biology
Josko Bozic, Marko Kumric, Tina Ticinovic Kurir, Hrvoje Urlic, Dinko Martinovic, Marino Vilovic, Nada Tomasovic Mrcela, Josip A. Borovac
Summary: Cardiovascular diseases account for a significant portion of global mortality, with traditional mechanistic explanations being questioned and the dysregulation of the sympathetic nervous system emerging as a key player in their pathophysiology.
Review
Biochemistry & Molecular Biology
Richa Garg, Arun Agarwal, Roshan Katekar, Shailesh Dadge, Shubhi Yadav, Jiaur R. Gayen
Summary: Chromogranin A (ChgA) is an acidic pro-protein that plays a diverse role in regulating cardiovascular functions, metabolism, and inflammation. Proteolytic processing of ChgA gives rise to biologically active peptides such as PST and CST, which have significant impacts on carbohydrate and lipid metabolism. The tissue-specific effects of these peptides in rodent models reveal their importance in metabolic syndrome and related diseases.
Article
Ecology
Pamela Gonzalez-Davila, Markus Schwalbe, Arpit Danewalia, Boushra Dalile, Kristin Verbeke, Sushil K. Mahata, Sahar El Aidy
Summary: The gut epithelium secretes antimicrobial peptides to control the action of gut microbes, and the microbes have evolved antimicrobial resistance mechanisms. This study found that the antimicrobial peptide CST can affect the diversity and composition of the gut microbiota, and it is related to the production of short-chain fatty acids by the microbiota. In addition, the study also found that a certain bacterium can degrade CST, and the gene abundance is higher in patients with Crohn's disease.
Article
Medical Laboratory Technology
Giuseppe Pinto, Barbara Colombo, Adriano Autieri, Luca Foppoli, Roberto Spoladore, Valentina Ardizzone, Alberto Margonato, Angelo Corti, Gabriele Fragasso
Summary: In patients with chronic systolic heart failure, vasostatin-1 and chromogranin A may serve as prognostic markers for cardiovascular events, providing complementary information to NT-proBNP and age, distinct from the association with left ventricular ejection fraction.
CLINICA CHIMICA ACTA
(2022)
Article
Medicine, General & Internal
Pilar Palmrich, Nawa Schirwani-Hartl, Christina Haberl, Peter Haslinger, Florian Heinzl, Harald Zeisler, Julia Binder
Summary: Decreased serum catestatin levels are associated with the development of preeclampsia. Further research on the diagnostic and therapeutic role of catestatin in preeclampsia is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Pingshan Wang, Wei Wang, Xingxing Peng, Fugui Ruan, Shiyao Yang
Summary: This study discussed the effects of transfection using VS-1 nanocarriers on the formation of abdominal aortic aneurysm (AAA) and analyzed its mechanism. The results showed that VS-1 nanoparticles could inhibit the formation of AAA by activating the AMPK/mTOR signaling pathway.
Article
Immunology
Francis Schneider, Pierrick Le Borgne, Jean-Etienne Herbrecht, Francois Danion, Morgane Solis, Sophie Helle, Cosette Betscha, Raphael Clere-Jehl, Francois Lefebvre, Vincent Castelain, Yannick Goumon, Marie-Helene Metz-Boutigue
Summary: Neuroendocrine cells release Catestatin (CST) from Chromogranin A (CgA) to regulate stress responses, and COVID patients with higher plasma CST levels may have an increased risk of in-hospital mortality. The study suggests that plasma CST could be a potential biomarker for predicting outcomes in COVID patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Petra Simac, Dijana Perkovic, Ivona Bozic, Marijana Matijas, Katarina Gugo, Dinko Martinovic, Josko Bozic
Summary: This study found that serum CST levels were significantly higher in patients with RA compared to healthy subjects. CST was correlated with patient age, disease activity, and disease duration. Linear regression analysis showed that serum CST levels were significantly associated with disease duration and disease activity in RA.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
V Andreasi, S. Partelli, M. F. Manzoni, F. Muffatti, L. Di Filippo, S. Crippa, A. Corti, M. Falconi
Summary: VS-1 is a more accurate biomarker than total-CgA for assessing the effectiveness of surgical resection in NF-PanNETs. PST and VS-2 have no clinical utility in this setting.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Immunology
Elke M. Muntjewerff, Gustaf Christoffersson, Sushil K. Mahata, Geert van den Bogaart
Summary: Catestatin (CST) is produced by macrophages and can exert anti-inflammatory and antiadrenergic effects. It is associated with chronic inflammation and could be a candidate target for treating certain inflammatory diseases.
TRENDS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Shu-Han Liu, Yang Du, Lei Chen, Yong Cheng
Summary: This review provides an overview of the structural changes of glial cells in major psychiatric diseases such as schizophrenia, bipolar disorder, and major depressive disorder. The findings suggest that astrocytes, microglial cells, and oligodendrocytes exhibit specific patterns of changes in each disease.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Yang Du, Ji-Hui Dong, Lei Chen, Hua Liu, Guang-En Zheng, Guang-Yang Chen, Yong Cheng
Summary: This study reveals the potential role of exosomal metabolite dysregulation in the onset and/or development of bipolar disorder (BD) and suggests that blood exosomal metabolites are strong candidates to inform the diagnosis of BD.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Psychiatry
Lin-Shuai Hao, Yang Du, Lei Chen, Yu-Guo Jiao, Yong Cheng
Summary: The present study conducted a systematic review with meta-analysis to compare peripheral blood BDNF levels between patients with OCD and healthy controls. The results showed that patients with OCD had significantly decreased peripheral blood levels of BDNF compared to the healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Neurosciences
Yang-wen Ai, Yang Du, Lei Chen, Shu-Han Liu, Qing-shan Liu, Yong Cheng
Summary: This study systematically reviewed the connection between brain inflammation markers and schizophrenia, bipolar disorder, and major depressive disorder. The results showed significant variations in the expression of inflammatory markers in these disorders, possibly influenced by various factors.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Hua Liu, Shan Lan, Xiao-Jie Shi, Fang-Cheng Fan, Qing-Shan Liu, Lin Cong, Yong Cheng
Summary: MicroRNAs (miRNAs) play a crucial role in the development of neurodegenerative disorders, particularly amyotrophic lateral sclerosis (ALS). Through a comprehensive systematic review and meta-analysis, the study identified elevated levels of miR-206, miR-133b, and miR-338-3p in patients with ALS compared to healthy controls. These findings suggest that miR-206, miR-133b, and miR-338-3p may serve as potential promising biomarkers for ALS, indicating their importance in the pathogenesis and progression of the disease.
BRAIN RESEARCH BULLETIN
(2023)
Article
Psychiatry
Xiao-Lin Zhong, Yang Du, Lei Chen, Yong Cheng
Summary: This paper reviews the functional roles and abnormal expression of long noncoding RNAs (lncRNAs) in the development, diagnosis, and treatment of depression, suggesting that lncRNAs may serve as biomarkers and potential therapeutic targets for depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Fan Luo, Zimo Zhu, Yang Du, Lei Chen, Yong Cheng
Summary: Postpartum depression is a serious mood disorder that occurs after childbirth and can have lifelong consequences for women and their families. It is influenced by various risk factors, including environmental and genetic factors. Gene-environment interactions play a role in postpartum depression, as evidenced by studies on genes related to neurotransmitters, the HPA axis, and the kynurenine pathway. However, the conclusions regarding these risk factors, especially genetic factors, are not consistent, and further research is needed to understand the heritability and susceptibility of postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yang Du, Lei Chen, Mei-Chen Yan, Yan-Li Wang, Xiao-Lin Zhong, Chen-Xi Xv, Yao-Bo Li, Yong Cheng
Summary: A meta-analysis of 54 studies revealed that patients with autism spectrum disorders (ASDs) have altered levels of neurometabolites in specific brain regions compared to healthy controls. Lower levels of N-acetyl-aspartate-containing compound (NAA), choline-containing compound (Cho), and NAA/(creatine-containing compound) Cr ratios in the gray matter, as well as lower levels of NAA and glutamate + glutamine (Glx) in the white matter, were observed in ASD patients. Additionally, the frontal cortex showed decreased NAA and gamma-aminobutyric acid (GABA) levels, NAA/Cr ratios, and increased glutamate (Glu) levels. These findings suggest that neurometabolite alterations in specific brain regions are associated with ASD, and age is a confounding factor for certain neurometabolite levels in patients with ASD.
MOLECULAR PSYCHIATRY
(2023)
Review
Behavioral Sciences
Heng-Chang Zhang, Yang Du, Lei Chen, Zeng-Qiang Yuan, Yong Cheng
Summary: Schizophrenia-related symptoms, including positive, negative, and cognitive symptoms, have serious effects on public health, affecting approximately 1% of the population. Recent studies have shown that besides the traditional dopaminergic pathway, the etiology of schizophrenia involves neuronal networks such as glutamate, GABA, serotonin, BDNF, oxidative stress, inflammation, and the immune system. MicroRNAs (miRNAs), small noncoding RNA molecules, have been identified as potential factors in the pathophysiology of schizophrenia, influencing these systems. Understanding how changes in miRNAs affect critical signaling pathways could lead to improved approaches in treating and diagnosing schizophrenia.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Fang-Cheng Fan, Yang Du, Wen-Hui Zheng, Y. Peng Loh, Yong Cheng
Summary: This study demonstrates that conditional knockout of neuronal CPE leads to learning and memory deficits, hippocampal and amygdala degeneration, and reduced neurogenesis in mice.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Mulan Bao, Rengui Bade, Hua Liu, Battseren Tsambaa, Guo Shao, Almaz Borjigidai, Yong Cheng
Summary: AS-IV from Huangqi may regulate inflammation and microglial activation in AD via EGFR-dependent pathways. EGFR and IL-113 could be important targets that co-regulate downstream molecular functions in the treatment of AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hua Liu, Yang Du, Lian Lin Liu, Qing Shan Liu, He Hui Mao, Yong Cheng
Summary: This study evaluated the neuroprotective and anti-depressive effects of Mogroside V (MGV), the main component of Siraitia grosvenorii (SG) extract, both in vitro and in vivo. MGV demonstrated a protective effect on PC12 cells with corticosterone-induced injury and relieved depressive symptoms in the chronic unpredictable mild stress (CUMS) depression model. Additionally, MGV significantly reduced inflammatory and oxidative stress levels, and decreased apoptosis in hippocampal nerve cells through the inhibition of the BDNF/TrkB/AKT pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Lei Chen, Qiang Fu, Yang Du, Zhong-Yong Jiang, Yong Cheng
Summary: Autism spectrum disorders (ASD) are a complex group of neurodevelopmental disorders caused by genetic and environmental factors. This study investigated gene expression abnormalities in the hippocampus and prefrontal cortex of a rat model of ASD, and found significant differences in gene expression between the ASD model and control groups. Additionally, a negative regulatory network of miRNAs-mRNAs was identified, which may play a key role in the development of ASD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychiatry
Qiang Fu, Rui Qiu, Lei Chen, Yuewen Chen, Wen Qi, Yong Cheng
Summary: This study provides the first evidence that listening to music can prevent stress-induced depression and anxiety-like behaviors in mice. The results show that music restores serum corticosterone levels and prevents oxidative stress, inflammation, and neurotrophic factor deficits in the mouse brain.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Plant Sciences
Xiao-Jie Shi, Yang Du, Lei Chen, Yuan-Yuan Chen, Man Luo, Yong Cheng
Summary: The Mongolian medicine Nuangong Qiwei Pill (NGQW) is a folk prescription used for gynecological diseases. This study aimed to investigate the mechanism of NGQW and macelignan in treating polycystic ovary syndrome (PCOS). The results showed that NGQW and macelignan regulate the secretion ability of ovarian granulosa cells through the TGF-β3/Smad/Cyp19a1 signaling pathway, thus treating PCOS.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)