Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Review
Behavioral Sciences
Maxime Levesque, Giuseppe Biagini, Marco de Curtis, Vadym Gnatkovsky, Julika Pitsch, Siyan Wang, Massimo Avoli
Summary: Research on the mechanisms of focal epileptic discharges in mesial temporal lobe epilepsy (MTLE) often utilizes rodent models induced by pilocarpine, revealing specific neuronal events during latent and chronic states, as well as the effects of optogenetic activation on spontaneous seizures.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Cell Biology
Bridget Martinez, Philip V. Peplow
Summary: Temporal lobe epilepsy is a common form of epilepsy in adults, with symptoms greatly affected by age and brain development. Diagnosis relies on clinical examination, patient history, electroencephalographic recordings, and brain imaging. Potential biomarkers for temporal lobe epilepsy have been found in body fluids and brain tissues, but further research is needed to understand the impact of anti-epileptic drugs.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Barbara Guerra Leal, Aurora Barros-Barbosa, Fatima Ferreirinha, Joao Chaves, Rui Rangel, Agostinho Santos, Claudia Carvalho, Ricardo Martins-Ferreira, Raquel Samoes, Joel Freitas, Joao Lopes, Joao Ramalheira, Maria Graca Lobo, Antonio Martins da Silva, Paulo P. Costa, Paulo Correia-de-Sa
Summary: P2X7R overexpression in nerve terminals of MTLE-HS patients is associated with seizures, glial cell activation, cytokines production, GABAergic rundown, and unrestrained glutamatergic excitation. Furthermore, miR-22 serum levels are diminished, especially in patients requiring multiple AED regimens.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ravi S. Nunna, Alireza Borghei, Bledi C. Brahimaj, Fiona Lynn, Diego Garibay-Pulido, Richard W. Byrne, Marvin A. Rossi, Sepehr Sani
Summary: Bilateral hippocampus-sparing implantation of RNS depth leads in patients with medically refractory bilateral MTLE showed a reduction in overall seizure frequency, with some patients achieving a 50% responder rate and even complete seizure freedom in certain cases. Larger controlled studies with longer follow-up are needed to further validate these findings.
Article
Clinical Neurology
Arthur Cukiert, Cristine Mella Cukiert, Jose Augusto Burattini, Pedro Paulo Mariani
Summary: The study investigated the outcomes of hippocampal deep brain stimulation (Hip-DBS) in patients with refractory temporal lobe epilepsy. The findings showed that Hip-DBS significantly reduced seizure frequency in patients with both focal aware and focal with impaired awareness seizures, suggesting it as a promising therapeutic option for patients who are not suitable for resective surgery.
Article
Clinical Neurology
Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi, Jafar Mehvari-Habibabadi, Roya Sharifpour, Bahram Mohajer, Neda Mohammadi-Mobarakeh, Seyed Sohrab Hashemi-Fesharaki, Kost Elisevich, Mohammad-Reza Nazem-Zadeh
Summary: The study demonstrates distinct patterns of hippocampal subfield atrophy in patients with left and right mesial temporal lobe epilepsy (mTLE), suggesting that the pathophysiology of epileptogenesis in left and right mTLE may be different.
NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Ning Chen, Jian-Guo Zhang, Chun-Lei Han, Fan-Gang Meng
Summary: This study systematically elucidated the molecular mechanisms underlying seizure suppression induced by hip-DBS in a macaque model of mTLE. Chronic hip-DBS modulated hippocampal gene expression, affecting pathways related to focal adhesion and extracellular matrix-receptor interaction. The findings suggest that hip-DBS could reverse abnormal gene expression in mTLE and lay the groundwork for further investigation into the regulatory mechanisms of DBS for this condition.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Rong Li, Chijun Deng, Xuyang Wang, Ting Zou, Bharat Biswal, Danni Guo, Bo Xiao, Xiaonan Zhang, Jing Liang Cheng, Ding Liu, Mi Yang, Huafu Chen, Qian Wu, Li Feng
Summary: This study reveals the patterns of brain network dynamic alterations in patients with mesial temporal lobe epilepsy (mTLE) and establishes a predicted model for seizure recurrence during interictal periods. The results show that mTLE patients have a higher dynamic network, with switching mainly in the epileptogenic regions. The dynamic network configuration in mTLE is characterized by decreased recruitment and increased integration among hippocampal systems and large-scale higher-order brain networks. The study also highlights the robust association between predicted seizure frequency based on the hippocampal-default-mode network (DMN) dynamics model and actual seizure frequency.
Review
Pharmacology & Pharmacy
Angelica Vega-Garcia, Rosalinda Guevara-Guzman, Omar Garcia-Gomez, Iris Feria-Romero, Francisca Fernandez-Valverde, Mario Alonso-Vanegas, Sandra Orozco-Suarez
Summary: Epilepsy is a common chronic neurological disease that affects approximately 65 million people worldwide. Mesial temporal lobe epilepsy (mTLE) is the most common type, characterized by focal seizures that originate in the hippocampus. Approximately 40% of mTLE patients develop drug resistance. This review explores the compensatory mechanisms activated in response to neurological damage caused by epileptic seizures, as well as factors that may affect the formation of inappropriate connections.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Clinical Neurology
Mani Ratnesh S. Sandhu, Benjamin F. Gruenbaum, Shaun E. Gruenbaum, Roni Dhaher, Ketaki Deshpande, Melissa C. Funaro, Tih-Shih W. Lee, Hitten P. Zaveri, Tore Eid
Summary: Glutamine synthetase (GS) in astrocytes plays a crucial role in epilepsy, with deficiency or dysfunction linked to various types of seizures. Experimental studies have shown that inhibition or deletion of GS in animals can lead to a syndrome resembling mesial temporal lobe epilepsy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Gavin J. B. Elias, Juergen Germann, Clemens Neudorfer, Andrew A. Namasivayam, Aaron Loh, Robert M. Gramer, George M. Ibrahim, Taufik Valiante, Jennifer C. Tomaszczyk, Mary Pat McAndrews, Walter Kucharczyk, Alexandre Boutet, Andres M. Lozano
Summary: Surgical resection can reduce seizure frequency in medically intractable temporal lobe epilepsy, but its effects on brain circuitry are poorly understood. This study found volume reductions in the contralesional hippocampus and bilateral mammillary bodies after surgery, as well as significant changes in cortical thickness across the brain. Postoperative verbal memory function was associated with cortical thickness changes in specific brain regions.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Elena A. Filimonova, Anton A. Pashkov, Galina I. Moysak, Anastasia Y. Tropynina, Svetlana Y. Zhanaeva, Anna A. Shvaikovskaya, Anna A. Akopyan, Konstantin V. Danilenko, Lyubomir I. Aftanas, Maria A. Tikhonova, Jamil A. Rzaev
Summary: Mesial temporal lobe epilepsy is a common focal epilepsy type that imposes a significant burden on the global healthcare system. Drug-resistant subjects account for approximately one-third of patients who do not respond well to pharmacotherapy. This study aimed to investigate the relationship between hippocampal and serum levels of BDNF and hippocampal subfield volumes in drug-resistant mesial temporal epilepsy patients undergoing neurosurgical treatment. The findings suggest a proepileptic nature of BDNF effects in the hippocampus and related structures.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Kristina D. Yakovleva, Diana V. Dmitrenko, Iulia S. Panina, Anna A. Usoltseva, Kirill A. Gazenkampf, Olga V. Konovalenko, Elena A. Kantimirova, Maxim A. Novitsky, Regina F. Nasyrova, Natalia A. Shnayder
Summary: This article systematically analyzes the role of miRs in the development of mesial TLE (mTLE) and provides an update on the existing knowledge about the biomarkers of this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jonas Christian Bruder, Kathrin Wagner, Daniel Lachner-Piza, Kerstin Alexandra Klotz, Andreas Schulze-Bonhage, Julia Jacobs
Summary: This study aimed to investigate the relationship between mesial-temporal spindle-ripples and memory performance. The study found that all ripple rates were significantly higher in seizure onset zone channels. Patients with pre-surgical verbal memory impairment had significantly higher overall ripple rates in the left mesial-temporal channels. There was a highly significant negative correlation between pre-surgical verbal memory performance and left mesial-temporal spike-associated ripples and overall ripples.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Bin Liu, Jinchao Wang, Guangchuan Wang, Wanli Jiang, Zhen Li, Yongjun Shi, Junyong Zhang, Qingshan Pei, Guangjun Huang, Lifen Wang, Shengqiang Zhao, Lei Wu, Mingyan Zhang, Wenwen Wang, Xiao Li, Tong Mou, Chunqing Zhang, Qian Ding
Summary: This study explores the effects of exosomal H2AFJ derived from hepatocytes on the activation of hepatic stellate cells (HSCs) and liver fibrosis. It was found that H2AFJ, released by hepatocytes through exosomes, promotes HSC migration and invasion by activating the MAPK/STMN1 signaling pathway, exacerbating liver fibrosis. Silencing H2AFJ attenuates liver fibrosis in mice, while restoration of STMN1 negates this effect. This study provides a potential therapeutic target for alleviating liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Chun-Qing Zhang, Xin Li, Gangyan Si, Pak-Kwong Chung, Zhijian Huang, Daniel F. Gucciardi
Summary: This study examined the mediating roles of experiential avoidance and cognitive fusion in the relationship between mindfulness and athlete burnout. The results showed that mindfulness had direct effects on experiential avoidance and cognitive fusion, which in turn influenced athlete burnout. These findings have important implications for reducing athlete burnout.
PSYCHOLOGY OF SPORT AND EXERCISE
(2023)
Article
Clinical Neurology
Shujing Li, Zeng He, Yang Li, Kaixuan Huang, Xiaolin Yang, Shufang Wang, Xianjun Shi, Lihong Liu, Miao Wang, Shu Xiang, Wei Wang, Jingyi Zhang, Shengqing Lv, Zhonghong Liu, Chunqing Zhang, Hui Yang, Shiyong Liu, Zhongke Wang
Summary: This study retrospectively analyzed the clinical characteristics and postsurgical seizure outcomes of 82 TSC patients, exploring the relationship between interictal epileptiform discharges (IEDs) and postsurgical outcomes. Results showed a significant association between IEDs and long-term postsurgical outcomes in TSC patients, with patients exhibiting focal, lateralized, and generalized IEDs achieving seizure freedom in the 1-year follow-up. Interestingly, patients with lateralized IEDs showed long-term seizure freedom in the 5-year and 10-year follow-ups. According to the study, IEDs may guide clinical care for TSC patients with intractable epilepsy.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Article
Gastroenterology & Hepatology
Yifu Xia, Jun Tie, Guangchuan Wang, Yuzheng Zhuge, Hao Wu, Hui Xue, Jiao Xu, Feng Zhang, Lianhui Zhao, Guangjun Huang, Mingyan Zhang, Bo Wei, Peijie Li, Wei Wu, Chao Chen, Chengwei Tang, Chunqing Zhang
Summary: This study aimed to find the optimal threshold of individualized portal pressure gradient (PPG) to balance rebleeding and overt hepatic encephalopathy. The study found that different PPG standards may be required for patients with different liver function categories. For patients in Child-Pugh class B, a PPG threshold <12 mmHg might be more suitable, while <14 mmHg might be optimal for patients in Child-Pugh class C.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Yong Lv, Wei Bai, Xuan Zhu, Hui Xue, Jianbo Zhao, Yuzheng Zhuge, Junhui Sun, Chunqing Zhang, Pengxu Ding, Zaibo Jiang, Xiaoli Zhu, Weixin Ren, Yingchun Kewei LiZhang, Wenguang Zhang, Kai Li, Zhengyu Wang, Bohan Luo, Xiaomei Li, Jie Yuan, Zhiping Yang, Wengang Guo, Dongdong Xia, Huahong Xie, Changbing Yang, Yanglin Pan, Zhanxin Yin, Daiming Fan, Guohong Han
Summary: This study aimed to assess the impact of portal vein thrombosis (PVT) on the outcomes of cirrhotic patients with acute variceal bleeding (AVB). The results showed that, compared to patients without PVT, patients with PVT had a similar risk of mortality, further bleeding, and new or worsening ascites after standard treatment.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Mingyan Zhang, Haijun Mou, Guangchuan Wang, Ping Li, Derun Kong, Senlin Li, Qian Feng, Ruonan Sun, Jinming Yan, Guangjun Huang, Yongjun Shi, Biguang Tuo, Chunqing Zhang
Summary: This study compared the clinical outcomes of clip-assisted endoscopic cyanoacrylate injection (clip-ECI) to conventional endoscopic cyanoacrylate injection (con-ECI) for the treatment of gastric varices (GVs) with a gastrorenal shunt. The results showed that clip-ECI was more effective than con-ECI, requiring fewer treatment sessions and achieving a lower 6-month rebleeding rate.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Guang-Chuan Wang, Guang-Jun Huang, Chun-Qing Zhang, Qian Ding
Summary: In this case, a histopathological diagnosis of pancreatic neuroendocrine neoplasm (G2) was obtained by performing a percutaneous transportal biopsy using a gastroscope biopsy forceps. This method appears to be a safe and effective way to obtain a pathological diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Neurosciences
Junjie Huang, Susu Liang, Longhui Li, Xingyi Li, Xiang Liao, Qianshuo Hu, Chunqing Zhang, Hongbo Jia, Xiaowei Chen, Meng Wang, Ruijie Li
Summary: Quantitative and mechanistic understanding of learning and long-term memory at the level of single neurons in living brains require highly demanding techniques, specifically the precise labeling of one cell and investigation of dendritic inputs through the learning process.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Editorial Material
Psychology, Multidisciplinary
Navin Kaushal, Chun-Qing Zhang, Cleoputri Yusainy
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Applied
Chun-Qing Zhang, Ru Zhang, Pak-Kwong Chung, Yanping Duan, Joseph Tak Fai Lau, Derwin King Chung Chan, Martin S. Hagger
Summary: This study examined the efficacy of a theory-based telephone-delivered intervention in promoting compliance with influenza preventive behaviors among older adults in Hong Kong. The results showed that participants in the motivational + volitional intervention group had improved preventive behaviors 3 months post-intervention, but no significant difference was observed at 6 and 12 months post-intervention compared to the control group.
APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
(2023)
Article
Psychology, Multidisciplinary
Martin S. S. Hagger, Kyra Hamilton, Daniel J. J. Phipps, Cleo Protogerou, Chun-Qing Zhang, Laura Girelli, Luca Mallia, Fabio Lucidi
Summary: In a meta-analysis, the researchers aimed to estimate the size and variability of habit-behavior and intention-behavior relations while investigating theory-consistent moderators. They found that habit and intention independently predicted behavior, with habit partially mediating past-future behavior relations. Larger habit-behavior relations were observed in studies targeting behaviors with high habit formation opportunity and lower complexity. The findings support and extend previous research on habit and its measures.
MOTIVATION SCIENCE
(2023)
Article
Neurosciences
Qing-Tian Duan, Lu Dai, Lu-Kang Wang, Xian-Jun Shi, Xiaowei Chen, Xiang Liao, Chun-Qing Zhang, Hui Yang
Summary: Memory performance evaluation has traditionally relied on behavioral tests, but the neural correlates, particularly in humans, have been unclear. In this study, we used intracranial electroencephalography in patients with refractory epilepsy to investigate the neural correlates of memory performance. We found that hippocampal ripples increased during visual stimulation or before verbal recall, and this increase was positively correlated with memory performance. On the other hand, memory performance was negatively correlated with hippocampal interictal epileptic discharges or epileptic ripples during the memory task. However, these correlations were not present during quiet wakefulness. Thus, our findings reveal the neural correlates of memory performance beyond traditional behavioral tests.
Article
Sport Sciences
Ru Zhang, Chun-Qing Zhang, Dacheng Gu
Summary: This study aimed to investigate the associations between perceived physical environments, constructs of the theory of planned behavior (TPB), habit strength, and adherence to 24-h movement guidelines in Chinese adolescents. The findings showed that attitude, subjective norm, and perceived behavioral control had direct effects on intention, and intention had a direct effect on the number of guidelines being met. Habit strength was a significant predictor of adherence to the guidelines.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Geriatrics & Gerontology
Ming Yu Claudia Wong, Palash Karmakar, Mezna A. Almarzooqi, Ryan E. Rhodes, Chun-Qing Zhang, Kai-ling Ou, Duan Yanping, Pak Kwong Chung, Nouf A. Alghamdi
Summary: This study aims to compare the effects of supervised group-based walking and non-supervised individual-based walking interventions on frailty, cognitive function, and quality of life among inactive older adults in Saudi Arabia.
Article
Psychology, Clinical
Palash Karmakar, Ming-Yu (Claudia) Wong, Mezna A. Almarzooqi, Nouf Alghamdi, Kailing Ou, Yanping Duan, Ryan E. Rhodes, Chun-Qing Zhang
Summary: This study compared the effects of supervised group-based intervention and non-supervised individual-based intervention on frailty syndrome, cognitive functions, and health-related quality of life among sedentary older adults in Saudi Arabia. The results showed that walking intervention significantly improved participants' physical function, health-related quality of life, and cognitive function.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2023)
