Article
Neurosciences
Zuo-Teng Wang, Yan Fu, Shi-Dong Chen, Yu-Yuan Huang, Ya-Hui Ma, Yan-Jiang Wang, Lan Tan, Jin-Tai Yu
Summary: This study is the first to identify significant associations between TREM1 rs2062323 and AD risk. The rs2062323T may be involved in AD by regulating the expression of TREM1, TREML1, TREM2, and sTREM2. The TREM family is expected to be a potential therapeutic target for AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Sanjay Arora, Buddhadev Layek, Jagdish Singh
Summary: This study demonstrated efficient brain-targeted delivery of ApoE2 gene therapy using surface-modified liposomes, with significantly higher ApoE2 expression in neurons and potential for effective AD treatment.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
David Vogrinc, Milica Gregoric Kramberger, Andreja Emersic, Sasa Cucnik, Katja Goricar, Vita Dolzan
Summary: Oxidative stress and neuroinflammation are important processes involved in Alzheimer's disease and mild cognitive impairment. This study evaluated the association of polymorphisms in oxidative stress- and inflammation-related genes with cerebrospinal fluid biomarker levels and cognitive test results. The results showed that IL1B rs16944 carriers had higher CSF A beta(1-42) levels, while NFE2L2 rs35652124 carriers had lower CSF A beta(1-42) levels. Several gene variants, including CAT rs1001179, GSTP1 rs1138272, KEAP1 rs1048290 and rs9676881, and NFE2L2 rs35652124, were significantly associated with cognitive test scores.
Article
Biochemistry & Molecular Biology
David Vogrinc, Milica Gregoric Kramberger, Andreja Emersic, Sasa Cucnik, Katja Goricar, Vita Dolzan
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with a complex genetic background. Genome-wide association studies (GWAS) have identified numerous AD risk loci. This study aims to assess the associations between SNPs in well-established GWAS AD risk loci and CSF biomarker levels or cognitive test results in Slovenian patients with cognitive decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Bei Zhang, Hong-Xiang Yu, Nan Zhi, Can Cui, Ying-Ying Han, Min Hu, Hao Shen, Huan Bao, Gang Li
Summary: The study discovered associations between HMOX-1 and Alzheimer's disease (AD), particularly in the dominant and recessive models of the gene after adjusting for age, gender, and education. This suggests a potential link between HMOX1 rs2071746 and AD, especially late-onset AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Cell Biology
Snehal Raut, Aditya Bhalerao, Michael Powers, Minelly Gonzalez, Salvatore Mancuso, Luca Cucullo
Summary: The brain relies on glucose as its main source of energy, which is transported across the blood-brain barrier by glucose transporters. Glucose is then metabolized into ATP to support cellular functions. Medical conditions like Alzheimer's disease and Parkinson's disease can impair brain metabolism, leading to neurological symptoms.
Article
Neurosciences
Chen-Yang He, Zuo-Teng Wang, Ying-Ying Shen, An-Yu Shi, Hui-Yun Li, Dong-Wan Chen, Gui-Hua Zeng, Cheng-Rong Tan, Jin-Tai Yu, Fan Zeng, Yan-Jiang Wang
Summary: This study analyzed the relationship between NGFR gene polymorphism and the risk of Alzheimer's disease (AD) in the Chinese Han population and the association of a tag-SNP (rs2072446) with amyloid-beta deposition in the ADNI cohort.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Minghang Pei, Xinshu Liu, Peizeng Yang, Chan Zhao, Fei Gao, Yi Qu, Anyi Liang, Junyan Xiao, Meifen Zhang
Summary: IL33/ST2 gene polymorphisms are associated with the development of BDU, with specific alleles showing significant differences in BD patients with different clinical features, indicating the important role of IL33/ST2 in the pathogenesis of BDU.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Alexander M. Kulminski, Ian Philipp, Yury Loika, Liang He, Irina Culminskaya
Summary: The protective role of the apolipoprotein E (APOE) epsilon 2 allele in Alzheimer's disease (AD) may be influenced by different immunomodulation functions of TOMM40 and APOE variants in a sex-specific manner, defining a more homogeneous AD-protective epsilon 2/epsilon 3-bearing profile in men.
ALZHEIMERS & DEMENTIA
(2021)
Article
Chemistry, Medicinal
Xiangbao Meng, Yuan Zhang, Zongyang Li, Guoxu Ma, Xiejun Zhang, Di Zhang, Weiwei Cao, Sicen Wang, Qian Cai, Ping Cui, Guodong Huang
Summary: In this study, it was found that Gypenoside LXXV improved cognitive deficits in APP/PS1 and APP/PS1xdb/db mice by enhancing glucose uptake via activation of the PPAR gamma/Akt/GLUT4 signaling pathways.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shin Kim, Hyon-Ah Yi, Kyoung Sook Won, Ji Soo Lee, Hae Won Kim
Summary: This study found an association between visceral adipose tissue (VAT) metabolism and Alzheimer's disease (AD) pathology. The high VAT metabolism group showed a higher cerebral amyloid-beta (A beta) burden than the low VAT metabolism group. Additionally, F-18-FDG uptake in VAT was significantly associated with the cerebral A beta burden. These findings suggest that VAT dysfunction may contribute to the development of AD.
Article
Genetics & Heredity
Jian-Yong Wang, Lei Cui, Hong-Yi Shi, Ling-Hao Chen, Ren-Wei Jin, Xiao-Xia Jiang, Zhu-Ling Chen, Jian-Hong Zhu, Xiong Zhang
Summary: This study found that the single nucleotide polymorphisms (SNPs) of the DNMT1 gene are associated with the risk of Parkinson's disease (PD). Among them, rs9305012 is significantly associated with PD risk, and rs9305012/C is a protective allele. The haplotypes of the 4 tag-SNPs show significant differences between PD patients and controls. The ACC module composed of the 3 alleles is the highest-risk haplotype associated with PD.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Vasileios Siokas, Dimitra S. Mouliou, Ioannis Liampas, Athina-Maria Aloizou, Vasiliki Folia, Elli Zoupa, Anastasios Papadimitriou, Eleftherios Lavdas, Dimitrios P. Bogdanos, Efthimios Dardiotis
Summary: This study found a significant association between the ADORA2A rs5760423 genetic variant and AD, while no related association was detected between CYP1A2 rs762551 and AD. The risk of AD was found to be stronger with the T allele of the ADORA2A gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Quanzhen Zheng, Rui Bi, Min Xu, Deng-Feng Zhang, Li-Wen Tan, Ya-Ping Lu, Yong-Gang Yao
Summary: Integrative study revealed a potential genetic association between the ABAT gene and Alzheimer's disease (AD), with genetic variants in the 3'-UTR of ABAT identified as top AD-associated SNPs. Functional annotation indicated these SNPs are located in regulatory regions affecting transcription factors or microRNAs. Overall, ABAT genetic variants may influence AD by disrupting GABAergic signal pathway in the brain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni
Summary: Advanced age is the biggest risk factor for late-onset Alzheimer's disease (LOAD), and it shares genetic signatures with longevity. The study found evidence that pathways leading to longevity also contribute to LOAD, and identified interacting genes that are associated with survival to old age. The findings suggest that interactions of risk factors may drive different trajectories of cognitive aging.
Article
Biochemistry & Molecular Biology
Ke-Liang Chen, He Wang, Gui-Xian Zhao, Lei Wei, Yu-Yuan Huang, Shi-Dong Chen, Jian Sun, Qiang Dong, Mei Cui, Jin-Tai Yu
Summary: A novel homozygous RNF216 p.E650X mutation causing Gordon Holmes syndrome was identified in this study, expanding the genetic knowledge of GHS and extending the ethnic distribution of RNF216 mutations.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jia-Hui Hou, Ya-Nan Ou, Wei Xu, Peng-Fei Zhang, Lan Tan, Jin-Tai Yu
Summary: This study found that peripheral immune cells and the ratio of these cells were associated with cognitive function, neuroimaging, and AD pathology. These associations may be mediated by beta-amyloid and tau pathology.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Bang-Sheng Wu, Shu-Fen Chen, Shu-Yi Huang, Ya-Nan Ou, Yue-Ting Deng, Shi-Dong Chen, Qiang Dong, Jin-Tai Yu
Summary: By integrating multidimensional data, we identified causal genes in the pathogenesis of small-vessel stroke (SVS), offering hints for future biological and therapeutic studies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Shu-Yu Liang, Zuo-Teng Wang, Lan Tan, Jin-Tai Yu
Summary: This article introduces the function and dysfunction of microtubule-associated protein tau in the central nervous system and discusses its role in neurodegenerative diseases, tau phosphorylation-related enzymes and proteins, and its relationship with cell dysfunction. The study of tau neurotoxicity provides new directions for the treatment of tauopathies.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Yi Zhang, Kai-Min Wu, Liu Yang, Qiang Dong, Jin-Tai Yu
Summary: In this article, emerging knowledge on tauopathies from clinical, pathological, genetic, and experimental studies is synthesized to accelerate the development of therapeutics for these diseases. The focus is on depicting pathological characteristics, identifying biomarkers, elucidating the underlying pathogenesis for early diagnosis, and the development of disease-modifying therapies.
MOLECULAR NEURODEGENERATION
(2022)
Article
Environmental Sciences
He-Ying Hu, Ya-Hui Ma, Yue-Ting Deng, Ya-Nan Ou, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Summary: This study found an association between residential greenness and dementia incidence, indicating that increasing greenspace can reduce the risk of dementia. The protective effect of greenness may be mediated through the reduction of particulate air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Review
Clinical Neurology
Na Zhang, Ke-Liang Chen, Yu-Yuan Huang, Shu-Fen Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Zuo-Teng Wang, Yan Fu, Shi-Dong Chen, Yu-Yuan Huang, Ya-Hui Ma, Yan-Jiang Wang, Lan Tan, Jin-Tai Yu
Summary: This study is the first to identify significant associations between TREM1 rs2062323 and AD risk. The rs2062323T may be involved in AD by regulating the expression of TREM1, TREML1, TREM2, and sTREM2. The TREM family is expected to be a potential therapeutic target for AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Yan Fu, Yan Sun, Zhi-Bo Wang, Dan-Dan Zhang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used the American Heart Association's Life's Simple 7 (LS7) metric to define cardiovascular and brain health and found that ideal LS7 cardiovascular health factors are associated with both macrostructural and microstructural markers of brain health. The results suggest that better LS7 profiles are linked to better brain health.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Sun, Yu Guo, Hong-Qi Li, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: White matter hyperintensities (WMH) are strongly associated with stroke, dementia, and early mortality. This study investigated the relationship between WMH and circulating metabolites in a large sample of individuals from the UK Biobank. The results showed that several metabolites, including high-density lipoprotein (HDL), fatty acids, and glycoprotein acetyls, were associated with WMH. Age and sex also had a significant influence on these associations. The findings suggest that specific metabolomic features accompany WMH and may provide insights into the implications of WMH in different populations.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Yu He, Shu-Yi Huang, Hui-Fu Wang, Wei Zhang, Yue-Ting Deng, Ya-Ru Zhang, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: Cohort studies have shown inconsistent associations between omega-3 polyunsaturated fatty acids (n-3 PUFA) or fish oil and dementia risk. This study included a large number of participants and found that higher plasma levels of PUFA and fish oil supplementation were associated with a lower risk of developing dementia.
Article
Biochemistry & Molecular Biology
Shu-Yi Huang, Ya-Ru Zhang, Liu Yang, Yu-Zhu Li, Bang-Sheng Wu, Shi-Dong Chen, Jian-Feng Feng, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: Identifying circulating metabolites associated with dementia, cognition, and brain volume could provide new insights into the pathogenesis of dementia. This cohort study found 26 metabolites associated with incident dementia, including specific associations with Alzheimer's disease (AD) and vascular dementia (VD). Circulating levels of certain lipoproteins were found to be associated with the risk of AD and AD phenotypes, while another lipoprotein was associated with the risk of VD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ji-Yun Cheng, Yue-Ting Deng, Jin-Tai Yu
Summary: Through a more robust analysis, we found potential associations between circulating levels of amino acids and the risk of neurodegenerative diseases. Increase in circulating levels of Glutamine (Gln) was associated with lower risk of Alzheimer's disease (AD), while increase in circulating levels of Leucine (Leu) was associated with lower risk of Parkinson's disease (PD). Replication tests further confirmed the potential association between circulating Gln levels and AD risk.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Wei-Shi Liu, Ya-Ru Zhang, Yi-Jun Ge, Hui-Fu Wang, Wei Cheng, Jin-Tai Yu
Summary: This study identified the association between TREM2, temporal lobe, and AD using genetic and transcriptomic data, and explored the complex associations among inflammation, brain structure, and neurodegenerative disorders, particularly AD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Hai-Shan Jiao, Peng Yuan, Jin-Tai Yu
Summary: Mutations in the TMEM106B gene are risk factors for various neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains mysterious.
MOLECULAR NEURODEGENERATION
(2023)