Article
Behavioral Sciences
Olga Rodriguez-Borillo, Lorena Rosello-Jimenez, Julian Guarque-Chabrera, Maria Palau-Batet, Isis Gil-Miravet, Raul Pastor, Marta Miquel, Laura Font
Summary: After cocaine exposure, increased cFos activity was observed in the granular cell layer at the top of the posterior vermis (lobules VIII and IX) in mice, and this activity was positively correlated with cFos expression in the medial prefrontal cortex. These findings suggest that certain regions of the cerebellum may be involved in the regulation of cocaine-conditioned behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Angela E. Gonzalez, Emily T. Jorgensen, Jonathan D. Ramos, John H. Harkness, Jake A. Aadland, Travis E. Brown, Barbara A. Sorg
Summary: Parvalbumin (PV) positive cells in the medial prefrontal cortex (mPFC) regulate the activity of pyramidal neurons and are surrounded by a structure called the perineuronal net (PNN). The removal of PNNs with chondroitinase-ABC (Ch-ABC) prevents the consolidation and reconsolidation of cocaine-associated conditioned place preference (CPP) memories. This study explores the effects of CPP memory retrieval during cocaine-primed reinstatement on PV neurons and PNNs, and the impact of PNN removal on PV intensity and function. The findings suggest that PNN removal partially reduces reinstatement and that cocaine-induced reinstatement leads to changes in PV intensity and excitability, potentially affecting the maintenance of cocaine memory during reconsolidation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Fahad S. Alshehri, Badrah S. Alghamdi, Alqassem Y. Hakami, Abdullah A. Alshehri, Yusuf S. Althobaiti
Summary: The study found that melatonin can attenuate morphine-seeking behavior and reduce morphine-induced place preference.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Todd Charlton Sacktor
Summary: Karim Nader's research explores memory reconsolidation and memory maintenance by PKM zeta. He found that inhibiting PKM zeta or blocking reconsolidation can erase long-term memory. The study also revealed a connection between PKM zeta's regulation of AMPAR trafficking and memory maintenance. PKM zeta inhibition erases all memories stored by the kinase, while reconsolidation blockade disrupts specific recalled memories by preventing the resynthesis of PKM zeta.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Wei Xu, Yuman He, Jiamei Zhang, Hongchun Li, Xuemei Wan, Menglu Li, Yonghai Wang, Rui Xu, Haoluo Zhang, Yanping Dai, Haxiaoyu Liu, Linhong Jiang, Ying Zhao, Xiaobo Cen
Summary: The study demonstrates that simvastatin can prevent the reinstatement of cocaine-induced conditioned place preference without affecting its acquisition, likely due to its administration during extinction phase. Lipidomic analysis reveals that the nucleus accumbens is the most affected brain region by simvastatin, with alterations in fatty acids, phospholipids, and triacylglycerol metabolism. Simvastatin reverses most effects on phospholipids induced by cocaine and reshapes lipid metabolic pathways in specific brain regions, ultimately facilitating cocaine extinction and preventing relapse.
NEUROSCIENCE BULLETIN
(2021)
Article
Behavioral Sciences
Zhi-yuan Wang, Liang-kun Guo, Xiao Han, Rui Song, Guo-ming Dong, Chun-ming Ma, Ning Wu, Jin Li
Summary: The study investigated the effects of naltrexone on the properties of incentive salience and reward-related memory in methamphetamine addiction using mouse models. Naltrexone was found to reduce methamphetamine-induced hyper locomotion and suppress the development of locomotor sensitization, suggesting its therapeutic potential in treating methamphetamine addiction. These findings demonstrate that naltrexone could intervene in the incentive salience and reward-related memory properties, contributing to its therapeutic effects on methamphetamine addicts in clinical studies.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Geriatrics & Gerontology
Shayan Aliakbari, Mohammad Sayyah, Hadi Mirzapourdelavar, Niloufar Amini, Naser Naghdi, Hamid Gholami Pourbadie
Summary: EC amyloidopathy leads to impaired synaptic transmission and memory deficits, while overexpression of PKM zeta in DG enhances synaptic responses and improves memory performance, suggesting PKM zeta may serve as a potential therapeutic target for early stage AD.
NEUROBIOLOGY OF AGING
(2021)
Article
Behavioral Sciences
Saurabh S. Kokane, Brandon D. Butler, Josimar Hernandez Antonio, Ross J. Armant, Adam C. Hoch, Clinton S. Coelho, Blake N. Brady, Houda H. Chamseddine, Linda I. Perrotti
Summary: Women show a faster progression, increased consumption, more positive subjective effects, and higher relapse rates during abstinence in cocaine addiction. Estradiol is a key mediator of these effects, and ERK1/2 and mTOR play a role in the underlying neurobiological mechanisms.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Nicole C. Reyna, John T. Madden, Kenneth J. Thiel, Nathan S. Pentkowski
Summary: This study used a conditioned place preference model to examine the influence of methamphetamine and social rewards in adolescent male rats. The results showed that rats receiving methamphetamine with a social partner demonstrated a significantly greater preference shift compared to other groups, highlighting the importance of social context in influencing drug reward during adolescence.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Changqiong Xu, Ran Li, Jie Wu
Summary: YHZTP can attenuate the expression of ethanol-induced CPP in mice, while a combination of l-THP and IMP exerts a synergistic effect on reducing ethanol-induced CPP. Possible pharmacological mechanisms include inhibition of inflammatory factors expression and regulation of neurotransmitter receptor levels.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Genetics & Heredity
Yan Wang, Lvyu Yang, Hansheng Zhou, Kunlin Zhang, Mei Zhao
Summary: In this study, it was found that L-methionine can reverse the expression of genes and miRNAs affected by cocaine. Furthermore, L-methionine was shown to counteract the effects of cocaine by modulating the calcium channel gene network and pathways associated with drug addiction. These findings provide insights into the underlying mechanisms of L-methionine in response to cocaine abuse.
FRONTIERS IN GENETICS
(2023)
Article
Pharmacology & Pharmacy
Laila Asth, Lia P. Iglesias, Rayssa C. Brianis, Anna P. Marcal, Nicia P. Soares, Daniele C. Aguiar, Fabricio A. Moreira
Summary: This study examined the effects of monoamine stabilizers and aripiprazole on cocaine-induced behaviors. The results showed that aripiprazole could prevent cocaine-induced hyperlocomotion, but also impaired spontaneous locomotion, while (-)-OSU6162 had a minor effect. (-)-OSU6162 also played a role in preventing the acquisition of cocaine-induced conditioned place preference.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Prableen K. Singh, Kabirullah Lutfy
Summary: The study found differences in cocaine-induced conditioned place preference (CPP) between male and female mice lacking beta-endorphin, with gender-related distinctions in CPP reinstatement. The results suggest a functional role for beta-endorphin in cocaine-induced CPP and reinstatement.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Matthias Linhardt, Dominik P. Kiser, Paul Pauli, Kirsten Hilger
Summary: This meta-analysis provides a systematic overview of the developing field of applying the conditioned place preference (CPP) paradigm in human research. The results indicate that CPP has great potential to study approach-avoidance behavior in humans, similar to animal studies. Guidelines for future CPP research are provided to improve comparability of studies and facilitate new insights into anxiety disorders and drug abuse.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Julian Guarque-Chabrera, Aitor Sanchez-Hernandez, Patricia Ibanez-Marin, Ignasi Melchor-Eixea, Marta Miquel
Summary: This study investigates the role of perineuronal nets (PNNs) in cocaine-induced conditioned preference. The results show that digestion of PNNs disrupts short-term memory of conditioned preference but facilitates extinction formation. Moreover, PNN degradation also encourages the reinstatement of cocaine-induced conditioned preference. Therefore, degradation of PNNs may be a promising tool to manipulate drug-induced memory.