Review
Biochemistry & Molecular Biology
Cecilia Chavarria, Rodrigo Ivagnes, Jose M. Souza
Summary: This review article discusses the mechanisms and processes associated with alpha-synuclein uptake in glial cells and the resulting neuronal death.
Article
Multidisciplinary Sciences
Carla Azevedo, Gabriel Teku, Yuriy Pomeshchik, Juan F. Reyes, Margarita Chumarina, Kaspar Russ, Ekaterina Savchenko, Anna Hammarberg, Nuno Jorge Lamas, Anna Collin, Gunnar K. Gouras, Oxana Klementieva, Martin Hallbeck, Ricardo Taipa, Mauno Vihinen, Laurent Roybon
Summary: Limited evidence has revealed how aSYN proteins impact the oligodendrocyte phenotype and pathogenesis in synucleinopathies like Parkinson's disease and multiple system atrophy. The study identified early phenotypic and pathogenic changes in human oligodendrocyte lineage cells derived from patients with Parkinson's disease and multiple system atrophy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Moutusi Manna, Rajesh K. Murarka
Summary: Extensive molecular dynamics simulations and enhanced sampling were used to explore the mechanism of fatty acid dependent regulation of monomeric alpha-Syn(100) in a native synaptic vesicle-like membrane. The study found that docosahexaenoic acid (DHA) plays a key role in modulating the microenvironment of alpha-synuclein, promoting protein adsorption and reducing cytotoxicity. This study provides atomistic insights into DHA-induced regulatory mechanisms of monomeric alpha-synuclein, with implications for protein structure and its physiological/pathological functions.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Arati Tripathi, Heba Alnakhala, Elizabeth Terry-Kantor, Andrew Newman, Lei Liu, Thibaut Imberdis, Saranna Fanning, Silke Nuber, Nagendran Ramalingam, Dennis Selkoe, Ulf Dettmer
Summary: Alpha-synuclein plays a key role in Parkinson's disease. Missense mutations in the conserved N-terminus of the protein affect its interaction with the cell membrane. Two clinical mutants, E46K and G51D, were studied and compared. Both mutants showed altered membrane interactions, with E46K increasing and G51D decreasing the interactions. Cellular stress and reduced growth were observed in neurons and neuroblastoma cells expressing the mutants. The study suggests that reducing fatty-acid unsaturation could be a potential therapeutic strategy for preventing neurotoxicity in both E46K and G51D mutants.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Xinguo Zhang, Ruiqi Zhang, Maher Un Nisa Awan, Jie Bai
Summary: Parkinson's disease is a neurodegenerative disease that primarily affects elderly people. The onset and progression mechanism is unknown, and there are currently no effective treatment strategies. In addition to the loss of midbrain dopaminergic neurons, glia cells also play a role in brain tissue homeostasis, defense, and repair in PD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Michael Bartl, Mohammed Dakna, Douglas Galasko, Samantha J. Hutten, Tatiana Foroud, Marian Quan, Kenneth Marek, Andrew Siderowf, Jonas Franz, Claudia Trenkwalder, Brit Mollenhauer
Summary: Except for alpha Syn, the additional biomarkers did not differentiate between PD and HC, and no significant longitudinal differences were shown, but most markers were able to predict cognitive decline in PD during follow-up.
Article
Chemistry, Multidisciplinary
An Cheng, Yi-Fei Wang, Yasuharu Shinoda, Ichiro Kawahata, Tetsunori Yamamoto, Wen-Bin Jia, Hanae Yamamoto, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga
Summary: The study demonstrates that FABP7 triggers alpha-synuclein oligomerization through oxidative stress, while FABP7 ligand 6 can inhibit FABP7-induced Syn oligomerization and aggregation, thereby rescuing glial cells and oligodendrocytes from cell death.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
An Cheng, Wenbin Jia, Ichiro Kawahata, Kohji Fukunaga
Summary: Synucleinopathies are a group of diverse diseases that can cause motor and cognitive dysfunction due to progressive neuronal loss or demyelination, often found in diseases like Parkinson's and dementia with Lewy bodies. Mitochondrial injury plays a crucial role in neuronal loss and oligodendrocyte dysfunction in these neurodegenerative disorders, with alpha-synuclein accumulation in the mitochondrial membrane being a key factor.
Article
Agriculture, Dairy & Animal Science
Chaiwat Arjin, Chanmany Souphannavong, Rakkiat Norkeaw, Niraporn Chaiwang, Supamit Mekchay, Apinya Sartsook, Maninphan Thongkham, Thanchanok Yosen, Warintorn Ruksiriwanich, Sarana Rose Sommano, Korawan Sringarm
Summary: The supplementation of perilla cake improved pig performance, increased PUFA fatty acids, and decreased the proportion of saturated and unsaturated fatty acids in pork, while not affecting carcass traits and meat quality. This alternative source of raw material can be considered for functional feed additives in livestock production.
Article
Psychiatry
Anh Thi Phuong Le, Yuko Higuchi, Tomiki Sumiyoshi, Hiroko Itoh, Daiki Sasabayashi, Tsutomu Takahashi, Michio Suzuki
Summary: Abnormalities in membrane phospholipids are considered to be one of the underlying causes of schizophrenia. This study examines the fatty acid composition of erythrocyte membranes in individuals at-risk of mental illness and those with a first-episode of schizophrenia, and links it to clinical characteristics. The results show that certain fatty acids were lower in both groups compared to healthy individuals, while nervonic acid levels were significantly higher. Oleic acid and nervonic acid levels were also associated with specific symptoms in both groups. These findings suggest that abnormal fatty acid compositions may be markers of vulnerability in the early stages of schizophrenia and in individuals at-risk of psychosis.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Neurosciences
Kreesan Reddy, Birger Victor Dieriks
Summary: This article discusses the evidence for MSA-specific alpha-Syn strains, proposes possible causes for strain formation, and explores the interactions between oligodendrocytes, neurons, and alpha-Syn, as well as the impact of additional variables.
MOLECULAR NEURODEGENERATION
(2022)
Article
Neurosciences
Lisa Meszaros, Marcus Himmler, Yanni Schneider, Philipp Arnold, Frank Doerje, Dirk W. Schubert, Juergen Winkler
Summary: The study found that sobetirome can enhance myelin generation in oligodendrocytes in an MSA model, making it a potential therapeutic option for MSA.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Applied
Katherine E. Chetta, Marcello Forconi, Danforth A. Newton, Carol L. Wagner, John E. Baatz
Summary: The oleic acid/alpha-lactalbumin complex HAMLET is cytotoxic to cancerous cell lines and normal immature intestinal cells. This study evaluates the digestibility and structural characteristics of HAMLET in frozen human milk over time. Timed proteolytic experiments and spectroscopy analysis were used to confirm the presence and transformation of HAMLET in human milk.
Article
Biochemistry & Molecular Biology
Kazuya Matsuo, Yasushi Yabuki, Ronald Melki, Luc Bousset, Yuji Owada, Kohji Fukunaga
Summary: The study demonstrates that injecting α-Syn fibrils into the dorsal striatum impairs cognition and leads to the accumulation of phosphorylated α-Syn and reduction of GABAergic neurons in the medial septum/diagonal band. Deletion of Fabp3 antagonizes the neurotoxicity of α-Syn and cognitive impairment, suggesting that FABP3 could be a therapeutic target for dementia in synucleinopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Hao Chen, Xuebing Leng, Shaohui Liu, Ziqi Zeng, Feng Huang, Rongjie Huang, Yunfeng Zou, Yunan Xu
Summary: This study found that dietary intake of omega-3 polyunsaturated fatty acids (N3-PUFA), particularly alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosapentaenoic acid (DPA), was associated with lower risk of all-cause and cardiovascular mortality among hypertensive adults in the U.S.
CLINICAL NUTRITION
(2023)