Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states

Effect of A2B Adenosine Receptor Gene Ablation on Proinflammatory Adenosine Signaling in Mast Cells

(2014) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo

(2012) Bart P. Ramakers et al.   CRITICAL CARE MEDICINE

Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

(2012) Divya Sekar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+T cells

(2012) Sandra Pommey et al.   HEPATOLOGY

A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental Autoimmune Encephalomyelitis

(2012) J. H. Mills et al.   JOURNAL OF IMMUNOLOGY

Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease

(2012) D Ishikawa et al.   Mucosal Immunology

The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity

(2012) Hillary Johnston-Cox et al.   PLoS One

Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets

(2012) Gary K. Yang et al.   Islets

Adenosine and Hypoxia-Inducible Factor Signaling in Intestinal Injury and Recovery

(2011) Sean P. Colgan et al.   Annual Review of Physiology

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

(2011) S. Serra et al.   BLOOD

Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice

(2011) V. Salvestrini et al.   BLOOD

A 2b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis

(2011) Milka Koupenova et al.   CIRCULATION

Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β

(2011) Frederico S. Regateiro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Altered purinergic signaling in CD73-deficient mice inhibits tumor progression

(2011) Gennady G. Yegutkin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Transgenic Overexpression of CD39 Protects Against Renal Ischemia-Reperfusion and Transplant Vascular Injury

(2010) S. Crikis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Adenosine receptors and cancer

(2010) Stefania Gessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice

(2010) Xiaofeng Sun et al.   GASTROENTEROLOGY

A2B Adenosine Receptors Protect against Sepsis-Induced Mortality by Dampening Excessive Inflammation

(2010) B. Csoka et al.   JOURNAL OF IMMUNOLOGY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary origins of the purinergic signalling system

(2009) G. Burnstock et al.   Acta Physiologica

Extracellular nucleotides as negative modulators of immunity

(2009) Francesco Di Virgilio et al.   CURRENT OPINION IN PHARMACOLOGY

Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice

(2009) Guido Beldi et al.   HEPATOLOGY

Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness

(2009) S. P. Hilchey et al.   JOURNAL OF IMMUNOLOGY

Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis

(2009) J.-S. Frick et al.   JOURNAL OF IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

Diminution of Circulating CD4+CD25high T Cells in Naïve Crohn’s Disease

(2008) Patrick Chamouard et al.   DIGESTIVE DISEASES AND SCIENCES

Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury

(2008) Melanie L. Hart et al.   FASEB JOURNAL

Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs

(2008) Jörg Reutershan et al.   FASEB JOURNAL

Extracellular Adenosine Production by Ecto-5′-Nucleotidase Protects During Murine Hepatic Ischemic Preconditioning

(2008) Melanie L. Hart et al.   GASTROENTEROLOGY

Novel Insights in Chronic Lymphocytic Leukemia: Are We Getting Closer to Understanding the Pathogenesis of the Disease?

(2008) Federico Caligaris-Cappio et al.   JOURNAL OF CLINICAL ONCOLOGY

Unresolved issues and controversies in purinergic signalling

(2008) Geoffrey Burnstock   JOURNAL OF PHYSIOLOGY-LONDON

Chronic lymphocytic leukaemia

(2008) G Dighiero et al.   LANCET

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY