Combination of MEK-ERK inhibitor and hyaluronic acid has a synergistic effect on anti-hypertrophic and pro-chondrogenic activities in osteoarthritis treatment

BMP13 Prevents the Effects of Annular Injury in an Ovine Model

(2012) Aiqun Wei et al.   International Journal of Biological Sciences

Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

(2011) Anna Plaas et al.   ARTHRITIS RESEARCH & THERAPY

ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts

(2010) Indira Prasadam et al.   ARTHRITIS AND RHEUMATISM

withdrawn The anti-inflammatory effects of apocynin, inhibitor of NADPH oxidase, contrasting hyaluronic acid on articular cartilage during the development of osteoarthritis in a rabbit model

(2010) Jing-Li Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Intra-articular hyaluronic acid increases cartilage breakdown biomarker in patients with knee osteoarthritis

(2010) Alexandra M. Gonzalez-Fuentes et al.   CLINICAL RHEUMATOLOGY

Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38

(2010) Sohel M. Julovi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The role of intra-articular hyaluronan (Sinovial®) in the treatment of osteoarthritis

(2010) Antonio Gigante et al.   RHEUMATOLOGY INTERNATIONAL

Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders

(2010) Rita Dreier   ARTHRITIS RESEARCH & THERAPY

Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2

(2009) Indira Prasadam et al.   BONE

Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation

(2009) C Thomas G Appleton et al.   LABORATORY INVESTIGATION

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

(2009) B.-C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE

Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism

(2008) M B Goldring et al.   ANNALS OF THE RHEUMATIC DISEASES

A Pilot Human Evaluation of a Formulation of Irinotecan and Hyaluronic Acid in 5-Fluorouracil-Refractory Metastatic Colorectal Cancer Patients

(2008) Peter Gibbs et al.   CHEMOTHERAPY

Mitogen-activated protein kinases as therapeutic targets in osteoarthritis

(2008) Richard F Loeser et al.   CURRENT OPINION IN RHEUMATOLOGY

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY