Danger signals activating innate immunity in graft-versus-host disease

Critical Role of TLR9 in Acute Graft-versus-Host Disease

(2014) C. Calcaterra et al.   JOURNAL OF IMMUNOLOGY

Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

(2011) S. M. Gregory et al.   SCIENCE

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

(2010) T. Müller et al.   ALLERGY

Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease

(2010) Marek Lommatzsch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses

(2010) C. Vogtenhuber et al.   BLOOD

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

(2010) T. Woehrle et al.   BLOOD

Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation

(2010) Y. Nguyen et al.   BLOOD

Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases

(2010) Liliana Schaefer   CURRENT OPINION IN PHARMACOLOGY

Mesenchymal stromal cells inhibit graft-versus-host disease of mice in a dose-dependent manner

(2010) Sun-Young Joo et al.   CYTOTHERAPY

Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes

(2010) M. Jurewicz et al.   DIABETES

Oxidized ATP inhibits T-cell-mediated autoimmunity

(2010) Philipp A. Lang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease

(2010) M. M. Heimesaat et al.   GUT

Lack of the purinergic receptor P2X7results in resistance to contact hypersensitivity

(2010) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular NAD+shapes the Foxp3+regulatory T cell compartment through the ART2–P2X7 pathway

(2010) Sandra Hubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells

(2010) H. Li et al.   JOURNAL OF IMMUNOLOGY

Purinergic Receptor Inhibition Prevents the Development of Smoke-Induced Lung Injury and Emphysema

(2010) S. Cicko et al.   JOURNAL OF IMMUNOLOGY

Activation of Macrophages by P2X7-Induced Microvesicles from Myeloid Cells Is Mediated by Phospholipids and Is Partially Dependent on TLR4

(2010) L. M. Thomas et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cell Dichotomy: Identification of IFN-  Producing Cells as a Phenotypically and Functionally Distinct Subset

(2010) P. Bjorck et al.   JOURNAL OF IMMUNOLOGY

Human Eosinophils Recognize Endogenous Danger Signal Crystalline Uric Acid and Produce Proinflammatory Cytokines Mediated by Autocrine ATP

(2010) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Transcriptional Regulation of the Endogenous Danger Signal Tenascin-C: A Novel Autocrine Loop in Inflammation

(2010) Fui G. Goh et al.   JOURNAL OF IMMUNOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Extracellular ATP induces albuminuria in pregnant rats

(2010) Marijke M. Faas et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

(2010) Y. Chen et al.   Science Signaling

Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality

(2009) L. K. Jasperson et al.   BLOOD

NOD2 polymorphisms predict severe acute graft-versus-host and treatment-related mortality in T-cell-depleted haematopoietic stem cell transplantation

(2009) W J F M van der Velden et al.   BONE MARROW TRANSPLANTATION

ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected byPorphyromonas gingivalis

(2009) Özlem Yilmaz et al.   CELLULAR MICROBIOLOGY

Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease

(2009) K. Landfried et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Extracellular nucleotides as negative modulators of immunity

(2009) Francesco Di Virgilio et al.   CURRENT OPINION IN PHARMACOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD2 regulates hematopoietic cell function during graft-versus-host disease

(2009) Olaf Penack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells

(2009) Paul L. Bollyky et al.   JOURNAL OF LEUKOCYTE BIOLOGY

P2X7 Deficiency Attenuates Renal Injury in Experimental Glomerulonephritis

(2009) S. R.J. Taylor et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

(2009) Tomoko Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP release from non-excitable cells

(2009) Helle A. Praetorius et al.   Purinergic Signalling

Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation

(2008) M. Granell et al.   BLOOD

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

(2008) P. A. Taylor et al.   BLOOD

No impact of NOD2/CARD15 on outcome after SCT

(2008) D Sairafi et al.   BONE MARROW TRANSPLANTATION

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

(2008) Anthony J Sharp et al.   Journal of Neuroinflammation

Role of TNF-α and extracellular ATP in THP-1 cell activation following allergen exposure

(2008) Masaaki Miyazawa et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling

Recipient NOD2/CARD15 Variants: A Novel Independent Risk Factor for the Development of Bronchiolitis Obliterans after Allogeneic Stem Cell Transplantation

(2007) Gerhard C. Hildebrandt et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION