Article
Cardiac & Cardiovascular Systems
Yang Zhang, Xiaoman Wang, Xun-Kai Li, Shuang-Jie Lv, He-Ping Wang, Yang Liu, Jingyue Zhou, Hui Gong, Xiao-Feng Chen, Si-Chong Ren, Huina Zhang, Yuxiang Dai, Hua Cai, Bo Yan, Hou-Zao Chen, Xiaoqiang Tang
Summary: This study investigates the role and mechanisms of the cytoplasmic deacetylase sirtuin 2 (SIRT2) in ageing-induced vascular remodelling. The results show that SIRT2 activity is reduced in aged aortas, and loss of SIRT2 accelerates vascular ageing. Further analysis reveals that SIRT2 regulates vascular ageing through deacetylating p66(Shc) protein activation and metabolism of mitochondrial reactive oxygen species (mROS). This study suggests that SIRT2 may serve as a potential therapeutic target for vascular rejuvenation.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Elena Succurro, Francesco Andreozzi, Roberto Carnevale, Angela Sciacqua, Vittoria Cammisotto, Velia Cassano, Gaia C. Mannino, Teresa V. Fiorentino, Daniele Pastori, Pasquale Pignatelli, Giorgio Sesti, Francesco Violi
Summary: The study suggests that redox status imbalance negatively influences vascular outcomes in patients with type 2 diabetes mellitus, with soluble NOX2 and serum albumin levels significantly correlated with the incidence of non-fatal myocardial infarction.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Nadia Di Pietrantonio, Pamela Di Tomo, Domitilla Mandatori, Gloria Formoso, Assunta Pandolfi
Summary: Diabetes accelerates vascular senescence, leading to chronic inflammation and oxidative stress, which in turn cause endothelial dysfunction and related cardiovascular complications. The acetyltransferase p300 has been suggested to play a crucial role in diabetes-associated inflammation and oxidative stress, potentially contributing to the development of vascular senescence. Understanding the mechanisms of p300 in diabetic vascular dysfunction could aid in finding new therapeutic strategies for cardiovascular diseases related to diabetes.
Article
Biochemistry & Molecular Biology
Hala Shokr, Irundika H. K. Dias, Doina Gherghel
Summary: The study found that oxysterol levels are related to retinal microvascular function, and abnormal levels of oxysterols may indicate early risk for cardiovascular diseases as individuals age.
Review
Nutrition & Dietetics
Stavroula A. Paschou, Evanthia Bletsa, Katerina Saltiki, Paraskevi Kazakou, Kanella Kantreva, Paraskevi Katsaounou, Nikoletta Rovina, Georgia Trakada, Petros Bakakos, Charalambos V. Vlachopoulos, Theodora Psaltopoulou
Summary: Obstructive sleep apnea (OSA) is a common and serious public health issue that is associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM). OSA is an independent risk factor for the development and progression of T2DM, as well as T2DM-related cardiovascular complications. OSA may also increase the risk of developing cardiovascular diseases, such as hypertension, coronary artery disease, heart failure, pulmonary hypertension, atrial fibrillation, and stroke. OSA and T2DM share common pathophysiological mechanisms that lead to atherosclerosis. Therefore, clinicians should be aware of the coexistence of OSA and T2DM, as it increases the risk of cardiovascular mortality, and screen for OSA in patients with T2DM. Targeted therapy for both conditions can significantly improve cardiovascular prognosis.
Review
Biochemistry & Molecular Biology
Grzegorz K. Jakubiak, Grzegorz Cieslar, Agata Stanek
Summary: Diabetes mellitus is closely associated with cardiovascular diseases, and the nitration of lipoproteins, especially high-density lipoprotein, may play an important role in the development of cardiovascular dysfunction. However, further research is needed to fully understand this relationship.
Article
Biochemistry & Molecular Biology
Stefano Masi, Samuele Ambrosini, Shafeeq A. Mohammed, Sebastiano Sciarretta, Thomas F. Luescher, Francesco Paneni, Sarah Costantino
Summary: The prevalence of obesity and cardiometabolic phenotypes is increasing globally, with epigenetic modifications emerging as a key regulator of gene transcription in vascular diseases. Deciphering the vascular epigenome is challenging but crucial for developing targeted therapies for obesity-related conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Pharmacology & Pharmacy
Fadia Mayyas, Tala Al Gharram
Summary: Oxidative stress and fibrosis contribute to the development of cardiovascular disease in diabetes. Atorvastatin can protect against cardiovascular diseases in diabetic patients by reducing oxidative stress, inflammation, and fibrosis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Kabelo Mokgalaboni, Bongani B. Nkambule, Yonela Ntamo, Khanyisani Ziqubu, Tawanda M. Nyambuya, Sithandiwe E. Mazibuko-Mbeje, Kwazikwakhe B. Gabuza, Nireshni Chellan, Ilenia Cirilli, Luca Tiano, Phiwayinkosi Dludla
Summary: This study focuses on the therapeutic effects of food-derived bioactive compounds, such as vitamin K, in protecting or managing metabolic diseases in patients with T2D. It discusses the potential benefits of vitamin K in attenuating CVD-risk factors, blood lipid profiles, blood pressure, as well as markers of oxidative stress and inflammation in patients with T2D. Additionally, it explores controversies related to the cardioprotective effects of vitamin K and highlights its therapeutic potential through a summary of preclinical evidence.
Article
Biochemistry & Molecular Biology
Andreas Daiber, Omar Hahad, Ioanna Andreadou, Sebastian Steven, Steffen Daub, Thomas Muenzel
Summary: Global epidemiological studies highlight the significance of chronic non-communicable diseases like atherosclerosis and metabolic disorders in premature mortality and morbidity, with cardiovascular diseases such as ischemic heart disease contributing significantly to the global disease burden and socioeconomic health costs. Research demonstrates a link between oxidative stress markers and major cardiovascular diseases, emphasizing the role of reactive oxygen and nitrogen species in conditions like hyperlipidemia, hypertension, and diabetes. In vivo redox biomarkers are discussed for their clinical relevance, while the potential prognostic value and limitations of these markers are critically examined.
Review
Medicine, Research & Experimental
Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Meiyu Lin, Junpeng Long, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen, Yantao Yang
Summary: Cardiovascular diseases have a significant impact on global mortality rates, and oxidative stress plays a crucial role in their pathogenesis and advancement. Herbal monomers can inhibit oxidative stress in cardiovascular diseases by activating multiple signaling pathways and protecting cardiac health.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Silvia Garcia, David Mateos, Cristina Gomez, Jose M. Gamez, Henrik E. Poulsen, Josep A. Tur, Antoni Sureda
Summary: This study aimed to assess the effects of a 2-year nutritional and lifestyle intervention on oxidative and inflammatory status in individuals at high cardiovascular disease risk. The results showed a greater reduction in abdominal obesity, blood pressure, and triglyceride levels after the intervention. Furthermore, an improvement in oxidative stress and proinflammatory status was observed.
Review
Biochemistry & Molecular Biology
Muhammad Ammar Zahid, Shahenda Salaheldin Abdelsalam, Hicham Raiq, Aijaz Parray, Hesham Mohamed Korashy, Asad Zeidan, Mohamed A. Elrayess, Abdelali Agouni
Summary: A timely and adequate response to stress is crucial for maintaining cell function, and disruptions in defense mechanisms against stress can lead to various pathologies. Aging and cardiovascular diseases can reduce the effectiveness of these defense mechanisms. Sestrin2 (SESN2) is a stress-inducible protein that can protect cells by increasing antioxidants, temporarily halting stressful reactions, and promoting autophagy. Maintaining sufficient levels/activity of SESN2 may prevent cardiovascular aging and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Francisco Canet, Francesca Iannantuoni, Aranzazu Martinez de Maranon, Pedro Diaz-Pozo, Sandra Lopez-Domenech, Teresa Vezza, Blanca Navarro, Eva Sola, Rosa Falcon, Celia Banuls, Carlos Morillas, Milagros Rocha, Victor M. Victor
Summary: This study demonstrated that empagliflozin treatment led to reductions in body weight, BMI, HbA1C levels, waist circumference, and glucose levels, as well as improvements in leukocyte-endothelium interactions, adhesion molecules, ROS production, and NFkB-p65 expression. These findings suggest that the anti-inflammatory and antioxidant properties of empagliflozin may contribute to its beneficial cardiovascular effects in patients with type 2 diabetes.
Review
Biochemistry & Molecular Biology
Maria A. Christou, Panagiota A. Christou, Christos Kyriakopoulos, Georgios A. Christou, Stelios Tigas
Summary: Hypoglycemia is common in diabetes patients treated with insulin or sulfonylureas and has significant implications on the cardiovascular system. Various mechanisms linking hypoglycemia to increased cardiovascular risk have been proposed, including changes in hemodynamics, myocardial ischemia, abnormal cardiac repolarization, arrhythmias, prothrombotic and proinflammatory effects, and oxidative stress. It remains uncertain whether the association between hypoglycemia and cardiovascular events in diabetes patients is causal. New therapeutic agents for type 2 diabetes do not cause hypoglycemia and have cardioprotective benefits, and the use of technologies such as continuous glucose monitoring devices and insulin pumps can potentially reduce hypoglycemia and its adverse cardiovascular outcomes in type 1 diabetes patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Mariann Gyongyosi, Pilar Alcaide, Folkert W. Asselbergs, Bianca J. J. M. Brundel, Giovanni G. Camici, Paula da Costa Martins, Peter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepekoylu, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G. Schiattarella, Joost P. G. Sluijter, Sabine Steffens, Carsten Tschope, Sophie Van Linthout, Sean M. Davidson
Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Liberale, Simon Kraler, Yustina M. Puspitasari, Nicole R. Bonetti, Alexander Akhmedov, Stefano Ministrini, Fabrizio Montecucco, Nikolaus Marx, Michael Lehrke, Niels Ulrik K. Hartmann, Jurg H. Beer, Florian A. Wenzl, Francesco Paneni, Thomas F. Luscher, Giovanni G. Camici
Summary: The study showed that SGLT-2 inhibition by empagliflozin does not impact experimental arterial thrombus formation, neither under baseline conditions nor during sustained low-grade inflammation. The results suggest that the beneficial effects of empagliflozin are likely independent of pathways mediating arterial thrombosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Federico Carbone, Edoardo Elia, Matteo Casula, Aldo Bonaventura, Maria Bertolotto, Silvia Minetti, Nathan Artom, Giovanni G. Camici, Paola Contini, Roberto Pontremoli, Francesca Viazzi, Stefano Bertolini, Aldo Pende, Livia Pisciotta, Fabrizio Montecucco, Luca Liberale
Summary: This study investigated the potential influence of neutrophils and their degranulation markers on the improvement of metabolic syndrome. The findings showed a negative correlation between baseline MMP8 levels and MetS improvement, suggesting the pivotal role of inflammation in metabolic alteration.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Francesco Cosentino, Nikolaus Marx, Subodh Verma
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Samuel Dagogo-Jack, Robert Frederich, Jie Liu, Christopher P. Cannon, Harry Shi, David Z. Cherney, Francesco Cosentino, Urszula Masiukiewicz, Ira Gantz, Richard E. Pratley
Summary: In the VERTIS CV trial, ertugliflozin treatment decreased the likelihood of insulin initiation, delayed the time to insulin initiation by up to approximately 1.8 years, and reduced insulin dose requirements without increasing the incidence of hypoglycemia events.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Giovanna Liuzzo, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Massimo Volpe, Giovanna Liuzzo
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Pedicino, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Pedicino, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Giovanna Liuzzo, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Pedicino, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Massimo Volpe, Carlo Patrono
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Volpe, Allegra Battistoni
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Kraler, Florian A. Wenzl, Jody Vykoukal, Johannes F. Fahrmann, Ming-Yi Shen, Der-Yuan Chen, Kuan-Cheng Chang, Ching-Kun Chang, Arnold von Eckardstein, Lorenz Raber, Francois Mach, David Nanchen, Christian M. Matter, Luca Liberale, Giovanni G. Camici, Alexander Akhmedov, Chu-Huang Chen, Thomas F. Luscher
Summary: Changes in LDL electronegativity are associated with adverse outcomes in patients with ACS, including increased all-cause and cardiovascular mortality. The LDL lipidome is also affected by these alterations, and specific lipid species are independently associated with fatal events.
Article
Cardiac & Cardiovascular Systems
Kangmin Yang, Srividya Velagapudi, Alexander Akhmedov, Simon Kraler, Tetiana Lapikova-Bryhinska, Martin O. Schmiady, Xiaoping Wu, Leiluo Geng, Giovanni G. Camici, Aimin Xu, Thomas F. Luscher
Summary: This study aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice. The results showed that arterial SIRT1 levels were significantly reduced in diabetic conditions, while rmSIRT1 supplementation restored SIRT1 levels and improved endothelial function and vascular compliance. The study suggests that SIRT1 supplementation may represent a novel therapeutic strategy to prevent and treat diabetic vascular disease by enhancing eNOS activity and suppressing NOX-related oxidative stress.
CARDIOVASCULAR RESEARCH
(2023)