Review
Multidisciplinary Sciences
Karen Alvarez, Mauricio Rojas
Summary: Autoimmune diseases are challenging to diagnose and treat. Nanoparticles offer promising strategies for targeting monocyte populations and delivering drugs for the diagnosis and treatment of autoimmune diseases. This field of research is of great importance.
Review
Endocrinology & Metabolism
Elisha Siwan, Stephen M. Twigg, Danqing Min
Summary: This review systematically examined the expression of CD163 in diabetes complications and found that soluble CD163 was upregulated, suggesting its potential utility as an inflammation biomarker. The variable expression of CD163 on cell surfaces and its mRNA across different diabetes complications warrants further investigation.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Xiaodan Zhang, Zirui Luo, Jiahong Li, Yaxuan Lin, Yu Li, Wangen Li
Summary: This article reviews the progress in investigating the correlations between Sestrin2 protein, diabetes, and diabetic complications. Sestrin2 plays a crucial role in regulating cellular events such as oxidative stress, mitochondrial function, and endoplasmic reticulum stress. By exploring the potential roles of Sestrin2 in the pathogenesis of diabetes and diabetic complications, the authors aim to highlight a promising therapeutic direction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Zongshan Shen, Shuhong Kuang, Min Zhang, Xin Huang, Jiayao Chen, Meiliang Guan, Wei Qin, Hockin H. K. Xu, Zhengmei Lin
Summary: The study showed that Diabetes-associated periodontitis is closely related to persistently elevated levels of CCL2 and proinflammatory monocyte infiltration in periodontal tissues. Oral administration of bindarit reduced bone loss and increased epithelial thickness by suppressing inflammation in periodontal tissues. Bindarit also suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Tongyi Li, Yanmei Wang, Chan Zhu, Yunjiao Yang, Cong Long, Qiu Chen
Summary: This study identified differentially expressed genes associated with immunity and inflammation in diabetic nephropathy and identified RNase6 as a key gene. Xcell analysis revealed significant changes in immune cells in diabetic nephropathy glomeruli, with positive correlations with RNase6 expression. Animal studies confirmed the increased expression of RNase6 in diabetic nephropathy models along with inflammatory factors.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Anna Alwani, Aneta Andreasik, Rafal Szatanek, Maciej Siedlar, Monika Baj-Krzyworzeka
Summary: Monocytes, as a type of blood cells, serve as a link between innate and adaptive immunity, being both precursors of macrophages and effector cells like phagocytes or cytotoxic cells. At the tumor site, monocytes/macrophages are important indicators for cancer recovery. The role of small regulatory miRNA in monocyte formation, maturation, and function is crucial.
Review
Biochemistry & Molecular Biology
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami
Summary: This review assesses the current state of research on macrophage polarity and discusses its prospects as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Sevgican Demir, Peter P. Nawroth, Stephan Herzig, Bilges Ekim Ustunel
Summary: Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance and high blood sugar levels, with complications affecting various organs. Effective therapies are lacking, and further research on novel treatment targets is needed to pave the way for potential prevention and treatment of this disease.
Review
Immunology
Yasuo Nagafuchi, Haruyuki Yanaoka, Keishi Fujio
Summary: Transcriptome analysis has improved our understanding of the pathological roles of immune cells in autoimmune diseases. Single-cell RNA-seq analysis has provided atlases of infiltrating immune cells and helped identify candidate causal genes and immune cells. The obtained information can be used practically to predict patient prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Jing Liu, Yanyan Zhang, Yan Tian, Wei Huang, Nanwei Tong, Xianghui Fu
Summary: Diabetes mellitus is a chronic disease with increasing prevalence globally, and extracellular vesicles (EVs) play important roles in its pathogenesis and clinical treatment.
Review
Endocrinology & Metabolism
Yuyan Zhu, Xuan Xia, Qian He, Qing-Ao Xiao, Decheng Wang, Meirong Huang, Xiaolin Zhang
Summary: Neutrophil extracellular traps (NETs) are released by activated neutrophils and consist of antimicrobial proteins and DNA. NETosis, a form of neutrophilic cell death, plays a crucial role in diabetes and its complications. Increased levels of NETs in the blood of diabetic patients confirm the association between NETosis and complications such as impaired wound healing, retinopathy, and atherosclerosis. This article summarizes the mechanisms of NETosis and discusses potential therapeutic targets using small molecule compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Yao Yao, Xiaoyu Cai, Fujia Ren, Yiqing Ye, Fengmei Wang, Caihong Zheng, Ying Qian, Meng Zhang
Summary: Osteoimmunity plays a crucial role in regulating the balance of bone remodeling and resorption, particularly through the macrophage-osteoclast axis. Understanding the role of this axis in osteoimmunity is significant for treating bone damage caused by inflammation and immune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Claudia Sirbe, Simona Rednic, Alina Grama, Tudor Lucian Pop
Summary: Vitamin D plays a crucial role in immune system and endothelial membrane stability, and low levels of serum 25(OH)D are associated with an increased risk of immune-related diseases. Although the outcomes of vitamin D supplementation vary greatly, it is recommended to increase vitamin D intake and ensure sufficient sunlight exposure to obtain optimal health benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiaoqian Wei, Shushan Pan, Zirui Wang, Jieru Chen, Li Lu, Qizhi Cao, Shuling Song, Huachang Zhang, Xiaohui Liu, Xianjun Qu, Xiukun Lin, Huanli Xu
Summary: This study uncovered the critical role of LAIR1 in facilitating the malignant progression of glioma and demonstrated its support of an immunosuppressive glioma microenvironment through CCL5-mediated cell polarization.
CELL DEATH & DISEASE
(2023)
Article
Food Science & Technology
Shengjun Chen, Feiyan Tao, Chuang Pan, Xiao Hu, Haixia Ma, Chunsheng Li, Yongqiang Zhao, Yueqi Wang
Summary: The study found that the Random Forest model has better fitting and higher predictive accuracy for quality changes of Pacific white shrimp compared to the Arrhenius model. Therefore, the Random Forest model is a hopeful method for predicting the changes in the quality of Pacific white shrimp.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Biochemistry & Molecular Biology
Yulei Guan, Xiangrui Meng, Xia Wang, Ru Liu, Haixia Ma, Jirong Song
Summary: Theoretical exploration of the reaction mechanism between CH3OCH2 and NO2 reveals key steps and two stable intermediates, shedding light on the rapid reaction kinetics and providing insights into the combustion chemistry of NO2.
JOURNAL OF MOLECULAR MODELING
(2021)
Article
Chemistry, Physical
Zhuo Li, Bing Wang, Bing-Bing Zhang, Hai-Xia Ma, Jia Xue, Long Xu, Lin-Yu Jiao, Xiao-Xun Ma
Summary: The novel SubPc-Br/Ag3PO4 composites showed significant enhancement in photocatalytic efficiency for degrading BB and MO under visible-light and ultraviolet-light, with the 4% SubPc-Br/Ag3PO4 composite displaying the most superior photocatalytic activity. The improved performance can be attributed to sensitization, broadening the absorption region and enhancing the separation of photogenerated electron-hole pairs, as well as reducing Ag+ reduction and enhancing cycling stability.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yulei Guan, Xia Wang, Xiangrui Meng, Haixia Ma, Jirong Song
Summary: This paper presents a detailed theoretical investigation on the interaction between methylmethoxy and nitrogen monoxide during thermal oxidation of dimethyl ether (DME). The results indicate that the reaction proceeds through addition of N atom of NO to CH3OCH2 radical, forming an energy-rich adduct. The most favored dissociation pathway leads to the production of CH3OCN + H2O as the main product.
STRUCTURAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Le Qi, Mou-Cui Li, Jia-Chao Bai, Ying-Hui Ren, Hai-Xia Ma
Summary: Six disubstituted Schiff base compounds were synthesized and characterized. Compounds A1 and A2 showed good antifungal activity against Wheat gibberellic, with A1 and A2 having the smallest docking energy. Analysis using density functional theory further explained the reasons behind the good activity of these compounds.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Zhuo Li, Bing Wang, Guo-Yi Cui, Bing-Bing Zhang, Ya-Fei Wang, Lin Yang, Hai-Xia Ma, Lin-Yu Jiao, Ling-Yan Pang, Xiao-Xun Ma
Summary: In this study, a highly active TiO2 sensitized by a novel axial substituted subphthalocyanine was successfully prepared, and a new packing motif of the sensitizer was discovered for the first time, showing significant impact on its catalytic performance. Through experimental and computational methods, the electronic properties of the sensitizer were studied, confirming the excellent photocatalytic performance of TiO2/SubPc-3 in degrading pollutants under visible light.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Analytical
Jing Zhang, Yufei Zhang, Haixia Ma, Fatang Yang, Tianjiao Duan, Yuhui Zhang, Yuming Dong
Summary: This study focuses on separating and quantifying isoflavones in traditional Chinese medicines using mixed micellar liquid chromatography, and validating the method efficiency by optimizing the chromatographic conditions. The existence of supramolecular amphiphilic vesicles in the mobile phase, verified by transmission electron microscopy, explains the increased chromatographic efficiency.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Chemistry, Physical
Guobin Li, Jiangxue Ning, Caixia Xu, Qinyuan Qiu, Haixia Ma, Liyu Chen
Summary: This study investigated the reaction path of PODEn synthesis from methanol and paraformaldehyde on the Al-MCM-41 zeolite, revealing key intermediate and transition structures. The rate-determining step was identified as the reaction of methanol with hemiacetal to form dimethoxymethane. Long-chain PODEn was found to be formed by chain growth from PODEn-1 and formaldehyde.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Haixia Ma, Yufei Zhang, Tianjiao Duan, Jing Zhang, Fatang Yang, Yuhui Zhang, Yuming Dong
Summary: The functionalized organic polymer monolithic column was successfully synthesized and showed excellent performance in separating neutral, phenolic, and aniline compounds. The addition of ionic liquid reduced the column pressure and improved the separation efficiency.
Article
Materials Science, Multidisciplinary
Pan Dong, Yanna Zhang, Shidong Zhu, Zhen Nie, Haixia Ma, Qiang Liu, Jinling Li
Summary: The adsorption characteristics of corrosive anions on the TiO2 surface of TC4 titanium alloy were studied using density functional theory. The results showed that the optimal adsorption positions were bridge positions, and the interface bonding was mainly caused by charge movement. The adsorption configurations were all chemical adsorption. A novel corrosion mechanism for the dynamic evolution processes of pits was proposed based on the findings.
Article
Chemistry, Physical
Shidong Zhu, Ke Wang, Haixia Ma, Pan Dong
Summary: The severe service environment of OCTG in oil and gas fields due to the affinity between corrosive species and metal ions necessitates the study of the corrosion-resistant behavior of TC4 alloys. In this paper, the thermodynamic characteristics of the TiO2(100) surface of TC4 alloys in the CO2-H2S-Cl- system were simulated and analyzed, and the simulation results were verified using corrosion electrochemical technologies. The results provide theoretical support for understanding the corrosion resistance mechanism of OCTG and developing novel corrosion inhibitors in CO2-H2S-Cl- environments.
Article
Chemistry, Multidisciplinary
Yu Wang, Siyu Xu, Heng Li, Haixia Ma, Yazhou Zhang, Zhaoqi Guo
Summary: The research indicates that different metal ions have significant effects on the laser ignition ability of energetic complexes, with alkali metal-containing complexes being easier to ignite and alkaline earth metal-containing complexes having longer initiation delay times.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiang Chen, Zhaoqi Guo, Cong Zhang, Jianguo Zhang, Haixia Ma
Summary: The study focuses on enhancing intermolecular interactions to improve the packing efficiency of energetic materials, resulting in the successful synthesis of two fused cyclic tetrazine explosives with strong hydrogen bonds and edge-to-face stacking. These compounds exhibit high density and good detonation properties.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Fei Yuan, Hai-Xia Ma, Chun-Mei Yuan, Chun-Sheng Zhou, Huai-Ming Hu, Abhinav Kumar, Mohd Muddassir
Summary: Three new Ln(iii)-based metal-organic frameworks were synthesized using multifunctional triazole-carboxylate linker and dicarboxylate ligand. The structures of the complexes were found to be isostructural, with Nd-based MOF 1 showing promising photocatalytic properties for degrading organic dye under UV light. The study also provided insights into the framework interactions and photocatalytic mechanisms through theoretical calculations.
Article
Chemistry, Multidisciplinary
Yanfei Cheng, Xiang Chen, Na Yang, Yazhou Zhang, Haixia Ma, Zhaoqi Guo
Summary: This study presents the design and synthesis of two new low-sensitive nitroamine explosives, with their molecular structures confirmed using X-ray diffraction. The explosives showed high positive enthalpies of formation and good detonation performances, as well as low impact sensitivity, making them promising candidates for practical applications. Additionally, analyses were conducted to investigate the intermolecular interactions and the relationship between structures and molecular stabilities.