期刊
JOURNAL OF MOLECULAR HISTOLOGY
卷 42, 期 6, 页码 499-504出版社
SPRINGER
DOI: 10.1007/s10735-011-9357-z
关键词
Dkk-3; beta-catenin; Immunohistochemistry; Oral squamous cell carcinoma
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology (Japan) [22791766, 22791977, 21592326]
- Grants-in-Aid for Scientific Research [22791766, 21592326, 22791977, 10F00130] Funding Source: KAKEN
Dickkopf (Dkk)-3, an inhibitor of the Wnt/beta-catenin pathway, is reported as a potential tumor suppressor gene in many cancers. To gain a better comprehension of the mechanisms involved in the carcinogenesis of oral squamous epithelium, protein expression and localization of Dkk-3 and beta-catenin was investigated in normal epithelium, dysplasias and squamous cell carcinoma (SCC). An increase in beta-catenin and Ki-67 expressions was observed from dysplasias to poorly differentiated SCC. Interestingly, an increase in Dkk-3 positive cells was also noted, which was correlated to the cancer progression step. A change in Dkk-3 localization during the transformation of normal oral epithelium to SCC was clearly observed. Dkk-3 was localized in the cell membrane in normal oral epithelium and in dysplasias, whereas that was localized in both cell membrane and cytoplasm in SCC. These results suggest that Dkk-3 is involved in the carcinogenesis of SCC with a distinct function from those in other cancers.
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