Article
Oncology
Eugen Bellon, Katharina Grupp, Tarik Ghadban, Michael Tachezy, Kai Bachmann, Jakob Robert Izbicki, Ronald Simon, Guido Sauter, Claudia Hube-Magg, Nathaniel Melling
Summary: LPCAT1 expression is increased in malignant esophageal tissue and correlated with undifferentiated tumor grading, but it is not associated with prognosis in esophageal cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Chemistry, Analytical
Shupei Zhang, Yitian Huang, Feng Lin, Yanjie Chen, Hong Dai, Yanyu Lin
Summary: A stable and reusable electrochemiluminescent (ECL) signal amplification strategy was proposed using a pyrene-based conjugated polymer (Py-CP) to trigger a self-circulating enhancement system. The incorporation of Nb2C MXene quantum dots shortened the sensitization evoking phase (SSEP) and introduced a photoacoustic (PA) transduce mechanism for dual-signal outputting. The portable and miniaturized ECL-PA synergetic sensing platform based on the closed-bipolar electrode achieved sensitive let-7a detection with good selectivity, stability, and reliability.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jiaqi Li, Bo Li, Xin Yao, Wenyao Duan, Wen Zhang, Yupeng Tian, Dandan Li
Summary: In this work, a high-order multiphoton-excited fluorescence (H-MPEF) material, ZLPH, was developed by confining a two-photon active unit (ZL) within a metal-organic framework. The obtained material exhibited bright four-photon-excited fluorescence under the excitation of a 1550 nm femtosecond laser, showing great potential for deep-tissue bioimaging applications.
INORGANIC CHEMISTRY
(2022)
Review
Cell Biology
Sreerama Shetty, Steven Idell
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no effective treatments. Lung transplantation is limited to a small number of patients, therefore, new therapies targeting caveolin-1 could provide a promising treatment option for IPF patients.
Article
Chemistry, Multidisciplinary
Emel Kirbas Cilingir, Meghana Sankaran, Jordan M. Garber, Frederic Anthony Vallejo, Mattia Bartoli, Alberto Tagliaferro, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Summary: Carbon dots (CDs) have gained attention for their biocompatibility and tunable photoluminescence, but further analysis is needed before their use in clinical trials. A new type of carbon nitride dot (CND) has been found to selectively uptake cancer cells due to structural similarities with glutamine. The study investigates the effects of surface structural differences on the cellular uptake of CNDs and finds that the uptake mechanism is linked with ASCT2 and LAT1 transporters. CNDs show promise for selective cancer cell targeting by utilizing highly expressed transporters on cancer cells.
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, a new approach for synthesizing carbon dots (CDs) with improved electrochemiluminescent (ECL) performance was disclosed. By engineering luminol as molecular emission centers into the CDs, luminescent groups rich in CDs (Lu-CDs) were synthesized. Lu-CDs exhibited significantly stronger ECL intensity and better consistency between ECL and fluorescence emission compared to traditional CDs. Lu-CDs were employed to construct an ECL biosensor for tumor cell analysis, demonstrating wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, luminescent groups rich carbon dots (Lu-CDs) were synthesized by incorporating luminol into the CDs, resulting in a significantly enhanced electrochemiluminescent (ECL) performance. The ECL emission of Lu-CDs showed excellent consistency with its fluorescence emission, unlike other surface state-dominated CDs. Furthermore, Lu-CDs were used to develop an ECL biosensor for tumor cell analysis, demonstrating a wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Lijiao Ao, Tao Liao, Liang Huang, Shan Lin, Kui Xu, Jiangtao Ma, Shaorong Qiu, Xiangyu Wang, Qiqing Zhang
Summary: This study developed a highly sensitive and portable multi-target serum cancer biomarker detection method. By using NIR-II emitting quantum dots and three-dimensional distribution assembly, the sensitivity and fluorescence signals of the test strip were successfully enhanced. With this method, simultaneous detection and quantitative analysis of CEA, Cyfra21-1, and NSE tumor biomarkers were achieved, with high sensitivity and specificity demonstrated in lung cancer patients and healthy individuals.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Dominic Leiser, Santanu Samanta, John Eley, Josh Strauss, Michael Creed, Tami Kingsbury, Paul N. Staats, Binny Bhandary, Minjie Chen, Tijana Dukic, Sanjit Roy, Javed Mahmood, Zeljko Vujaskovic, Hem D. Shukla
Summary: The study highlights the role of Caveolin-1 in radioresistance of lung cancer cells, as well as its contribution to tumor aggression. The heterogeneous expression of the CAV-1 gene in human lung cancer tissues is similar to its enhanced expression in human lung cancer cell line and mouse orthotopic xenograft models. Alterations in the CAV-1 gene have been linked to poor prognosis and survival in lung cancer patients.
Article
Multidisciplinary Sciences
Taryn B. Hogan, Nivedita Tiwari, M. R. Nagaraja, Shwetha K. Shetty, Liang Fan, Rashmi S. Shetty, Yashodhar P. Bhandary, Sreerama Shetty
Summary: Idiopathic pulmonary fibrosis (IPF) is a life-threatening disease caused by abnormal repair responses to lung injury. The expression of miR-34a and its regulation of p53 have been found to play a role in reducing fibrotic markers in fLfs. Increasing the expression of miR-34a can reduce the severity of lung fibrosis. Furthermore, treating fLfs with CSP or CSP7 can restore miR-34a expression and reduce expression of fibrotic markers.
Review
Pharmacology & Pharmacy
Ruchita Shandilya, Shashi Ranjan, Surbhi Khare, Arpit Bhargava, Irina Yu Goryacheva, Pradyumna Kumar Mishra
Summary: This review discusses various point-of-care (POC) approaches for detecting ccf-miRs and emphasizes the utility of incorporating nanomaterials to enhance biorecognition and signal transduction, further improving their diagnostic applicability in lung cancer (LC) settings.
DRUG DISCOVERY TODAY
(2021)
Article
Materials Science, Biomaterials
Bo Wang, Peipei Liu, Hui Huang, Xiting Wang, Mengling Zhang, Jian Huang, Fang Lu, Jian Chen, Yang Liu, Zhenhui Kang
Summary: It is demonstrated that degradable carbon dots (from l-ascorbic acid, CDs-1) can up-regulate the expression of HMOX1 in animal cells and tissues, which has a therapeutic effect on LPS-induced acute lung injury in mice. CDs-1 can significantly increase the expression of HMOX1 by 5 times in a short time, decreasing the reactive oxygen species level and improving the survival rate of mice to 80% in vivo experiments. This study provides a practical approach for the treatment of acute inflammation and the potential application of carbon dots in anti-inflammatory therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Oncology
Kenji Nakahama, Motohiro Izumi, Naoki Yoshimoto, Mitsuru Fukui, Akira Sugimoto, Hiroaki Nagamine, Koichi Ogawa, Kenji Sawa, Yoko Tani, Hiroyasu Kaneda, Shigeki Mitsuoka, Tetsuya Watanabe, Kazuhisa Asai, Tomoya Kawaguchi
Summary: Vimentin expression in NSCLC is associated with immune-checkpoint inhibitor efficacy. Measurement of vimentin expression can help determine appropriate immunotherapy strategies.
Article
Plant Sciences
Peng Xi, Yuji Niu, Yaru Zhang, Wenwen Li, Fan Gao, Wenwen Gu, Fuguang Kui, Zhongqiu Liu, Linlin Lu, Gangjun Du
Summary: This study confirmed that dioscin can prevent lung cancer, and its key target is AKT1 kinase, a central protein of the PI3K/AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hanaa Mohammed Elsayed Mohammed El-brolsy, Nemany A. N. Hanafy, Maged A. El-Kemary
Summary: In this study, ethylene-diamine doped carbon quantum dots (CQDs) were found to enhance their cytotoxicity against non-small cell lung cancer cells. Functionalizing the CQDs with folic acid improved their targeting ability to specific tumor sites and induced apoptosis. Furthermore, the functionalization of CQDs was shown to strongly reduce cell DNA synthesis and increase Caspase-3 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Software Engineering
Yulei Sui, Jingling Xue
IEEE TRANSACTIONS ON SOFTWARE ENGINEERING
(2020)
Article
Computer Science, Hardware & Architecture
Qinggang Wang, Long Zheng, Jieshan Zhao, Xiaofei Liao, Hai Jin, Jingling Xue
ACM TRANSACTIONS ON ARCHITECTURE AND CODE OPTIMIZATION
(2020)
Proceedings Paper
Computer Science, Software Engineering
Diyu Wu, Dongjie He, Shiping Chen, Jingling Xue
2020 IEEE 31ST INTERNATIONAL SYMPOSIUM ON SOFTWARE RELIABILITY ENGINEERING (ISSRE 2020)
(2020)
Proceedings Paper
Computer Science, Hardware & Architecture
Mingchuan Wu, Ying Liu, Huimin Cui, Qingfu Wei, Quanfeng Li, Limin Li, Fang Lv, Jingling Xue, Xiaobing Feng
PACT '20: PROCEEDINGS OF THE ACM INTERNATIONAL CONFERENCE ON PARALLEL ARCHITECTURES AND COMPILATION TECHNIQUES
(2020)
Proceedings Paper
Computer Science, Hardware & Architecture
Feng Yu, Jiacheng Zhao, Huimin Cui, Xiaobing Feng, Jingling Xue
PACT '20: PROCEEDINGS OF THE ACM INTERNATIONAL CONFERENCE ON PARALLEL ARCHITECTURES AND COMPILATION TECHNIQUES
(2020)
Proceedings Paper
Computer Science, Software Engineering
Jie Liu, Dongjie He, Diyu Wu, Jingling Xue
2020 IEEE 31ST INTERNATIONAL SYMPOSIUM ON SOFTWARE RELIABILITY ENGINEERING (ISSRE 2020)
(2020)
Proceedings Paper
Computer Science, Hardware & Architecture
Long Zheng, Xianliang Li, Yaohui Zheng, Yu Huang, Xiaofei Liao, Hai Jin, Jingling Xue, Zhiyuan Shao, Qiang-Sheng Hua
PROCEEDINGS OF THE 2020 USENIX ANNUAL TECHNICAL CONFERENCE
(2020)
Proceedings Paper
Computer Science, Software Engineering
Changwei Zou, Jingling Xue
2020 ACM/IEEE 42ND INTERNATIONAL CONFERENCE ON SOFTWARE ENGINEERING (ICSE 2020)
(2020)
Proceedings Paper
Computer Science, Hardware & Architecture
Long Zheng, Jieshan Zhao, Yu Huang, Qinggang Wang, Zhen Zeng, Jingling Xue, Xiaofei Liao, Hai Jin
2020 IEEE 34TH INTERNATIONAL PARALLEL AND DISTRIBUTED PROCESSING SYMPOSIUM IPDPS 2020
(2020)
Proceedings Paper
Computer Science, Hardware & Architecture
Yu Huang, Long Zheng, Pengcheng Yao, Jieshan Zhao, Xiaofei Liao, Hai Jin, Jingling Xue
2020 IEEE 34TH INTERNATIONAL PARALLEL AND DISTRIBUTED PROCESSING SYMPOSIUM IPDPS 2020
(2020)
Proceedings Paper
Computer Science, Software Engineering
Xuezheng Xu, Changwei Zou, Jingling Xue
2020 IEEE INTERNATIONAL CONFERENCE ON SOFTWARE MAINTENANCE AND EVOLUTION (ICSME 2020)
(2020)
Article
Computer Science, Hardware & Architecture
Guangli Li, Xiu Ma, Xueying Wang, Lei Liu, Jingling Xue, Xiaobing Feng
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
(2020)
Proceedings Paper
Computer Science, Software Engineering
Fang Lv, Hao Li, Lei Wang, Ying Liu, Huimin Cui, Jingling Xue, Xiaobing Feng
PROCEEDINGS OF THE 2020 IEEE 27TH INTERNATIONAL CONFERENCE ON SOFTWARE ANALYSIS, EVOLUTION, AND REENGINEERING (SANER '20)
(2020)
Proceedings Paper
Computer Science, Software Engineering
Yulei Sui, Yifei Zhang, Wei Zheng, Manqing Zhang, Jingling Xue
ESEC/FSE'2019: PROCEEDINGS OF THE 2019 27TH ACM JOINT MEETING ON EUROPEAN SOFTWARE ENGINEERING CONFERENCE AND SYMPOSIUM ON THE FOUNDATIONS OF SOFTWARE ENGINEERING
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Diyu Wu, Jie Liu, Yulei Sui, Shiping Chen, Jingling Xue
2019 IEEE 12TH CONFERENCE ON SOFTWARE TESTING, VALIDATION AND VERIFICATION (ICST 2019)
(2019)
