Article
Biochemistry & Molecular Biology
Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stephanie Clerget-Froidevaux, Valerie Enderlin
Summary: This study investigated the protective mechanisms linking hypothyroidism and neuroinflammation. Hypothyroid WSB/EiJ mice showed no neuroinflammatory response and maintained hippocampal thyroid signaling despite low circulating thyroid hormone levels, while C57BL/6J mice exhibited disturbed thyroid signaling, accompanied by neuroinflammation and memory impairment. The results highlight the importance of the hippocampal thyroid regulatory system in glial reactivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Claudia Alia, Daniele Cangi, Verediana Massa, Marco Salluzzo, Livia Vignozzi, Matteo Caleo, Cristina Spalletti
Summary: Ischemic damage in brain tissue leads to plastic changes in cell-to-cell interactions, influencing a wide range of molecular and structural interactions. Understanding and manipulating these intercellular connections is crucial for post-stroke neurorehabilitation.
Review
Biochemistry & Molecular Biology
Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli
Summary: This study systematically reviewed the role of glial cells in Lafora disease (LD). The findings suggest that glial cells accumulate polyglucosan bodies (PBs) in LD and contribute to neurodegeneration and epilepsy. Future research should consider glial cells as a potential therapeutic target.
Review
Medicine, General & Internal
Lilian M. Mennink, Marlien W. Aalbers, Pim van Dijk, J. Marc C. van Dijk
Summary: This systematic review examines the role of inflammation in subjective tinnitus, finding that increased levels of TNF-alpha and IL-1 beta, as well as activation of microglia and astrocytes, may be associated with tinnitus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Shu-Han Liu, Yang Du, Lei Chen, Yong Cheng
Summary: This review provides an overview of the structural changes of glial cells in major psychiatric diseases such as schizophrenia, bipolar disorder, and major depressive disorder. The findings suggest that astrocytes, microglial cells, and oligodendrocytes exhibit specific patterns of changes in each disease.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Barbora Salcman, Karen Affleck, Silvia Bulfone-Paus
Summary: Localisation of mast cells at the abluminal side of blood vessels in the brain promotes their interaction with other brain cells, leading to the release of inflammatory mediators. Furthermore, activation of P2X receptors in mast cells and glial cells plays a crucial role in regulating neuroinflammation.
Review
Biochemistry & Molecular Biology
Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodia
Summary: Neurodegeneration is a progressive phenomenon associated with aging, where activated microglia and neuroinflammation play crucial roles. Mitochondrial dysfunction and excessive neuroinflammatory responses are important factors contributing to age-dependent neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Cecilia Chavarria, Rodrigo Ivagnes, Jose M. Souza
Summary: This review article discusses the mechanisms and processes associated with alpha-synuclein uptake in glial cells and the resulting neuronal death.
Article
Biochemistry & Molecular Biology
Yukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki, Minoru Narita
Summary: The study found that aging in the hypothalamus contributes to increased anxiety, impaired motor coordination, and reduced muscle strength in mice. Aging leads to the production of PD-1-enriched exhausted microglia and neuroinflammatory A1-like reactive astrocytes in the hypothalamus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Stefano Garofalo, Germana Cocozza, Giovanni Bernardini, Julie Savage, Marcello Raspa, Eleonora Aronica, Marie-Eve Tremblay, Richard M. Ransohoff, Angela Santoni, Cristina Limatola
Summary: Neuroinflammation is a significant feature of ALS, in which peripheral immune cells play a role in accelerating neurodegeneration. Blocking the infiltration of immune cells in the central nervous system can reduce interferon-gamma levels, modify glial cell phenotype, increase motor neuron count, and prolong survival time.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Emilie Dugast, Sita Shah, David-Axel Laplaud
Summary: Multiple sclerosis is a chronic and inflammatory disease of the central nervous system. The exact mechanisms involved are still not well understood, but recent studies using single-cell technologies have identified various immune cell subsets and potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nour F. Al-Ghraiybah, Junwei Wang, Amer E. Alkhalifa, Andrew B. Roberts, Ruchika Raj, Euitaek Yang, Amal Kaddoumi
Summary: This review provides an overview of recent advances on the role of microglia and astrocytes in neuroinflammation and provides updates on neuroinflammation diagnostic markers and investigational therapeutics currently in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Christiane Kruse Faeste, Anita Solhaug, Marion Gaborit, Florian Pierre, Dominique Massotte
Summary: Chronic exposure to the mycotoxin deoxynivalenol (DON) can have neurotoxic effects on brain cells, including impacts on glial cells, cell cycle, inflammatory cytokine release, and neuronal morphology.
Article
Neurosciences
Rajesh Kushwaha, Anshuman Sinha, Natallia Makarava, Kara Molesworth, Ilia V. Baskakov
Summary: This study demonstrated that reactive astrocytes in prion diseases have a neurotoxic effect on neuronal growth, dendritic spine development, and synapse maturation. Additionally, the conditioned media from reactive astrocytes was found to impair synapse integrity and reduce spine size and density, suggesting a synaptotoxic role of the reactive astrocyte phenotype associated with prion diseases.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Jens R. Nyengaard, Connie Sanchez, Gregers Wegener
Summary: Vortioxetine has early effects on hippocampal neurons and the vascular system in rats, increasing the number of astrocytes and microglia cells with elevated VEGF levels. Fluoxetine, on the other hand, did not have an impact on these measures after 7 days of treatment. These findings suggest that astrocytes and microglia may play a role in mediating the pharmacological effects of vortioxetine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Anatomy & Morphology
Stella M. P. Vecchiatti, Chin Jia Lin, Vera L. Capelozzi, Adhemar Longatto-Filho, Helio Bisi
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2015)
Article
Medical Laboratory Technology
Maria Beatriz Monteiro, Daniele Pereira Santos-Bezerra, Karina Thieme, Marisa Passarelli, Ubiratan Fabres Machado, Chin Jia Lin, Maria Lucia Correa-Giannella
CLINICA CHIMICA ACTA
(2016)
Article
Oncology
Tonielli Cristina Sousa de Lacerda, Bruno Costa-Silva, Fernanda Salgueiredo Giudice, Marcos Vinicios Salles Dias, Gabriela Pintar de Oliveira, Bianca Luise Teixeira, Tiago Goss dos Santos, Vilma Regina Martins
CLINICAL & EXPERIMENTAL METASTASIS
(2016)
Article
Immunology
Ricardo Wesley Alberca-Custodio, Flavia Regina Greiffo, BreAnne MacKenzie, Manoel Carneiro Oliveira-Junior, Adilson Santos Andrade-Sousa, Gustavo Silveira Graudenz, Angela Batista Gomes Santos, Nilsa Regina Damaceno-Rodrigues, Hugo Caire Castro-Faria-Neto, Fernanda Magalhaes Arantes-Costa, Milton De Arruda Martins, Asghar Abbasi, Chin Jia Lin, Marco Idzko, Ana Paula Ligeiro Oliveira, Hinnak Northoff, Rodolfo Paula Vieira
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Genetics & Heredity
Natalia Gomes Goncalves, Stephanie Heffer Cavaletti, Carlos Augusto Pasqualucci, Milton Arruda Martins, Chin Jia Lin
GENES AND NUTRITION
(2017)
Article
Physiology
Alessandra C. Toledo-Arruda, Rodolfo P. Vieira, Flavia A. Guarnier, Camila L. Suehiro, Agostinho Caleman-Neto, Clarice R. Olivo, Petra M. M. Arantes, Francine M. Almeida, Fernanda D. T. Q. S. Lopes, Ercy M. C. Ramos, Rubens Cecchini, Chin Jia Lin, Milton Arruda Martins
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Genetics & Heredity
Natalia Gomes Goncalves, Stephanie Heffer Cavaletti, Carlos Augusto Pasqualucci, Milton Arruda Martins, Chin Jia Lin
GENES AND NUTRITION
(2017)
Article
Biochemistry & Molecular Biology
Michele Christine Landemberger, Gabriela Pintar de Oliveira, Cleiton Fagundes Machado, Kenneth John Gollob, Vilma Regina Martins
JOURNAL OF NEUROCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Fabola S. Z. Robertoni, Clarice R. Olivo, Juliana D. Lourenco, Natalia G. Goncalves, Ana Paula P. Velosa, Chin J. Lin, Claudia M. Flo, Beatriz M. Saraiva-Romanholo, Sergio D. Sasaki, Milton A. Martins, Walcy R. Teodoro, Fernanda Degobbi T. Q. S. Lopes
Article
Neurosciences
Jessica R. Maximino, Gabriela P. de Oliveira, Chrystian J. Alves, Gerson Chadi
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Juliana Tiyaki Ito, Daniela Aparecida de Brito Cervilha, Juliana Dias Lourenco, Natalia Gomes Goncalves, Rildo Aparecido Volpini, Elia Garcia Caldini, Gilles Landman, Chin Jia Lin, Ana Paula Pereira Velosa, Walcy Paganelli Rosolia Teodoro, Iolanda de Fatima Lopes Calvo Tiberio, Thais Mauad, Milton de Arruda Martins, Mariangela Macchione, Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Article
Nutrition & Dietetics
Maria Silvia Ferrari Lavrador, Milessa Silva Afonso, Dennys Esper Cintra, Marcia Koike, Valeria Sutti Nunes, Marina Demasi, Chin Jia Lin, Lis Mie Masuzawa Beda, Luiz Antonio Gioielli, Renata de Paula Assis Bombo, Roberta Marcondes Machado, Sergio Catanozi, Edna Regina Nakandakare, Ana Maria Lottenberg
Article
Multidisciplinary Sciences
Camila Liyoko Suehiro, Alessandra Choqueta de Toledo-Arruda, Rodolfo de Paula Vieira, Francine Maria de Almeida, Clarice Rosa Olivo, Milton de Arruda Martins, Chin Jia Lin
SCIENTIFIC REPORTS
(2019)
Article
Physiology
Renata Alves, Camila Liyoko Suehiro, Flavia Garcia de Oliveira, Eliete Dalla Corte Frantz, Renata Frauches de Medeiros, Rodolfo de Paula Vieira, Milton de Arruda Martins, Chin Jia Lin, Antonio Claudio Lucas da Nobrega, Alessandra Choqueta de Toledo-Arruda
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Amanda Shinzato, Antonio M. Lerario, Chin J. Lin, Debora S. Danilovic, Suemi Marui, Ericka B. Trarbach
MEDICAL SCIENCE MONITOR BASIC RESEARCH
(2015)