Article
Biochemistry & Molecular Biology
Magdalene K. Montgomery, Amanuiel Z. Taddese, Jacqueline Bayliss, Shuai Nie, Nicholas A. Williamson, Matthew J. Watt
Summary: Hepatic HexA expression is influenced by lipid availability and steatosis, with overexpression leading to increased hepatic GM3 content and upregulation of enzymes involved in glycated sphingolipid degradation, ultimately resulting in sphingomyelin accumulation in the liver. Additionally, overexpression of HEXA in the liver causes significant changes in cell surface lipid rafts, affecting VLDL processing and secretion, leading to hypertriglyceridemia and ectopic lipid accumulation in peripheral tissues. This study highlights the important role of HEXA in modulating hepatic sphingolipid and lipoprotein metabolism.
Article
Biochemistry & Molecular Biology
Hasna Ahyayauch, Massimo Masserini, Felix M. Goni, Alicia Alonso
Summary: The β42 peptide, a component of Alzheimer's disease plaques, binds neuronal membranes and tends to aggregate in various states, with ganglioside GM1 being a major facilitator. Thermodynamic data suggests a strong tendency for peptide-membrane binding, mainly driven by entropy. The Langmuir balance demonstrated the ability of all peptide preparations to insert into lipid monolayers, with fibrils having lower capability compared to oligomers or monomers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Patrick Tai, Matt Golding, Harjinder Singh, David Everett
Summary: The milk fat globule membrane (MFGM) has gained attention in nutritional sciences due to recent research on the heterogenous, lateral milk polar lipids assemblies. It has been discovered that these assemblies, enriched with sphingomyelin and cholesterol, can form a liquid-ordered (L-o) phase, challenging previous assumptions about milk fat digestion. This review critically examines the anticholesteremic effect of milk polar lipids, the structure and properties of L-o domains, and hypotheses on the interactions between sphingomyelin and cholesterol in the establishment of L-o structures.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Li Liang, Yu Liu, Junlong Zhu, Chaoting Wen, Xiaofang Liu, Jixian Zhang, Youdong Li, Guoyan Liu, Xin Xu
Summary: The emulsifying performance of glycerophospholipids alone is inferior to proteins, but the interaction with sphingomyelin and cholesterol can improve the stability and protective effect of emulsions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Nouara Yahi, Coralie Di Scala, Henri Chahinian, Jacques Fantini
Summary: Parkinson's disease is a major neurodegenerative disorder that requires a treatment targeting the root cause of the disease. This article highlights the role of lipid rafts in forming alpha-synuclein pore-like oligomers, which trigger a cascade of neurotoxic events, proposing blocking alpha-synuclein-ganglioside interactions as a potential therapeutic avenue for PD.
GLYCOCONJUGATE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Anastasija Panevska, Nastja Cegovnik, Klavdija Fortuna, Alen Vukovic, Maja Grundner, Spela Modic, Gregor Bajc, Matej Skocaj, Martina Mravinec Bohte, Lara Larisa Poposek, Primoz Zigon, Jaka Razinger, Peter Veranic, Natasa Resnik, Kristina Sepcic
Summary: OlyA6 protein binds to cholesterol-complexed sphingomyelin and can label lipid rafts. It forms pores in insect midgut cell membranes and acts as a potent bioinsecticide when combined with pleurotolysin B. A point mutation (E69A) enhances the interaction of OlyA6 with sphingomyelin and CPE, allowing recognition of these sphingolipids even in the absence of cholesterol. However, the mutation does not improve its membrane-permeabilizing activity after addition of pleurotolysin B.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Elisabetta Albi, Martina Mandarano, Samuela Cataldi, Maria Rachele Ceccarini, Federico Fiorani, Tommaso Beccari, Angelo Sidoni, Michela Codini
Summary: In this study, the effects of hypocholesterolemia and hypercholesterolemia on different types of human breast cancer cells were investigated. It was found that hypocholesterolemia inhibited cell growth and promoted the expression of certain genes, while hypercholesterolemia reversed these effects. Therefore, it is suggested that cholesterol levels should be controlled in hormone receptor-positive breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Eun-Bi Lim, Seungjoo Haam, Sang-Wha Lee
Summary: Sphingomyelin-based liposomes exhibited different loading and release behaviors of encapsulated drugs depending on cholesterol contents and polydopamine coating layer. The loading of hydrophobic ibuprofen increased with higher cholesterol contents, while the loading of hydrophilic acetaminophen decreased. The release rates of the drugs were affected by the cholesterol content and PDA coating, demonstrating potential for lipid-based nanocarriers in preclinical development.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Geriatrics & Gerontology
Wen Yu, Jun Ying, Xifeng Wang, Xing Liu, Tiancheng Zhao, Sungtae Yoon, Qingcui Zheng, Yang Fang, Danying Yang, Fuzhou Hua
Summary: Neurodegenerative diseases are slow-progressing terminal illnesses characterized by neuronal lesions, with increasing incidence and burden on families and society due to aging populations. Recent studies have shown the crucial role of LacCer in driving neurodegeneration, offering new strategies and ideas for future research and drug development.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Virology
Jacques Fantini, Henri Chahinian, Nouara Yahi
Summary: This article proposes a new vaccine strategy against Monkeypox virus based on a two-step analysis combining viral protein binding with gangliosides in host cells' lipid rafts. The authors identify a ganglioside-binding motif in the viral protein E8L and suggest using it as an immunogen to generate neutralizing antibodies. They propose this lipid raft/ganglioside-based strategy for developing vaccines against future virus outbreaks.
Article
Microbiology
Heidi Wolfmeier, Samuel J. T. Wardell, Leo T. Liu, Reza Falsafi, Annette Draeger, Eduard B. Babiychuk, Daniel Pletzer, Robert E. W. Hancock
Summary: Engineered liposomes containing sphingomyelin and cholesterol can effectively neutralize toxins secreted by Gram-negative bacteria Pseudomonas aeruginosa, reducing the cytolytic effects and attenuating the infection in vivo. The liposomes sequester and neutralize the virulence-promoting hemolytic phospholipase C (PlcH), offering a potential therapy to treat complex infections caused by P. aeruginosa and other Gram-negative pathogens expressing PlcH.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jhan-Jhang Syu, Chieh-Hsiang Chang, Pei-Yu Chang, Chia-Hsiung Liu, Chia-Jung Yu, Tzuu-Shuh Jou
Summary: The study shows that galectin 8 promotes the rapid elongation of primary cilia by binding to lipid raft components at the base of cilia and interfering with the interaction between caveolin 1 and TMEM231. The functional barrier of the transition zone is disrupted, resulting in the redistribution of cilia proteins and the elongation of primary cilia.
Article
Cell Biology
Amina Mohammadalipour, Christian A. Showalter, Harrison T. Muturi, Amir M. Farnoud, Sonia M. Najjar, Monica M. Burdick
Summary: This study investigates the effects of cholesterol on the adhesive behaviors of lung cancer cells in recruitment at metastatic sites. Using cholesterol-modulating compounds, we found that reducing cholesterol decreases the adhesion of non-small cell lung cancer (NSCLC) cells while having no significant effect on small cell lung cancer (SCLC) cells. The study suggests that cholesterol regulates NSCLC cell metastasis by redistributing the adhesion proteins on the cells and modulating cells' membrane fluidity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Shuo Zhang, Ya-Ning Shi, Jia Gu, Peng He, Qi-Di Ai, Xu-Dong Zhou, Wei Wang, Li Qin
Summary: This study investigates the mechanism of DMY against hepatocellular carcinoma (HCC), revealing that it inhibits the proliferation, migration, and invasion of HCC cells by reducing cholesterol to disrupt lipid rafts.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Microbiology
Ines Ripa, Sabina Andreu, Jose Antonio Lopez-Guerrero, Raquel Bello-Morales
Summary: Membrane rafts are small dynamic domains enriched with cholesterol and sphingolipids that play essential roles in processes such as virus entry. They participate in virus attachment, recruitment to the cell surface, and entry mechanisms used by viruses. This review will introduce the specific role of rafts in viral entry and summarize their participation in the entry process of enveloped and non-enveloped viruses.
FRONTIERS IN MICROBIOLOGY
(2021)