期刊
JOURNAL OF MOLECULAR EVOLUTION
卷 74, 期 1-2, 页码 69-80出版社
SPRINGER
DOI: 10.1007/s00239-012-9489-0
关键词
COX I; Cytochrome b; Evolvability; mtDNA; Natural selection; Protein evolution
资金
- Ministerio de Ciencia e Innovacion, Spain [CGL2010-18124]
By using a combination of evolutionary and structural data from 231 species, we have addressed the relationship between evolution and structural features of cytochrome b and COX I, two mtDNA-encoded proteins. The interior of cytochrome b, in contrast to that of COX I, exhibits a remarkable tolerance to changes. The higher evolvability of cytochrome b contrasts with the lower rate of synonymous substitutions of its gene when compared to that of COX I, suggesting that the latter is subjected to a stronger purifying selection. We present evidences that the stability effect of mutations (Delta Delta G) may be behind these differential behaviour.
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