Article
Biochemistry & Molecular Biology
Luiz Gustavo Almeida de Carvalho, Tatiana Takahasi Komoto, Daniel Antunes Moreno, Joao Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Mayara Magna de Lima Melo, Mariela Estefany Gislene Vera Roa, Paola Gyuliane Goncalves, Carlos Victor Montefusco-Pereira, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro Jr
Summary: The aim of this study was to evaluate the expression of USP7, USP15, UBE2O, and UBE2T genes in Myelodysplastic neoplasm (MDS) and identify their roles in MDS pathobiology. Through analyzing eight datasets from the GEO database, the expression relationship of these genes was analyzed in 1092 MDS patients and healthy controls. The results showed differential expression patterns of these genes in MDS patients, suggesting their potential involvement in controlling genomic instability and chromosomal abnormalities in MDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
C. Pawan K. Patro, Nupur Biswas, Sandeep C. Pingle, Feng Lin, Misa Anekoji, Lawrence D. Jones, Santosh Kesari, Feng Wang, Shashaanka Ashili
Summary: This article reviews the potential therapeutic approach of 5 & PRIME;-methylthioadenosine phosphorylase (MTAP) gene loss for treating glioblastoma. It discusses the relevance of MTAP loss in mitigating the effects of glioblastoma and explores various aspects of MTAP loss in the field of glioblastoma therapeutics.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yun Wei, Zhi Liu, Tianxing Lv, Yaxiu Xu, Yajing Wei, Weiting Liu, Li Liu, Aide Wang, Tong Li
Summary: This study identifies MdMAPK3 as a key regulator in ethylene-induced apple fruit softening during storage. MdMAPK3 interacts with and phosphorylates MdNAC72, leading to the degradation of MdNAC72 through the ubiquitin-proteasome pathway. The degradation of MdNAC72 increases the expression of MdPG1, promoting apple fruit softening.
Article
Evolutionary Biology
Hideyuki Miyazawa, Hans-Juergen Osigus, Sarah Rolfes, Kai Kamm, Bernd Schierwater, Hiroaki Nakano
Summary: Placozoans, the simplest known metazoan animals, are classified into 20 haplotypes belonging to three genera. Their mitochondrial genomes show unique features and variations in size, gene order, and exon-intron boundaries among different clades. Phylogenomic analyses reveal a different tree topology from previous studies, with interesting patterns of small inverted repeats present in all mitochondrial genomes of the Trichoplax and Hoilungia genera.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Yunwon Moon, Sehyun Chae, Sujin Yim, Eun Gyeong Yang, Jungwoo Choe, Jiyeon Hyun, Rakwoo Chang, Daehee Hwang, Hyunsung Park
Summary: The study demonstrates that CQ can be used as a JmjC-KDM inhibitor and affects the transcription of multiple genes, with an impact on H3K4me3, H3K9me3, and H3K27me3 marks. CQ and hypoxia commonly affect the response to hypoxia, VEGF signaling, and glycolysis, while CQ uniquely alters apoptosis/autophagy and cytoskeleton/extracellular matrix organization.
Article
Chemistry, Multidisciplinary
Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki
Summary: A first-in-class proteolysis targeting chimera (PROTAC) was developed to selectively degrade HDAC8, without affecting other HDACs, and exhibited stronger growth inhibition in T-cell leukemia Jurkat cells compared to a conventional HDAC8 inhibitor.
CHEMICAL COMMUNICATIONS
(2022)
Review
Plant Sciences
Maria Vranceanu, Simona-Codruta Heghes, Anamaria Cozma-Petrut, Roxana Banc, Carmina Mariana Stroia, Viorica Raischi, Doina Miere, Daniela-Saveta Popa, Lorena Filip
Summary: Obesity is a prevalent health problem in the Western world, with various factors like diet, sedentary lifestyle, and genetics contributing to its development. Recent scientific evidence suggests that both genetic and environmental factors play a role in obesity. Epigenetic changes, which can be influenced by variables such as diet and exercise, are reversible and attractive targets for therapeutic interventions. While anti-obesity drugs have numerous side effects, some nutraceuticals like resveratrol, curcumin, and caffeine have been shown to alter gene expression and aid weight loss.
Article
Biochemistry & Molecular Biology
Me-Sun Kim, Kwon-Kyoo Kang, Yong-Gu Cho
Summary: This study identified the characteristics of 77 OsPUB genes in rice and conducted a systematic and comprehensive analysis including conserved domains, phylogenetic relationships, and gene structure. 16 OsPUB genes showed similar expression patterns in drought stress and blast infection, with numerous cis-acting elements in their promoter sequences suggesting involvement in complex regulatory networks. The results indicate that OsPUB genes have various functions in the responses of rice to abiotic and biotic stresses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Samuel B. Anyona, Evans Raballah, Qiuying Cheng, Ivy Hurwitz, Caroline Ndege, Elly Munde, Walter Otieno, Philip D. Seidenberg, Kristan A. Schneider, Christophe G. Lambert, Benjamin H. McMahon, Collins Ouma, Douglas J. Perkins
Summary: A study conducted on Kenyan children revealed that the expression of certain ubiquitination genes is regulated in children with SMA, affecting the Ubiquitin-Proteasomal Proteolysis process. These results demonstrate a novel mechanism by which protein coding genes of the ubiquitination processes are involved in the pathogenesis of SMA.
FRONTIERS IN GENETICS
(2021)
Article
Biology
Matthew Travert, Reed Boohar, Steven M. Sanders, Manon Boosten, Lucas Leclere, Robert E. Steele, Paulyn Cartwright
Summary: Cnidarians have diverse life cycles, and only Medusozoa has a swimming stage called the medusa, alternating with a benthic polyp stage. The presence of the homeobox gene Tlx in Cnidaria is correlated with the presence of the medusa stage, and its loss is linked to the repeated loss of medusa in Hydrozoa evolution. Tlx plays a key role in medusa development, and its expression patterns support this role.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fang Wang, Farrah El-Saafin, Tao Ye, Matthieu Stierle, Luc Negroni, Matej Durik, Veronique Fischer, Didier Devys, Stephane D. Vincent, Laszlo Tora
Summary: The co-activator complex SAGA, containing USP22 and ATXN7L3, is essential for normal embryonic development in mice, with Atxn7l3(-/-) embryos showing developmental delay at E7.5 and Usp22(-/-) embryos dying at E14.5. Deubiquitylation of histone H2Bub1 by these proteins does not directly regulate global Pol II transcription elongation.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Multidisciplinary Sciences
Linlin Li, Aidong Zhou, Yanjun Wei, Feng Liu, Peng Li, Runping Fang, Li Ma, Sicong Zhang, Longqiang Wang, Jinze Liu, Hope T. Richard, Yiwen Chen, Hengbin Wang, Suyun Huang
Summary: In this study, a previously unidentified oncogenic lncRNA called lncEPAT was discovered to mediate the integration of the dysregulated EGFR pathway with H2A deubiquitination in tumorigenesis. LncEPAT interacts with deubiquitinase USP16 and inhibits its recruitment to chromatin, thereby blocking USP16-mediated H2A deubiquitination and repressing target gene expression. Depletion of lncEPAT promotes USP16-induced cell cycle arrest and cellular senescence, and represses tumor formation in GBM cells.
Article
Microbiology
Teng Long, Robert D. Burk, Paul K. S. Chan, Zigui Chen
Summary: The study reveals the potential of host degradation by macaque PV types, emphasizing the complex interactions between viral oncogenes and host proteomes. These findings provide important insights into viral fitness and pathological consequences, expanding the understanding of the phenotype-genotype relationship from an evolutionary perspective.
Article
Multidisciplinary Sciences
Eva Hoellmueller, Simon Geigges, Marie L. Niedermeier, Kai-Michael Kammer, Simon M. Kienle, Daniel Roesner, Martin Scheffner, Andreas Marx, Florian Stengel
Summary: The site-specific ubiquitylation of H1 results in distinct interactomes, regulates phase separation, and modulates assembly of chromatosomes, highlighting a general regulatory role for linker histone H1.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Qiaoying Pei, Tong Yu, Tong Wu, Qihang Yang, Ke Gong, Rong Zhou, Chunlin Cui, Ying Yu, Wei Zhao, Xi Kang, Rui Cao, Xiaoming Song
Summary: The study identified a total of 73 Hsf genes in three representative Apiaceae species and revealed the role of whole-genome duplication in the expansion of the Hsf gene family within Apiaceae. Coriander was found to have more Hsf genes than celery and carrot, with considerable positive selection identified in 27 branches of the phylogenetic tree in these Apiaceae species. This research will guide future comparative and functional genomic studies on the Hsf gene family and others in Apiaceae.
HORTICULTURAL PLANT JOURNAL
(2021)
Article
Developmental Biology
Jordana M. Henderson, Sean V. Nisperos, Joi Weeks, Mahjoobah Ghulam, Ignacio Marin, Ricardo M. Zayas
DEVELOPMENTAL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Ignacio Marin
SCIENTIFIC REPORTS
(2018)
Article
Biochemical Research Methods
Rodrigo Aldecoa, Ignacio Marin
Article
Evolutionary Biology
Ignacio Marin
BMC EVOLUTIONARY BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Ignacio Marin
MOLECULAR BIOLOGY AND EVOLUTION
(2010)
Article
Physics, Fluids & Plasmas
Rodrigo Aldecoa, Ignacio Marin
Article
Multidisciplinary Sciences
Rodrigo Aldecoa, Ignacio Marin
Article
Multidisciplinary Sciences
Rodrigo Aldecoa, Ignacio Marin
Article
Multidisciplinary Sciences
Ignacio Marin
Article
Multidisciplinary Sciences
Ignacio Marin
Article
Multidisciplinary Sciences
Ignacio Marin
Article
Multidisciplinary Sciences
Rodrigo Aldecoa, Ignacio Marin
SCIENTIFIC REPORTS
(2013)
Article
Multidisciplinary Sciences
Rodrigo Aldecoa, Ignacio Marin
SCIENTIFIC REPORTS
(2013)
Article
Evolutionary Biology
Ignacio Marin
GENOME BIOLOGY AND EVOLUTION
(2020)
Article
Biology
Ignacio Marin
Summary: This study investigates the origin and evolutionary history of the synuclein genes, revealing that they are the result of whole-genome duplications in vertebrates, rather than individual gene duplications. These findings have important implications for understanding the diversity of synuclein genes and further exploring their structural and functional features.