期刊
JOURNAL OF MOLECULAR EVOLUTION
卷 67, 期 4, 页码 358-367出版社
SPRINGER
DOI: 10.1007/s00239-008-9150-0
关键词
Recombination rate; Dinucleotide bias; Neighbor-dependent mutational bias; GC content; Selection; Hill-Robertson interference
资金
- National Natural Science Foundation of China [30660044]
- Ph.D. Programs Foundation of Ministry of Education of China [20050126003]
Revealing how recombination affects genomic sequence is of great significance to our understanding of genome evolution. The present paper focuses on the correlation between recombination rate and dinucleotide bias in Drosophila melanogaster genome. Our results show that the overall dinucleotide bias is positively correlated with recombination rate for genomic sequences including untranslated regions, introns, intergenic regions, and coding sequences. The correlation patterns of individual dinucleotide biases with recombination rate are presented. Possible mechanisms of interaction between recombination and dinucleotide bias are discussed. Our data indicate that there may be a genome-wide universal mechanism acting between recombination rate and dinucleotide bias, which is likely to be neighbor-dependent biased gene conversion.
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