Article
Biology
Takeshi Ito, Yohei Kawai, Yutaka Yasui, Shoichi Iriguchi, Atsutaka Minagawa, Tomoko Ishii, Hiroyuki Miyoshi, M. Mark Taketo, Kenji Kawada, Kazutaka Obama, Yoshiharu Sakai, Shin Kaneko
Summary: Ito et al. generated and characterized multiclonal tumoricidal T cells derived from TIL-iPSC, showing improved functions and potential therapeutic use. The study also investigated the optimization of TIL preparation to enhance anti-cancer effects, suggesting that cell reprogramming could play a role in improving outcomes of TIL-based therapies.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Meng-Chien Willie Hsieh, Wei-Ting Wang, Chuang-Yu Lin, Yur-Ren Kuo, Su-Shin Lee, Ming-Feng Hou, Yi-Chia Wu
Summary: This review summarizes the therapeutic benefits of using various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, and adipose-derived stem cells, in diabetic wound healing. The focus is on autologous adipose-derived stem cells and laboratory expandable induced pluripotent stem cells. The study aims to shed more light on this attractive therapy in order to improve the efficacy of wound healing in diabetic patients.
Review
Biochemistry & Molecular Biology
Tomasz Staniowski, Anna Zawadzka-Knefel, Katarzyna Skoskiewicz-Malinowska
Summary: Stem cells are undifferentiated cells capable of self-renewal, proliferation, and differentiation, with potential applications in tissue regeneration. Recent interest in obtaining stem cells from human teeth for biomedical applications has grown, particularly in utilizing Dental Pulp Stem Cells (DPSCs) for various therapeutic possibilities. In vivo studies have shown that DPSCs can differentiate into various tissues, offering hope for regenerative therapy and immunotherapy.
Article
Cell Biology
Deepa Bhartiya, Nitu Jha, Anish Tripathi, Ashish Tripathi
Summary: The concept of dedifferentiation and reprogramming of mature somatic cells shows promise in the battle against tissue damage, cancer, and aging. However, clinical applications remain challenging due to various factors such as instability, tumorigenicity, immunogenicity, and heterogeneity. The potential of very small embryonic-like stem cells (VSELs) in addressing these issues is examined, as they have been found to replace diseased tissue, ensure regeneration, and differentiate into adult counterparts.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Quan-Wen Liu, Qi-Ming Huang, Han-You Wu, Guo-Si-Lang Zuo, Hao-Cheng Gu, Ke-Yu Deng, Hong-Bo Xin
Summary: Stem cell therapy has the potential to repair tissues and improve functional recovery, but faces challenges such as ethical barriers and immune rejection. Human amnion-derived stem cells (hADSCs) show advantages over other stem cells, including high pluripotency and immunomodulatory effects, making them a promising source for cell therapy and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Win Sen Heng, Frank A. E. Kruyt, Shiau-Chuen Cheah
Summary: Lung cancer, one of the deadliest cancers, can be effectively reduced through prevention measures, though treatment improvements are still needed to address therapeutic resistance caused by cancer stem cells; phytochemicals in plant-based diets are believed to have efficacy in targeting lung cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Tao Wang, Yingyu Li, Yu Zhu, Zebiao Liu, Li Huang, Hongxia Zhao, Zuping Zhou, Qiong Wu
Summary: This study reveals the anti-aging and anti-obesity effects of adipose-derived stem cells (ASCs) in aged animals, while the underlying molecular mechanism remains unknown. The transplantation effects of ASCs from different age donors on natural aging and leptin knockout mice were evaluated, and the multi-omics expression profiles of ASCs from young and aged mouse donors were analyzed. It was found that ASCs from young donors induced weight and abdominal fat loss in older recipients but not in young or leptin knockout mice, and young and aged mouse donor ASCs displayed significant phenotypic differences contributing to the distinguished effects in aged mice.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Genetics & Heredity
Huajin Li, Wenting Xu, Sijia Xiang, Leiting Tao, Wen Fu, Jinhui Liu, Wenbin Liu, Yamei Xiao, Liangyue Peng
Summary: Pluripotency is a transient state in early embryos regulated by a network of pluripotency-related genes. This study identified four pluripotent genes in zebrafish and crucian carp and verified that three of them can be used as markers for pluripotency in induced pluripotent stem cells in fish.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Kiyofumi Takabatake, Masakazu Matsubara, Eiki Yamachika, Yuki Fujita, Yuki Arimura, Kazuki Nakatsuji, Keisuke Nakano, Histoshi Nagatsuka, Seiji Iida
Summary: The study found that DFAT cells had weaker calcification ability initially, but similar to ASCs at three weeks; ASCs showed earlier increase in alkaline phosphatase levels compared to DFAT cells, with significant differences at 6 and 9 days; DFAT cells exhibited higher alkaline phosphatase levels than ASCs after 12 days.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Zijun Cai, Di Liu, Yuntao Yang, Wenqing Xie, Miao He, Dengjie Yu, Yuxiang Wu, Xiuhua Wang, Wenfeng Xiao, Yusheng Li
Summary: This article reviews the relationship between sarcopenia and stem cells, discussing the roles of satellite cells (SCs) and muscle-derived stem cells (MDSCs) in sarcopenia. Studies have shown that changes in the number and function of stem cells can trigger sarcopenia and have adverse effects on stem cells. A better understanding of the role of stem cells, especially SCs and MDSCs, in muscle, is important for developing novel therapeutic approaches to combat sarcopenia.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Qing Zhang, Jialin Wang, Junwen Zhang, Fusheng Liu
Summary: Mesenchymal stem cells (MSCs) play crucial roles in the tumor microenvironment (TME), contributing to tumor progression and therapeutic resistance. Glioma-resident MSCs (GR-MSCs) enhance the tumorigenicity of glioma stem cells (GSCs) through the IL-6/gp130/STAT3 pathway. Higher percentage of GR-MSCs in the TME leads to poor prognosis of glioma patients and their secretion of specific miRNA promotes tumor growth. Novel therapeutic strategies targeting GR-MSCs are urgently needed for GBM patients.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Oncology
Abigail Harland, Xia Liu, Mattia Ghirardello, M. Carmen Galan, Claire M. Perks, Kathreena M. Kurian
Summary: This review explores the characteristics of glioma stem-like cells (GSCs), their metabolic interactions, and potential strategies for overcoming GSC resistance.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Mohammed Zayed, Sung-Ho Kook, Byung-Hoon Jeong
Summary: Prion diseases are progressive, incurable, and deadly neurodegenerative disorders. Prion protein plays an important role in stem cells and offers therapeutic potential for prion diseases. Regenerative medicine, particularly the use of stem cell therapy, has revolutionized disease treatment.
Article
Endocrinology & Metabolism
Hanyue Li, Yu Yuan, Hongying Chen, Hongwei Dai, Jie Li
Summary: This study investigated the effects and underlying mechanism of adipose-derived stromal/stem cell (ASC) therapy in experimental periodontitis. The results showed that ASCs can alleviate periodontitis by modulating macrophage polarization through the IDO-dependent Kyn-AhR-NRF2 pathway.
MOLECULAR METABOLISM
(2022)
Review
Biotechnology & Applied Microbiology
Sara Al-Ghadban, Maria Artiles, Bruce A. Bunnell
Summary: This article discusses the progress and applications of stem cell-based regenerative medicine in the past decade. Adult stem cells from adipose tissue show promise in treating various diseases and regenerating damaged tissues. Recent developments focus on creating more complex structures, such as organoids and tissue elements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medical Laboratory Technology
Tamara Camino, Nerea Lago-Baameiro, Susana Belen Bravo, Alberto Molares-Vila, Aurelio Sueiro, Ivan Couto, Javier Baltar, Eelipe F. Casanueva, Maria Pardo
Summary: This study characterized the protein cargo of extracellular vesicles (EVs) released by adipose tissue (AT) in obese individuals using mass spectrometry analysis. The results revealed that EVs shed by visceral adipose tissue (VAT) in obese individuals contained more inflammation-related proteins compared to those shed by subcutaneous adipose tissue (SAT). Additionally, specific proteins identified in the EVs were associated with disease status and could serve as candidate biomarkers. These findings provide important insights into the mechanisms underlying obesity and related metabolic disorders.
TRANSLATIONAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Natalia da Silva Lima, Marcos F. Fondevila, Eva Novoa, Xabier Buque, Maria Mercado-Gomez, Sarah Gallet, Maria J. Gonzalez-Rellan, Uxia Fernandez, Anne Loyens, Maria Garcia-Vence, Maria Del Pilar Chantada-Vazquez, Susana B. Bravo, Patricia Maranon, Ana Senra, Adriana Escudero, Magdalena Leiva, Diana Guallar, Miguel Fidalgo, Pedro Gomes, Marc Claret, Guadalupe Sabio, Marta Varela-Rey, Teresa C. Delgado, Rocio Montero-Vallejo, Javier Ampuero, Miguel Lopez, Carlos Dieguez, Laura Herrero, Dolors Serra, Markus Schwaninger, Vincent Prevot, Rocio Gallego-Duran, Manuel Romero-Gomez, Paula Iruzubieta, Javier Crespo, Maria L. Martinez-Chantar, Carmelo Garcia-Monzon, Agueda Gonzalez-Rodriguez, Patricia Aspichueta, Ruben Nogueiras
Summary: ATG3, induced in the liver of NAFLD patients, plays a role in lipid metabolism and may contribute to the development of steatosis. Inhibition of hepatic ATG3 can improve fatty acid metabolism by reducing JNK1, leading to increased SIRT1, CPT1a, and mitochondrial function, independent of its autophagic action.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luis Varela, Maria E. R. Garcia-Rendueles
Summary: Cancer and neurodegenerative diseases are leading causes of premature death in modern societies, with increasing incidence. They share dysregulation of molecular signaling pathways, but elicit opposite responses. Understanding these mechanisms is crucial for disease understanding and precise treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alejandro Lorenzo-Pouso, Susana B. Bravo, Javier Carballo, Maria del Pilar Chantada-Vazquez, Jose Bagan, Leticia Bagan, Cintia M. Chamorro-Petronacci, Mercedes Conde-Amboage, Rafael Lopez-Lopez, Abel Garcia-Garcia, Mario Perez-Sayans
Summary: This study investigated the salivary proteome in MRONJ patients and identified differentially expressed proteins. Three prioritized proteins were identified, which may serve as a potential biomarker panel for the prediction or diagnosis of MRONJ.
Article
Biochemistry & Molecular Biology
Maria E. R. Garcia-Rendueles, Gnana Krishnamoorthy, Mahesh Saqcena, Adrian Acuna-Ruiz, Giovanna Revilla, Elisa de Stanchina, Jeffrey A. A. Knauf, Rona Lester, Bin Xu, Ronald A. A. Ghossein, James A. A. Fagin
Summary: The study demonstrates the relationship between aberrant YAP nuclear localization and dependency in thyroid cancer cells. YAP activation leads to resistance to RAF kinase inhibitors, which is associated with the NRG1 signaling pathway.
Article
Neurosciences
Fernando Laso-Garcia, Dolores Piniella, Frutos Mari Carmen Gomez-de, Laura Casado-Fernandez, Maria Perez-Mato, Elisa Alonso-Lopez, Laura Otero-Ortega, Susana Belen Bravo, Maria Del Pilar Chantada-Vazquez, Lucia Trilla-Fuertes, Juan angel Fresno-Vara, Blanca Fuentes, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez, Maria Alonso De Lecinana
Summary: Extracellular vesicles (EVs) play a role in intercellular communication and can serve as biomarkers for disease processes. In the context of intracerebral hemorrhage, studying the number and protein content of circulating EVs can provide insights into the underlying biological mechanisms of damage and repair, aiding in the identification of potential therapeutic targets.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Eloi Franco-Trepat, Ana Alonso-Perez, Maria Guillan-Fresco, Miriam Lopez-Fagundez, Andres Pazos-Perez, Antia Crespo-Golmar, Susana Belen Bravo, Veronica Lopez-Lopez, Alberto Jorge-Mora, Jose P. Ceron-Carrasco, Ana Lois Iglesias, Rodolfo Gomez
Summary: Osteoarthritis is a progressive rheumatic disease characterized by joint inflammation and degradation. The compound beta boswellic acid (BBA) has shown potential in reducing cartilage loss by inhibiting TLR4 and IL1R signaling in OA joint cells. This study presents solid evidence of BBA's therapeutic properties, suggesting its potential as a treatment for OA after further clinical evaluations.
Article
Dentistry, Oral Surgery & Medicine
Mario Perez-Sayans, Cintia M. Chamorro-Petronacci, Susana B. Bravo, Maria E. Padin-Iruegas, Esteban Guitian-Fernandez, Francisco Barros-Angueira, Rita Quintas-Rey, Abel Garcia-Garcia
Summary: This study describes the genetic variants associated with the development of head and neck cancer (HNC) and validates their molecular implications. A family of 3 generations, where 3 members had developed HNC, was observed. It was found that 6 out of 13 members carried the same mutation of CYP26B1, and lower levels of all-trans retinoic acid (atRA) were confirmed in their plasma.
Article
Food Science & Technology
Manuela Alonso-Sampedro, Xesus Feas, Susana Belen Bravo, Maria Pilar Chantada-Vazquez, Carmen Vidal
Summary: Health risks caused by stings from the yellow-legged Asian hornet, Vespa velutina nigrithorax (VV), have raised concerns. However, little is known about the composition of its venom. This study analyzed the proteome profile of VV's venom sac and identified differential expression of proteins between future queens and workers.
Article
Medicine, Research & Experimental
Fernando Laso-Garcia, Laura Casado-Fernandez, Dolores Piniella, Mari Carmen Gomez-de Frutos, Jone Karmele Arizaga-Echebarria, Maria Perez-Mato, Elisa Alonso-Lopez, Laura Otero-Ortega, Susana Belen Bravo, Maria del Pilar Chantada-Vazquez, Jose Avendano-Ortiz, Eduardo Lopez-Collazo, Maria Isabel Lumbreras-Herrera, Angelo Gamez-Pozo, Blanca Fuentes, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez, Maria Alonso de Lecinana
Summary: Treatment with EVs derived from blood can enhance recovery after intracerebral hemorrhage by downregulating immune system activation pathways and upregulating repair pathways, leading to better tissue preservation.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Immunology
Gabriel Torres Iglesias, Mireya Fernandez-Fournier, Lucia Botella, Dolores Piniella, Fernando Laso-Garcia, Mari Carmen Gomez-de Frutos, Beatriz Chamorro, Inmaculada Puertas, Antonio Tallon Barranco, Blanca Fuentes, Maria Alonso de Lecinana, Elisa Alonso-Lopez, Susana B. Bravo, Maria Eugenia Miranda-Carus, Ana Montero-Calle, Rodrigo Barderas, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez, Laura Otero-Ortega
Summary: Blood extracellular vesicles (EVs) derived from T cells and neurons have been identified as specific biomarkers in multiple sclerosis (MS). Proteomic analysis revealed MS-associated proteins in these EVs, which correlated with disease activity.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Cell Biology
Maria J. Gonzalez-Rellan, Uxia Fernandez, Tamara Parracho, Eva Novoa, Marcos F. Fondevila, Natalia da Silva Lima, Lucia Ramos, Amaia Rodriguez, Marina Serrano-Macia, Gonzalo Perez-Mejias, Pilar Chantada-Vazquez, Cristina Riobello, Christelle Veyrat-Durebex, Sulay Tovar, Roberto Coppari, Ashwin Woodhoo, Markus Schwaninger, Vincent Prevot, Teresa C. Delgado, Miguel Lopez, Antonio Diaz-Quintana, Carlos Dieguez, Diana Guallar, Gema Fruhbeck, Irene Diaz-Moreno, Susana B. Bravo, Maria L. Martinez-Chantar, Ruben Nogueiras
Summary: Neddylation is a post-translational modification mechanism that regulates metabolism in the liver of mice and is associated with liver pathology in patients with type 2 diabetes. Fasting or calorie restriction leads to neddylation of phosphoenolpyruvate carboxykinase 1 (PCK1), affecting its metabolic activity.
Correction
Biochemistry & Molecular Biology
Angela R. Garcia-Rendueles, Miguel Chenlo, Fernando Oroz-Gonjar, Antonia Solomou, Anisha Mistry, Sayka Barry, Carles Gaston-Massuet, Montserrat Garcia-Lavandeira, Sihara Perez-Romero, Maria Suarez-Farina, Alberto Pradilla-Dieste, Carlos Dieguez, Patrick Mehlen, Marta Korbonits, Clara V. Alvarez
Article
Endocrinology & Metabolism
Maria J. Gonzalez-Rellan, Tamara Parracho, Violeta Heras, Amaia Rodriguez, Marcos F. Fondevila, Eva Novoa, Natalia Lima, Marta Varela-Rey, Ana Senra, Maria D. P. Chantada-Vazquez, Cristina Ameneiro, Ganeko Bernardo, David Fernandez-Ramos, Fernando Lopitz-Otsoa, Jon Bilbao, Diana Guallar, Miguel Fidalgo, Susana Bravo, Carlos Dieguez, Maria L. Martinez-Chantar, Oscar Millet, Jose M. Mato, Markus Schwaninger, Vincent Prevot, Javier Crespo, Gema Fruhbeck, Paul Iruzubieta, Ruben Nogueiras
Summary: O-GlcNAcylation is a post-translational modification that affects protein function and localization, and its deregulation is associated with various human diseases. This study reveals the role of O-GlcNAcylation in the progression of NAFLD, providing new avenues for therapeutic intervention.
MOLECULAR METABOLISM
(2023)
Article
Ophthalmology
Maite Lopez-Lopez, Uxia Regueiro, Susana Belen Bravo, Maria del Pilar Chantada-Vazquez, Carmen Pena, Elio Diez-Feijoo, Pablo Hervella, Isabel Lema
Summary: This study utilized a qualitative approach to explore the tear proteome of patients with keratoconus (KC), finding that the expression of certain proteins in tears of KC patients differed from the control group. These differences were linked to processes such as cell death, oxidative damage, and inflammation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
