Article
Food Science & Technology
Jasmine F. Plows, Mark H. Vickers, Thashma P. Ganapathy, Pania E. Bridge-Comer, Joanna L. Stanley, Clare M. Reynolds
Summary: The knockout of IL1R1 does not protect nulliparous or pregnant females from glucose intolerance induced by a high-fat diet. Postpartum, IL1R1(-/-) mice still have impaired glucose tolerance compared to control mice. These effects are associated with adipocyte hypertrophy, hyperleptinemia, and increased expression of inflammatory genes in adipose tissue.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shenglu Jiang, Jiayan Lin, Qian Zhang, Yunjun Liao, Feng Lu, Junrong Cai
Summary: This study investigates the fate of fat grafting of three different types of fat tissue (white, beige, brown) and shows that beige adipose tissue has superior survival and lower inflammation, making it a potential choice for fat grafting, while brown adipose tissue may not be ideal due to poor survival.
Article
Biochemistry & Molecular Biology
Da Hea Seo, Eugene Shin, Yong-ho Lee, Se-Eun Park, Ki Taek Nam, Jae-woo Kim, Bong-Soo Cha
Summary: Cilostazol treatment promotes browning of visceral adipose tissue by activating the cAMP/PKA signaling pathway and improves overall metabolism in HFD-fed mice.
Article
Medicine, Research & Experimental
Akiko Yano, Shuang Liu, Yasuyuki Suzuki, Matome Imai, Masaki Mogi, Takashi Sugiyama
Summary: This study used single-cell RNA sequencing to uncover the cellular composition and functional shift in the adipose tissue during pregnancy. It identified unique properties of adipocytes in response to pregnancy processes and their potential contribution to maternal-fetal immune tolerance. The study also highlighted the role of adipocytes in pregnancy-induced vesicular remodeling.
Article
Endocrinology & Metabolism
Elna Dickson, Rana Soylu-Kucharz, Asa Petersen, Maria Bjorkqvist
Summary: This study aimed to investigate the effects of hypothalamic huntingtin (HTT) protein levels on metabolic phenotype and disease features in Huntington's disease (HD). The results showed that hypothalamic overexpression of mutant HTT led to weight gain, particularly in the early stages of the disease, accompanied by behavioral alterations and transcriptional changes.
MOLECULAR METABOLISM
(2022)
Article
Agriculture, Dairy & Animal Science
M. M. McGuckin, S. L. Giesy, T. R. Overton, Y. R. Boisclair
Summary: The transition from late pregnancy to early lactation in dairy cows involves major changes in metabolic activities of liver and adipose tissue. The variation in plasma concentration and actions of hormones, along with the activation of the immune system, contribute to these changes. However, the possibility of resident macrophages adopting a proinflammatory state in parallel with the rise in plasma acute-phase proteins has received less attention.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Food Science & Technology
Caroline Bertoncini-Silva, Priscila Giacomo Fassini, Daniela Carlos, Natalia Aparecida de Paula, Leandra Naira Zambelli Ramalho, Marina Rodrigues Giuliani, italo Sousa Pereira, Jhefferson Barbosa Guimaraes, Vivian Marques Miguel Suen
Summary: After 12 weeks of high-fat diet feeding and oral supplementation with curcumin in mice, it was found that curcumin reduces inflammatory markers and increases anti-inflammatory markers in the liver and white adipose tissue. In the gut, curcumin promotes the growth of beneficial bacteria and reduces harmful bacteria.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Afroditi Kastrenopoulou, Kyriakos E. Kypreos, Nicholaos Papachristou, Stavros Georgopoulos, Ioulia Mastora, Ioanna Papadimitriou-Olivgeri, Argyro Spentzopoulou, Dragana Nikitovic, Vassilios Kontogeorgakos, Harry C. Blair, Dionysios J. Papachristou
Summary: In this study, the researchers investigated the impact of APOA1 on bone marrow adipocytes using ApoA1 knockout mice. The results showed that APOA1 deficiency led to an increase in the number of adipocytes in the bone marrow, which resembled white adipocytes. Furthermore, the expression of brown/beige adipocyte-specific markers was reduced, and there was a decrease in the compartments of hematopoietic stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Alberto Mestres-Arenas, Joan Villarroya, Marta Giralt, Francesc Villarroya, Marion Peyrou
Summary: The study found that PVAT depots increase the expression of specific genes under cold-induced thermogenic activation, suggesting that both thoracic and abdominal aortas would experience intense local exposure to these PVAT-secreted batokines. In contrast, under short-term high-fat diet-induced thermogenic activation, the thoracic aorta specifically experiences a local increase in BMP8B, FGF21, and KNG2 originating from PVAT. These findings support the idea that acquisition of a brown/beige phenotype in PVAT involves upregulation of specific batokines that can affect the vascular system differentially.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Johanna Bruder, Tobias Fromme
Summary: Within the first month after birth, mice undergo a drastic but transient remodeling process in their adipose tissue depots. This process involves the sudden emergence and subsequent reversal of beige adipocytes in white fat depots, along with an opposite phenomenon in brown fat depots. The remodeling process is influenced by various environmental and genetic factors and may contribute to the lasting adaptive capacity in adult animals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jesus Fernandez-Felipe, Adrian Plaza, Gema Dominguez, Javier Perez-Castells, Victoria Cano, Francesco Cioni, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merino
Summary: High-fat diets enriched with lauric acid do not increase leptin production and reduce the effect of leptin on kinase phosphorylation. Both high-fat diets affect adipocyte-size distribution and gene expression related to adipogenesis and inflammation. The composition of white adipose tissue is different between the two diets, which may impact the biophysical properties and signaling of leptin receptor.
Article
Nutrition & Dietetics
Katrin Schmitz, Eva-Maria Turnwald, Tobias Kretschmer, Ruth Janoschek, Inga Bae-Gartz, Kathrin Vossbrecher, Merlin D. Kammerer, Angela Koeninger, Alexandra Gellhaus, Marion Handwerk, Maria Wohlfarth, Dirk Gruendemann, Eva Hucklenbruch-Rother, Joerg Doetsch, Sarah Appel
Summary: With the increasing prevalence of obesity, the risks associated with pregnancy are also rising. Inflammation and oxidative stress are identified as key mechanisms in white adipose tissue (WAT) that contribute to obesity-associated complications and diseases. The anti-diabetic drug metformin has known systemic effects, but its effects on WAT are not well understood. This study investigated the effects of metformin treatment during pregnancy using a mouse model of diet-induced maternal obesity. The results showed that metformin treatment reduced weight gain and visceral fat accumulation, and regulated several potential adipokines to mediate anti-diabetic, anti-inflammatory, and oxidative stress-modulating effects.
Article
Biochemistry & Molecular Biology
Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hoerl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl
Summary: This study investigates the impact of PEMT on aging-associated energy metabolism using metabolomics. The results show that the effect of PEMT knockout is tissue-specific and age-dependent. Additionally, the absence of PEMT increases the divergence of the metabolome during aging in the liver, adipose tissues, and intestines.
Article
Medicine, Research & Experimental
Khanyisani Ziqubu, Phiwayinkosi V. Dludla, Marakiya T. Moetlediwa, Thembeka A. Nyawo, Carmen Pheiffer, Babalwa U. Jack, Bongani Nkambule, Sithandiwe E. Mazibuko-Mbeje
Summary: This study used an animal model of type 2 diabetes to investigate the effects of the disease on adipose tissue morphology and gene regulation. The results showed that both white and brown adipose tissue from diabetic mice displayed hypertrophy and increased expression of pro-inflammatory cytokines. Additionally, the brown adipose tissue showed impairment in glucose regulation, inflammatory profile, and thermogenic regulation. Gene expression of batokines involved in sympathetic neurite outgrowth and vascularization was also altered in the brown adipose tissue of diabetic mice. These findings provide new insights into the mechanisms of BAT hypertrophy and batokine disturbances in the development of type 2 diabetes.
Article
Geriatrics & Gerontology
Alessio Molfino, Raffaella Carletti, Giovanni Imbimbo, Maria Ida Amabile, Roberta Belli, Cira R. T. Gioia, Elena Belloni, Francesco Spinelli, Veronica Rizzo, Carlo Catalano, Giuseppe Nigri, Maurizio Muscaritoli
Summary: Among cancer patients, particularly those with cachexia, histological alterations and infiltration of inflammatory cells were observed in subcutaneous adipose tissue. These changes included reduced adipocyte size, increased fibrosis, and higher numbers of macrophages and T lymphocytes. These histomorphological parameters were associated with lower body mass index and reduced visceral and subcutaneous adipose tissue on CT scan.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Gastroenterology & Hepatology
Kazuhide Matsumoto, Nao Fujimori, Yoshitaka Hata, Yosuke Minoda, Masatoshi Murakami, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Eikichi Ihara, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa
Summary: This study investigated the clinical characteristics of ampullary neuroendocrine neoplasms (NENs) and found distinct differences between ampullary NENs and pancreatic NENs, such as higher incidences of NEC and cholangitis in ampullary NENs. Furthermore, the study discovered identifiable distinctions between ampullary NETs and NECs through endoscopic findings.
DIGESTIVE DISEASES
(2023)
Article
Integrative & Complementary Medicine
Teruhisa Yamamoto, Jun Kawanokuchi, Nobuyuki Nagaoka, Ken Takagi, Torao Ishida, Tomoya Hayashi, Ning Ma
Summary: This study suggests that simultaneous acupuncture stimulation at GV20 and Yintang is effective for the prevention and treatment of depression, and this effect may involve the modulation of multiple neurotrophic factors.
ACUPUNCTURE IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa
Summary: This study investigated the region-specific role of the M-3 receptor in gastrointestinal motility using a novel positive allosteric modulator (PAM-369). The results showed that PAM-369 selectively potentiated the M-3 receptor without agonistic or antagonistic activity and increased small intestinal transit in mice. However, it had no effect on colonic transit. This study provides the first direct evidence of the different functional roles of the M-3 receptor between the small intestine and colon.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Peripheral Vascular Disease
Motoko Nomura, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Takashi Yoneda, Masakatsu Sone, Kenji Oki, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Nobuya Inagaki, Koichi Yamamoto, Michio Otsuki, Daisuke Yabe, Shoichiro Izawa, Yutaka Takahashi, Tomoko Suzuki, Akihiro Yasoda, Akiyo Tanabe, Mitsuhide Naruse
Summary: A recent study suggests that patients with primary aldosteronism who remain renin suppressed during mineralocorticoid receptor antagonist treatment may have a higher risk of developing cardiovascular disease. The study found that patients with a high change in plasma renin activity after treatment had a significantly higher risk of cardiovascular disease compared to those with an intermediate change in renin activity. Age and body mass index were identified as independent risk factors for cardiovascular disease.
HYPERTENSION RESEARCH
(2022)
Article
Hematology
Mariko Tsuda, Akie Hirata, Shoji Tokunaga, Toru Masuda, Shojiro Haji, Daisaku Kimura, Chinatsu Nojiri, Yasuhiro Nakashima, Motoaki Shiratsuchi, Koji Kato, Toshihiro Miyamoto, Koichi Akashi, Naoki Nakashima, Yoshihiro Ogawa
Summary: Our study found that the use of specific types of antihypertensive drugs may accelerate the decline of glomerular filtration rate in patients during TKI treatment. Particularly, patients using renin-aldosterone-angiotensin system inhibitors showed the most notable decrease in glomerular filtration rate.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2022)
Article
Surgery
Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa
Summary: Mucosal incision-assisted biopsy (MIAB) is a safe procedure with minimal impact on postoperative prognosis for sampling gastric subepithelial lesions (SELs). MIAB releases some tumor cells after damaging the SEL's pseudocapsule, but it does not significantly affect the 5-year disease-free survival rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Gastroenterology & Hepatology
Akihisa Ohno, Nao Fujimori, Toshiya Abe, Masafumi Nakamura, Yoshihiro Ogawa
Article
Peripheral Vascular Disease
Shintaro Sakaguchi, Ryuji Okamoto, Chisa Inoue, Masaharu Akao, Kohei Kamemura, Isao Kurihara, Yoshiyu Takeda, Youichi Ohno, Nobuya Inagaki, Hiromi Rakugi, Takuyuki Katabami, Mika Tsuiki, Akiyo Tanabe, Kouichi Tamura, Satoshi Fujita, Yutaka Yano, Kaoru Dohi, Mitsuhide Naruse
Summary: This study investigated the factors associated with comorbid atrial fibrillation (AF) and cardiovascular events in patients with primary aldosteronism (PA), as well as the effect of PA treatment. The study found that age, sex, cardiothoracic ratio, and history of coronary artery disease and heart failure were associated with AF, and PA patients with AF had a higher frequency of cardiovascular events. After PA treatment, AF, in addition to age, duration of hypertension, body mass index, and chronic kidney disease, was an independent prognostic factor for cardiovascular events. The incidence of cardiovascular events was lower in PA patients with AF compared to AF patients without PA.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Food Science & Technology
Shigeru Murakami, Chihiro Hirazawa, Toshiki Mizutani, Rina Yoshikawa, Takuma Ohya, Ning Ma, Yutaka Owaki, Toyohiro Owaki, Takashi Ito, Chiaki Matsuzaki
Summary: This study found that the polysaccharides from Gloiopeltis furcata can alleviate obesity, diabetes, and metabolic diseases by inhibiting intestinal fat absorption and reducing inflammation and oxidative stress.
FOOD SCIENCE & NUTRITION
(2023)
Article
Endocrinology & Metabolism
Hiroki Kaneko, Hironobu Umakoshi, Tazuru Fukumoto, Norio Wada, Takamasa Ichijo, Shohei Sakamoto, Tetsuhiro Watanabe, Yuki Ishihara, Tetsuya Tagami, Masatoshi Ogata, Norifusa Iwahashi, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The clinical practice guideline emphasizes the importance of confirmatory tests for primary aldosteronism in order to avoid unnecessary adrenal venous sampling for false-positive cases. However, the study found that a combination of multiple confirmatory tests did not yield better results than individual tests in predicting subtypes of primary aldosteronism.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mitsuru Esaki, Eikichi Ihara, Yorinobu Sumida, Hiroyuki Fujii, Shunsuke Takahashi, Kazuhiro Haraguchi, Tsutomu Iwasa, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa
Summary: This study aimed to compare the treatment outcomes of hybrid endoscopic submucosal dissection (H-ESD) and conventional endoscopic submucosal dissection (C-ESD) for small early gastric neoplasms (EGNs). The results showed that H-ESD had significantly shorter procedure time than C-ESD, with comparable curability and safety. Therefore, H-ESD could be a good option for the endoscopic treatment of small EGNs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Hematology
Shojiro Haji, Motoaki Shiratsuchi, Akiko Takamatsu, Mariko Tsuda, Hiroki Muta, Toru Masuda, Yasuhiro Nakashima, Yoshihiro Ogawa
Summary: Non-invasive reactive hyperemia peripheral arterial tonometry (RH-PAT) can predict transplantation-related complications in hematopoietic stem cell transplantation (HSCT). Endothelial dysfunction is associated with the occurrence of thrombotic microangiopathy and acute graft-versus-host disease (aGVHD).
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B. Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki
Summary: By studying a Bcl11b-deficient mouse model, the authors found that MR1-reactive T cells have pathogenic potential and that MR1 functions as an antigen presenting protein on cells other than MAIT cells.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Mitsuhiro Kometani, Takashi Yoneda, Shigehiro Karashima, Yoshiyu Takeda, Mika Tsuiki, Akihiro Yasoda, Isao Kurihara, Norio Wada, Takuyuki Katabami, Masakatsu Sone, Takamasa Ichijo, Kouichi Tamura, Yoshihiro Ogawa, Hiroki Kobayashi, Shintaro Okamura, Nobuya Inagaki, Junji Kawashima, Megumi Fujita, Kenji Oki, Yuichi Matsuda, Akiyo Tanabe, Mitsuhide Naruse
Summary: A multicenter observational study found that intraprocedural cortisol measurement (ICM) significantly increased the success rate of adrenal vein sampling (AVS). However, ICM had no significant impact on subtype diagnosis. Therefore, the use of ICM during AVS is recommended.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Endocrinology & Metabolism
Masatoshi Murakami, Nao Fujimori, Kazuhide Matsumoto, Akihisa Ohno, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Keijiro Ueda, Takamasa Oono, Tetsuhide Ito, Yoshihiro Ogawa
Summary: VIPomas are rare functioning pancreatic neuroendocrine tumors that can cause symptoms such as watery diarrhea. This study found that VIPomas have distinct clinicopathological features compared to other PanNETs, including different tumor locations, sizes, and rates of metastasis. The prognosis for VIPomas is generally poor, with shorter median survival times compared to other types of PanNETs.
