Review
Biochemistry & Molecular Biology
Maria Teresa Hernandez-Huerta, Alma Dolores Perez-Santiago, Laura Perez-Campos Mayoral, Luis Manuel Sanchez Navarro, Francisco Javier Rodal Canales, Abraham Majluf-Cruz, Carlos Alberto Matias-Cervantes, Eduardo Perez-Campos Mayoral, Carlos Romero Diaz, Gabriel Mayoral-Andrade, Margarito Martinez Cruz, Judith Luna Angel, Eduardo Perez-Campos
Summary: This article discusses the molecular mechanisms of immunothrombosis caused by the SARS-CoV-2 virus, including the imbalance of different molecules, the role of cells, and the pathogenic mechanism. Overall, COVID-19 patients are simultaneously but differentially affected by endothelial damage, microthrombosis, and inflammation at different stages.
Review
Endocrinology & Metabolism
Martina Tetti, Siyuan Gong, Franco Veglio, Martin Reincke, Tracy Ann Williams
Summary: Primary aldosteronism is the most common surgically curable form of hypertension. Recent advances in our understanding of the disease have focused on the underlying genetic variants that cause excess aldosterone production. The mechanisms of increased adrenal cortex mass are still not well understood, but the application of transcriptomics, metabolomics, and epigenetics has provided valuable insights.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wei Xie, Ce Zhang, Tian Wang, Jianshe Wang, Fenghua Fu
Summary: The cortex of adrenal gland produces various hormones that play important roles in regulating blood pressure, metabolism, and glucose or electrolyte homeostasis. The medulla secretes catecholamines. Abnormal secretion of these hormones can lead to diseases such as Addison's disease, Cushing's syndrome, and congenital adrenal cortical hyperplasia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Heba Ali Hassan, Sara S. Muhammed, Ahmad Al-Khdhairawi, Sayed F. Abdelwahab, Islam M. Abdel-Rahman, Mahmoud M. Abdelhamid
Summary: In this study, a deep-learning protocol was used to design 100 compounds by modifying the chemical structure of DHC to improve its inhibitory performance against ERK-2. Calculations and molecular docking revealed that five compounds had better docking scores and higher stability compared to DHC. Further molecular mechanics and MM/PBSA binding energy calculations confirmed that Cmd-1 and Cmd-4 showed superior stability and inhibition against ERK-2. This study highlights the potential of using Cmd-1 and Cmd-4 as promising anti-ERK-2 drug candidates.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Yoon Jin Cha, Ja Seung Koo
Summary: The study investigates the expression of EMP 1, 2, and 3 in adrenal gland neoplasms and explores their broader implications. Immunohistochemical staining of tissue microarrays shows higher expression of EMP 3 in pheochromocytoma compared to adrenal cortical neoplasms, and higher expression of EMP 1 and EMP 3 in adrenal cortical carcinomas compared to adrenal cortical adenomas. High levels of EMP 1 and EMP 3 expression in adrenal cortical neoplasms are associated with shorter overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Henriett Butz, Katalin Meszaros, Istvan Liko, Attila Patocs
Summary: The study found that glucocorticoid treatment led to miRNA expression changes in different cell types. 19.5% of the influenced signaling pathways were common in all experiments, with the Wnt signaling pathway being the most affected. Transcriptome data and tissue-specific target prediction showed similar results, indicating significant alterations in the Wnt pathway in both the GC-producing adrenal gland and all investigated GC target tissue types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ruoqi Yang, Guiping Zhao, Lili Zhang, Yu Xia, Huijuan Yu, Bin Yan, Bin Cheng
Summary: This study constructed an efficient and reliable multi-stage virtual screening-in vitro biological validation system to identify potential inhibitors targeting ERK2. By using machine learning models, ADME/T prediction, and molecular docking, several candidate inhibitors were identified from natural products, and one of them exhibited acceptable inhibitory activity in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Ming Huang, Chih-Wen Chi, Pao-Shu Wu, Hung-Chi Tai, Ming-Nan Chien, Yu-Jen Chen
Summary: Adrenal radiotherapy may lead to fatigue and alterations in adrenal hormones.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Urology & Nephrology
Marissa Maas, Nima Nassiri, Sumeet Bhanvadia, John D. Carmichael, Vinay Duddalwar, Siamak Daneshmand
Summary: Guidelines for the diagnosis and treatment of adrenal incidentalomas vary among specialties, particularly in terms of reimaging, repeat hormone testing, and management of tumors characterized as benign or malignant. Consensus on initial evaluation exists, but discrepancies arise in follow-up recommendations. Recommendations range from avoiding repeat imaging and hormone testing to frequent monitoring over several years. Best practices may lie in finding common ground among divergent guidelines.
JOURNAL OF UROLOGY
(2021)
Article
Environmental Sciences
Jiao Yin, Aiming Lu, Tuanjie Che, Lihong He, Songdong Shen
Summary: This study found that 13 degrees Celsius is the optimal temperature for the growth of Neopyropia yezoensis. As the temperature increases, the survival and division rates of protoplasts decrease, which may be related to the downregulation of Cyclin B and the inactivation of ERK.
Article
Biology
Fatma F. Mohamed, Chunxi Ge, Shawn A. Hallett, Alec C. Bancroft, Randy T. Cowling, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Benjamin Levi, Vesa M. Kaartinen, Renny T. Franceschi
Summary: The development of the craniofacial skeleton requires interactions between progenitor cells and the extracellular matrix that is rich in collagen. Mutations in the DDR2 gene, which codes for a collagen receptor, have been linked to craniofacial abnormalities in humans. This study shows that mice lacking Ddr2 exhibit defects in craniofacial bones, including impaired calvarial growth and frontal suture formation. These defects are associated with abnormal collagen organization, chondrocyte proliferation, and orientation.
Article
Plant Sciences
Satoshi Okuyama, Yoshiko Furukawa, Morio Yoshimura, Yoshiaki Amakura, Mitsunari Nakajima, Takashi Yoshida
Summary: The study results showed that Oenothein B can reduce brain inflammation and enhance neuronal signaling pathways, thus exerting neuroprotective effects on the central nervous system.
Review
Cell Biology
Li Yang, Jing Li, Shen Li, Wei Dang, Shuyu Xin, Sijing Long, Wentao Zhang, Pengfei Cao, Jianhong Lu
Summary: Extracellular vesicles (EVs) serve as a tool for intercellular communication and are closely related to human health. Viruses can modulate their infection ability and pathogenicity by regulating the component and function of EVs, which in turn affects the occurrence and development of diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kanako Miyano, Seiya Hasegawa, Noriho Asai, Miaki Uzu, Wakako Yatsuoka, Takao Ueno, Miki Nonaka, Hideaki Fujii, Yasuhito Uezono
Summary: The Japanese herbal medicine Hangeshashinto (HST) has been shown to improve chemotherapy-induced oral ulcerative mucositis (OUM) through enhancing the migration of human oral keratinocytes (HOK) by upregulating CXCL12 via ERK.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sven Wolfgang Goergens, Kerstin Jahn-Hofmann, Dinesh Bangari, Sheila Cummings, Christiane Metz-Weidmann, Uwe Schwahn, Paulus Wohlfart, Matthias Schaefer, Maximilian Bielohuby
Article
Cell Biology
Markus Wolfien, Anne-Marie Galow, Paula Mueller, Madeleine Bartsch, Ronald M. Brunner, Tom Goldammer, Olaf Wolkenhauer, Andreas Hoeflich, Robert David
Article
Cell Biology
Anne-Marie Galow, Markus Wolfien, Paula Mueller, Madeleine Bartsch, Ronald M. Brunner, Andreas Hoeflich, Olaf Wolkenhauer, Robert David, Tom Goldammer
Article
Cell Biology
Michael Walz, Luong Chau, Christina Walz, Mandy Sawitzky, Daniela Ohde, Julia Brenmoehl, Armin Tuchscherer, Martina Langhammer, Friedrich Metzger, Christine Hoeflich, Andreas Hoeflich
Article
Cell Biology
Daniela Ohde, Michael Walz, Christina Walz, Antonia Noce, Julia Brenmoehl, Martina Langhammer, Andreas Hoeflich
Review
Biochemistry & Molecular Biology
Anne-Marie Galow, Tom Goldammer, Andreas Hoeflich
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Agriculture, Dairy & Animal Science
L. Vogel, M. Gnott, C. Kroeger-Koch, S. Goers, J. M. Weitzel, E. Kanitz, A. Hoeflich, A. Tuchscherer, A. Troescher, J. J. Gross, R. M. Bruckmaier, A. Starke, L. Bachmann, H. M. Hammon
Summary: The study found that treating cows with CLA can increase the concentration of plasma glucose and insulin, while stimulating the action of the somatotropic axis; whereas treating with EFA can stimulate the increase in eGP, but does not affect the mRNA abundance related to eGP.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Cell Biology
Julia Brenmoehl, Daniela Ohde, Christina Walz, Martina Langhammer, Julia Schultz, Andreas Hoeflich
Article
Agriculture, Dairy & Animal Science
K. L. Uken, L. Vogel, M. Gnott, S. Goers, C. T. Schaeff, A. Tuchscherer, A. Hoeflich, J. M. Weitzel, E. Kanitz, A. Troescher, H. Sauerwein, R. Zitnan, R. M. Bruckmaier, J. J. Gross, W. Liermann, H. M. Hammon
Summary: This study investigated the impact of maternal supply of essential fatty acids and conjugated linoleic acid on glucose metabolism, endocrine regulation, energy metabolism, and intestinal development in neonatal calves. The results showed that a combination of EFA and CLA may improve the glucose metabolism and insulin response in calves.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Cell Biology
Michael Walz, Christine Hoeflich, Christina Walz, Daniela Ohde, Julia Brenmoehl, Mandy Sawitzky, Andreas Vernunft, Uwe K. Zettl, Susanne Holtze, Thomas B. Hildebrandt, Eckhard Wolf, Andreas Hoeflich
Summary: The bioactivity of the IGF system is regulated by IGFBPs, IGFBP proteases, and inhibitors. The effects of the IGF system on the AKT/mTOR pathway are of interest. Using IGFBP2 to enhance the sensitivity of IGF-dependent bioactivity, phosphorylation of AKT-Ser473 was assessed as a readout of pathway activity.
Article
Cell Biology
Christina Walz, Julia Brenmoehl, Nares Trakooljul, Antonia Noce, Caroline Caffier, Daniela Ohde, Martina Langhammer, Klaus Wimmers, Siriluck Ponsuksili, Andreas Hoeflich
Summary: The study investigated the effects of training and genetic predisposition on mRNA expression in the pituitary gland of a marathon mouse model, revealing a strong impact of genetic selection for enhanced running performance on gene expression in the pituitary gland. Training induced differential expression of genes in both mouse lines, but DUhTP mice showed resistance to the positive effects of training on protein and energy metabolism in the pituitary gland.
Article
Cell Biology
Julia Brenmoehl, Christina Walz, Caroline Caffier, Elli Brosig, Michael Walz, Daniela Ohde, Nares Trakooljul, Martina Langhammer, Siriluck Ponsuksili, Klaus Wimmers, Uwe K. Zettl, Andreas Hoeflich
Summary: The study investigated the regulation of the GH/IGF system in physical performance using a mouse model selected for high running performance. Results showed coordinated downregulation of the somatotropic pathway and a lack of mTORC1 and mTORC2 activation in marathon mice in response to exercise. Additionally, the study found enhanced expression of certain genes related to endurance exercise in the muscle of the selected marathon mouse model.
Article
Cell Biology
Stefan Petkov, Julia Brenmoehl, Martina Langhammer, Andreas Hoeflich, Monika Roentgen
Summary: This study investigates the effect of long-term high-intensity exercise on Satellite cells (SATC) in mice. The results show that mice trained in high-intensity running have higher SATC activity and proliferation rate, indicating increased sensitivity to external stimuli and an easier transition into differentiation. Additionally, these trained mice produce more large myotubes. The findings suggest that long-term high-intensity exercise can promote muscle growth by altering the characteristics of SATC.
Article
Biology
Julia Hinterseher, Juliane Guenther, Kristina Zlatina, Lisa Isernhagen, Torsten Viergutz, Elisa Wirthgen, Andreas Hoeflich, Andreas Vernunft, Sebastian Peter Galuska
Summary: In addition to being energy sources, monosaccharides are used to construct complex oligo- and polysaccharides, which have important roles as functional biomolecules. These bioactive sugars are key components of milk and have positive impacts on intestinal development, gut microbiome, immune system, and learning and memory ability of offspring. Additionally, milk oligo- and polysaccharides have anti-adhesive properties against pathogens, making them important for mammary gland and offspring health.
Article
Agriculture, Dairy & Animal Science
Andreas Hoeflich, Anne-Marie Galow, Julia Brenmoehl, Frieder Hadlich