期刊
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
卷 106, 期 -, 页码 100-104出版社
ELSEVIER
DOI: 10.1016/j.molcatb.2014.05.004
关键词
Asymmetric synthesis; Chiral sulfoxides; Enzyme catalysis; oxidation; Pseudomonas monteilii CCTCC M2013683
资金
- Guizhou Science and Technology Department [QKHGZ-2011-7017, QKHSZ-2012-3078, QKHRZ-2013-47]
- National Natural Science Foundation of China [NSFC 21162047, 21262051]
- New Century Excellent Talent of the Ministry of Education [NCET-13-1069]
In this paper, the ability of Pseudomonas monteilii to selectively oxidize aryl sulfides has been investigated. Especially, a toluene-degrading strain, P. monteilii (CCTCCM2013683), was isolated form soil samples that exhibit excellent activity, stereoselectivity and high substrate tolerance to perform oxidation of organic sulfides. Several biotransformation parameters such as the employment of substrate concentration, cell density, reaction temperature, pH value and cosolvent system resulted crucial in the optimization of the processes. Under optimal reaction parameters, whole-cells catalyzed the asymmetric oxidation of sulfides to chiral sulfoxides (R)-2a-2e with 54-99% yields in 63-99% enantiomeric excess (ee), respectively. (C) 2014 Elsevier B.V. All rights reserved.
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