期刊
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
卷 302, 期 1-2, 页码 76-79出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molcata.2008.11.035
关键词
Double carbonylation; alpha-Ketoamides; Palladium; Flow reactor
资金
- Hungarian National Science Foundation [T048391]
- National Office for Research and Technology
Double carbonylation of iodobenzene in the presence of amines were carried out effectively in a microfluidics-based flow reactor (X-Cube (TM)) of high throughput capability using immobilized Pd(PPh3)(4) catalyst. By the proper tuning of the reaction conditions alpha-ketoamides could be synthesized with 70-96% selectivities depending on the choice of the nucleophile. The highest yields of double carbonylation products were obtained at relatively low temperature (80 degrees C) and using DBU as the base with primary amines as the reaction partners. Imine formation was observed only at higher temperatures. (C) 2008 Elsevier B.V. All rights reserved.
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