期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 410, 期 4, 页码 512-524出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2011.04.015
关键词
PI(4,5)P2; Gag; plasma membrane; assembly; matrix
资金
- National Institute of Allergy and Infectious Diseases [R01 AI071727, R56 AI089282]
- American Heart Association [0850133Z]
- amfAR [107449-45-RGHF]
Human immunodeficiency virus type 1 assembly is a multistep process that occurs at the plasma membrane (PM). Targeting and binding of Gag to the PM are the first steps in this assembly process and are mediated by the matrix domain of Gag. This review highlights our current knowledge on viral and cellular determinants that affect specific interactions between Gag and the PM. We will discuss potential mechanisms by which the matrix domain might integrate three regulatory components, myristate, phosphatidylinositol-(4,5)-bisphosphate, and RNA, to ensure that human immunodeficiency virus type 1 assembly occurs at the PM. (C) 2011 Elsevier Ltd. All rights reserved.
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