Article
Biochemistry & Molecular Biology
Javier Fernandez, Constanza Jimenez, Dafna Benadof, Paulina Morales, Jessica Astorga, Felipe Caceres, Marcela Hernandez, Alejandra Fernandez, Fernando Valenzuela
Summary: The study aimed to evaluate the levels of MMP-2 and MMP-9 in gingival crevicular fluid as novel biomarkers for rosacea. The results showed a significant increase in MMP-9 concentration in the GCF of patients with rosacea compared to healthy patients. MMP-9 levels can be used as a diagnostic biomarker for rosacea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Luigi Nibali, Abish Stephen, Eleni Hagi-Pavli, Robert Allaker, Antonino Di Pino, Valentina Terranova, Marcella Pisano, Salvatore Di Marca, Viviana Ferrara, Roberto Scicali, Mauro Giordano, Francesco Purrello, Nikolaos Donos, Lorenzo Malatino
Summary: The study suggests that GCF markers in patients with metabolic syndrome may be associated with concomitant periodontitis, particularly the levels of markers such as Aggrecan, IL-6, and IL-8 are correlated with the severity of the disease.
JOURNAL OF DENTISTRY
(2022)
Article
Multidisciplinary Sciences
Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Toshihito Isono, Satoru Hirayama, Karin Sasagawa, Fumio Takizawa, Koichi Tabeta, Yutaka Terao
Summary: This study reveals the mechanisms by which neutrophil elastase (NE) exacerbates periodontitis. NE induces increased neutrophil recruitment and activity in the periodontal tissue, leading to worsened periodontal bone loss. Administration of an NE inhibitor reduces NE activity and attenuates periodontal bone loss. NE also promotes bacterial invasion in periodontal tissues by cleaving cell adhesion molecules and disrupting the gingival epithelial barrier.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Xiaoping Xiao, Tingting Song, Xiaolian Xiao, Yaoran Liu, Haidan Sun, Zhengguang Guo, Xiaoyan Liu, Chen Shao, Qian Li, Wei Sun
Summary: By analyzing the composition of human GCF proteome and metaproteome, this study revealed rich information related to immune function and inflammation. Some genera were found in the GCF metaproteome but not in the metagenomic analysis. The abundance of GCF metaproteome contributes approximately 4.17% to the total GCF proteome.
Article
Biochemical Research Methods
Xin Zhang, Xiaoping Xiao, Yue Mu, Yao Ran Liu, Xinxin Lin, Qian Li, Wei Sun
Summary: This study investigated the influence of tooth site, sex, and age on the normal GCF proteome in periodontal health. Results showed that tooth site had a small impact, while sex and age were important factors affecting the GCF proteome, with sex having a significant influence on young adults.
JOURNAL OF PROTEOMICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bardia Vadiati Saberi, Farouq Yousefi, Tooba Yousefi, Durdi Qujeq
Summary: This study determined the correlation between mucin and alpha-amylase protein levels in gingival crevicular fluid (GCF) with chronic periodontitis. The results showed that the levels of both markers were higher in patients with chronic periodontitis compared to successfully recovered patients, suggesting that they could be used to determine the activity of periodontal disease.
Review
Dentistry, Oral Surgery & Medicine
Tamires Pereira Dutra, Catharina Marques Sacramento, Bruna Egumi Nagay, Marcela Barauna Magno, Guido Artemio Maranon-Vasquez, Lucianne Cople Maia, Enilson Antonio Sallum, Karina Gonzales Silverio Ruiz
Summary: The study did not find distinct GCF cytokine profiles for smokers and non-smokers. However, lower levels of SOD were identified in smokers, despite the limitations observed in the included studies.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeliha Guney, Sivge Kurgan, Canan Onder, Cavid Mammadov, Muhittin A. Serdar, Meral Gunhan
Summary: This study aimed to evaluate the levels of ADMA, SDMA, and IL-1 beta in GCF from periodontitis patients. The results showed that the levels of IL-1 beta, ADMA, and SDMA in GCF were significantly higher in periodontitis patients compared to the control group, and they were positively correlated with clinical periodontal parameters. It suggests that ADMA and SDMA may be involved in the pathogenesis of periodontal disease.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Fatemeh Abdolalian, Mojtaba Bayani, Saeid Afzali, Afrooz Nakhostin, Amir Almasi-Hashiani
Summary: This meta-analysis studied the gingival crevicular fluid (GCF) periostin levels in subjects with periodontal disease and healthy periodontium. The results showed a significant decrease in GCF periostin levels in individuals with chronic periodontitis compared to healthy individuals, while no significant difference was observed between individuals with gingivitis and healthy individuals. Further studies are needed to validate the use of GCF periostin as a diagnostic marker for this disease.
Article
Health Care Sciences & Services
Hammam Ibrahim Fageeh, Hytham N. Fageeh, Shankargouda Patil
Summary: Periodontitis is an inflammatory condition caused by pathogenic bacteria in dental plaque. Macrophages derived from monocytes play a dual role in periodontitis, presenting antigens to lymphocytes while also contributing to periodontal destruction. The study found that GCF samples from periodontitis patients have higher levels of specific cytokines, and that treatment with these samples can induce monocytes to differentiate into destructive macrophages, affecting the phenotype and function of resident cells in the periodontium.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Harraa S. Mohammed-Salih, Hadeel Adel Al-lami, Hayder F. Saloom, Ali Abbas Abdulkareem, Jameel R. Al-Obaidi, Nurhanani Razali
Summary: This study aimed to identify biomarkers associated with orthodontically induced inflammatory root resorption (OIIRR) in gingival crevicular fluid (GCF) using proteomic analysis. The up-regulation of S100A9, CASR, and K2C1 suggested a response to inflammation, chemotactic activities, osteoclastogenesis, and epithelial cell breakdown. Meanwhile, the up-regulation of IGKC, NGAL, and K2C1 indicated a response to the inflammatory process, innate immunity activation, and epithelial cell breakdown.
Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Jie Zhang, Wenjing Li, Hongye Lu, Ruifang Lu, Yalin Zhan, Huanxin Meng
Summary: The level of platelets in the GCF of patients with periodontitis is higher than that of healthy individuals. Platelets can interact with periodontal pathogens and neutrophils, and promote the formation of NETs.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alfredo Torres, M. Angelica Michea, Akos Vegvari, Marion Arce, Alicia Morales, Elias Lanyon, Marcela Alcota, Camila Fuentes, Rolando Vernal, Mauricio Budini, Roman A. Zubarev, Fermin E. Gonzalez
Summary: The study aimed to explore the qualitative and quantitative differences in gingival crevicular fluid (GCF) proteome of periodontitis patients during disease progression. It was found that the GCF proteome of progressive periodontitis was associated with metabolic processes, immune response, and cellular stress, while the proteome of stable periodontitis was mainly related to wound repair, cell death regulation, and autophagy.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hyun-Duck Kim, Sandeep Karna, YooJin Shin, Huong Vu, Hyun-Jae Cho, Sungtae Kim
Summary: This study compared the association and screening ability of S100A8 and S100A9 in saliva, blood, and gingival crevicular fluid for periodontitis status. Salivary S100A8 was significantly higher in established periodontitis, while GCF S100A8 and S100A9 were higher in no or initial periodontitis. Salivary S100A8 could be a potential diagnostic marker for established periodontitis.
Review
Dentistry, Oral Surgery & Medicine
Andrew R. Geddis-Regan, Margaret Stewart, Rebecca R. Wassall
JOURNAL OF ORAL REHABILITATION
(2019)
Editorial Material
Dentistry, Oral Surgery & Medicine
Rebecca Wassall
BRITISH DENTAL JOURNAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Paul R. Brocklehurst, Joe Langley, Sarah R. Baker, Gerald McKenna, Craig Smith, Rebecca Wassall
BRITISH DENTAL JOURNAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Charlotte Bowes, Geoff Page, Rebecca Wassall, Charlie Lloyd
BRITISH DENTAL JOURNAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Andrew Geddis-Regan, Abisola Asuni, Graham Walton, Rebecca Wassall
BRITISH DENTAL JOURNAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Philip M. Preshaw, John J. Taylor, Katrin M. Jaedicke, Marko De Jager, Jan Willem Bikker, Wieke Selten, Susan M. Bissett, Kerry M. Whall, Rachel van de Merwe, Aisha Areibi, Paiboon Jitprasertwong, Rana Al-Shahwani, Jolanta Weaver, Roy Taylor, Rebecca R. Wassall
JOURNAL OF CLINICAL PERIODONTOLOGY
(2020)
Article
Medicine, Research & Experimental
Sinead Watson, Julie McMullan, Paul Brocklehurst, Georgios Tsakos, Richard G. Watt, Rebecca R. Wassall, Andrea Sherriff, Sheena E. Ramsay, Anup J. Karki, Sayaka Tada, Caroline Lappin, Michael Donaldson, Gerald McKenna
Review
Health Care Sciences & Services
Andrew Geddis-Regan, Linda Errington, Clare Abley, Rebecca Wassall, Catherine Exley, Richard Thomson
Summary: This narrative systematic review identified eight studies examining interventions for decision making in people living with dementia. Decision aids and advance care planning interventions were found to be effective, but the impact on decision quality and concordance with personal values was limited. Patient involvement in the study design further enhanced the relevance and applicability of the findings.
HEALTH EXPECTATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Joe Langley, Rebecca Wassall, Andrew Geddis-Regan, Sinead Watson, Anna Verey, Gerald McKenna, Paul Brocklehurst, Georgios Tsakos
Summary: This study explores the challenges of providing daily oral care in care homes, understanding the oral care practices of care home staff, and co-designing practical resources to support these activities. Findings reveal that care home staff face time and resource constraints, as well as challenges posed by residents with dementia and refusal behaviors. The study highlights the importance of making guidelines usable in practice and implementing evidence-based guidelines.
Review
Dentistry, Oral Surgery & Medicine
Fahad A. BaHammam, Giles McCracken, Rebecca Wassall, Justin Durham, Bana Abdulmohsen
Summary: This systematic review aimed to investigate measurement properties, interpretability and feasibility of instruments assessing oral health and orofacial pain in dependent adults. The results showed that more evidence is needed to comprehensively evaluate these instruments. Among the identified instruments, OPS-NVI demonstrated sufficient construct validity, while OHAT and THROAT demonstrated sufficient reliability. However, further testing and evaluation are required for these instruments to be confidently used.
Article
Dentistry, Oral Surgery & Medicine
Andrew Geddis-Regan, Rebecca R. Wassall, Clare Abley, Catherine Exley
Summary: This study aimed to explore the perspectives and experiences of dental treatment decision-making among people living with dementia and their family members. It was found that individuals with dementia wanted to be seen as unique individuals with specific needs, and they desired to be actively involved in dental treatment decisions. However, many felt that they were not sufficiently involved in the decision-making process.
Article
Dentistry, Oral Surgery & Medicine
Fahad A. A. BaHammam, Jamal Akhil, Margaret Stewart, Bana Abdulmohsen, Justin Durham, Giles I. I. McCracken, Rebecca Wassall
Summary: This qualitative evidence synthesis aimed to establish a conceptual model of oral health in dependent adults based on their experiences and views. Twenty-seven eligible studies were included, and four main themes were generated to understand oral health in dependent adults. This synthesis and conceptual model provide insights for the development of person-centred oral care interventions.
SPECIAL CARE IN DENTISTRY
(2023)
Article
Medicine, Research & Experimental
Georgios Tsakos, Paul R. Brocklehurst, Sinead Watson, Anna Verey, Nia Goulden, Alison Jenkins, Zoe Hoare, Kirstie Pye, Rebecca R. Wassall, Andrea Sherriff, Anja Heilmann, Ciaran O'Neill, Craig J. Smith, Joe Langley, Renato Venturelli, Peter Cairns, Nat Lievesley, Richard G. Watt, Frank Kee, Gerald McKenna
Summary: This study aims to assess the feasibility of an intervention promoting oral health in care homes through a co-design process, to provide information for a future larger scale definitive trial.
PILOT AND FEASIBILITY STUDIES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Radhika Desai, Bhushan Khobaragade, Giles McCracken, Rebecca Wassall, John J. Taylor, Susan M. Bissett, Andrew S. Pumerantz, Philip M. Preshaw
Summary: The study found that T1D patients had higher quality of life compared to T2D patients at baseline, with improvement in QoL post-treatment for T1D patients. Diabetes has an impact on quality of life, especially in terms of freedom to eat and family life.
Article
Endocrinology & Metabolism
Andrew S. Pumerantz, Susan M. Bissett, Fanglong Dong, Cesar Ochoa, Rebecca R. Wassall, Heidi Davila, Melanie Barbee, John Nguyen, Pamela Vila, Philip M. Preshaw
BMJ OPEN DIABETES RESEARCH & CARE
(2017)