Article
Biochemistry & Molecular Biology
Toshisuke Kaku, Kaori Tsukakoshi, Kazunori Ikebukuro
Summary: Significant research on Alzheimer's disease has found that toxic Aβ protofilaments are generated during the disaggregation of Aβ fibrils, suggesting that the disaggregation of Aβ fibrils by small compounds may be one possible mechanism for the generation of toxic Aβ aggregates in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Erica Caballero, Elena Hernando-Perez, Victor Tapias, Maria Calvo-Rodriguez, Carlos Villalobos, Lucia Nunez
Summary: The Aβ oligomers in Alzheimer's disease promote calcium influx by amyloid channels and NMDA receptors, leading to excitotoxicity and neuron degeneration.
Article
Biochemistry & Molecular Biology
Panagiotis M. Spatharas, Georgia I. Nasi, Paraskevi L. Tsiolaki, Marilena K. Theodoropoulou, Nikos C. Papandreou, Andreas Hoenger, Ioannis P. Trougakos, Vassiliki A. Iconomidou
Summary: Clusterin is identified as a glycoprotein involved in amyloid formation and has aggregation-prone regions that can form amyloid-like fibrils while also inhibiting amyloid-beta fibril formation. These findings suggest a potential role of clusterin in the molecular mechanism of inhibiting amyloid formation and indicate a possible involvement of molecular chaperones with amyloidogenic properties in regulating amyloid formation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Oxana V. Galzitskaya, Sergei Y. Grishin, Anna V. Glyakina, Nikita V. Dovidchenko, Anastasiia V. Konstantinova, Sergey V. Kravchenko, Alexey K. Surin
Summary: In recent years, there has been an increase in the number of identified diseases associated with the accumulation of amyloid proteins, which are known to cause degenerative diseases in humans. Therefore, it is important to develop strategies for the search and development of effective inhibitors of amyloid formation. This review focuses on three amyloidogenic peptides and proteins - A beta, alpha-synuclein, and insulin - and analyzes existing and prospective strategies for the development of effective and non-toxic inhibitors of amyloid formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yasuteru Inoue, Masayoshi Tasaki, Teruaki Masuda, Yohei Misumi, Toshiya Nomura, Yukio Ando, Mitsuharu Ueda
Summary: In this study, the researchers found that α-enolase (ENO1) can interact with amyloid beta (Aβ) and inhibit its fibril formation. They also demonstrated that ENO1 can disrupt Aβ fibrils and weaken their cytotoxic effects by degrading Aβ peptides. Additionally, infusion of ENO1 into mouse brains reduced cerebrovascular Aβ deposits and improved cognitive impairment. These findings suggest that ENO1 may be a therapeutic target in cerebral amyloid angiopathy (CAA).
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Laila Abdulmohsen Jaragh-Alhadad, Mojtaba Falahati
Summary: Alzheimer's disease (AD) is a common form of dementia caused by the clumping of amyloid beta peptides. This study shows that tin oxide nanoparticles can accelerate the aggregation of AD-related proteins and increase their toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Gary T. Jennings, Mona O. Mohsen, Monique Vogel, Martin F. Bachmann
Summary: Alzheimer's disease is the most common form of dementia and is responsible for 60-70% of cases. The number of people with dementia is expected to triple by 2050 due to an aging population. Currently, there are only symptomatic treatments available, making it crucial to develop novel therapeutic strategies to prevent or delay the onset of Alzheimer's disease. This mini-review focuses on the understanding of Alzheimer's disease pathobiology and discusses current immunomodulating therapies targeting amyloid-beta protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Willy Smeralda, Marc Since, Julien Cardin, Sophie Corvaisier, Sophie Lecomte, Christophe Cullin, Aurelie Malzert-Freon
Summary: The study focused on the molecular interactions between the amyloid beta peptide associated with Alzheimer's disease and biological membranes, developing simple liposomal formulations mimicking neuronal cell membranes. Characterization of interactions through a multiparametric procedure laid the methodological foundation for developing an original model describing interactions between A beta peptide and lipids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Christopher Sun, Leah Slade, Prisca Mbonu, Hunter Ordner, Connor Mitchell, Matthew Mitchell, Fu-Cheng Liang
Summary: This study investigates the effect of a novel protein chaperone, cpSRP43, on Aβ aggregation. The results show that cpSRP43 can effectively prevent and reverse Aβ aggregation, keeping Aβ in the soluble monomeric form. This research may provide new insights for the treatment of Alzheimer's disease.
Review
Chemistry, Medicinal
Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun
Summary: Alzheimer's disease (AD) is a difficult to treat progressive neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques in the brain. A beta interacts with various receptors on the plasma membrane and mediates signaling pathways that contribute to the development of AD. Despite ongoing research, there are currently no effective medications for AD. This review discusses the importance of A beta in the pathogenesis of AD, recent progress in targeting A beta-related receptors and compounds, and the challenges and opportunities in developing effective therapies for AD.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Hannah Ennerfelt, Coco Holliday, Daniel A. Shapiro, Kristine E. Zengeler, Ashley C. Bolte, Tyler K. Ulland, John R. Lukens
Summary: Recent advances have shown the importance of microglia-expressed innate immune receptors in Alzheimer's disease (AD), specifically TREM2, CD33, and CD22. However, the downstream signaling molecules used by these receptors in AD are still not well understood. This study demonstrates that CARD9, an intracellular adaptor molecule, plays a crucial role in A(3-mediated disease and microglial responses in AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Nicolas Papadopoulos, Nuria Suelves, Florian Perrin, Devkee M. Vadukul, Celine Vrancx, Stefan N. Constantinescu, Pascal Kienlen-Campard
Summary: Most neurodegenerative diseases are characterized by protein folding disorders, such as Alzheimer's disease. These diseases lead to the appearance of protein aggregates in vulnerable regions of the nervous system, which progressively spread through the neuronal network. Alzheimer's disease is characterized by neurofibrillary tangles composed of tau proteins and senile plaques composed of amyloid peptides. Understanding the structural determinants of the precursor protein APP and the formation of different A beta aggregates is crucial in deciphering the pathological conformational changes and mechanisms underlying amyloid fibril formation.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Review
Immunology
Zachary Valiukas, Ramya Ephraim, Kathy Tangalakis, Majid Davidson, Vasso Apostolopoulos, Jack Feehan
Summary: Alzheimer's disease is a chronic neurodegenerative disorder characterized by the presence of toxic substances in the brain. Traditional drug treatments have limitations, leading to the exploration of immunotherapies, which target the production and deposition of these substances.
Article
Neurosciences
Muriel Arimon, Shuko Takeda, Kathryn L. Post, Sarah Svirsky, Bradley T. Hyman, Oksana Berezovska
NEUROBIOLOGY OF DISEASE
(2015)
Article
Clinical Neurology
Lara Wahlster, Muriel Arimon, Navine Nasser-Ghodsi, Kathryn Leigh Post, Alberto Serrano-Pozo, Kengo Uemura, Oksana Berezovska
ACTA NEUROPATHOLOGICA
(2013)
Article
Biochemical Research Methods
Muriel Arimon, Fausto Sanz, Ernest Giralt, Natalia Carulla
BIOCONJUGATE CHEMISTRY
(2012)
Article
Clinical Neurology
X. Fernandez-Busquets, J. Ponce, R. Bravo, M. Arimon, T. Martianez, A. Gella, J. Cladera, N. Durany
CURRENT ALZHEIMER RESEARCH
(2010)
Article
Medicine, Research & Experimental
Francesc X. Guix, Tina Wahle, Kristel Vennekens, An Snellinx, Lucia Chavez-Gutierrez, Gerard Ill-Raga, Eva Ramos-Fernandez, Cristina Guardia-Laguarta, Alberto Lleo, Muriel Arimon, Oksana Berezovska, Francisco J. Munoz, Carlos G. Dotti, Bart De Strooper
EMBO MOLECULAR MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Ramona Bravo, Muriel Arimon, Juan Jose Valle-Delgado, Raquel Garcia, Nuria Durany, Susanna Castel, Montserrat Cruz, Salvador Ventura, Xavier Fernandez-Busquets
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Neurosciences
Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M. Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T. Hyman, Oksana Berezovska
NEUROBIOLOGY OF DISEASE
(2013)
Article
Multidisciplinary Sciences
Natalia Carullaa, Min Zhou, Muriel Arimon, Margarida Gairi, Ernest Giralt, Carol V. Robinson, Christopher M. Dobson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Biochemistry & Molecular Biology
Yi Li, Stephen Hsueh-Jeng Lu, Ching-Ju Tsai, Christopher Bohm, Seema Qamar, Roger B. Dodd, William Meadows, Amy Jeon, Adam McLeod, Fusheng Chen, Muriel Arimon, Oksana Berezovska, Bradley T. Hyman, Taisuke Tomita, Takeshi Iwatsubo, Christopher M. Johnson, Lindsay A. Farrer, Gerold Schmitt-Ulms, Paul E. Fraser, Peter H. St George-Hyslop
Article
Biochemistry & Molecular Biology
Joan J. Guinovart, Muriel Arimon
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION
(2020)
Article
Biochemistry & Molecular Biology
M Arimon, I Díez-Pérez, MJ Kogan, N Durany, E Giralt, F Sanz, X Fernàndez-Busquets
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)