Article
Multidisciplinary Sciences
Majid Khan, Sanaullah Khan, Mehrunnisa Fatima Gondal, Safia Bibi, Bakht Tarin Khan, Abdul Majid, Ayesha Khattak, Muhammad Nasir Khabir, Muhammad Anwar, Aisha Gul, Maryam Naseem, Sobia Attaullah
Summary: This study analyzed mutations in the Enh-II region of the X gene in HBV positive patients in Pakistan, finding a high prevalence of mutations associated with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Article
Microbiology
Umar Saeed, Zahra Zahid Piracha, Hyeonjoong Kwon, Jumi Kim, Fadia Kalsoom, Yong-Joon Chwae, Sun Park, Ho-Joon Shin, Hyun Woong Lee, Jin Hong Lim, Kyongmin Kim
Summary: The study reveals that Par14/Par17 interact with HBc and core particles through binding to the RP134-R-133 motif, enhancing the stability of HBc and core particles and playing a crucial role in HBV replication. These interactions are important for efficient replication of HBV.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cell Biology
Fei Sun, Terrence Sun, Michael Kronenberg, Xianglong Tan, Chengyang Huang, Michael F. Carey
Summary: The degradation of TAF12 and MED4 in murine embryonic stem cells revealed their different roles in P-E communication, with neither directly controlling P-E looping. Degradation of TAF12 led to a significant decrease in gene expression, while degradation of MED4 consistently led to a twofold loss in gene expression.
GENES & DEVELOPMENT
(2021)
Article
Medicine, Research & Experimental
Guangyuan Song, Xingxin Zhu, Zefeng Xuan, Long Zhao, Haijiang Dong, Jian Chen, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Summary: In this study, we identified that GNA14 is downregulated in HCC and negatively correlated with HBV infection, vascular invasion, and prognosis. HBx regulates GNA14 through DNA methylation, affecting the Notch1 and JMJD6 pathways to inhibit tumor proliferation and metastasis. GNA14 shows potential as a biomarker and therapeutic target in HCC.
Article
Immunology
Mei-Ling Dong, Xu Wen, Xin He, Ji-Hua Ren, Hai-Bo Yu, Yi-Ping Qin, Zhen Yang, Min-Li Yang, Chong-Yang Zhou, Hui Zhang, Sheng-Tao Cheng, Juan Chen
Summary: The study found that DDX17 plays an important role in the replication of HBV and the metastasis of HBV-related HCC. By promoting HBV replication and transcription as well as HBx-mediated HCC metastasis, DDX17 has a promotive effect on the development of HBV and HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julien Jarroux, Dominika Foretek, Claire Bertrand, Marc Gabriel, Ugo Szachnowski, Zohra Saci, Shuling Guo, Arturo Londono-Vallejo, Marina Pinskaya, Antonin Morillon
Summary: The research reveals that the interaction between HOTAIR and LSD1 promotes the migration of epithelial cells and induces partial reprogramming of the epithelial transcriptome by altering LSD1 distribution at promoter and enhancer regions. This uncovers an unexpected role of HOTAIR in EMT as an LSD1 decommissioning factor, counteracting its activity in the control of epithelial identity.
Article
Medical Laboratory Technology
Ziyu Liu, Yanan Li, Yufeng Wang, Xinquan Bai, Ying Zhang
Summary: Exosomes play a crucial role in intercellular communication during HBV infection, promoting its spread and development of related diseases. They also have the potential to serve as biomarkers for HBV diagnosis and can be utilized in the treatment of HBV infection by inhibiting replication and transcription.
CLINICA CHIMICA ACTA
(2023)
Article
Gastroenterology & Hepatology
Dieudonne Buh Kum, Hannah Vanrusselt, Abel Acosta Sanchez, Valerio Taverniti, Eloi R. Verrier, Thomas F. Baumert, Cheng Liu, Jerome Deval, Nikky Corthout, Sebastian Munck, Leonid Beigelman, Lawrence M. Blatt, Julian A. Symons, Pierre Raboisson, Andreas Jekle, Sandrine Vendeville, Yannick Debing
Summary: This study uncovers a novel mechanism of action for CAM-As in the treatment of chronic hepatitis B, where HBc aggregation induces cell death, leading to hepatocyte proliferation and loss of covalently closed circular DNA or its equivalent, possibly assisted by an induced innate immune response.
Article
Oncology
Haixia Shan, Bo Wang, Xiaodong Zhang, Hui Song, Xi Li, Yongxin Zou, Baichun Jiang, Huili Hu, Hao Dou, Changshun Shao, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong Liang, Yaoqin Gong
Summary: The study found that CUL4B enhances HBV replication by interacting with HBx and disrupting its ubiquitin-dependent proteasomal degradation. The results of this study are of great significance for the development of potential targets for anti-HBV therapy.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Oncology
Tommaso Stroffolini, Giacomo Stroffolini
Summary: This expert narrative review discusses the roles of hepatitis B and C viruses in the development of hepatocellular carcinoma (HCC) and explores future research directions and the potential of new technologies. Understanding the historical context of hepatitis viruses in HCC development is important for understanding the mechanisms by which these viruses contribute to cancer, improving prevention and treatment strategies, and reducing the burden of HCC.
Article
Plant Sciences
Osval Antonio Montesinos-Lopez, Abelardo Montesinos-Lopez, Carlos Moises Hernandez-Suarez, Jose Alberto Barron-Lopez, Jose Crossa
Summary: Deep learning is revolutionizing artificial intelligence systems, surpassing human abilities in tasks such as image classification and computer vision. Its application in genomic selection has significant implications for plant breeding, accelerating the revolution in this field.
Article
Plant Sciences
Osval Antonio Montesinos-Lopez, Abelardo Montesinos-Lopez, Carlos Moises Hernandez-Suarez, Jose Alberto Barron-Lopez, Jose Crossa
Summary: Deep learning is revolutionizing artificial intelligence systems, surpassing human capabilities in tasks like image classification. Applying DL models in genomic selection can accelerate revolution in plant breeding, but more research is needed for adaptation and development in this field.
Article
Gastroenterology & Hepatology
Anthony Tanoto Tan, Fanping Meng, Jiehua Jin, Ji-Yuan Zhang, Si-Yu Wang, Lei Shi, Ming Shi, Yuanyuan Li, Yunbo Xie, Li-Min Liu, Chun-Bao Zhou, Alicia Chua, Zi Zong Ho, Junqing Luan, Jinfang Zhao, Jing Li, Lu-En Wai, Sarene Koh, Tingting Wang, Antonio Bertoletti, Fu-Sheng Wang
Summary: The study demonstrates the feasibility of using messenger RNA HBV-TCR-redirected T cells for treating patients with HBV-HCC, resulting in long-term clinical benefits. However, further validation is needed to assess the reliability and longevity of immune monitoring.
HEPATOLOGY COMMUNICATIONS
(2022)
Review
Cell Biology
Xiaoyu Liu, Wan Xie, Silu Meng, Xiaoyan Kang, Yuhuan Liu, Lili Guo, Changyu Wang
Summary: Recent research suggests that snoRNAs play a pivotal role in hepatocellular carcinoma and related diseases, potentially serving as diagnostic and prognostic biomarkers. SnoRNAs can act as oncogenes or tumor suppressors in liver cancer through multiple mechanisms.
Review
Immunology
Evanthia Tourkochristou, Stelios F. Assimakopoulos, Konstantinos Thomopoulos, Markos Marangos, Christos Triantos
Summary: Non-alcoholic fatty liver disease (NAFLD) and Hepatitis B virus infection (HBV) are common chronic liver diseases with worldwide distribution. The co-occurrence of both diseases has gained great research and clinical interest. Despite the organized HBV vaccinations and use of anti-viral therapies globally, HBV infection remains endemic and challenging public health issue.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)