Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Janina Burk, Anna Sassmann, Cornelia Kasper, Ariane Nimptsch, Susanna Schubert
Summary: Matrix remodeling by MSC in ECM disease could be influenced by the ECM environment. MSC adapt to the ECM conditions, including pathological adaptations, which may affect therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud
Summary: This review summarizes the importance of cellular processes and dysfunction in the development of pulmonary arterial hypertension, as well as the roles of circulating and resident vascular cells in pulmonary vascular remodeling.
Review
Pharmacology & Pharmacy
Guang-Xuan Zhu, Jian-Li Zuo, Lin Xu, Shu-Qing Li
Summary: Abnormal vascular remodeling (VR) precedes many cardiovascular diseases, highlighting the potential of ginsenoside as a pivotal target for treatment and prevention. Research suggests that ginsenosides can improve VR caused by vasodilation dysfunction, abnormal structure, and blood pressure.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Jun-Lan Tan, Jian Yi, Xian-Ya Cao, Fei-Ying Wang, Si-Lin Xie, Ling-Ling Zhou, Li Qin, Ai-Guo Dai
Summary: There is increasing evidence that abnormal vascular remodeling plays a role in cardiovascular diseases (CVDs), making it a potential target for prevention and treatment. Celastrol, an active ingredient of the Chinese herb Tripterygium wilfordii Hook F, has shown promise in improving vascular remodeling through various mechanisms. It has been proven to ameliorate inflammation, hyperproliferation, and migration of vascular smooth muscle cells, as well as other factors involved in vascular remodeling. Celastrol has also demonstrated positive effects in treating hypertension, atherosclerosis, and pulmonary artery hypertension.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Pei-Ling Chi, Chin-Chang Cheng, Cheng-Chung Hung, Mei-Tzu Wang, Hsien-Yueh Liu, Meng-Wei Ke, Min-Ci Shen, Kun-Chang Lin, Shu-Hung Kuo, Pin-Pen Hsieh, Shue-Ren Wann, Wei-Chun Huang
Summary: This study found that levels of MMP-1 and MMP-10 were increased in the vessel wall, serum, and M1-polarized macrophages of PAH patients and PAH rodent models. MMP-10 promotes the malignant phenotype of PASMCs by promoting their proliferation and migration. Inhibition of STAT1 can suppress hypoxia-induced MMP-10 expression in M1-polarized macrophages.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Laura Locatelli, Sara Castiglioni, Jeanette A. M. Maier
Summary: This review article discusses the effects of space environment on the human vasculature and the adaptive responses activated in such conditions. The study suggests that oxidative stress and mitochondrial dysfunction might be mediators of vascular alterations in space. Understanding the cellular and molecular mechanisms involved in these adaptive processes could provide insights for designing proper countermeasures for space exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aneta Choreziak-Michalak, Dawid Szpecht, Anna Chmielarz-Czarnocinska, Agnieszka Seremak-Mrozikiewicz, Krzysztof Drews, Grazyna Kurzawinska, Ewa Strauss, Anna Gotz-Wieckowska
Summary: This study investigates the relationship between genetic variations in matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) and the development of retinopathy of prematurity (ROP) in the Polish population. The results suggest that certain genetic variants, including the MMP-1 rs179975 1G deletion allele and TIMP-1 rs4898C allele, are associated with an increased risk of ROP. The study also identifies interactions between multiple genetic loci that impact the risk of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Joao Carlos Ribeiro-Silva, Patricia Nolasco, Jose Eduardo Krieger, Ayumi Aurea Miyakawa
Summary: Vascular aging is characterized by the fragmentation of elastic fibers and collagen deposition, leading to reduced distensibility and increased stiffness in the blood vessels. Research shows that aging promotes changes in smooth muscle cell phenotypes, ultimately resulting in mechanical impairment of aging arteries. Understanding the role of ECM changes during aging may help in developing new strategies to prevent or delay arterial aging and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Mee-Hae Kim, Shao Ying Tan, Kenichi Yamahara, Masahiro Kino-Oka
Summary: Assessing the ability of cultured cells to degrade extracellular matrix (ECM) is crucial for evaluating the effectiveness of mesenchymal stem cell (MSC)-based therapies. However, current methods to assess this ability in vitro are lacking. In this study, a simple culture platform using high-density collagen surfaces was developed to study the ECM remodeling potential of cultured MSCs. This platform was used to evaluate the ECM remodeling potential of long-term ex vivo-expanded MSCs in vitro.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Luis Placido, Yair Romero, Mariel Maldonado, Fernanda Toscano-Marquez, Remedios Ramirez, Jazmin Calyeca, Ana L. Mora, Moises Selman, Annie Pardo
Summary: This study explored the role of MMP14 in idiopathic pulmonary fibrosis (IPF) and found that its deficiency exacerbates fibrotic injury and affects repair, possibly through its anti-senescent activity. Increased MMP14 in IPF may represent an anti-fibrotic mechanism overwhelmed by the strong profibrotic microenvironment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Yinping Song, Hao Jia, Yijie Hua, Chen Wu, Sujuan Li, Kunzhe Li, Zhicheng Liang, Youhua Wang
Summary: This article mainly discusses the molecular mechanisms of vascular remodeling in hypertension and the protective effects of aerobic exercise against vascular remodeling in the pathological process of hypertension. The focus is on oxidative stress, inflammation, and the roles of the trilaminar structure of vascular endothelial cells, smooth muscle cells, and extracellular matrix in vascular remodeling in hypertension.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ghassan Bkaily, Yanick Simon, Ashley Jazzar, Houssein Najibeddine, Alexandre Normand, Danielle Jacques
Summary: Our understanding of essential hypertension is extensive, and while its treatment is well-known, not all individuals with hypertension are salt-sensitive. Even normotensive individuals may face increased cardiovascular risks with a high salt diet. Research on the mechanisms and treatment of hypertension sensitive to high-sodium diets is crucial.
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Andrey Grechko, Varvara A. Orekhova, Victoria Khotina, Ekaterina A. Ivanova, Alexander N. Orekhov
Review
Biochemistry & Molecular Biology
Taisiia Shemiakova, Ekaterina Ivanova, Andrey Grechko, Elena Gerasimova, Igor A. Sobenin, Alexander N. Orekhov
Article
Biology
Tatiana Kirichenko, Igor A. Sobenin, Yuliya Markina, Elena Gerasimova, Andrey Grechko, Dmitry A. Kashirskikh, Elena B. Romanenko, Wei-Kai Wu, Alexander N. Orekhov
Review
Biochemistry & Molecular Biology
Olga A. Zhunina, Nikita G. Yabbarov, Andrey V. Grechko, Antonina V. Starodubova, Ekaterina Ivanova, Nikita G. Nikiforov, Alexander N. Orekhov
Summary: Mitochondrial dysfunction is closely associated with various human pathologies, with ROS and RNS playing a critical role in causing protein and mtDNA damage and leading to the development of diseases. Recent studies have identified numerous mtDNA mutations linked to different human pathologies, each having distinct effects in disease progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Dwaipayan Bharadwaj, Gauri Prasad, Andrey Grechko, Margarita A. Sazonova, Alexander N. Orekhov
Summary: Atherosclerosis has a complex pathogenesis involving inflammation, lipid metabolism alterations, and endothelial injury. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the inflammatory response regulation, making it a promising target for atherosclerosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Dwaipayan Bharadwaj, Gauri Prasad, Andrey V. Grechko, Margarita A. Sazonova, Alexander N. Orekhov
Summary: Atherosclerosis is a well-known global health problem with unclear pathogenesis. Inflammation is considered the preferred target for its treatment, with studies showing efficacy in animal models but inconclusive results in clinical studies. Anti-inflammatory therapy could be part of a complex treatment for atherosclerosis prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Diana Salnikova, Varvara Orekhova, Andrey Grechko, Antonina Starodubova, Evgeny Bezsonov, Tatyana Popkova, Alexander Orekhov
Summary: Altered mitochondrial function plays a crucial role in the initiation and progression of atherosclerosis, leading to changes in cellular metabolism, respiration, and increased production of reactive oxygen species. Mitochondrial dysfunction is associated with vascular disease and chronic inflammation, and targeted approaches to reduce oxidative stress and inflammation show promise in atherosclerosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anesthesiology
Valery Likhvantsev, Giovanni Landoni, Sergey Perekhodov, Nikolay Chaus, Kristina Kadantseva, Lyubov Ermokhina, Anastasia Baeva, Mikhail Yadgarov, Levan Berikashvili, Artem Kuzovlev, Andrey Grechko
Summary: This study aimed to identify predictors of poor quality of life in COVID-19 ICU survivors. The researchers found that treatment with low-molecular-weight heparin was associated with improved physical component of quality of life, while older age and female sex were associated with a decrease in the physical component. Patients with a medical history of cerebrovascular insufficiency had a decrease in the mental component, while a higher body mass index was associated with an increase in the mental health component.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Anastasiya S. Babkina, Irina V. Ostrova, Mikhail Ya Yadgarov, Artem N. Kuzovlev, Andrey V. Grechko, Alexey V. Volkov, Arkady M. Golubev
Summary: Increased plasma levels of VWF in COVID-19 patients are associated with thrombus formation. Duration of disease and thrombotic complications are independent predictors of increased VWF immunostaining in pulmonary vessels. Additionally, bacterial pneumonia and lung ventilation are also associated with increased VWF staining.
Article
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Andrey V. Grechko, Nikolay K. Shakhpazyan, Alexander N. Orekhov
Summary: KLF2 is a crucial factor in regulating atheroprotective effects in endothelial cells, preventing the development and progression of atherosclerosis. Recently, repurposed drugs and natural compounds targeting KLF2 have been identified, showing potential for treating atherosclerosis.
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Evgeny E. Bezsonov, Evgeny E. Borisov, Andrey V. Grechko, Andrey G. Kartuesov, Alexander N. Orekhov
Summary: HIV is one of the biggest global health problems, but modern antiretroviral therapy has improved patients' ability to manage the disease. Atherosclerosis, on the other hand, lacks an effective treatment. Understanding the characteristics of atherosclerosis development in HIV carriers is of great scientific interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alexander V. Blagov, Andrey V. Grechko, Nikita G. Nikiforov, Evgeny E. Borisov, Nikolay K. Sadykhov, Alexander N. Orekhov
Summary: Mitochondrial dysfunction is recognized as a contributor to neurodegenerative diseases, including Alzheimer's disease. The accurate dynamics of mitochondria are crucial for their complex functions, and disruption of these dynamics may play a key role in the pathogenesis of AD. Improving mitochondrial dynamics and function could provide an alternative treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Nikita G. Nikiforov, Alexander D. Zhuravlev, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: This review focuses on the roles of mitochondrial metabolism, ROS production, mitochondrial dynamics, and mitophagy in normal aging and pathological conditions. It also discusses the impact of inflammaging on neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
L. A. Mayorova, M. Petrova, I. Pryanikov, A. Grechko
Summary: The review focuses on analyzing literature concerning neuroimaging, electrophysiological, and other non-invasive methods used to study states of pathological impairment of consciousness, highlighting the challenges in diagnosing and predicting recovery in patients with chronic disorders of consciousness. It discusses neuroimaging, electrophysiological, physiological, and other correlates of chronic disturbances of consciousness, such as the minimally conscious state and the unresponsive wakefulness syndrome, as well as potential solutions for improving diagnosis and prognosis in chronic disorders of consciousness.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
