Article
Biochemistry & Molecular Biology
Rachel S. Resop, Bradley Salvatore, Shawn J. Kim, Brent R. Gordon, Bianca Blom, Dimitrios N. Vatakis, Christel H. Uittenbogaart
Summary: HIV-1 infection leads to upregulation of S1P receptor 1 (S1PR1) in the human thymus, potentially increasing the number and speed of thymocyte egress. This may have implications for immune function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Biochemistry & Molecular Biology
Federica Pierucci, Antony Chirco, Elisabetta Meacci
Summary: Irisin is a hormone-like myokine that is produced in skeletal muscle in response to exercise. Sphingosine-1-phosphate (S1P), a bioactive lipid, plays a crucial role in the formation and release of irisin. It also has autocrine and paracrine effects on myoblast proliferation and differentiation. These findings suggest that the S1P/S1PR axis could be a potential therapeutic target for muscle dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Xuehui Fan, Lili Liu, Yue Shi, Fanghan Guo, Xiao He, Xiuli Zhao, Di Zhong, Guozhong Li
Summary: Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite found in various cells and body fluids, with five receptors, S1P1-S1P5, exhibiting tissue selectivity. Among these receptors, S1P3 plays a crucial role in processes related to inflammation, cell migration, tumor invasion and metastasis, and other pathophysiological processes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Li-Guo Yang, Ai-Ling Wang, Lu Li, Hong Yang, Xi Jie, Zong-Feng Zhu, Xiao-Juan Zhang, Hui-Ping Zhao, Rui-Fang Chi, Bao Li, Fu-Zhong Qin, Jia-Pu Wang, Ke Wang
Summary: S1P treatment induces myocyte autophagy through mTOR inhibition, leading to the improvement of left ventricular function after myocardial infarction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rachel S. Knipe, Jillian J. Spinney, Elizabeth A. Abe, Clemens K. Probst, Alicia Franklin, Amanda Logue, Francesca Giacona, Matt Drummond, Jason Griffith, Patricia L. Brazee, Lida P. Hariri, Sydney B. Montesi, Katherine E. Black, Timothy Hla, Andrew Kuo, Andreane Cartier, Eric Engelbrecht, Christina Christoffersen, Barry S. Shea, Andrew M. Tager, Benjamin D. Medoff
Summary: Idiopathic pulmonary fibrosis is a chronic disease that causes respiratory failure. This study reveals the importance of vascular permeability in lung repair and fibrosis following injury, and the potential role of lipid mediator S1P in regulating this process.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Caterina Bernacchioni, Pasquapina Ciarmela, Valentina Vannuzzi, Stefania Greco, Silvia Vannuccini, Francesca Malentacchi, Pamela Pellegrino, Tommaso Capezzuoli, Flavia Sorbi, Francesca Cencetti, Paola Bruni, Chiara Donati, Felice Petraglia
Summary: The study revealed that S1P signaling is dysregulated in uterine fibroids and involved in activin A-induced fibrosis, presenting new perspectives for the treatment of uterine fibroids.
FERTILITY AND STERILITY
(2021)
Review
Biology
Kana Masuda-Kuroki, Anna Di Nardo
Summary: Sphingosine 1-phosphate (S1P) and its receptors play important roles in the skin barrier interface, affecting cell differentiation, proliferation, immune responses, and mast cell immune response. They are also associated with various skin diseases.
Article
Biochemistry & Molecular Biology
Georgina C. Wilkins, Jenny Gilmour, Eirini Giannoudaki, John A. Kirby, Neil S. Sheerin, Simi Ali
Summary: The study showed that S1P reduces neutrophil recruitment and adhesion by acting on endothelial cells through the S1PR1 signaling pathway and inhibiting CXCL8 mediated migration and TNF-α induced adhesion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Review
Virology
Lu Zhang, Juan Liu, Erya Xiao, Qingzhen Han, Lin Wang
Summary: Viruses can create a unique cellular environment that facilitates replication and transmission. The SphK/S1P axis plays a crucial role in regulating cellular activities during viral infections. Depending on the type of virus, the SphK/S1P axis can have pro- or anti-viral activities through the host immune system or intracellular signaling pathways and cell proliferation.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Neurosciences
Sandeep K. Singh, Tomasz Kordula, Sarah Spiegel
Summary: This study reveals that neuronal contact induces expression of S1PR1 on perisynaptic astrocyte processes, driving astrocyte morphological complexity and morphogenesis. Additionally, the S1P/S1PR1 axis enhances expression of astrocyte-secreted synaptogenic factors involved in neural circuit assembly. These findings highlight new functions of astrocytic S1PR1 signaling in regulating bi-directional astrocyte-neuron crosstalk during astrocyte morphogenesis and synaptogenesis.
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Clinical Neurology
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters, Ian Galea
Summary: Sphingosine-1-phosphate (S1P) plays a role in the pathophysiology of neurological injury after aneurysmal subarachnoid haemorrhage (aSAH). The literature agrees that S1P increases in cerebrospinal fluid following aSAH and contributes to cerebral artery vasospasm. However, the role of S1P in the parenchyma is less clear, with conflicting studies suggesting both beneficial and harmful effects. This review provides a concise interpretation of the conflicting data and discusses the potential repurposing of S1P receptor modulators for aSAH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Mariusz Tomaniak, Wolfgang Koenig, Ramzi Khamis, Ranil de Silva, Ply Chichareon, Hideyuki Kawashima, Hironori Hara, Chao Gao, Rutao Wang, Kurt Huber, Mathias Vrolix, Pawel Jasionowicz, Joanna J. Wykrzykowska, Jan J. Piek, Peter Juni, Christian Hamm, Philippe Gabriel Steg, Stephan Windecker, Yoshinobu Onuma, Robert F. Storey, Patrick W. Serruys
Summary: This study investigated the efficacy and safety of ticagrelor monotherapy in patients undergoing percutaneous coronary intervention (PCI) stratified according to their baseline white blood cell (WBC) count. The findings showed that ticagrelor monotherapy was more effective than aspirin monotherapy in reducing the primary endpoint in patients with lower WBC counts. However, there was no significant difference in the effectiveness of the two treatment strategies in patients with higher WBC counts, and there were no significant differences in bleeding risks between the two strategies regardless of the WBC groups.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Kuniaki Takahashi, Daniel J. F. M. Thuijs, Chao Gao, Masafumi Ono, David R. Holmes, Michael J. Mack, Marie-Claude Morice, Friedrich-Wilhelm Mohr, Nick Curzen, Piroze M. Davierwala, Milan Milojevic, Keith D. Dawkins, Joanna J. Wykrzykowska, Robbert J. de Winter, John William McEvoy, Yoshinobu Onuma, Stuart J. Head, Arie Pieter Kappetein, Patrick W. Serruys
Summary: This study evaluated the impact of different smoking statuses on 10-year all-cause mortality and the relative treatment benefit of CABG vs. PCI according to smoking habits. The results showed that current smokers had a higher risk of 10-year all-cause mortality compared to never smokers, while former smokers did not. There was no significant difference in the treatment effect of CABG vs. PCI based on smoking status.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kai Ninomiya, Patrick W. Serruys, Scot Garg, Chao Gao, Shinichiro Masuda, Mattia Lunardi, Jens F. Lassen, Adrian P. Banning, Antonio Colombo, Francesco Burzotta, Marie-Claude Morice, Michael J. Mack, David R. Holmes, Piroze M. Davierwala, Daniel J. F. M. Thuijs, David van Klaveren, Yoshinobu Onuma
Summary: This study investigated the impact of bifurcation lesions on the predicted and observed all-cause 10-year mortality in the SYNTAX trial. The results showed that patients with >1 bifurcation lesion treated with PCI had a significantly higher risk of all-cause death compared to those without bifurcation lesions.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Fangju Su, Chao Gao, Jianzheng Liu, Zhongping Ning, Beng He, Yi Liu, Yawei Xu, Bing Yang, Yuechun Li, Junfeng Zhang, Xianxian Zhao, Yushun Zhang, Hao Hu, Xianfeng Du, Ruiqin Xie, Ling Zhou, Jie Zeng, Zhongbao Ruan, Haitao Liu, Jun Guo, Rutao Wang, Scot Garg, Osama Soliman, David R. Holmes, Patrick W. Serruys, Ling Tao
Summary: This study aimed to investigate the outcomes and risks of left atrial appendage occlusion (LAAO) procedures in Chinese patients. The results showed that patients with a high risk of stroke and moderate to high risk of bleeding who underwent LAAO implantation in Chinese centers had high rates of procedural success and low rates of short-term ischemic and bleeding events.
Article
Cardiac & Cardiovascular Systems
Yuan He, Rutao Wang, Jianzheng Liu, Fei Li, Jiayi Li, Chengxiang Li, Jingyu Zhou, Zhijing Zhao, Wangwei Yang, Fangjun Mou, Jing Wang, Jing Kan, Xiaobo Li, Yan Li, Ming Zheng, Shaoliang Chen, Chao Gao, Ling Tao
Summary: This study compared the vascular healing of Firehawk and Xience stents in patients with STEMI who underwent PCI. The Firehawk stent was found to be non-inferior to the Xience stent in terms of neointimal thickness at 6 months. Both stents exhibited good strut coverage and healing.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Hironori Hara, Chao Gao, Hideyuki Kawashima, Rutao Wang, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, Michael J. Mack, David Holmes, Marie-Claude Morice, Stuart Head, Arie Pieter Kappetein, Thilo Noack, Piroze M. Davierwala, Friedrich W. Mohr, Scot Garg, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study investigated whether there are differences in long-term clinical outcomes between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with three-vessel disease and lesions in the proximal left anterior descending artery. The results showed that regardless of the presence or absence of lesions in the proximal left anterior descending artery, the incidence of major adverse cardiac or cerebrovascular events was significantly higher with PCI compared to CABG. However, there was no significant difference in 10-year mortality between the two procedures.
Article
Cardiac & Cardiovascular Systems
Robbert J. de Winter, Azfar Zaman, Hironori Hara, Chao Gao, Masafumi Ono, Scot Garg, Pieter C. Smits, Pim A. L. Tonino, Sjoerd H. Hofma, Raul Moreno, Anirban Choudhury, Ivo Petrov, Angel Cequier, Antonio Colombo, Upendra Kaul, Yoshinobu Onuma, Patrick W. Serruys
Summary: In the TALENT study, the ultrathin strut Supraflex stent showed similar safety and efficacy to the XIENCE stent at 3-year follow-up. There were no significant differences between the two groups in terms of cardiac death, target vessel myocardial infarction, or clinically indicated target lesion revascularisation.
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Patrick W. Serruys, Scot Garg, Hideyuki Kawashima, Chao Gao, Hironori Hara, Mattia Lunardi, Rutao Wang, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, Michael J. Mack, David R. Holmes, Marie-Claude Morice, Arie Pieter Kappetein, Daniel J. F. M. Thuijs, Thilo Noack, Friedrich W. Mohr, Piroze M. Davierwala, John A. Spertus, David J. Cohen, Yoshinobu Onuma
Summary: In patients with left-main CAD or 3-vessel disease, self-reported preprocedural physical and mental health status was strongly associated with long-term mortality. Patients with the best physical and mental health had better 10-year survival with CABG compared with PCI.
Review
Cardiac & Cardiovascular Systems
Bing Sun, Rui Rui Chen, Chao Gao, Ling Tao
Summary: This study compared the efficacy and safety of new oral anticoagulants (NOAC) with warfarin monotherapy in patients undergoing percutaneous left atrial appendage closure (LAAC). The findings showed that NOAC monotherapy was associated with a lower risk of bleeding compared to warfarin monotherapy for 45 days, and there were no significant differences in other outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Patrick W. Serruys, Hideyuki Kawashima, Mattia Lunardi, Rutao Wang, Hironori Hara, Chao Gao, Scot Garg, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, David R. Holmes, Marie-Claude Morice, Arie Pieter Kappetein, Thilo Noack, Piroze M. Davierwala, John A. Spertus, David J. Cohen, Yoshinobu Onuma
Summary: The aim of this study was to investigate the impact of patient-reported anginal status at 1 year following percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) on 10-year survival in patients with left main coronary artery disease (LMCAD) and/or three-vessel CAD (3VD). The study found that while angina at 1 year was associated with repeat revascularization at 5 years, it did not significantly increase 10-year mortality.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Review
Respiratory System
Yong-Ming He, Shinichiro Masuda, Chao Gao
Summary: The authors have recently developed the CatLet or Hexu angiographic scoring system, which can be used to predict clinical outcomes for patients with acute myocardial infarction. This system takes into account the diversity of coronary anatomy, the degree of stenosis in the coronary artery, and the myocardial territory supplied by the diseased artery. It has significant value for clinical practice and coronary artery disease research. Rating: 9 out of 10.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Lanyan Guo, Zhiling Ma, Weiping Yang, Fuyang Zhang, Hong Shao, Liwen Liu, Chao Gao, Ling Tao
Summary: This study aimed to develop a pragmatic model based on common 12-lead ECG features for the initial identification of obstructive hypertrophic cardiomyopathy (HOCM) and nonobstructive hypertrophic cardiomyopathy (HNCM). The study found that 10 variables out of 30 ECG parameters were significantly different between HOCM and HNCM. The constructed model using P wave interval and SV1 showed a useful ability to discriminate between HOCM and HNCM, and demonstrated good fitness and clinical utility.
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick Serruys, Shinichiro Masuda, Kai Ninomiya, Shigetaka Kageyama, Chao Gao, Michael Mack, David Holmes, Milan Milojevic, Marie-Claude Morice, Scot Garg, Yoshinobu Onuma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Hironori Hara, Hideyuki Kawashima, Chao Gao, Rutao Wang, Joanna J. Wykrzykowska, Jan J. Piek, Scot Garg, Christian Hamm, Philippe Gabriel Steg, Marco Valgimigli, Stephan Windecker, Pascal Vranckx, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study compared ticagrelor monotherapy with aspirin monotherapy in the second year post-PCI, and found that patients who were event-free at the end of the first year and adhered to their prescribed regimen had a reduced risk of ischemic events with ticagrelor monotherapy in the second year.
Meeting Abstract
Cardiac & Cardiovascular Systems
Chao Gao, Fangju Su, Jianzheng Liu, David R. Holmes, Patrick W. Serruys, Ling Tao
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
