Article
Biochemistry & Molecular Biology
Megumi Miyabe, Nobuhisa Nakamura, Tomokazu Saiki, Satoru Miyabe, Mizuho Ito, Sachiko Sasajima, Tomomi Minato, Tatsuaki Matsubara, Keiko Naruse
Summary: Atherosclerosis is a leading cause of death globally, and there is a correlation between periodontal disease and atherosclerosis. This study used Porphyromonas gingivalis-derived LPS (Pg-LPS) to investigate the proliferation and migration of human aortic smooth muscle cells (HASMCs). The results suggest that Pg-LPS promotes atherosclerosis through the activation of the TLR4-MAPK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zara, Marco Cafora, Chiara Favero, Giulia Solazzo, Ilaria Giusti, Maria Pia Adorni, Francesca Zimetti, Vincenza Dolo, Cristina Banfi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Silvia Stella Barbieri, Anna Pistocchi, Valentina Bollati, Chiara Macchi, Massimiliano Ruscica
Summary: This study reveals that PCSK9 plays an inflammatory role through EVs released by vascular smooth muscle cells, affecting the function and content of neighboring cells, and may have a significant role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jaqueline Herrmann, Mengdi Xia, Manasa Reddy Gummi, Anna Greco, Annika Schacke, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Vessel wall calcification is a structural pathology of aged vessels associated with high cardiovascular mortality in elderly patients. Chronic inflammation and oxidative stress in aging lead to activation of PRRs in vascular cells, contributing to VSMC calcification. Inhibition of PRR activation may be a potential target for reducing vascular calcification and subsequent cardiovascular mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mojtaba Parvizi, Zachary C. Ryan, Sanam Ebtehaj, Bonnie K. Arendt, Ian R. Lanza
Summary: Research has shown that senescent preadipocytes can induce an inflammatory phenotype, decrease cell viability, disrupt proliferation and migration, affecting the occurrence of vascular diseases by triggering phenotypic and functional changes in key cellular components of blood vessels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Developmental Biology
Arndt F. Siekmann
Summary: This review discusses the functions of vascular mural cells in blood vessel formation and diameter regulation, as well as their interactions with endothelial cells. It also introduces the signaling pathways controlling mural cell development and highlights distinguishing features of mural cells located on different types of blood vessels. Therapeutic strategies involving mural cells to improve tissue ischemia and vascular efficiency in various diseases are explored.
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xuelin Zhang, Yang Che, Lin Mao, Dandan Li, Jianqing Deng, Yilong Guo, Quanyi Zhao, Xingzhong Zhang, Li Wang, Xiang Gao, Yinan Chen, Tao Zhang
Summary: This study reveals the important role of histone variant H3.3B in aortic dissection by regulating gene expression and influencing the phenotype transition of vascular smooth muscle cells.
Article
Biochemistry & Molecular Biology
Dawid M. Kaczor, Rafael Kramann, Tilman M. Hackeng, Leon J. Schurgers, Rory R. Koenen
Summary: Platelet factor 4 (CXCL4) is a chemokine stored in platelets that modulates the function of vascular smooth muscle cells (VSMCs). Variant CXCL4L1, despite minor differences, has distinct effects on VSMCs compared to CXCL4. Both CXCL4 and CXCL4L1 regulate gene expression, but only CXCL4 increases VSMC proliferation and calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Christina Wenglen, Isak Demirel, Anna Göthlin Eremo, Magnus Grenegard, Geena Paramel
Summary: Vascular smooth muscle cells (VSMCs) play a crucial role in intimal thickening and atherosclerosis progression. This study identified the expression of the 5-HT2B receptor in human atherosclerotic lesions and its positive correlation with VSMC markers. Additionally, a selective inhibitor of the 5-HT2B receptor was found to effectively inhibit TGF131-induced collagen and CTGF production through blocking the phospho-Smad2-mediated downstream signaling. This HTR2B/TGF-131/Phospho-Smad2 pathway is critical for VSMC differentiation regulation, suggesting the 5-HT2B receptor as a potential therapeutic target for limiting TGF-131-induced VSMC differentiation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Hematology
Huan Yang, Ting Zhou, Amelia Stranz, Elise DeRoo, Bo Liu
Summary: A study using single-cell RNA sequencing on mouse AAA tissues revealed 12 distinct populations of 8 cell types. The percentages of each population and gene expression were compared between sham and AAA tissue, showing that populations within major cell types such as smooth muscle cells, fibroblasts, and macrophages may contribute differently to AAA pathogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chuanlin Zhang, MeiJuan Xiao, Nan Cao, Lei Zhang, Qiong He, Jianing Wang, Rui Wang, Lu Wang, Lei Zhao, Junqiang Si
Summary: The study aimed to investigate the mechanical and electrophysiological effects of emodin on BK channels in rat interlobar renal artery smooth muscle cells (IRASMCs). The results showed that emodin induced vasorelaxation and enhanced outward currents in a concentration-dependent manner. These effects were mediated through the activation of BK channels.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ye Liu, Yan Duan, Nan Zhao, Xinxin Zhu, Xiaoting Yu, Shiyu Jiao, Yanting Song, Li Shi, Yutao Ma, Xia Wang, Baoqi Yu, Aijuan Qu
Summary: The study reveals that PPAR alpha plays a critical protective role in Ang II-induced hypertension by attenuating ROS production in VSMCs, providing a potential therapeutic target for hypertensive diseases.
Article
Biochemistry & Molecular Biology
Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Karim J. Brandt, Kapka Miteva
Summary: The study demonstrated that oxLDL-activated monocytes can directly affect VSMCs in a co-culture system, leading to reduced expression of certain markers and upregulation of others, as well as activation of caspase 1, secretion of IL-1 beta, and pyroptosis in VSMCs. The activation of VSMC NLRP3 inflammasome by monocytes may play a detrimental role in atherosclerotic plaque stability in human atherosclerosis, as evidenced by findings in both mice and human atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph M. Miano, Edward A. Fisher, Mark W. Majesky
Summary: Studying the phenotypic modulation of vascular smooth muscle cells is crucial for understanding the pathogenesis of atherosclerosis and developing new therapies. Recent technological and conceptual advances shed light on the multifunctionality and plasticity of VSMCs.
Article
Peripheral Vascular Disease
Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, Satoru Eguchi
Summary: Smooth muscle AT(1A) receptors mediate Ang II-induced vascular remodeling in both hypertensive and non-hypertensive conditions, contributing to medial hypertrophy and perivascular fibrosis. These findings indicate an independent etiology of blood pressure elevation and hypertensive vascular remodeling in response to Ang II.
Article
Endocrinology & Metabolism
Parnian Kalbasi Anaraki, Margret Patecki, Sergey Tkachuk, Yulia Kiyan, Hermann Haller, Inna Dumler
JOURNAL OF BONE AND MINERAL RESEARCH
(2015)
Article
Cell Biology
Pavan B. Narayanaswamy, Sergey Tkachuk, Hermann Haller, Inna Dumler, Yulia Kiyan
CELL DEATH & DISEASE
(2016)
Article
Oncology
Pavan B. Narayanaswamy, Tapan K. Baral, Hermann Haller, Inna Dumler, Kshitish Acharya, Yulia Kiyan
Article
Physiology
Mahshid Hodjat, Hermann Haller, Inna Dumler, Yulia Kiyan
JOURNAL OF VASCULAR RESEARCH
(2013)
Article
Transplantation
Michael S. Balzer, Alexandra Helmke, Martina Ackermann, Janis Casper, Lei Dong, Marcus Hiss, Yulia Kiyan, Song Rong, Kai Timrott, Sibylle von Vietinghoff, Le Wang, Hermann Haller, Nelli Shushakova
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Article
Multidisciplinary Sciences
Pavan B. Narayanaswamy, Mahshid Hodjat, Hermann Haller, Inna Dumler, Yulia Kiyan
Article
Multidisciplinary Sciences
Damilola Dawodu, Margret Patecki, Jan Hegermann, Inna Dumler, Hermann Haller, Yulia Kiyan
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Damilola Dawodu, Margret Patecki, Inna Dumler, Hermann Haller, Yulia Kiyan
MOLECULAR BIOLOGY REPORTS
(2019)
Article
Cardiac & Cardiovascular Systems
Melanie Ricke-Hoch, Martijn F. Hoes, Tobias J. Pfeffer, Stella Schlothauer, Justus Nonhoff, Susanna Haidari, Nils Bomer, Michaela Scherr, Britta Stapel, Elisabeth Stelling, Yulia Kiyan, Christine Falk, Arash Haghikia, Ofer Binah, Zolt Arany, Thomas Thum, Johann Bauersachs, Peter van der Meer, Denise Hilfiker-Kleiner
CARDIOVASCULAR RESEARCH
(2020)
Article
Multidisciplinary Sciences
Yulia Kiyan, Sergey Tkachuk, Kestutis Kurselis, Nelli Shushakova, Klaus Stahl, Damilola Dawodu, Roman Kiyan, Boris Chichkov, Hermann Haller
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Gwenaelle Le Roux, Rafika Jarray, Anne-Cecile Guyot, Serena Pavoni, Narciso Costa, Frederic Theodoro, Ferid Nassor, Alain Pruvost, Nicolas Tournier, Yulia Kiyan, Oliver Langer, Frank Yates, Jean Philippe Deslys, Aloise Mabondzo
SCIENTIFIC REPORTS
(2019)
Letter
Critical Care Medicine
Klaus Stahl, Phillip Alexander Gronski, Yulia Kiyan, Benjamin Seeliger, Anna Bertram, Thorben Pape, Tobias Welte, Marius M. Hoeper, Hermann Haller, Sascha David
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Immunology
Yulia Kiyan, Sergey Tkachuk, Song Rong, Anna Gorrasi, Pia Ragno, Inna Dumler, Hermann Haller, Nelli Shushakova
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Critical Care Medicine
Klaus Stahl, Uta Carola Hillebrand, Yulia Kiyan, Benjamin Seeliger, Julius J. Schmidt, Heiko Schenk, Thorben Pape, Bernhard M. W. Schmidt, Tobias Welte, Marius M. Hoeper, Agnes Sauer, Malgorzata Wygrecka, Christian Bode, Heiner Wedemeyer, Hermann Haller, Sascha David
Summary: Therapeutic plasma exchange using fresh frozen plasma may play a role in mitigating endothelial glycocalyx damage in patients with septic shock, reducing injurious degradation products and partially restoring protective factors.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)