Article
Multidisciplinary Sciences
Shohei Yamamoto, Yosuke Inoue, Keisuke Kuwahara, Takako Miki, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Takeshi Hayashi, Tetsuya Mizoue
Summary: The study found that being active at work, such as standing or walking, was associated with a lower risk of chronic kidney disease compared to sedentary behavior. Leisure-time physical activity and walking for commute were not found to be associated with chronic kidney disease risk.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Adrian E. Bauman, Masamitsu Kamada, Rodrigo S. Reis, Richard P. Troiano, Ding Ding, Karen Milton, Niamh Murphy, Pedro C. Hallal
Summary: Pre-Olympic predictions often include an increase in population-based physical activity, while the post-Olympic effects on physical activity remain largely unsummarized. Most pre-Olympic documents set targets for population physical activity or sports participation; however, analysis of surveillance data shows little change in physical activity prevalence in most cases. Google Trends data demonstrates a sharp increase in searches related to the Olympics during the event, and sustained growth in searches related to exercise throughout the Olympic period.
Article
Biochemistry & Molecular Biology
Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimoto
Summary: This study reveals the significance of GATA4 homomultimerization in cardiac hypertrophy, with the acetylation by p300 promoting the multimerization and DNA binding activity of GATA4. Inhibition of GATA4 multimerization suppresses phenylephrine-induced hypertrophic response in cardiomyocytes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Romanika Okraszewska, Noah Peters, Lucia A. Reisch, Marion Flechtner-Mors, Carlijn B. M. Kamphuis, Janine Wendt, Daniel A. Scheller, Karolina Konsur, Joanna Zukowska
Summary: This study examines the drivers and barriers to Sustainable Urban Mobility Plan (SUMP) implementation in European cities and assesses its impact on physical activity. The results show that SUMP implementation is hindered by complex institutional structures and regional policy integration. Different cities face varying financial and policy guideline contexts. The study highlights the importance of consistent indicators and data transparency for evaluating the effectiveness of SUMPs and their influence on physical activity.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ozgul Ozturk, Onur Aydogdu, Seval Kutlutuerk Yikilmaz, Ozlem Feyzioglu, Pelin Pisirici
Summary: This study aimed to investigate physical literacy among late adolescents and its relationship with current physical activity, barriers to engaging in physical activity, and enjoyment of physical activity. The findings showed that highly physically active adolescents had better scores on physical literacy, enjoyment of activity, and barriers to physical activity. Physical literacy, gender, and enjoyment of activity were found to be determinants of high or moderate physical activity levels.
Article
Sport Sciences
Pedro L. Valenzuela, Alejandro Santos-Lozano, Javier S. Morales, Adrian Castillo-Garcia, Alejandro Lucia
Summary: This study analyzed the association between self-reported sleep characteristics and major cardiovascular disease (CVD) risk factors, and found that physical activity and weight status can attenuate this association. Therefore, maintaining optimal levels of physical activity and weight is crucial in reducing CVD risk associated with poor sleep quantity or quality.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Temesgen Muche Ewunie, Daniel Sisay, Birhanie Mekuriaw, Robel Hussen Kabthymer
Summary: Physical inactivity is a risk factor for hypertension among adults, and the pooled magnitude of physical inactivity among adults in Ethiopia is high.
Article
Peripheral Vascular Disease
Chang-Hoon Lee, Kyung-Do Han, Juhwan Yoo, Min-Sun Kwak
Summary: This study evaluated the interaction between temporal physical activity profiles and hypertension or diabetes mellitus on the risk for all-cause mortality, and found that sustained physical inactivity was associated with increased risk of all-cause mortality in those with hypertension or diabetes mellitus.
JOURNAL OF HYPERTENSION
(2021)
Review
Nutrition & Dietetics
Sisitha Jayasinghe, Andrew P. Hills
Summary: Despite the acknowledgement of the benefits of physical activity in preventing and controlling obesity, most children and adolescents are not sufficiently active to reap these benefits. Sedentary lifestyle and unhealthy dietary patterns during key development stages have a negative impact on young people. Unhealthy behaviors during the growth years predispose them to chronic conditions, such as obesity. Clear and consistent strategies are urgently needed to improve eating and activity behaviors of children and adolescents. Based on existing evidence, a set of non-negotiable strategies is presented as a roadmap to prevention and improving their health.
Review
Endocrinology & Metabolism
Pierre Bourdier, Chantal Simon, Daniel H. Bessesen, Stephane Blanc, Audrey Bergouignan
Summary: The role of physical activity in regulating body weight is still debated. Studies have mainly focused on the effects of moderate/vigorous physical activity, ignoring the impact of light-intensity physical activity and sedentary behaviors. Recent findings suggest that all components of physical activity, including light-intensity activity and sedentary behaviors, play an important role in weight regulation.
Review
Cardiac & Cardiovascular Systems
James E. Peterman, Steven Loy, Joshua Carlos, Ross Arena, Leonard A. Kaminsky
Summary: The community environment and community-based programs can impact levels of physical activity, but differences in community characteristics may mean strategies to promote physical activity are not universally effective.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Matias Mosqueira, Roland Konietzny, Carolin Andresen, Chao Wang, Rainer H.A. Fink
Summary: The study shows that cardiomyocytes produce transient nitric oxide signals after electrical stimulation, which impact the subsequent Ca2+ transient through different NOS isoform dependencies. This mechanism helps regulate Ca2+ homeostasis in the heart.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Tadeja Volmut, Rado Pisot, Jurij Planinsec, Bostjan Simunic
Summary: Research on children's physical activity has found that during summer holidays, children's overall activity levels significantly decrease, with obesity status and physical fitness test results being associated with changes in activity levels. Thus, future studies and interventions should pay more attention to intervening in children's physical activity during summer holidays.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Chemistry, Multidisciplinary
Carlos Salazar, Cesar Martin, Adriana Aguirre, Parisa Eslambolchilar, Victor Asanza
Summary: Physical inactivity poses a significant threat to public health, and the COVID-19 pandemic has further reduced physical activity levels due to restrictions. This study proposes physical activity interventions using mobile devices and control engineering principles. The model is based on the fluid analogy of Social Cognitive Theory and validated using data from a real intervention. The inclusion of new technology, such as phone-based ecological momentary assessments and simulations with logical reward conditions, enhances the understanding of behavior change interventions.
APPLIED SCIENCES-BASEL
(2023)
Article
Neurosciences
Raphael Teixeira Rocha Melo, Laila Cristina Moreira Damazio, Maira de Castro Lima, Pablo Herthel de Carvalho, Vanessa Guedes Pereira, Barbara Silva Okano, Betania Souza Monteiro, Antonio Jose Natali, Ricardo Junqueira Del Carlo, Izabel Regina dos Santos Costa Maldonado
Summary: This study analyzed the impact of treadmill training on muscle fiber atrophy and motor performance in rats after cerebral ischemia induction. The results showed that low-intensity exercise can reduce muscle fiber atrophy and improve motor performance.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Aline Rosignoli da Conceicao, Kelly A. Dias, Stephanie Michelin Santana Pereira, Luis Claudio Saraiva, Livya Alves Oliveira, Eliana Carla Gomes de Souza, Reggiani Vilela Goncalves, Sergio Luis Pinto da Matta, Antonio J. Natali, Hercia Stampini D. Martino, Ceres Mattos Della Lucia
Summary: The study showed that the combination of whey protein concentrate and curcumin can reduce blood glucose levels, oxidative damage, and inflammatory responses, which helps mitigate the effects of exhaustive physical exercise in swimming.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Sport Sciences
Victor Neiva Lavorato, Denise Coutinho de Miranda, Filipe Rios Drummond, Leonardo Matheus Teixeira Rezende, Maria do Carmo Gouveia Peluzio, Marcelo Eustaquio Silva, Antonio Jose Natali
Summary: The study found that acai consumption reduced serum total cholesterol levels, while AET increased exercise capacity and decreased body fat. Both AET and acai consumption reduced the concentrations of aspartate aminotransferase and TBARS, and also decreased the degree of macrovesicular steatosis. However, the combination of acai consumption and AET did not have additional effects on the development of NAFLD induced by a high-fat diet in rats.
SPORT SCIENCES FOR HEALTH
(2022)
Article
Medicine, Research & Experimental
Pedro Z. Suarez, Antonio J. Natali, Jose G. Mill, Leonardo M. T. de Rezende, Leoncio L. Soares, Filipe R. Drummond, Lucas C. C. Cardoso, Emily C. C. Reis, Victor N. Lavorato, Miguel A. Carneiro-Junior
Summary: This study aimed to investigate the effects of moderate-intensity continuous (MICT) and high-intensity interval (HIIT) aerobic training on cardiac morphology and function and the mechanical properties of single cardiomyocytes in spontaneously hypertensive rats (SHR). The results showed that both training programs led to beneficial adaptations to cardiac morphology, function, and mechanical properties in SHR.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Victor Hugo Antonio Joaquim, Noemy Pinto Pereira, Tiago Fernandes, Edilamar Menezes Oliveira
Summary: Circular RNAs (circRNAs) are endogenous noncoding RNAs (ncRNAs) that play various roles, mainly involving microRNAs (miRNAs) and RNA-binding proteins. With cardiovascular diseases (CVDs) being the leading cause of global death, it is crucial to develop new therapies and strategies, such as gene therapies or nonpharmacological interventions like physical exercise, for the alleviation of these diseases. Increasing evidence suggests that ncRNAs, including circRNAs, could serve as promising targets for the diagnosis and treatment of CVDs. However, little is known about the role of circRNAs in CVDs compared to miRNAs and lncRNAs. In this mini review, we focus on the mechanisms of circRNAs and their involvement in CVDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Natan D. D. da Silva Jr, Aluisio Andrade-Lima, Marcel R. R. Chehuen, Anthony S. S. Leicht, Patricia C. C. Brum, Edilamar M. M. Oliveira, Nelson Wolosker, Bruno R. A. Pelozin, Tiago Fernandes, Claudia L. M. Forjaz
Summary: Peripheral artery disease (PAD) patients have reduced muscle capillary density. Walking training (WT) promotes angiogenesis in PAD-affected muscle by increasing the gastrocnemius capillary-fiber ratio and the expression of miRNA-126 and vascular endothelium growth factor (VEGF) while decreasing the expression of PI3KR2. These findings suggest that miRNA-126 may play a role in this adaptation by inhibiting PI3KR2 and enabling the progression of the VEGF signaling pathway.
Article
Engineering, Biomedical
Ana Paula de Souza, Quenaz B. Soares, Eduardo M. A. M. Mendes, Leonardo B. Felix
Summary: This study investigates Auditory Selective Attention (ASA) using stimuli with AM modulation and spatial coherence to identify optimal combinations of electrodes and evaluate repetition rates and intervals in an inter-individual approach. The best result achieved an average hit rate of 75% and an information transfer rate (ITR) of 2.217 bits/min using AM stimuli and a combination of frontal and prefrontal electrodes with a 5-second interval between repetitions. These findings suggest the potential for a vision-free BCI that caters to individual differences and allows for communication through selective auditory attention without prior training.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Materials Science, Multidisciplinary
Luiz Otavio Guimaraes-Ervilha, Leoncio Lopes Soares, Isabela da Silva Pereira Bento, Renner Philipe Rodrigues Carvalho, Thaina Iasbik Lima, Fernanda Carolina Ribeiro Dias, Daniel Silva Sena Bastos, Jamile Fernanda Silva Cossolin, Ana Claudia Ferreira Souza, Emily Correna Carlo Reis, Jose Eduardo Serrao, Antonio Jose Natali, Mariana Machado-Neves
Summary: Pulmonary arterial hypertension (PAH) is characterized by elevated arterial pressure and vascular resistance. PAH may cause alterations in the microcirculation of several organs, including the kidney, liver, brain, and testes. This study investigated the impact of PAH on testicular morphology and function and found that PAH has deleterious effects on these parameters. However, resistance exercise training (RT) was shown to attenuate the negative effects of PAH on testicular parameters and improve testosterone levels.
MICROSCOPY AND MICROANALYSIS
(2023)
Review
Physiology
Filipe Rios Drummond, Luciano Bernardes Leite, Denise Coutinho de Miranda, Lucas Rios Drummond, Victor Neiva Lavorato, Leoncio Lopes Soares, Clovis Andrade Neves, Antonio Jose Natali
Summary: Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Filipe Rios Drummond, Leoncio Lopes Soares, Tiago Ferreira Leal, Luciano Bernardes Leite, Leonardo Mateus Teixeira Rezende, Meilene Ribeiro Fidelis, Victor Neiva Lavorato, Denise Coutinho Miranda, Miguel Araujo Carneiro Jr, Mariana Machado Neves, Luciane Carla Alberici, Emily Correna Carlo Reis, Clovis Andrade Neves, Antonio Jose Natali
Summary: The effects of voluntary running on skeletal muscle in rats with pulmonary arterial hypertension (PAH) were examined. Rats were induced with PAH using a single injection of monocrotaline (MCT). Sedentary hypertensive rats showed reduced physical exertion tolerance throughout the experiment, while those in the sedentary control, exercise control, exercise hypertension, and median exercise groups maintained or increased their tolerance. Muscle citrate synthase activity did not differ between groups. The EH group showed a higher survival time compared to the SH group. The EM and EH groups had a higher proportion of muscle fiber and lower extracellular matrix compared to the SH group. Gene expression analysis revealed lower PGC1-a expression and higher VEGF expression in the SH and EM groups compared to the SC group, with elevated PGC1-a expression in the EH group. The carbonylated protein levels did not differ between groups, but the TNF-a/IL-10 ratio was increased in the EH group. In conclusion, voluntary running improves the survival and physical tolerance in rats with MCT-induced PAH by increasing the proportion of muscle fiber and affecting gene expression of inflammatory and mitochondrial biogenesis markers.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Filipe Rios Drummond, Lucas Rios Drummond, Helton Oliveira Campos, Joao Guilhermo Rios Pimenta Fernandes, Mateus da Costa Monteiro, Henrique Fernandes Gerspacher Lara, Tito Cardoso de Almeida Mafra, Victor Neiva Lavorato, Andre Bahia Pereira, Laura Hora Rios Leite, Maristela de Oliveira Poletini, Candido Celso Coimbra
Summary: This study systematically analyzed the effects of melatonin supplementation on physical performance and recovery, as well as the impact of exercise on melatonin secretion. The results showed that melatonin supplementation did not improve aerobic or strength performance, but it did enhance post-exercise recovery. Furthermore, exercise did not immediately affect melatonin secretion.
Article
Biology
J. M. C. R. J. Bertoldi, R. Kindlovits, H. N. M. Rocha, C. Fernandes-Santos, J. L. P. Gomes, E. M. Oliveira, I. C. Muniz, M. M. Santos, J. F. Pereira, N. G. Rocha, A. C. L. da Nobrega, R. F. Medeiros
Summary: L-arginine and chronic exercise reduce oxidative stress. The aim of this research was to explore the effects of L-arginine supplementation and aerobic training on systemic oxidative stress and their consequences on cardiomyocytes during cardiometabolic disease caused by excessive fructose. The findings showed that moderate aerobic exercise reduced lipid peroxidation, and both training and L-arginine prevented metabolic changes caused by excess fructose. Myocardial vascularization was impaired by fructose, and cardiomyocyte hypertrophy appeared to be influenced by pro-inflammatory and oxidative environments.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Ian Alves Prado, Luciano Bernardes Leite, Davi Correia da Silva, Daniela Gomes Rosado, Victor Neiva Lavorato
Summary: In football, the effect of relative age plays a role in the success of players, especially those born in the first months of the year. A study conducted during the 2019 FIFA U-17 Men's World Cup revealed that the effect of relative age was present among the athletes, with variations observed between players in different positions.
REVISTA BRASILEIRA DE FUTSAL E FUTEBOL
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
