Review
Physiology
Kunal R. Shah, Xin Guan, Jiusheng Yan
Summary: Ion channels can form macromolecular signaling complexes to ensure accurate signal transduction. The BK channel limits increases in [Ca2+]i levels through K+ efflux and rapid membrane repolarization, serving as a negative feedback regulator.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ning Wei, Elena G. Tolkacheva
Summary: The study revealed that ephaptic coupling and the complex geometry of the ischemic zone have opposite effects on reentry termination. While ephaptic coupling and homogeneous EpC can terminate reentry, the presence of complex geometry in the border zone facilitates reentry.
Article
Cardiac & Cardiovascular Systems
Dorothee Jakob, Alexander Klesen, Benoit Allegrini, Elisa Darkow, Diana Aria, Ramona Emig, Ana Simon Chica, Eva A. Rog-Zielinska, Tim Guth, Friedhelm Beyersdorf, Fabian A. Kari, Susanne Proksch, Stephane N. Hatem, Matthias Karck, Stephan R. Kunzel, Helene Guizouarn, Constanze Schmidt, Peter Kohl, Ursula Ravens, Remi Peyronnet
Summary: The study found that human atrial fibroblasts contain at least two types of ion channels activated during stretch: Piezol and BKca. Sustained atrial fibrillation is associated with increased Piezol and decreased BKca activity, indicating differential regulation of these channels.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Polina Gross, Jaslyn Johnson, Carlos M. Romero, Deborah M. Eaton, Claire Poulet, Jose Sanchez-Alonso, Carla Lucarelli, Jean Ross, Andrew A. Gibb, Joanne F. Garbincius, Jonathan Lambert, Erdem Varol, Yijun Yang, Markus Wallner, Eric A. Feldsott, Hajime Kubo, Remus M. Berretta, Daohai Yu, Victor Rizzo, John Elrod, Abdelkarim Sabri, Julia Gorelik, Xiongwen Chen, Steven R. Houser
Summary: The joining region in JPH2 interacts with LTCC-alpha 1C subunit, causing LTCCs to distribute to dyads and colocalize with RyRs, facilitating dyad assembly and maintaining normal CICR in cardiomyocytes. Disruption of this interaction leads to T-tubule remodeling, impaired excitation-contraction coupling, and altered myocyte bioenergetics.
CIRCULATION RESEARCH
(2021)
Review
Cell Biology
Sebastien Chaigne, Solene Barbeau, Thomas Ducret, Romain Guinamard, David Benoist
Summary: The TRPV4 channel plays a role in intracellular calcium handling in cardiac cells and is involved in various physiological functions in the cardiovascular system. It modulates mitochondrial activity, calcium homeostasis, electrical activity and contractility of cardiomyocytes, as well as vascular permeability, dilatation and constriction. Furthermore, TRPV4 channels are implicated in cardiac pathological processes such as fibrosis, hypertrophy, ischemia-reperfusion injuries, heart failure, myocardial infarction and arrhythmia. This manuscript provides an overview of the implications of TRPV4 channel in cardiac physiology and discusses its potential as a therapeutic target for cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Jerome Anthony E. Alvarez, M. Saleet Jafri, Aman Ullah
Summary: This study developed a stochastic ventricular cardiomyocyte model that can adapt to intracellular calcium dynamics, spark regulation, and frequency-dependent changes. The model demonstrated that calcium release events and ion channel responses are dynamically altered under different stimuli.
Article
Multidisciplinary Sciences
Nicholas C. Vierra, Samantha C. O'Dwyer, Collin Matsumoto, L. Fernando Santana, James S. Trimmer
Summary: In mammalian brain neurons, membrane depolarization triggers Ca2+ influx through voltage-gated Ca2+ channels, leading to diverse cellular responses, including gene expression. The L-type Ca2+ channels in neuronal soma and dendrites play a key role in this process. The organization of signaling complexes by Kv2.1 at endoplasmic reticulum-plasma membrane junctions enhances the clustering and activity of Cav1.2 channels, impacting somatic Ca2+ signals and excitation-transcription coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Ludmila Zylinska, Malwina Lisek, Feng Guo, Tomasz Boczek
Summary: Vitamin C is important for antioxidant defense and its deficiency in the nervous tissue can lead to disruptions in neurotransmission and brain function. Calcium plays a crucial role in neuronal processes and Vitamin C has a unique role in regulating calcium-involved pathways in the brain.
Article
Environmental Sciences
Thimo Philipp, Nina Huittinen, Salim Shams Aldin Azzam, Robin Stohr, Janina Stietz, Tobias Reich, Katja Schmeide
Summary: This study comprehensively evaluates the effect of Ca2+ on the retention of U(VI) and Np(VI) on alumosilicate minerals using batch sorption experiments and time-resolved laser-induced luminescence spectroscopy (TRLFS). The results confirm that alkaline earth elements enable strong retention of hexavalent actinides on clay minerals under hyperalkaline repository conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Physical
Zheng-Wang Qu, Hui Zhu, Rainer Streubel, Stefan Grimme
Summary: Recently, monomeric calcium hydride intermediates with reactive terminal Ca-H bond were found to deprotonate N-heterocyclic olefin ligands upon moderate heating with dimeric amidinate calcium hydride complexes. However, dispersion-corrected DFT calculations revealed that cooperative Ca-H-Ca bridges exhibit frustrated Lewis pair (FLP) like reactivity, enabling stoichiometric C-H deprotonation and kinetically more favorable catalytic C=C hydrogenation with pressured H-2. These findings provide valuable insights for metal hydride based hydrogenation catalysts.
Article
Chemistry, Multidisciplinary
Masayuki Kawaguchi, Hiromichi Ishikawa, Pascal Berger, Melissa Fauchard, Sebastien Cahen, Claire Herold
Summary: Boron/carbon/nitrogen (B/C/N) materials and boron/carbon (B/C) materials have been synthesized using a chemical vapor deposition (CVD) method. Calcium (Ca) was intercalated into the B/C and B/C/N materials, forming intercalation compounds. Nuclear microprobe analysis confirmed the homogeneity of these materials and compounds.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Plant Sciences
Szymon Chowanski, Magdalena Winkiel, Monika Szymczak-Cendlak, Pawel Marciniak, Dominika Manczak, Karolina Walkowiak-Nowicka, Marta Spochacz, Sabino A. Bufo, Laura Scrano, Zbigniew Adamski
Summary: This study investigated the potential interaction between verapamil and Solanaceae glycoalkaloids (SGAs) and their effects on cardiac activity. The results showed that verapamil, alpha-solanine, and alpha-chaconine exhibited cardioinhibitory activity. When SGAs were applied simultaneously with verapamil, an antagonistic effect was observed.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Giampaolo Morciano, Alessandro Rimessi, Simone Patergnani, Veronica A. M. Vitto, Alberto Danese, Asrat Kahsay, Laura Palumbo, Massimo Bonora, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
Summary: Intracellular calcium signaling is a universal language shared by various biological entities inside cells, regulating physiological functions like muscle contraction through calcium channels, pumps, and exchangers. Abnormal calcium homeostasis can lead to heart diseases, but can be corrected through chemical, peptide-based, and pharmacological modulators.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biology
Maura Greiser, Mariusz Karbowski, Aaron David Kaplan, Andrew Kyle Coleman, Nicolas Verhoeven, Carmen A. Mannella, W. Jonathan Lederer, Liron Boyman
Summary: Mitochondrial ATP production in ventricular cardiomyocytes is regulated by the CO2/bicarbonate signaling cascade activated by soluble adenylyl cyclase (sAC), which is primarily located inside the mitochondria. Activation of sAC by bicarbonate generates cAMP, which activates local EPAC1 and subsequently turns on Rap1, increasing mitochondrial ATP production. This bicarbonate- and sAC-mediated signaling process works independently of, yet in conjunction with, [Ca2+](m)-dependent ATP production in ventricular cardiomyocytes.
Article
Multidisciplinary Sciences
Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui
Summary: Researchers have discovered a compound, BC5, that interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism. BC5 can activate the channel in the absence of Ca2+ binding, but Ca2+ binding inhibits BC5 effects. This study reveals the importance of the CTD-VSD interaction in the Ca2+ activation mechanism and provides insights for allosteric agonists to modulate BK channel activation.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)