Article
Cardiac & Cardiovascular Systems
Yiru Guo, Qianhong Li, Yu-Ting Xuan, Wen-Jian Wu, Wei Tan, Jan Slezak, Xiaoping Zhu, Alex Tomlin, Roberto Bolli
Summary: This study demonstrates that short-term, mild exercise induces delayed cardioprotective effects against myocardial infarction, dependent on the activation of eNOS, eNOS-derived NO generation, and subsequent PKC epsilon activation during preconditioning. Furthermore, the protection 24 hours after exercise is mediated by iNOS activity.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Xiangrong Cui, Hongping Liang, Chonghua Hao, Xuan Jing
Summary: Liraglutide protects cardiomyocytes under hypoxia/reoxygenation conditions by regulating homer1 gene expression, inhibiting intracellular calcium overload, and enhancing cell survival.
Article
Medicine, Research & Experimental
Wei Xiong, Rui Zhou, Yan Qu, Yuqiao Yang, Zhuoran Wang, Ning Song, Rongbi Liang, Jinqiao Qian
Summary: The study demonstrated that dexmedetomidine preconditioning can alleviate degranulation of mast cells and apoptosis of cardiomyocytes caused by I/R injury, and inhibit the activation of inflammatory related factors HMGB1, TLR4, and NF-KB p65.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
David Peter Obert, Alexander Karl Wolpert, Nathan Lewis Grimm, Sebastian Korff
Summary: The study investigated the mechanism of ER stress preconditioning in alleviating post-hemorrhagic liver damage. Preconditioning with ER stress inducer tunicamycin increased BiP expression and modified topographic expression patterns of UPR signaling proteins, leading to a significant reduction in cell death areas post-hemorrhagic shock. These results suggest that UPR plays a crucial role in HS/R and may serve as a potential therapeutic target for liver damage.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Csaba Horvath, Megan Young, Izabela Jarabicova, Lucia Kindernay, Kristina Ferenczyova, Tanya Ravingerova, Martin Lewis, M. Saadeh Suleiman, Adriana Adameova
Summary: RIP3 is a central point of multiple signaling pathways, but the acute myocardial ischemia/reperfusion injury is not mediated by necroptotic cell death. The study shows that RIP3 regulates reperfusion injury through oxidative stress and mitochondrial activity effects, rather than cell loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carmine Rocca, Anna De Bartolo, Maria Concetta Granieri, Vittoria Rago, Daniela Amelio, Flavia Falbo, Rocco Malivindi, Rosa Mazza, Maria Carmela Cerra, Loubna Boukhzar, Benjamin Lefranc, Jerome Leprince, Youssef Anouar, Tommaso Angelone
Summary: The cell-permeable PSELT provides pharmacological preconditioning cardioprotection by mitigating ERS and oxidative stress, and by regulating endogenous SELENOT.
Review
Surgery
Glauber C. de Oliveira, Walmar K. de Oliveira, Winston B. Yoshida, Marcone L. Sobreira
Summary: This study assessed the beneficial effects of ischemic preconditioning (IPC) in liver resection and evaluated its applicability in clinical practice. The results showed that IPC can reduce intraoperative blood loss and the risk of postoperative ascites, but it has no significant impact on postoperative liver function and length of hospital stay. Therefore, although IPC is feasible in clinical practice, more evidence is needed to support its routine use.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Li Yu, Yangyang Zhang, Xixi Zhao, Haitong Wan, Yu He, Weifeng Jin
Summary: This study investigated the therapeutic effect of Guhong injection (GHI) on cerebral ischemia-reperfusion injury in rats through the PKC/HIF-1 alpha pathway. The results demonstrated that GHI can ameliorate neurological damage in MCAO rats by reducing levels of HIF-1 alpha, PKC, and other related markers in the brain.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Qiaoling Wu, You Shang, Yanli Bai, Yuanyuan Wu, Hao Wang, Tu Shen
Summary: Sufentanil pretreatment can alleviate myocardial IRI damage by inhibiting oxidative stress and mitochondrial autophagy. The cardioprotective mechanism of sufentanil is mainly mediated by the miR-125a/DRAM2 signaling axis.
Article
Chemistry, Multidisciplinary
Mihaela Roxana Popescu, Bogdan Pavel, Gheorghita Isvoranu, Laura Cristina Ceafalan, Anca Maria Panaitescu, Ruxandra Irina Sava, Adelina Vlad, Leon Zagrean
Summary: The interrupted sevoflurane administration protocol for preconditioning was found to effectively protect the myocardium against ischemia/reperfusion injury, reducing fibrosis area and apoptosis degree. This suggests potential benefits for patients with increased cardiovascular risk to reduce perioperative or periprocedural ischemia.
APPLIED SCIENCES-BASEL
(2022)
Article
Clinical Neurology
Yi-Na Zhang, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: Ischemic preconditioning (IPC) can protect the blood-brain barrier (BBB) by interfering with glycocalyx, improving neurological pathology in rat models of cerebral ischemia-reperfusion injury (IRI).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Romina Hermann, Victoria Evangelina Mestre Cordero, Maria de las Mercedes Fernandez Pazos, Federico Joaquin Reznik, Debora Elisabet Velez, Maria Gabriela Marina Prendes
Summary: The study investigates the role of autophagy in ischemic-reperfused atrial myocardium. The results suggest that inhibition of autophagy leads to deterioration in mitochondrial structure and function, as well as impaired metabolic recovery and contractile reserve.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Veterinary Sciences
Tanya M. Rossi, Peter A. Kavsak, M. Grant Maxie, David L. Pearl, W. Glen Pyle, Peter W. Physick-Sheard
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2018)
Article
Veterinary Sciences
T. M. Rossi, P. A. Kavsak, M. G. Maxie, D. L. Pearl, W. G. Pyle, P. W. Physick-Sheard
EQUINE VETERINARY JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Omar Ayaz, Shubham Banga, Stefan Heinze-Milne, Robert A. Rose, W. Glen Pyle, Susan E. Howlett
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Physiology
L. A. Gatrell, E. Farhat, W. G. Pyle, Todd E. Gillis
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2019)
Article
Physiology
Rosephine Del Fernandes, Alexandra Hall, Melissa Ferguson, Ilka Lorenzen-Schmidt, Vishali Balasubramaniam, W. Glen Pyle
Article
Multidisciplinary Sciences
Melissa Ferguson, Ilka Lorenzen-Schmidt, W. Glen Pyle
SCIENTIFIC REPORTS
(2019)
Article
Physiology
Xiang Li, Shuang Zheng, Weijiang Tan, Hongqi Chen, Xiaohui Li, Jian Wu, Ting Luo, Xuecong Ren, W. Glen Pyle, Lijing Wang, Peter H. Backx, Ren Huang, Feng Hua Yang
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Alice E. Kane, Elise S. Bisset, Kaitlyn M. Keller, Anjali Ghimire, W. Glen Pyle, Susan E. Howlett
SCIENTIFIC REPORTS
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Sarah K. Brown, Glen W. Pyle, Michael Drozd, Alexios S. Antonopoulos
CARDIOVASCULAR RESEARCH
(2020)
Article
Veterinary Sciences
T. M. Rossi, P. A. Kavsak, M. G. Maxie, D. L. Pearl, W. G. Pyle, P. W. Physick-Sheard
Summary: This study investigated the effects of racing on serum cardiac troponin I (cTnI) in Standardbred horses, using high-sensitivity assays. Results showed a significant increase in cTnI concentration post-race. Factors such as age, gait, and pre-race cTnI concentration were found to be positively associated with cTnI levels. Horses finishing distanced and experiencing arrhythmia exhibited higher cTnI release, suggesting potential myocardial compromise.
JOURNAL OF VETERINARY CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
W. Glen Pyle
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Cristine J. Reitz, Mina Rasouli, Faisal J. Alibhai, Tarak N. Khatua, W. Glen Pyle, Tami A. Martino
Summary: A study in mice showed that extending the morning rest period can limit cardiac remodeling and benefit cardiovascular disease outcomes. The mechanism involves mitigating hemodynamic stress, relaxing myofilament contractility, and attenuating cardiac remodeling genes. This suggests the potential of rest-based therapy for major clinical diseases.
Article
Cell Biology
Emma F. Hubbard, Parastoo Mashouri, W. Glen Pyle, Geoffrey A. Power
Summary: Menopause impairs skeletal muscle contractile function, but high-intensity interval training (HIIT) may help mitigate this decline.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sarah Rouhana, Kathy Jacyniak, Magen E. Francis, Darryl Falzarano, Alyson A. Kelvin, W. Glen Pyle
Summary: SARS-CoV-2 infection damages the heart and increases the risk of adverse cardiovascular events. Females are less likely to experience severe illness or death, but have a higher risk of long-term sequelae of COVID-19. This study identifies myocardial stress responses following SARS-CoV-2 infection and reveals sex differences that may contribute to differential outcomes.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Physiology
W. Glen Pyle, Tami A. Martino
CURRENT OPINION IN PHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)