Article
Multidisciplinary Sciences
Bowen Wang, Zhiheng Zhao, Michael Xiong, Rui Yan, Ke Xu
Summary: The endoplasmic reticulum (ER) is a versatile organelle with distinct forms of tubules, regulated by Rtn4 and Climp63, that together form a ribbon-like structure of well-defined width.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Merel Stiekema, Frederik Houben, Fons Verheyen, Marcel Borgers, Julia Menzel, Martin Meschkat, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Jos L. Broers
Summary: Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. The nucleoplasmic reticulum (NR) is composed of tubular invaginations consisting of either both the inner and outer nuclear membrane or only the inner nuclear membrane. The formation and structure of the NR are determined by proteins associated with the nuclear membrane. The study of nuclear invaginations and the NR is important for understanding various diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Deepak Anand, Arunima Chaudhuri
Summary: The nuclear membrane plays a crucial role in separating the nucleus from the cytoplasm and maintaining the shape of the nucleus through its connection with other cellular structures. The lipid-protein composition of the nuclear membrane is important for understanding its function and signaling pathways.
JOURNAL OF MEMBRANE BIOLOGY
(2023)
Article
Parasitology
Cudjoe Obed, Minmin Wu, Ying Chen, Ran An, Haijian Cai, Qingli Luo, Li Yu, Jie Wang, Fang Liu, Jilong Shen, Jian Du
Summary: Toxoplasma infection can cause ER stress and apoptosis in host cells. The dense granule protein GRA3 plays a role in the virulence of T. gondii, and it induces neural cell apoptosis via the ER stress signaling pathway.
PARASITES & VECTORS
(2022)
Article
Neurosciences
Xianwei Zhang, Charlotte E. R. Smith, Stefano Morotti, Andrew G. Edwards, Daisuke Sato, William E. Louch, Haibo Ni, Eleonora Grandi
Summary: This study investigates the independent and interactive effects of TATS and Ca2+-handling protein remodelling on Ca2+-handling abnormality driven membrane instabilities. The results show that the impact of protein remodelling on Ca2+-driven proarrhythmic behaviour varies depending on TATS density.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Plant Sciences
Jens Tilsner, Verena Kriechbaumer
Summary: This research reveals the interaction between plant reticulon proteins (RTN) and viral movement proteins (vMP), indicating their potential role in the formation and regulation of plasmodesmata (PD) in plants.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Praveen Jaiswar, Mitali Bhate, Avadhesha Surolia
Summary: Damage to the central or peripheral nervous system causes neuropathic pain. Endoplasmic reticulum (ER) stress plays a role in peripheral neuropathy. Increase in ER stress is seen in diabetic neuropathy. Inducers of ER stress also give rise to peripheral neuropathy. ER stress leads to the formation of autophagosomes but their degradation is stalled, leading to accumulation of autophagosomes. Accumulation of autophagosomes has deleterious effects on cells. In this study, treatment with the ER stress inducer tunicamycin (TM) in mice resulted in peripheral neuropathy, which was decreased by subsequent treatment with 6-bromoindirubin-3'-oxime (6-BIO), a promoter of autophagy. 6-BIO also reduced diabetic peripheral neuropathy. Activation of degradative autophagy and reduction of secretory autophagy by 6-BIO contributed to its neuroprotective effects.
Article
Biochemistry & Molecular Biology
Luisa Galla, Nicola Vajente, Diana Pendin, Paola Pizzo, Tullio Pozzan, Elisa Greotti
Summary: Calcium (Ca2+) plays a crucial role in controlling both physiological and pathological cellular processes, with a new nuclear-targeted calcium probe developed for more accurate quantitative measurements. This study successfully demonstrated similar levels of calcium in cytoplasm and nucleoplasm in resting and stimulated cells, highlighting the importance of localized calcium monitoring for cell function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Harsha Samtani, Aishwarye Sharma, Paramjit Khurana
Summary: The study identifies two homoeologs of wheat ocs-element binding factor 1 (TaOBF1-5B and TaOBF1-5D) as heat-responsive members of the TabZIP transcription factor family. Overexpression of TaOBF1-5B in Arabidopsis thaliana and Oryza sativa enhances stress-responsive gene expression and promotes thermotolerance in transgenic plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ella P. Dennis, Robyn N. Watson, Florence McPate, Michael D. Briggs
Summary: By using our luciferase ER stress screening assay, we have found that curcumin can reduce pathological ER stress in a cell model of EDM5 by promoting the degradation of mutant matrilin-3. This is an important in vitro study that introduces a natural chemical as a potential treatment for the currently incurable rare skeletal disease, EDM5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yafeng Gao, Wenhui Li, Zhenghao Wang, Cangang Zhang, Yaping He, Xiaowei Liu, Kexin Tang, Weiguo Zhang, Qiaoming Long, Yong Liu, Jinping Zhang, Baojun Zhang, Lianjun Zhang
Summary: Studies have shown that SEL1L deficiency leads to reduced frequency and number of peripheral T cells, especially naive CD8(+) T cells. SEL1L deficiency also results in activation of mTORC1/c-MYC and metabolic shift, as well as excessive endoplasmic reticulum stress. These findings suggest that SEL1L plays an important role in preserving the survival and homeostasis of peripheral T cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Cell Biology
Sanju Ashraf, Ye Dee Tay, David A. Kelly, Kenneth E. Sawin
Summary: A novel microtubule-independent form of nuclear movement has been discovered in fission yeast, which relies on actin cables but not actin polymerization or myosin V forces. This movement is directed towards growing cell tips and is influenced by the proximity of the nucleus to the tip. Additionally, vesicle-associated membrane proteins are found to be critical for this microtubule-independent nuclear movement.
JOURNAL OF CELL SCIENCE
(2021)
Review
Cell Biology
Giovanna Carra, Lidia Avalle, Laura Secli, Mara Brancaccio, Alessandro Morotti
Summary: NF-kappa B is not only a transcription factor regulating gene expression within the nucleus, but also has functions within cellular organelles. The crosstalk between NF-kappa B and cellular organelles is significant for anticancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hui -Lam Rachel Kwan, Zora Chui-Kuen Chan, Xinyi Bi, Justyna Kutkowska, Tomasz J. Proszynski, Chi Bun Chan, Chi Wai Lee
Summary: Junctional folds are unique membrane specializations that develop during the postnatal maturation of vertebrate neuromuscular junctions (NMJs). This study demonstrates the progressive development of membrane infoldings via nerve-independent, caveolin-3-dependent mechanisms and identifies their roles in AChR trafficking and redistribution during the structural maturation of NMJs.
Article
Chemistry, Medicinal
Ryota Nakajima, Hiroyuki Oono, Keiko Kumazawa, Tomohide Ida, Jun Hirata, Ryan D. White, Xiaoshan Min, Angel Guzman-Perez, Zhulun Wang, Antony Symons, Sanjay K. Singh, Srinivasa Reddy Mothe, Sergei Belyakov, Anjan Chakrabarti, Satoshi Shuto
Summary: The study focused on ROR gamma t, a potential therapeutic target for immune diseases, and successfully identified a compound with potent inhibitory activity and favorable pharmacokinetic properties through structure-activity relationship studies.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)