期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 51, 期 4, 页码 619-625出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2011.05.015
关键词
Chemokines; Growth factors; Small molecules; Stem cell; Cardiogenesis; Regeneration
资金
- NIH [RO1 HL094849, P20 HL101443, RO1 HL084275, RO1 HL107110, U54 HL081028]
Cell-based therapy is emerging as an exciting potential therapeutic approach for cardiac regeneration following myocardial infarction (MI). As heart failure (HF) prevalence increases over time, development of new interventions designed to aid cardiac recovery from injury are crucial and should be considered more broadly. In this regard, substantial efforts to enhance the efficacy and safety of cell therapy are continuously growing along several fronts, including modifications to improve the reprogramming efficiency of inducible pluripotent stem cells (iPS), genetic engineering of adult stem cells, and administration of growth factors or small molecules to activate regenerative pathways in the injured heart. These interventions are emerging as potential therapeutic alternatives and/or adjuncts based on their potential to promote stem cell homing, proliferation, differentiation, and/or survival. Given the promise of therapeutic interventions to enhance the regenerative capacity of multipotent stem cells as well as specifically guide endogenous or exogenous stem cells into a cardiac lineage, their application in cardiac regenerative medicine should be the focus of future clinical research. This article is part of a special issue entitled Key Signaling Molecules in Hypertrophy and Heart Failure. (C) 2011 Elsevier Ltd. All rights reserved.
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