Article
Cardiac & Cardiovascular Systems
Jochen Dutzmann, Marco Haertle, Jan-Marcus Daniel, Frederik Kloss, Robert-Jonathan Musmann, Katrin Kalies, Kai Knopp, Claudia Pilowski, Mirja Sirisko, Jan-Thorben Sieweke, Johann Bauersachs, Daniel G. Sedding, Simona Gegel
Summary: Selective inhibition of BET proteins can reduce proliferation and migration of SMCs by regulating FOXO1 transcription factor, leading to cell cycle arrest and prevention of neointima formation. Inhibition of BET epigenetic reader proteins may represent a promising therapeutic strategy to prevent adverse vascular remodeling.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Utsab Subedi, Shrivats Manikandan, Susmita Bhattarai, Papori Sharma, Sudha Sharma, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Neointimal hyperplasia is characterized by a loss of the contractile phenotype of vascular smooth muscle cells (VSMCs). Our study found that autotaxin (ATX) and lysophosphatidic acid (LPA) play a role in VSMC proliferation and migration during restenosis. Inhibition of the ATX-LPA axis could potentially be used as a therapeutic target to minimize VSMC phenotypic modulation and inflammation after vascular injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiujie Xie, Lian-Wang Guo, K. Craig Kent
Summary: Communication between endothelial cells and smooth muscle cells is crucial for vascular homeostasis, with miR548ai potentially serving as a molecular target for protection against dysfunction induced by proliferative cell-derived exosomes.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs and SMCs interact through the CXCL12-CXCR4 axis to establish an amplifying feedback loop, promoting regenerative processes and mediating SMC phenotype control to potentially maintain vascular homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Dongxu Qiu, Yalan Deng, Yanbin Wen, Jun Yin, Jie Feng, Jiabing Huang, Mingyu Song, Gui Zhang, Changqing Chen, Jian Xia
Summary: This study demonstrated that corroded granules produced by iron stents inhibit vascular smooth muscle cell (VSMC) proliferation and reduce neointimal hyperplasia in an atherosclerotic artery stenosis model. The corroded granules were found to primarily consist of iron oxide. Furthermore, the inhibitory effect on VSMC proliferation was observed to be mediated by the activation of autophagy through the AMPK/mTOR signaling pathway. The safety of iron corroded granules was also confirmed in a rabbit model.
MATERIALS TODAY BIO
(2022)
Review
Developmental Biology
Michael Donadon, Massimo M. Santoro
Summary: The article primarily describes the developmental origin of smooth muscle cells in different organs, as well as their specification and differentiation in the cardiovascular, respiratory, and intestinal systems. It discusses the important roles of smooth muscle in organ development and how they instruct the development of other organs through signaling and mechanical feedback mechanisms. By understanding smooth muscle cell development, the aim is to advance therapeutic approaches related to tissue regeneration and other smooth muscle-related diseases.
Article
Biochemistry & Molecular Biology
Ya-Ning Shi, Le-Ping Liu, Chang-Feng Deng, Tan-Jun Zhao, Zhe Shi, Jian-Ye Yan, Yong-Zhen Gong, Duan-Fang Liao, Li Qin
Summary: The study found that celastrol effectively inhibited intimal hyperplasia and hyperproliferation of VSMCs by inducing autophagy, suggesting it may be a novel drug with great potential to prevent restenosis. The mechanism behind this effect involves lysosomal degradation of c-MYC and the Wnt5a/PKC/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Manish Jain, Anil K. Chauhan
Summary: Integrins play a crucial role in modulating the functional properties of smooth muscle cells and their implications in vascular pathology.
Article
Cardiac & Cardiovascular Systems
Sen Li, Zhiwei Gao, Haiqing Li, Chang Xu, Bing Chen, Qing Zha, Ke Yang, Weilin Wang
Summary: This study found that Slit2 can inhibit the migration and proliferation of vascular smooth muscle cells, delay vascular restenosis, maintain the patency of artery bypass grafts, and suppress cell phenotype transformation. This has important implications for the prevention and treatment of restenosis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Review
Materials Science, Biomaterials
Meichun Wu, Min Xun, Yuping Chen
Summary: Iron-, magnesium-, or zinc-based metal vessel stents support vessel expansion and degrade away after vascular reconstruction, eliminating side effects and risks. However, their degradation alters the vascular microenvironment and induces adaptive responses of vascular cells. This review discusses how biodegradable metal stents modify vascular conditions and how vascular smooth muscle cells (VSMCs) respond to stent implantation, highlighting the importance of VSMC transformation in future stent design.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Xin Xu, Xiao-Qin Liu, Xin-Long Liu, Xu Wang, Wen-Di Zhang, Xiao-Fu Huang, Fang-Yue Jia, Peng Kong, Mei Han
Summary: Considerable evidence suggests that cognitive impairment is primarily a vascular disorder. The depletion of SM22 alpha in VSMCs contributes to their phenotypic switching and inflammation, but the role of VSMCs in cognitive impairment is still uncertain. This study shows a possible link between VSMC phenotypic switching and neurodegenerative diseases, supporting the idea of VSMCs and SM22 alpha as therapeutic targets in cognitive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Islam Osman, Kunzhe Dong, Xiuhua Kang, Luyi Yu, Fei Xu, Abu Shufian Ishtiaq Ahmed, Xiangqin He, Jian Shen, Guoqing Hu, Wei Zhang, Jiliang Zhou
Summary: This study reveals a novel mechanism by which YAP1/TEAD1 promote VSMC proliferation through transcriptional induction of PDGFR beta, thereby enhancing PDGF-BB downstream signaling and promoting neointima formation.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao-Fei Gao, Ai-Qun Chen, Zhi-Mei Wang, Feng Wang, Shuai Luo, Si-Yu Chen, Yue Gu, Xiang-Quan Kong, Guang-Feng Zuo, Yan Chen, Zhen Ge, Jun-Jie Zhang, Shao-Liang Chen
Summary: This study mapped potential cellular targets of neointimal hyperplasia by comparing normal and stenotic arteries, and highlighted the crucial role of VSMC phenotype switching in the progression of neointimal hyperplasia. Additionally, several novel target genes were proposed through disease susceptibility gene analysis, such as Cyp7a1 and Cdk4.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Francisco X. Galdos, Sidra Xu, William R. Goodyer, Lauren Duan, Yuhsin Huang, Soah Lee, Han Zhu, Carissa Lee, Nicholas Wei, Daniel Lee, Sean M. Wu
Summary: devCellPy is a highly accurate and precise machine learning-enabled tool for automated prediction of cell types across complex cellular hierarchies. It has been demonstrated to be useful in constructing a murine cardiac developmental atlas and predicting cardiomyocyte subtypes in human induced pluripotent stem cells.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Pilar Cidad, Esperanza Alonso, Marycarmen Arevalo-Martinez, Enrique Calvo, Miguel A. de la Fuente, M. Teresa Perez-Garcia, Jose R. Lopez-Lopez
Summary: The voltage-dependent potassium channel Kv1.3 plays a role in proliferation by modulating membrane potential and interacting with IQGAP3, a scaffold protein involved in proliferation. Voltage-dependent conformational changes of Kv1.3 are essential in Kv1.3-induced proliferation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Luca Baldetti, Francesco Giannini, Nicolas Van Mieghem, Nahid El Faquir, Didier Tchetche, Chiara De Biase, Anna Sonia Petronio, Cristina Giannini, Giuseppe Tarantini, Chiara Fraccaro, Ariel Finkelstein, Amit Segev, Israel Barbash, Giuseppe Bruschi, Corrado Tamburino, Marco Barbanti, Scott Lim, Ivandito Kuntjoro, Mohamed Abdel-Wahab, Antonio Colombo, Azeem Latib
CANADIAN JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Zach Rozenbaum, Ariel Finkelstein, Sophia Zhitomirsky, Yan Topilsky, Amir Halkin, Shmuel Banai, Samuel Bazan, Israel Barbash, Amit Segev, Victor Guetta, Haim Danenberg, David Planner, Katia Orvin, Hana Vaknin Assa, Abid Assali, Ran Kornowski, Arie Steinvil
AMERICAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Oren Zusman, M. Israel Barbash, Victor Guetta, Ariel Finkelstein, Abid Assali, Amit Segev, Katia Orvin, Alon Barsheshet, Arwa Younis, Guy Witberg, Ran Kornowski, Haim Danenberg, Uri Landes
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Israel M. Barbash, Ran Kornowski, Anat Berkovitch, Abid Assali, Magdalena Erlebach, Victor Guetta, Hana Vaknin Assa, Ruediger Lange, Amit Segev, Hendrik Ruge
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Anat Berkovitch, Israel M. Barbash, Ariel Finkelstein, Abid R. Assali, Haim Danenberg, Paul Fefer, Elad Maor, Sophia Zhitomirsky, Katia Orvin, Sagit Ben Zekry, Arik Steinvil, Alon Barsheshet, Amir Halkin, Victor Guetta, Ran Kornowski, Amit Segev
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Alexander Fardman, Daniel Oren, Anat Berkovitch, Amit Segev, Yuval Levy, Roy Beigel, Shlomi Matetzky
CANADIAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Elad Asher, Arsalan Abu -Much, Nicola L. Bragazzi, Anan Younis, Arwa Younis, Eyas Masalha, Ronen Goldkorn, Israel Mazin, Paul Fefer, Israel M. Barbash, Amit Segev, Roy Beigel, Shlomi Matetzky
Summary: This study aimed to evaluate the CHADS2 and CHA2DS2-VASc scores as predictors for platelet reactivity in ACS patients. The results showed that lower CHADS2 and CHA2DS2-VASc scores were associated with lower mean platelet ADP-induced aggregation.
JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Martin Valdebenito, Eias Massalha, Israel M. Barbash, Elad Maor, Paul Fefer, Victor Guetta, Amit Segev
Summary: The study compared patients undergoing TAVI during the COVID-19 pandemic and non-pandemic periods, and found no significant differences in procedural success rate, complications, permanent pacemaker implantation, length of hospital stay, and 30-day mortality rate between the two groups.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Guy Witberg, Amit Segev, Yaron D. Barac, Ehud Raanani, Abid Assali, Ariel Finkelstein, Ariel Roguin, Gideon Sahar, Hana Vaknin-Assa, Gil Bolotin, Amnon Eitan, Robert Klempfner, Ilan Goldenberg, Ran Kornowski
Summary: Discordance between heart team decisions and guidelines is common in patients with complex coronary artery disease undergoing revascularization, particularly in elderly patients with more complex disease and those treated at centers without cardiac surgery services. These patients have a higher risk for mid-term mortality.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Yoav Granot, Ilan Merdler, Ariel Finkelstein, Yaron Arbel, Shmuel Banai, Yan Topilsky, Lorin Arie Scwartz, Amit Segev, Israel Barbash, Paul Fefer, Haim Danenberg, Mony Shuvy, Gidon Perlman, Ran Kornowski, Yaron Shapira, Katia Orvina, Arie Steinvil
Summary: This study evaluated the association between >= moderate tricuspid regurgitation (TR) and right ventricular (RV) dysfunction with long-term mortality following transcatheter aortic valve replacement (TAVR). The findings showed that persistent RV dysfunction after TAVR was associated with the highest risk for mortality. Adjusted for multiple echocardiographic characteristics, baseline TR and RV dysfunction were not associated with long-term mortality following TAVR.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Eilon Ram, Pazit Beckerman, Amit Segev, Nir Shlomo, Abigail Atlas-Lazar, Leonid Sternik, Ehud Raanani
Summary: Renal function is crucial in the prognosis and management of multi-vessel CAD patients, but current data lack precise risk stratification using eGFR. This study found differences in eGFR values calculated by different formulas, and demonstrated that decreased renal function is an independent predictor of 3-year mortality with risk increasing by 15-25% for each 10-unit decrease in eGFR.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Yael Peled, Eilon Ram, Jacob Lavee, Leonid Sternik, Amit Segev, Anat Wieder-Finesod, Michal Mandelboim, Victoria Indenbaum, Itzchak Levy, Ehud Raanani, Yaniv Lustig, Galia Rahav
Summary: The study investigated the safety and efficacy of BNT162b2 vaccine in heart transplant recipients, showing a low rate of adverse events and some individuals developing antibody responses. The presence of IgG anti-RBD antibodies was associated with neutralizing SARS-CoV-2 pseudo-virus, but certain immunosuppressive regimens may impact the odds of an antibody response. Further research is needed to determine the optimal observation period for antibody response in immunocompromised individuals.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Gingy Ronen Balmor, Michael J. Segel, Paul Fefer, Elad Maor, Sagit Ben-Zekrey, Amit Segev
Summary: In patients suspected of having PHTN, ventricular septal motion abnormalities are strongly associated with pre-capillary PHTN, indicating that these patients should undergo further evaluation with right heart catheterization.
HEART LUNG AND CIRCULATION
(2022)
Article
Cardiac & Cardiovascular Systems
Binyamin B. Neeman, Elad Maor, Israel M. Barbash, Ilan Hai, Ori Vaturi, Sagit Ben Zekry, Amit Segev, Micha Feinberg, Victor Guetta, Paul Fefer
JOURNAL OF INVASIVE CARDIOLOGY
(2020)
Article
Medicine, General & Internal
Eilon Ram, Jacob Lavee, Leonid Sternik, Amit Segev, Yael Peled
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)