Article
Biochemistry & Molecular Biology
Jennifer Maning, Victoria L. Desimine, Celina M. Pollard, Jennifer Ghandour, Anastasios Lymperopoulos
Summary: Carvedilol, but not metoprolol, can stimulate beta arrestin2-mediated SERCA2a SUMOylation and activity, leading to enhanced cardiac contractility. However, this effect may be opposed or masked by carvedilol-bound beta(2)AR subtype signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rushita A. Bagchi, Emma L. Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A. Tharp, Hanan Qasim, Kathleen M. Gavin, Julie Pires da Silva, Jennifer L. Major, Bradley K. McConnell, Edward Seto, Hening Lin, Timothy A. McKinsey
Summary: This article highlights the importance of lysine myristoylation in regulating protein localization and function, as well as its role in controlling G protein-coupled receptor signaling. Inhibiting HDAC11 may have therapeutic potential for manipulating adipocyte phenotypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Hanne Friis Berntsen, Johanna Bodin, Johan Ovrevik, Christopher Friis Berntsen, Gunn C. Ostby, Bendik C. Brinchmann, Erik Ropstad, Oddvar Myhre
Summary: Exposure to chlorinated, brominated, and perfluoroalkyl acid persistent organic pollutants is linked to immunotoxicity and other adverse effects in humans and animals. Mixtures of these POPs may trigger stress responses in circulating immune cells and interfere with adrenergic pathways.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Gerd Wallukat, Stephan Mattecka, Katrin Wenzel, Wieland Schroedl, Birgit Vogt, Patrizia Brunner, Ahmed Sheriff, Rudolf Kunze
Summary: This study found that C-reactive protein (CRP) affects intracellular calcium signaling and blood pressure. When CRP is combined with GPCR agonists in cardiomyocytes, it can interfere with the desensitization of GPCRs, regardless of the type of GPCR, but dependent on the concentration of CRP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: By studying the molecular signaling and positive cardiac contractility induced by beta-blockers in the heart, it was found that carvedilol can promote cardiac inotropy and have a protective effect in diabetic mice. The observations suggest a novel beta(1)AR-NOS3 signaling pathway that may be targeted in therapy for heart diseases with reduced ejection fraction.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: The study investigated the molecular signaling and effects of beta-blockers on cardiac inotropy in animal hearts. The results showed that carvedilol, a beta-blocker, can promote cardiac contractility through a specific signaling pathway, restoring heart function in diabetic mice and reducing cell apoptosis and hypertrophy in diabetic hearts.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hiroko P. Indo, Daisuke Masuda, Sompong Sriburee, Hiromu Ito, Ikuo Nakanishi, Ken-ichiro Matsumoto, Samlee Mankhetkorn, Moragot Chatatikun, Sirirat Surinkaew, Lunla Udomwech, Fumitaka Kawakami, Takafumi Ichikawa, Hirofumi Matsui, Jitbanjong Tangpong, Hideyuki J. Majima
Summary: This study aims to prove that mitochondrial reactive oxygen species (mtROS) can be released from mitochondria and initiate cellular signals in the nucleus. By comparing two cell lines with different levels of mtROS, the researchers found differential expression of various cellular signal proteins. Transfection of human MnSOD in the cell line with higher mtROS levels resulted in a decrease in the expression of these signal proteins, suggesting the involvement of mtROS in cellular signals in the nucleus.
Article
Multidisciplinary Sciences
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselee, Shannon O'Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigne, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Summary: This study provides an alternative mechanism for carvedilol's cellular signaling, demonstrating that G proteins drive all detectable signals through beta(2)-adrenoceptors.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Hao Chen, Suli Zhang, Ruiqi Hou, Huirong Liu
Summary: This review summarizes the discovery of the beta(1)-AR-Gi pathway and its significance in the treatment of heart diseases.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Biotechnology & Applied Microbiology
Jianan Jiang, Nianjun Xu, Jie Yuan, Wenrong Zhu, Yahe Li
Summary: This study reveals the effect and mechanism of reactive oxygen species (ROS) in the sporogenesis of Ulva prolifera, the dominant species of green tide bloom. It shows that the ROS content is significantly enhanced during the early sporogenesis and the antioxidant capacity increases with spore formation. The up-regulation of MAPK is associated with sporogenesis and the presence of GSH can inhibit sporogenesis.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Plant Sciences
Kun Li, Qianyun Jia, Jinggong Guo, Zhijuan Zhu, Mengying Shao, Jin Wang, Weiqiang Li, Jie Dai, Minghui Guo, Rui Li, Jieqiong Song, Fengbo Yang, Jingyi Du, Jose R. Botella, Chun-Peng Song, Yuchen Miao
Summary: Mutations in the GPX7 gene in plants lead to increased photo-bleaching under high light conditions, and GPX7 plays a crucial role in chloroplast function.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Review
Biochemistry & Molecular Biology
Anastasios Lymperopoulos, Natalie Cora, Jennifer Maning, Ava R. Brill, Anastasiya Sizova
Summary: The autonomic nervous system exerts its effects on the human myocardium through distinct G protein-coupled receptors on the plasma membranes of cardiac cells. Neurotransmitters like NE/Epi and ACh mediate these effects by activating specific adrenergic or muscarinic receptors. Other neurotransmitters/hormones also play a role in regulating cardiac function by utilizing different GPCRs in the heart.
Article
Biochemistry & Molecular Biology
Argha Mitra, Arijit Sarkar, Attila Borics
Summary: Research has revealed both structural similarities and receptor-specific differences between G protein-coupled receptors, which could be associated with different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kangkang Chen, Xinyan Wang, Xiangyi Wei, Jiaqian Chen, Youheng Wei, Haobo Jiang, Zhiqiang Lu, Congjing Feng
Summary: This study investigated the impact of nitric oxide (NO) signaling on antimicrobial peptide (AMP) production using the lepidopteran pest Ostrinia furnacalis and Drosophila S2 cells. The findings suggest that NO-induced AMP production is mediated by the enzyme CanA1 via the IMD pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, John C. Kube, Stephen B. Smith
Summary: The study demonstrated that lubabegron fumarate acts as an antagonist to beta-adrenergic receptor subtypes in subcutaneous adipocytes and exhibits different responses to beta-AA and LUB in subcutaneous and intramuscular adipocytes.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Medicine, General & Internal
Konyi Attila
Article
Biochemistry & Molecular Biology
Zsolt Sarszegi, Dora Szabo, Balazs Gaszner, Attila Konyi, Dora Reglodi, Jozsef Nemeth, Beata Lelesz, Beata Polgar, Adel Jungling, Andrea Tamas
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Correction
Medicine, General & Internal
Konyi Attila
Review
Immunology
Veronika Szentes, Maria Gazdag, Istvan Szokodi, Csaba A. Dezsi
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Peter Sogaard, Steffen Behrens, Attila Konyi, Milos Taborsky, Per Dahl Christiansen, Peter Karl Jacobsen, Jozsef Falukozy, Jerzy Malczynski, Johannes Brachmann, Alexander Samol, Maike Kluding, Jurgen Schrader, Poul-Erik Bloch Thomsen, Christian Jons
JOURNAL OF ELECTROCARDIOLOGY
(2019)
Article
Medical Laboratory Technology
Ied Al-Sadoon, Istvan Wittmann, Szilard Kun, Mercedesz Ahmann, Attila Konyi, Zsofia Verzar
Summary: The study found that in STEMI patients, serum levels of Phe were significantly higher near the culprit lesion compared to the aortic root, with lower concentration ratios of p-Tyr/Phe and m-Tyr/Phe near the lesion. However, there were no significant differences in serum levels of Phe and Tyr isomers between the aortic root and distal to the culprit lesion in NSTEMI patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Pharmacology & Pharmacy
Attila Cziraki, Zsofia Lenkey, Endre Sulyok, Istvan Szokodi, Akos Koller
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Laszlo Hejjel, Marianna Nemeth, Laszlo Melczer, Attila Konyi
Summary: This study conducted left anterior minithoracotomy surgery on 57 patients who had unsuccessful transvenous CRT, showing that this method is a safe, efficient, simple, and reproducible alternative to transvenous CRT, improving LVEF and dimensions, and increasing survival rates.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Laszlo B. Szapary, Zsolt Szakacs, Nelli Farkas, Kristof Schonfeld, Dora Babocsay, Mate Gajer, Balint Kittka, Balazs Magyari, Peter Hegyi, Istvan Szokodi, Ivan G. Horvath
Summary: The role of magnesium in preventing reperfusion arrhythmia associated with primary PCI remains controversial, and our study found that magnesium is ineffective with weak evidence, indicating the need for further well-designed clinical trials in this area.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Peter Ezer, Nelli Farkas, Istvan Szokodi, Attila Konyi
Summary: This study compared the impact of a remote monitoring (RM) follow-up protocol with modified criteria to conventional follow-up in heart failure patients. The results showed that the RM group had significantly reduced cardiovascular mortality and hospitalization events, as well as a decreased number of ambulatory visits. Therefore, using automatic RM for follow-up can indirectly improve cardiovascular survival and directly reduce the burden of hospitalization and ambulatory visits in heart failure patients.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Sport Sciences
Dora Szabo, Dora Nagy, Csaba Melczer, Pongrac Acs, Laszlo Ratgeber, Istvan Szokodi, Miklos Toth, Attila Cziraki, Kata Eklics, Zsolt Sarszegi
Summary: Endurance training-induced changes in left ventricular diastolic function and right ventricular parameters were investigated in adolescent athletes, showing significantly higher E/A and e' values compared to non-athletes and adult athletes. Factors such as lean body mass, body surface area, age, and cumulative training time were identified as strong predictive factors of these cardiac adaptations. Additionally, well-defined cut-off values should be applied to differentiate pathological conditions related to influencing factors.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Peter Ezer, Marin Gergics, Istvan Szokodi, Attila Konyi
Summary: This study compared the clinical outcomes of heart failure patients with implanted cardiac devices in a remote monitored group and a conventionally followed group during the COVID-19 pandemic. The results showed that patients in the remote monitored group had relatively stable worsening of heart failure, lower elevation of N terminal-pro BNP levels, and lower hospitalization rates for worsening heart failure compared to the conventionally followed group. The specified remote monitoring alert-based detection algorithm may indicate early worsening of heart failure status and prevent heart failure hospitalizations.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Roland Ligetvari, Istvan Szokodi, Gabriella Far, Eva Csondor, Akos Mora, Zsolt Komka, Miklos Toth, Andras Olah, Pongrac acs
Summary: In this paper, the impact of maximal cardiorespiratory exercise testing on plasma apelin levels of 58 male professional soccer players was assessed. It was found that apelin-13 and apelin-36 levels transiently increased after treadmill exercise, but with significant interindividual variability. Additionally, changes in apelin-13 levels were correlated with indicators of physical performance. Therefore, apelin may play a role in determining peak athletic performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)