Article
Cardiac & Cardiovascular Systems
Yoshiko Murakata, Fumi Yamagami, Nobuyuki Murakoshi, DongZhu Xu, Zhonghu Song, Siqi Li, Yuta Okabe, Kazuhiro Aonuma, ZiXun Yuan, Haruka Mori, Kazutaka Aonuma, Kazuko Tajiri, Masaki Ieda
Summary: Inflammatory atrial cardiomyopathy can lead to atrial fibrillation, characterized by enlarged atria, infiltration of inflammatory cells, and fibrosis. These changes increase susceptibility to arrhythmias by affecting electrical conduction, genetic factors, and autonomic regulation. Therefore, reducing inflammation is important in preventing atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Wei-Chung Tsai, Tien-Chi Hung, Takashi Kusayama, Seongwook Han, Michael C. Fishbein, Lan S. Chen, Peng-Sheng Chen
Summary: This review summarizes the relationship between the autonomic nervous system and atrial fibrillation, as well as the methods and mechanisms of neuromodulation. It proposes that noninvasive or minimally invasive neuromodulation methods will be most useful in the future management of atrial fibrillation.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Neurosciences
Mariela Mitre, Khalil Saadipour, Kevin Williams, Latika Khatri, Robert C. Froemke, Moses V. Chao
Summary: The study shows that oxytocin can enhance the activity of BDNF in neurons by transactivating the TrkB receptor. This finding is important for understanding the mechanism of oxytocin and its relationship with neural development and social behaviors.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Wei-Ting Sung, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Fa-Po Chung, Jo-Nan Liao, Ta-Chuan Tuan, Tze-Fan Chao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Shin-Huei Liu, Wen-Han Cheng, An Khanh-Nu Ton, Chu-Yu Hsu, Chheng Chhay, Ahmed Moustafa Elimam, Ming-Jen Kuo, Pei-Heng Kao, Wei-Tso Chen, Shih-Ann Chen
Summary: The autonomic system plays a key role in the pathogenesis of paroxysmal atrial fibrillation (AF). Skin sympathetic nerve activity (SKNA) is a noninvasive tool for assessing sympathetic tone. SKNA significantly increased 1 day after ablation and returned to baseline levels 3 months after ablation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chao Gong, Yu Ding, Feng Liang, Shuang Wu, Xiruo Tang, Hongzhang Ding, Wenjing Huang, Xiaotong Yu, Likun Zhou, Jun Li, Shaowen Liu
Summary: This study found that chronic pain can increase the susceptibility of atrial fibrillation in mice, possibly through the mediation of autonomic cholinergic nerves.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jacinta N. Conroy, Elizabeth J. Coulson
Summary: Neurotrophin signaling is crucial for normal nervous system development and function. Understanding the mechanism of high-affinity receptor generation will facilitate the development of pharmaceuticals for the treatment of nervous system disorders. Despite decades of research, the modulation mechanism of the high-affinity complex remains unclear.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Peter Hanna, Eric Buch, Stavros Stavrakis, Christian Meyer, John D. Tompkins, Jeffrey L. Ardell, Kalyanam Shivkumar
Summary: The cardiac autonomic nervous system is crucial in cardiac physiology and disease, with therapies targeting the cardiac neuraxis showing promising results in pre-clinical and clinical studies.
CARDIOVASCULAR RESEARCH
(2021)
Article
Physiology
Yankai Guo, Jiasuoer Xiaokereti, Qingjun Meng, Guiqiu Cao, Huaxin Sun, Xianhui Zhou, Ling Zhang, Baopeng Tang
Summary: This study investigated the mechanisms underlying acute OSA-induced AF, and found that low-level vagus nerve stimulation (LLVS) could attenuate AF by ameliorating sympathetic hyperactivity and atrial myocyte injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jien-Jiun Chen, Chen Lin, Yuan-Cheng Chuang, Shu-Fang Lee, Tse-Yu Lin, Chieh-Cheh Yu, Chia-Ti Tsai, Min-Tsun Liao, Tin-Tse Lin, Lian-Yu Lin, Men-Tzung Lo
Summary: This study investigated the effect of ablation on autonomic modulation and predicted the treatment success in atrial fibrillation patients. Skin sympathetic nerve activity (SKNA) was recorded using conventional electrocardiogram (ECG) electrodes. The results showed that decreasing sympathetic activity is crucial for successful ablation, and higher bursting frequency and less change in firing duration were associated with AF recurrence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Oncology
Maude Sestier, Christopher Hillis, Graeme Fraser, Darryl Leong
Summary: This review summarizes the epidemiology, mechanisms, and management of cardiovascular complications of Bruton's Tyrosine Kinase inhibitors (BTKIs). Although Ibrutinib has been associated with an increased risk of atrial fibrillation, bleeding, and hypertension, evidence linking it to other cardiovascular complications is limited. The effects of more selective BTKIs, such as acalabrutinib, on cardiovascular health remain to be determined, and further research is needed to fully evaluate the risks and benefits compared with Ibrutinib.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Computer Science, Interdisciplinary Applications
Heng-An Tzou, Shien-Fong Lin, Peng-Sheng Chen
Summary: The study introduces a deep learning-based AF risk prediction method called MVPNet, which combines P-wave and SKNA features to accurately predict the onset of AF using neuECG. Compared to traditional ECG, MVPNet achieves higher accuracy and inference speed with less computational resources. The gradient activation map suggests that neuECG recordings may serve as a superior predictor for AF risk.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Neurosciences
Lolita Dokshokova, Mauro Franzoso, Anna Di Bona, Nicola Moro, Jose Luis Sanchez Alonso, Valentina Prando, Michele Sandre, Cristina Basso, Giuseppe Faggian, Hugues Abriel, Oriano Marin, Julia Gorelik, Tania Zaglia, Marco Mongillo
Summary: Cardiomyocytes release nerve growth factor (NGF) to support innervating sympathetic neurons in the heart, with neuro-cardiac junctions (NCJ) playing a crucial role in supporting retrograde neurotrophic signaling. The direct link between sympathetic neuron survival and neurotrophin release by cardiomyocytes is essential for heart cellular homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Bianca J. J. M. Brundel, Xun Ai, Mellanie True Hills, Myrthe F. Kuipers, Gregory Y. H. Lip, Natasja M. S. de Groot
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence. Understanding the molecular mechanisms underlying AF is crucial for the development of personalized diagnostic tools and mechanism-based therapies. Co-creation with patients is essential for successful management of AF.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Review
Biochemistry & Molecular Biology
Manali Tilak, Jennifer Holborn, Laura A. New, Jasmin Lalonde, Nina Jones
Summary: Glioblastoma multiforme (GBM) is a deadly cancer with limited response to existing therapies. Subtypes of GBM with distinct genetic signatures show aberrant activation of signal transduction pathways. Current research focuses on understanding these molecular alterations to develop more efficient targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Thanasis Rogdakis, Despoina Charou, Alessia Latorrata, Eleni Papadimitriou, Alexandros Tsengenes, Christina Athanasiou, Marianna Papadopoulou, Constantina Chalikiopoulou, Theodora Katsila, Isbaal Ramos, Kyriakos C. Prousis, Rebecca C. Wade, Kyriaki Sidiropoulou, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos
Summary: A new NGF mimetic, ENT-A013, has been identified to selectively activate TrkA receptor and exert neuroprotective effects, showing potential for therapeutic development against neurodegenerative disorders, such as Alzheimer's Disease.
Review
Medicine, General & Internal
C. A. Bonfiglio, C. Weber, D. Atzler, E. Lutgens
Summary: Current therapies for cardiovascular disease primarily focus on lipid lowering and face residual risk. Inflammation, along with lipids, plays a significant role in atherosclerosis. Clinical trials targeting the interleukin-1 beta-inflammasome pathway have successfully reduced cardiovascular events but not overall CVD mortality. Novel and improved immunotherapeutics for CVD are eagerly anticipated.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Virginia Egea, Remco Theodorus Adrianus Megens, Donato Santovito, Sarawuth Wantha, Richard Brandl, Wolfgang Siess, Sajjad Khani, Oliver Soehnlein, Alexander Bartelt, Christian Weber, Christian Ries
Summary: let-7f promotes hMSC tropism towards atheromas through the LL-37/FPR2 axis and demonstrates that hMSCs develop a potentially athero-protective signature upon contact with the human plaque environment.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Laura A. Bosmans, Claudia M. van Tiel, Suzanne A. B. M. Aarts, Lisa Willemsen, Jeroen Baardman, Bram W. van Os, Myrthe den Toom, Linda Beckers, David J. Ahern, Johannes H. M. Levels, Aldo Jongejan, Perry D. Moerland, Sanne G. S. Verberk, Jan van den Bossche, Menno M. P. J. de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens
Summary: This study investigates the role of CD40 in atherosclerosis and shows that inhibiting CD40 signaling can reduce atherosclerosis. The researchers used myeloid-specific CD40-deficient mice and found that the absence of CD40 in myeloid cells reduces atherosclerosis and systemic inflammation by preventing pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2023)
Article
Hematology
Christian Weber, Xavier Blanchet, Gregory Y. H. Lip
THROMBOSIS AND HAEMOSTASIS
(2023)
Editorial Material
Hematology
Gregory Y. H. Lip, Anne Rigby, Christian Weber
THROMBOSIS AND HAEMOSTASIS
(2023)
Letter
Neurosciences
Juliane Bremer, Johannes Friemann, Saskia von Stillfried, Peter Boor, Joachim Weis
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Cell Biology
Sarajo K. Mohanta, Changjun Yin, Christian Weber, Andreas J. R. Habenicht
Summary: Two pairs of biological systems, namely the nervous and vascular systems, and the nervous and immune systems, have been defined as major participants in the regulation of physiological and pathological tissue reactions. The interactions between these systems have led to the concepts of neurovascular link and neuroimmunology. Recent studies on atherosclerosis have proposed the concept of neuroimmune cardiovascular interfaces (NICIs), which involve complex crosstalks between the nervous system, immune system, and cardiovascular system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Franzka, Svenja Caren Schueler, Takfarinas Kentache, Robert Storm, Andrea Bock, Istvan Katona, Joachim Weis, Katrin Buder, Christoph Kaether, Christian A. Hubner
Summary: Proteins of the secretory pathway undergo glycosylation in the ER and Golgi apparatus. Mutations in GMPPA can cause AAMR syndrome with various symptoms. Loss of GMPPA leads to Golgi fragmentation, altered protein abundance, reduced furin activity, and increased retention of alpha-DG.
Article
Cardiac & Cardiovascular Systems
Emiel P. C. van der Vorst, Sanne L. Maas, Kosta Theodorou, Linsey J. F. Peters, Han Jin, Timo Rademakers, Marion J. Gijbels, Mat Rousch, Yvonne Jansen, Christian Weber, Michael Lehrke, Corinna Lebherz, Daniela Yildiz, Andreas Ludwig, Jacob F. Bentzon, Erik A. L. Biessen, Marjo M. P. C. Donners
Summary: This study demonstrates that endothelial ADAM10 plays a protective role in the development of murine atherosclerosis, primarily by limiting inflammation induced by oxidized low-density lipoprotein (oxLDL). The findings provide novel opportunities for treating atherosclerosis progression, but caution should be exercised when considering the use of ADAM10 inhibitors for therapy in other diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Sarajo K. K. Mohanta, Changjun Yin, Christian Weber, Cristina Godinho-Silva, Henrique Veiga-Fernandes, Qian J. J. Xu, Rui B. B. Chang, Andreas J. R. Habenicht
Summary: The cardiovascular system is connected to the brain through complex axonal connections. Two distinct subcircuits, the artery-brain circuit and the heart-brain circuit, have recently been defined. The impact of the nervous system on the progression of cardiovascular disease is not well understood. This review explores the anatomy and inner workings of these subcircuits and discusses the possibility of a systemic cardiovascular brain circuit.
CIRCULATION RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Christian Weber, Andreas J. R. Habenicht, Philipp von Hundelshausen
Summary: This review summarizes recent progress in the therapeutic targeting of inflammatory components in atherosclerosis. Novel strategies, such as interference with the CD40L-CD40 dyad and selective targeting of TRAFs, show potential in reducing atherosclerosis and plaque instability without immune side effects. Additionally, modulation of the chemokine system and disruption of the adventitial neuroimmune cardiovascular interfaces offer promising avenues for intervention beyond anti-inflammatory approaches.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Christine Krammer, Bishan Yang, Sabrina Reichl, Simon Besson-Girard, Hao Ji, Verena Bolini, Corinna Schulte, Heidi Noels, Kai Schlepckow, Georg Jocher, Georg Werner, Michael Willem, Omar El Bounkari, Aphrodite Kapurniotu, Ozgun Gokce, Christian Weber, Sarajo Mohanta, Jurgen Bernhagen
Summary: Atherosclerosis is a chronic inflammatory condition of our arteries and the underlying pathology of heart attacks and strokes. The role of the inflammatory cytokine MIF in the progression of atherosclerosis and its relationship with age and atherogenic cytokines are not fully understood.
Article
Cardiac & Cardiovascular Systems
Stephan Sachs, Anna Goetz, Brian Finan, Annette Feuchtinger, Richard D. DiMarchi, Yvonne Doering, Christian Weber, Matthias H. Tschoep, Timo D. Mueller, Susanna M. Hofmann
Summary: Long-acting acylated GIP analog (acyl-GIP) treatment can improve dyslipidemia and atherosclerosis independently of body weight loss. This treatment may improve dyslipidemia by directly modulating lipid metabolism in the inguinal fat depot.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell Biology
Simon Ebert, Lan Zang, Noor Ismail, Michael Otabil, Adrian Frohlich, Virginia Egea, Susann Acs, Mikkel Hoeberg, Marie-Luise Berres, Christian Weber, Jose M. A. Moreira, Christian Ries, Juergen Bernhagen, Omar El Bounkari
Summary: TIMP-1 interacts with CD74 to regulate vascular inflammation and atherosclerosis. TIMP-1 binding to CD74 promotes monocyte migration and vascular smooth muscle cell proliferation, playing a crucial role in vascular inflammation and atherosclerosis.
Article
Cell Biology
Sarajo K. Mohanta, Ting Sun, Shu Lu, Zhihua Wang, Xi Zhang, Changjun Yin, Christian Weber, Andreas J. R. Habenicht
Summary: The nervous, immune, and cardiovascular systems form a tissue network that regulate cardiovascular function. The different systems interact with each other, and further research may lead to new therapies for cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
