Article
Virology
Yawei Wang, Min Wang, Renlong Bao, Ligui Wang, Xinying Du, Shaofu Qiu, Chaojie Yang, Hongbin Song
Summary: In this study, a tri-receptor transgenic mouse model expressing the three best-characterized human cellular receptors for HAdV was generated. The model accurately represents human HAdV infection and pathogenesis, making it useful for studying the mechanisms of HAdV and evaluating potential vaccines and therapeutic modalities.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Taylor G. Eggertsen, Jeffrey J. Saucerman
Summary: In this study, a network model was used to predict the effects of FDA-approved drugs on cardiomyocyte hypertrophy, and the predictions were validated through experiments. The researchers found that midostaurin has an inhibitory effect on cardiomyocyte hypertrophy induced by TGF beta. Overall, this study provides a reliable platform for exploring the efficacy of drugs on cardiomyocyte hypertrophy.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ulrich Gergs, Timo Gerigk, Jonas Wittschier, Constanze T. Schmidbaur, Clara Rottger, Mareen Mahnkopf, Hanna Edler, Hartmut Wache, Joachim Neumann
Summary: The study found that cardiac function is affected by 5-HT4 receptor overexpression under pathophysiological conditions, with potential benefits or drawbacks depending on the type of stress. 5-HT4 receptor overexpression influenced the response of the heart to hypoxia and ischemia, as well as cardiac hypertrophy.
Article
Multidisciplinary Sciences
Jerry Wang, Ying Xia, Aizhu Lu, Hongwei Wang, Darryl R. Davis, Peter Liu, Rob S. Beanlands, Wenbin Liang
Summary: This study demonstrates that susceptibility to ventricular tachycardias in mice after myocardial infarction is reduced in the chronic phase with cardiomyocyte-specific beta-catenin deletion, primarily through attenuated structural remodeling rather than ion channel gene alterations.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xingjuan Shi, Yu Zhang, Yijie Gong, Mengying Chen, Koroboshka Brand-Arzamendi, Xiangdong Liu, Xiao-Yan Wen
Summary: Cardiac hypertrophy is a compensatory response to pathological stimuli that may progress to cardiomyopathy, heart failure, or sudden death. The decreased expression of Hhatl in the heart is associated with cardiac hypertrophy, as demonstrated by the depletion of Hhatl leading to cardiac defects and enhanced hypertrophic markers in zebrafish. Calcineurin signaling is implicated in Hhatl depletion-induced cardiac hypertrophy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Luo, Stephen D. D. Farris, Deri Helterline, April Stempien-Otero
Summary: Cardiomyocytes increase DNA content in response to stress in humans, but this study found that DNA content decreases in unloaded hearts. Changes in DNA content were independent of cell proliferation. The study used a novel imaging flow cytometry methodology to compare human subjects with LVAD implantation or primary transplantation. Results showed that cardiomyocyte size decreased and DNA content per nucleus significantly decreased in unloaded hearts, while cell-cycle markers were not increased.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Preetinder K. K. Aujla, Mei Hu, Bridgette Hartley, Joshua W. W. Kranrod, Anissa Viveiros, Tolga Kilic, Caroline A. A. Owen, Gavin Y. Y. Oudit, John M. M. Seubert, Olivier Julien, Zamaneh Kassiri
Summary: ADAM15 plays a role in suppressing myocardial hypertrophy in pressure overload cardiomyopathy by regulating the interaction between integrins and laminin, as well as the calcineurin pathway. Loss of ADAM15 leads to worsened hypertrophy and dilation in a mouse model of cardiomyopathy. This study provides new insights into the pathogenesis of cardiomyopathies.
Article
Environmental Sciences
Chin-Yi Lin, Marthandam Asokan Shibu, Renee Wen, Cecilia Hsuan Day, Ray-Jade Chen, Chia-Hua Kuo, Tsung-Jung Ho, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Summary: The study found that saffron extract can ameliorate Leu(27)IGF-II-induced hypertrophy seemingly through regulation of calcineurin-NFAT3 and CaMKII-HDAC4 signaling cascade.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ningning Guo, Di Zheng, Jiaxin Sun, Jian Lv, Shun Wang, Yu Fang, Zhenyi Zhao, Sai Zeng, Qiuxiao Guo, Jingjing Tong, Zhihua Wang
Summary: Nap1l5 plays a crucial role in regulating protein synthesis and hypertrophy in cardiomyocytes, and its overexpression exacerbates hypertrophic effects. Knockdown of Nap1l5 reverses the transcriptional reprogramming associated with hypertrophy, highlighting its potential as a target for therapeutic interventions in cardiac hypertrophy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Stephanie L. Padula, Nivedhitha Velayutham, Katherine E. Yutzey
Summary: During the postnatal period, mammalian cardiomyocytes undergo significant maturational changes related to increased cardiac function, such as hypertrophic growth, cell cycle exit, sarcomeric protein isoform switching, and mitochondrial maturation. These changes lead to a loss of regenerative capacity in the heart, contributing to heart failure after cardiac injury in adults. Understanding the transcriptional regulators responsible for these maturation processes could have potential therapeutic implications in cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
XiaoQiang Chen, XinTao Li, XiaoYu Wu, Yu Ding, Ya Li, GenQing Zhou, Yong Wei, SongWen Chen, XiaoFeng Lu, Juan Xu, ShaoWen Liu, Jun Li, LiDong Cai
Summary: This study identifies ITGBL1 as an important mediator in fibroblast-cardiomyocyte crosstalk, contributing to cardiac remodeling in heart failure (HF). ITGBL1 promotes fibroblast activation and hypertrophy of cardiomyocytes through signaling pathways, and its knockdown improves cardiac function in a mouse model of HF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimoto
Summary: This study reveals the significance of GATA4 homomultimerization in cardiac hypertrophy, with the acetylation by p300 promoting the multimerization and DNA binding activity of GATA4. Inhibition of GATA4 multimerization suppresses phenylephrine-induced hypertrophic response in cardiomyocytes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medical Laboratory Technology
Chi-Sheng Hung, Yi-Yao Chang, Cheng-Hsuan Tsai, Che-Wei Liao, Shih-Yuan Peng, Bo-Ching Lee, Chien-Ting Pan, Xue-Ming Wu, Zheng-Wei Chen, Vin-Cent Wu, Cho-Hua Wan, Morag J. Young, Chia-Hung Chou, Yen-Hung Lin
Summary: Aldosterone suppresses cardiac mitochondria through MR-ROS signaling pathway in vivo and directly.
TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hui Gao, Kunming Tian, Yichong Meng, Xueping Liu, Yingfu Peng
Summary: Salidroside alleviates cardiomyocyte hypertrophy by enhancing PPAR alpha function, and it also demonstrates a dosage-dependent effect on inhibiting cardiomyocyte hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Lama Awwad, Ami Aronheim
Summary: Cardiovascular diseases and cancer are the leading causes of death worldwide. Recent studies have shown that heart failure promotes tumor growth and metastasis, but little is known about the effect of tumors on heart failure. A recent study suggests that tumor growth positively affects cardiac remodeling, but its impact on existing heart failure outcomes is inconclusive.
Article
Cardiac & Cardiovascular Systems
Moritz Biener, Evangelos Giannitsis, Katharina Hogrefe, Matthias Mueller-Hennessen, Hanna Froehlich, Hugo A. Katus, Norbert Frey, Lutz Frankenstein, Tobias Taeger
Summary: For stable outpatients, MID calculated from changes in hs-cTnT measured 365 +/- 120 days apart can help predict an uneventful clinical course.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Evangelos Giannitsis, Norbert Frey
EUROPEAN HEART JOURNAL
(2022)
Review
Hematology
Samer Al Said, Michael Ellscheid, Eleftherios T. Beltsios, Norbert Frey
Article
Immunology
Mariella Bockstahler, Christian Salbach, Anna-Maria Mueller, Andrea Kuebler, Oliver J. Mueller, Hugo A. Katus, Norbert Frey, Ziya Kaya
Summary: The study investigated the therapeutic potential of locked nucleic acid antisense oligonucleotides (LNA ASOs) in autoimmune myocarditis using an experimental autoimmune myocarditis (EAM) model in A/J mice. Results showed that administration of LNA ASO MB_1114 and mLdhb-specific GapmeR led to increased levels of cardiac mLDHB protein, suppression of mBax, and reduction in ROS activation, demonstrating an unexpected anti-inflammatory effect. This suggests that LDHB and LNA ASOs may be promising targets for directed therapy of myocarditis, but further research is needed to understand the underlying mechanisms.
Article
Medicine, General & Internal
Hatim Seoudy, Jasmin Shamekhi, Lisa Voigtlaender, Sebastian Ludwig, Johanne Frank, Tim Kujat, Peter Bramlage, Baravan Al-Kassou, Atsushi Sugiura, Ashraf Yusuf Rangrez, Niklas Schofer, Thomas Puehler, Georg Lutter, Moritz Seiffert, Georg Nickenig, Lenard Conradi, Norbert Frey, Dirk Westermann, Jan -Malte Sinning, Derk Frank
Summary: This study evaluated the risk stratification ability of serum C-reactive protein to albumin ratio (CAR) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), and the results showed that CAR was associated with increased all-cause mortality.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Cardiac & Cardiovascular Systems
Felix Wiedmann, Manuel Kraft, Stefan Kallenberger, Antonius Buscher, Amelie Paasche, Pablo L. Blochberger, Timon Seeger, Natasa Javorszky, Gregor Warnecke, Rawa Arif, Jamila Kremer, Matthias Karck, Norbert Frey, Constanze Schmidt
Summary: miRNAs play an important role in the regulation of atrial expression of the TASK-1 potassium channel in patients with atrial cardiomyopathy, and may be involved in the initiation and maintenance of atrial fibrillation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pharmacology & Pharmacy
Manuel Kraft, Kathrin Foerster, Felix Wiedmann, Max Sauter, Amelie Paasche, Pablo L. Blochberger, Baran Yesilgoez, Yannick L'hoste, Norbert Frey, Walter E. Haefeli, Jurgen Burhenne, Constanze Schmidt
Summary: Doxapram has been investigated as a potential new treatment for atrial fibrillation in a porcine animal model. The pharmacokinetics of doxapram and its active metabolite were studied, revealing a biphasic elimination pattern with a short half-life and high peak concentration.
Article
Biochemistry & Molecular Biology
Fabrice F. Darche, Nina D. Ullrich, Ziqiang Huang, Michael Koenen, Rasmus Rivinius, Norbert Frey, Patrick A. Schweizer
Summary: “Novel protocols for the differentiation of hiPSC into cardiac pacemaker cells were established, with protocol E being the most efficient among them. The protocols were characterized by their ability to upregulate cardiac pacemaker-specific genes and induce excellent rate responsiveness to stimulation.”
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Florian Andre, Philipp Fortner, Mostafa Emami, Sebastian Seitz, Matthias Brado, Friedemann Gueckel, Roman Sokiranski, Andre Sommer, Norbert Frey, Johannes Goerich, Sebastian J. Buss
Summary: The safety of coronary CT angiography (CTA) is of great importance, and this study aimed to assess influencing factors. The results showed that coronary CTA with intravenous beta-blocker administration is a safe procedure in an outpatient setting, with rare and mostly mild adverse events. Reducing the dosage of glyceryl trinitrate (GTN) can further improve safety.
Article
Cardiac & Cardiovascular Systems
Rasmus Rivinius, Carolin Gralla, Matthias Helmschrott, Fabrice F. Darche, Philipp Ehlermann, Tom Bruckner, Wiebke Sommer, Gregor Warnecke, Stefan Kopf, Julia Szendroedi, Norbert Frey, Lars P. Kihm
Summary: The presence of pre-transplant type 2 diabetes mellitus (T2DM) in cardiac transplant recipients is associated with increased graft failure and 5-year mortality after transplantation. Well-controlled T2DM is clinically relevant for improving the survival rate of heart transplant recipients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Johann Bauersachs, Samira Soltani, Matthias Eden, Norbert Frey, Michael Boehm
Summary: Heart failure remains a global healthcare challenge despite significant developments in pharmacotherapies. There are concerns regarding low medication dosages and incomplete drug classes in real-world settings, and current guidelines lack detailed recommendations. A practical approach algorithm is proposed to assist physicians in treating HF patients.
Article
Biochemistry & Molecular Biology
Martin Kim, Sonja Reidenbach, Tanja Schlechter, Ann Christin Rothmann, Rainer Will, Ilse Hofmann
Summary: PKP1 is an important component of cell-cell adhesion and involved in the post-transcriptional regulation of gene expression. Downregulation of PKP1 in prostate cancer is associated with increased recruitment of immune cells, establishment of a tumor-specific environment, and accelerated tumor progression and metastasis.
Article
Pharmacology & Pharmacy
Panagiotis Xynogalos, Ann-Kathrin Rahm, Sebastian Fried, Safak Chasan, Daniel Scherer, Claudia Seyler, Hugo A. Katus, Norbert Frey, Edgar Zitron
Summary: This study analyzed the effect of the antiarrhythmic drug verapamil on the inwardly rectifying potassium current of cardiomyocytes. The results showed that verapamil inhibited the Kir2.1, Kir2.2, and Kir2.3 channels, with the inhibition of Kir2.3 being a previously unknown finding. Further experiments revealed that the inhibition of Kir2.3 by verapamil was dependent on specific binding sites and interference with PIP2 activation. This finding provides a potential target for the development of selective antiarrhythmic drugs targeting Kir2.3 channels.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Oncology
Zhen Chen, Rainer Will, Su Na Kim, Maike Anna Busch, Nicole Duenker, Philipp Dammann, Ulrich Sure, Yuan Zhu
Summary: Hyper-angiogenesis is a characteristic of glioblastoma (GBM), and ALDH1A3 has been found to be highly expressed in proliferating vasculature in GBM patients. This study demonstrated that ALDH1A3 acts as an angiogenesis promoter in GBM through the paracrine upregulation of PAI-1 and IL-8. Inhibition of PAI-1 or IL-8 hindered the hyper-angiogenesis phenotype caused by ALDH1A3. These findings highlight ALDH1A3-PAI-1/IL-8 as a potential target for anti-angiogenesis therapy in GBM.
Article
Cardiac & Cardiovascular Systems
Ann-Kathrin Rahm, Susanne Reinhardt, Matthias Helmschrott, Fabrice F. Darche, Tom Bruckner, Patrick Lugenbiel, Dierk Thomas, Philipp Ehlermann, Wiebke Sommer, Gregor Warnecke, Norbert Frey, Rasmus Rivinius
Summary: Late-onset post-transplant atrial flutter (AFL) has negative effects on clinical outcomes in transplant patients. This study found that patients with late-onset AFL were younger at the time of transplantation, received more biatrial anastomosis, and had moderate or severe tricuspid regurgitation. Typical AFL was associated with graft rejection, while atypical AFL was associated with myocardial ischemia, graft failure, and mortality. Catheter ablation was a viable option to prevent further episodes of late-onset AFL after transplantation.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)