Article
Cardiac & Cardiovascular Systems
Christine Hirschhaeuser, Alessio Lissoni, Philipp Maximilian Goerge, Paul D. Lampe, Jacqueline Heger, Klaus-Dieter Schlueter, Luc Leybaert, Rainer Schulz, Kerstin Boengler
Summary: The study shows that alterations of Cx43 phosphorylation affect specific cellular functions and highlights the importance of Cx43 phosphorylation by CK1 for IPC's cardioprotection.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Physiology
Claire C. C. Whisenant, Robin M. M. Shaw
Summary: This review discusses the role of internal translation in maintaining cardiac electrical rhythm and ischemic preconditioning, highlighting its significance in ion channel biology.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ioanna Papatheodorou, Eleftheria Galatou, Georgios-Dimitrios Panagiotidis, Tana Ravingerova, Antigone Lazou
Summary: Evidence suggests that PPAR beta/delta activation has cardioprotective effects by enhancing antioxidant defense and preserving mitochondrial function to alleviate myocardial I/R injury, with ALDH2 identified as a crucial downstream target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lei-Lei Ma, Zhi-Wen Ding, Pei-Pei Yin, Jian Wu, Kai Hu, Ai-Jun Sun, Yun-Zeng Zou, Jun-Bo Ge
Summary: The study shows that preconditioning with hypertrophic stress protects the heart from I/R injury by improving mitochondrial metabolism, reducing oxidative/nitrative stress and inhibiting apoptosis. ALDH2 is obligatorily required for the development of cardiac hypertrophic preconditioning and acts as the mediator of this process.
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla
Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yilong Zhao, Huajun Yang, Wei Shan, Anchen Guo, Qun Wang
Summary: Moderate ethanol preconditioning protects against ischemic brain injury by upregulating the expression of BKCa channels in rats.
NEUROCHEMICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Geetanjali Singh, Vibhav Varshney, Ahsas Goyal, Nemat Ali, Muzaffar Iqbal, Ishnoor Kaur, Celia Vargas-De-La-Cruz, Tapan Behl
Summary: The study found that chrysin enhances the therapeutic effect of ischemic preconditioning (IPC) in diabetic rat hearts via the PI3K-Akt-eNOS signaling pathway, reducing ischemia-reperfusion injury.
Review
Cell Biology
Jae-Sung Kim, William C. Chapman, Yiing Lin
Summary: Mitophagy is essential for mitochondrial quality control and its dysregulation can lead to mitochondrial dysfunction and cell death. Elderly patients have a reduced tolerance to injury, which may be associated with altered autophagy.
Review
Surgery
Glauber C. de Oliveira, Walmar K. de Oliveira, Winston B. Yoshida, Marcone L. Sobreira
Summary: This study assessed the beneficial effects of ischemic preconditioning (IPC) in liver resection and evaluated its applicability in clinical practice. The results showed that IPC can reduce intraoperative blood loss and the risk of postoperative ascites, but it has no significant impact on postoperative liver function and length of hospital stay. Therefore, although IPC is feasible in clinical practice, more evidence is needed to support its routine use.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Immunology
Erliang Kong, Yongchang Li, Xuqiang Geng, Jianxin Wang, Yan He, Xudong Feng
Summary: This study demonstrated that ischemic preconditioning (IPC) could protect against hepatic ischemia-reperfusion injury (HIRI) by activating autophagy and regulating endoplasmic reticulum stress (ERS)-dependent apoptosis in hepatocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Yi-Na Zhang, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: Ischemic preconditioning (IPC) can protect the blood-brain barrier (BBB) by interfering with glycocalyx, improving neurological pathology in rat models of cerebral ischemia-reperfusion injury (IRI).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Engineering, Biomedical
Jinyan Zhang, Liwei Liu, Zhen Dong, Xicun Lu, Wenxuan Hong, Jin Liu, Xiaoyi Zou, Jinfeng Gao, Hao Jiang, Xiaolei Sun, Kai Hu, Youjun Yang, Junbo Ge, Xiao Luo, Aijun Sun
Summary: This study utilizes a peroxynitrite-triggered carbon monoxide donor to generate a biomimetic carbon monoxide nanogenerator, which is coated with macrophage membrane for targeted delivery to the ischemic area and neutralization of proinflammatory cytokines, effectively improving myocardial ischemia-reperfusion injury. This research provides a new perspective on the safe therapeutic use of carbon monoxide for myocardial ischemia-reperfusion injury by utilizing a novel carbon monoxide donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of carbon monoxide to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Hongchao Guo, Xuan Yu, Yu Liu, David T. Paik, Johanne Marie Justesen, Mark Chandy, James W. S. Jahng, Tiejun Zhang, Weijun Wu, Freeborn Rwere, Shane Rui Zhao, Suman Pokhrel, Rabindra V. Shivnaraine, Souhrid Mukherjee, Daniel J. Simon, Amit Manhas, Angela Zhang, Che-Hong Chen, Manuel A. Rivas, Eric R. Gross, Daria Mochly-Rosen, Joseph C. Wu
Summary: The common ALDH2*2 variant affects around 8% of the global population and is associated with a severe loss of ALDH2 enzymatic activity and an increased risk of CAD. Empagliflozin, an SGLT2 inhibitor, has been shown to improve EC dysfunction caused by ALDH2*2, suggesting a potential preventive measure against CAD.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Ming-Chyi Huang, Hsueh-Yuan Tu, Ren-Hua Chung, Hsiang-Wei Kuo, Tung-Hsia Liu, Che-Hong Chen, Daria Mochly-Rosen, Yu-Li Liu
Summary: Blood NFL levels are increased in patients with alcohol dependence and decrease after early abstinence. The ALDH2 rs671 polymorphism is associated with NFL levels. Reduction in NFL levels correlates with improvement of clinical symptoms.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Riddhita Mukherjee, Laura H. Tetri, Sin-Jin Li, Giovanni Fajardo, Nicolai P. Ostberg, Kaleb B. Tsegay, Kanika Gera, Timothy T. Cornell, Daniel Bernstein, Daria Mochly-Rosen, Bereketeab Haileselassie
Summary: This study investigates the role of Drp1/p53 interaction in sepsis-induced myocardial dysfunction (SIMD). The results show that there is an increase in Drp1/p53 interaction following LPS treatment, leading to p53 localization to the mitochondria and mitochondrial dysfunction. Inhibiting the Drp1/p53 interaction can improve mitochondrial damage in SIMD.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Biology
An-Sheng Lee, Yen-Ling Sung, Szu-Hua Pan, Kuo-Tzu Sung, Cheng-Huang Su, Shiao-Li Ding, Ying-Jui Lu, Chin-Ling Hsieh, Yun-Fang Chen, Chuan-Chuan Liu, Wei-Yu Chen, Xuan-Ren Chen, Fa-Po Chung, Shih-Wei Wang, Che-Hong Chen, Daria Mochly-Rosen, Chung-Lieh Hung, Hung- Yeh, Shien-Fong Lin
Summary: This study reveals that the East Asian-specific aldehyde dehydrogenase deficiency (ALDH2*2) is associated with the risk of ventricular arrhythmia caused by low-level alcohol consumption. Both human and mouse models demonstrate prolonged QT interval and increased ventricular arrhythmia episodes in individuals carrying ALDH2 variants. This research is important for formulating safe drinking guidelines and developing protective agents for ALDH2 deficient individuals.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Scott Burkholz, Michael Rubsamen, Luke Blankenberg, Richard T. Carback III, Daria Mochly-Rosen, Paul E. Harris
Summary: Analysis of next-generation sequencing data linked with clinical metadata reveals that Omicron reinfections occur at a higher frequency and within a shorter time interval compared to pre-Omicron variants. This suggests that a single infection may not generate the protective immunity required to defend against Omicron reinfections. Continued next-generation sequencing and inclusion of clinical metadata is necessary for effective surveillance, treatment, vaccine development, and public health recommendations.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yi-Cheng Chang, Hsiao-Lin Lee, Wenjin Yang, Meng-Lun Hsieh, Cai-Cin Liu, Tung-Yuan Lee, Jing-Yong Huang, Jiun-Yi Nong, Fu-An Li, Hsiao-Li Chuang, Zhi-Zhong Ding, Wei-Lun Su, Li-Yun Chueh, Yi-Ting Tsai, Che-Hong Chen, Daria Mochly-Rosen, Lee-Ming Chuang
Summary: Obesity and type 2 diabetes are global pandemics. Mutations in the ALDH2 gene result in reduced enzymatic activity, leading to metabolic disorders. Activating ALDH2 can improve diet-induced obesity, fatty liver, and glucose homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Luis Rios, Suman Pokhrel, Sin-Jin Li, Gwangbeom Heo, Bereketeab Haileselassie, Daria Mochly-Rosen
Summary: The researchers have identified a small molecule that can mimic the effects of a peptide inhibitor and reduce the burden of protein-related diseases. This study is important for understanding and potentially treating various pathologies associated with protein dysregulation.
NATURE COMMUNICATIONS
(2023)
Review
Geriatrics & Gerontology
Tetsumori Yamashima, Takuya Seike, Daria Mochly-Rosen, Che-Hong Chen, Mitsuru Kikuchi, Eishiro Mizukoshi
Summary: This review discusses the mechanism of neuronal death in Alzheimer's disease by focusing on Hsp70.1, which has a dual function as a chaperone protein and lysosomal stabilizer. It suggests that A beta is not the root cause of Alzheimer's disease, but rather a byproduct of autophagy/lysosomal failure resulting from hydroxynonenal-induced Hsp70.1 disorder. Enhancing ALDH2 activity to detoxify hydroxynonenal emerges as a promising strategy for preventing and treating Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Takuya Seike, Che-Hong Chen, Daria Mochly-Rosen
Summary: Aldehyde dehydrogenase 2 (ALDH2) is an enzyme that is crucial for alcohol and aldehyde metabolism. A common ALDH2 polymorphism found in East Asians, known as ALDH2*2 or E504K missense variant (SNP ID: rs671), has been associated with various diseases, including Alzheimer's disease (AD). Studies on mice have shown that ALDH2 deficiency and the presence of ALDH2*2 exacerbate the pathology of AD, indicating their involvement in the development of AD. Additionally, the relationship between heavy alcohol consumption and AD has also been explored, with chronic alcohol administration in ALDH2*2/*2 mice worsening the onset of AD-like symptoms. Therefore, ALDH2 polymorphism and alcohol consumption are likely to play important roles in the pathogenesis of AD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Meeting Abstract
Critical Care Medicine
Laura Tetri, Riddhita Mukherjee, Sin Jin Li, Giovanni Fajardo, Nicolai Ostberg, Kaleb Tsegay, Kanika Gera, Timothy Cornell, Daniel Bernstein, Daria Mochly-Rosen, Bereketeab Haileselassie
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Vijith Vijayan, Hao Yan, Juliane Lohmeyer, Kolten Peterson, James Harden, Rachana Patil, Giulia Barbarito, Alice Bertaina, Robert Negrin, Daria Mochly-Rosen, Kenneth Weinberg, Bereketeab Haileselassie
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Sin Jin Li, Ching-Yi Chen, Nicolai Ostberg, Laura Tetri, Timothy Cornell, Daria Mochly-Rosen, Bereketeab Haileselassie
CRITICAL CARE MEDICINE
(2023)
Article
Oncology
Samuel Flashner, Masataka Shimonosono, Yasuto Tomita, Norihiro Matsuura, Shinya Ohashi, Manabu Muto, Andres J. Klein-Szanto, J. Alan Diehl, Che-Hong Chen, Daria Mochly-Rosen, Kenneth Weinberg, Hiroshi Nakagawa
Summary: The carcinogenic alcohol metabolite acetaldehyde drives ESCC. Acetaldehyde is detoxified by ALDH2 which is suppressed by its common polymorphism. Here, we demonstrate that ALDH2 dysfunction and alcohol exposure cooperate in ESCC progression through cancer stem cell enrichment.
Article
Cardiac & Cardiovascular Systems
Ligia A. Kiyuna, Darlan S. Candido, Luiz R. G. Bechara, Itamar C. G. Jesus, Lisley S. Ramalho, Barbara Krum, Ruda P. Albuquerque, Juliane C. Campos, Luiz H. M. Bozi, Vanessa O. Zambelli, Ariane N. Alves, Nicolas Campolo, Mauricio Mastrogiovanni, Silvina Bartesaghi, Alejandro Leyva, Rosario Duran, Rafael Radi, Guilherme M. Arantes, Edecio Cunha-Neto, Marcelo A. Mori, Che-Hong Chen, Wenjin Yang, Daria Mochly-Rosen, Ian J. MacRae, Ludmila R. P. Ferreira, Julio C. B. Ferreira
Summary: This study investigates the mechanisms and potential treatment for the deleterious effects of 4-hydroxynonenal (4-HNE) in heart failure. The results show that 4-HNE inhibits Dicer, which impairs miRNA processing. Boosting 4-HNE clearance through pharmacological activation of aldehyde dehydrogenase 2 (ALDH2) restores Dicer activity and miRNA biogenesis, offering a potential treatment for heart failure patients.
EUROPEAN HEART JOURNAL
(2023)
Meeting Abstract
Oncology
Che-Hong Chen, Daria Mochly-Rosen, Su-I Hou
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)