☆ 4.5 Article

Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

获取全文
添加到收藏夹

期刊

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 46, 期 4, 页码 579-586

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2009.01.002

关键词

5-Lipoxygenase pathway; Ischemic cerebrovascular disease; Transient ischemic attack; Ischemic stroke; Ischemic heart disease; Asthma; Chronic obstructive pulmonary disease; Cysteinyl leukotrienes; Leukotriene C4 synthase

类别

Cardiac & Cardiovascular Systems Cell Biology

资金

  1. University of Copenhagen
  2. Danish Heart Foundation
  3. Danish Medical Research Council
  4. Copenhagen County Foundation
  5. Research Fund at Rigshospitalet
  6. Copenhagen University Hospital

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

Ischemic cardiovascular disease and obstructive pulmonary disease involve inflammation. Leukotrienes may be important pro-inflammatory mediators. We tested the hypothesis that the (-1072)G>A and (-444) A>C promoter polymorphisms of leukotriene C-4 synthase confer risk of transient ischemic attack (TIA), ischemic stroke, ischemic heart disease (IHD), asthma, and chronic obstructive pulmonary disease (COPD). We genotyped individuals from the Danish general population, the Copenhagen City Heart Study, and Danish patients with IHD/coronary atherosclerosis, the Copenhagen Ischemic Heart Disease Study. We used prospective (n=10,386), cross-sectional (n=10,386), and case-control (n=2392+5012) designs. Allele frequency was 0.07 for (-1072)A and 0.29 for (-444)C. Cumulative incidence for TIA was higher for (-1072)AA versus GG genotype (log-rank: p<0.001), and lower for (-444)CC versus AA genotype (log-rank: p=0.03). Cumulative incidence for ischemic stroke was also lower for (-444)CC versus AA genotype (log-rank: p=0.04). Multifactorially adjusted hazard ratios for TIA were 5.2(95% CI:1.9-14) for (-1072)AA versus GG genotype, and 0.4(0.2-1.0) for (-444)CC versus AA genotype. Corresponding values were 1.9 (0.7-5.2) and 0.7 (0.5-1.0) for ischemic stroke, and 0.8 (0.4-1.6) and 1.0 (0.9-1.2) for IHD. In the case-control study, corresponding multifactorially adjusted odds ratios for IHD/coronary atherosclerosis were 0.5 (0.2-1.3) and 1.2 (1.0-1.5). These genotypes were not associated with risk of asthma or CCPD. Leukotriene C4 synthase promoter genotypes influence risk of TIA and ischemic stroke, but not risk of IHD/coronary atherosclerosis, asthma, or COPD. (C) 2009 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Cardiac & Cardiovascular Systems

Obesity increases heart failure incidence and mortality: observational and Mendelian randomization studies totalling over 1 million individuals

Marianne Benn, Sarah C. W. Marott, Anne Tybjaerg-Hansen, Borge G. Nordestgaard

Summary: High BMI causally increases the risk of both heart failure incidence and mortality.

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹
Article Clinical Neurology

Small Dense Low-Density Lipoprotein Cholesterol and Ischemic Stroke

Mie Balling, Borge G. Nordestgaard, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Shoaib Afzal

Summary: This study explored the association between high levels of small dense low-density lipoprotein (sdLDL) and the risk of ischemic stroke in a large prospective study. The findings revealed a robust relationship between elevated sdLDL cholesterol levels and increased risk of ischemic stroke.

ANNALS OF NEUROLOGY (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Elevated LDL Triglycerides and Atherosclerotic Risk

Mie Balling, Shoaib Afzal, George Davey Smith, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Borge G. Nordestgaard

Summary: Elevated LDL triglycerides are associated with an increased risk of ASCVD and its individual components, as shown in two prospective cohort studies and meta-analyses.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)

添加到收藏夹
Article Gastroenterology & Hepatology

Genetic risk of fatty liver disease and mortality in the general population: A Mendelian randomization study

Helene Gellert-Kristensen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard, Jonas Ghouse, Andreas Fuchs, Jorgen T. Kuhl, Per E. Sigvardsen, Klaus F. Kofoed, Stefan Stender

Summary: Observational epidemiological studies have shown that fatty liver disease is associated with higher all-cause mortality, liver-related mortality, ischemic heart disease-related mortality, and extrahepatic cancer-related mortality. In this genetic study, we found that seven genetic variants associated with fatty liver disease were significantly correlated with liver-related mortality. Using a Mendelian randomization framework, we further demonstrated that hepatic steatosis and elevated plasma ALT, as genetically determined factors, are associated with liver-related mortality.

LIVER INTERNATIONAL (2023)

添加到收藏夹
Article Medicine, General & Internal

Height Explains Sex Difference in Atrial Fibrillation Risk: Copenhagen General Population Study

Jacob Louis Marott, Magnus T. Jensen, Marianne Benn, Martina Chantal de Knegt, James H. O'Keefe, Carl J. Lavie, Peter Schnohr, Berge Gronne Nordestgaard, Gorm Boje Jensen

Summary: This study aimed to test the hypothesis that the increased risk of atrial fibrillation in men compared with women is explained by height. The results showed that the higher risk of atrial fibrillation in men can indeed be explained by differences in height. The study also suggested that height is one of the most important risk factors for atrial fibrillation in both men and women.

MAYO CLINIC PROCEEDINGS (2023)

添加到收藏夹
Correction Multidisciplinary Sciences

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores (vol 12, 3417, 2021)

Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris Jansen, Nancy L. Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernandez, Laura Montrreal, Carmen Antunez, Anna Antonell, Rick M. Tankard, Joshua Bis, Rebecca Sims, Celine Bellenguez, Ines Quintela, Antonio Gonzalez-Perez, Miguel Calero, Emilio Franco-Macias, Juan Macias, Rafael Blesa, Laura Cervera-Carles, Manuel Menendez-Gonzalez, Ana C. Frank-Garcia, Jose Luis W. Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Monica Diez-Fairen, Carmen Lage, Sebastian Garcia-Madrona, Pablo Garcia-Gonzalez, Emilio Alarcon-Martin, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C. Naj, Afina W. Lemstra, Alba Benaque, Alba Perez-Cordon, Alberto L. Benussi, Alberto Rabano, Alessandro Padovani, Alessio Squassina, Alexandre de Mendonca, Alfonso M. Arias Pastor, Almar A. L. Kok, Alun Meggy, Ana Belen Pastor, Ana Espinosa, Anais Corma-Gomez, Angel Martin Montes, Angela Sanabria, Anita W. DeStefano, Anja Schneider, Annakaisa Haapasalo, Anne Kinhult Stahlbom, Anne Tybjaerg-Hansen, Annette M. Hartmann, Annika Spottke, Arturo Corbaton-Anchuelo, Arvid B. Rongve, Barbara Borroni, Beatrice Arosio, Benedetta Nacmias, Borge G. Nordestgaard, Brian W. Kunkle, Camille Charbonnier, Carla Abdelnour, Carlo Masullo, Carmen Martinez Rodriguez, Carmen Munoz-Fernandez, Carole Dufouil, Caroline Graff, Catarina Ferreira, Caterina Chillotti, Chandra A. Reynolds, Chiara Fenoglio, Christine Van Broeckhoven, Christopher Clark, Claudia Pisanu, Claudia L. Satizabal, Clive Holmes, Dolores Buiza-Rueda, Dag Aarsland, Dan Rujescu, Daniel Alcolea, Daniela Galimberti, David Wallon, Davide Seripa, Edna Grunblatt, Efthimios Dardiotis, Emrah Duezel, Elio Scarpini, Elisa Conti, Elisa Rubino, Ellen Gelpi, Eloy Rodriguez-Rodriguez, Emmanuelle Duron, Eric Boerwinkle, Evelyn Ferri, Fabrizio Tagliavini, Fahri Kuecuekali, Florence Pasquier, Florentino Sanchez-Garcia, Francesca Mangialasche, Frank Jessen, Gael Nicolas, Geir Selbaek, Gemma K. Ortega, Genevieve Chene, Georgios Hadjigeorgiou, Giacomina Rossi, Gianfranco Spalletta, Giorgio Giaccone, Giulia Grande, Giuliano Binetti, Goran Papenberg, Harald Hampel, Henri Bailly, Henrik Zetterberg, Hilkka Soininen, Ida Karlsson, Ignacio Alvarez, Ildebrando Appollonio, Ina Giegling, Ingmar Skoog, Ingvild Saltvedt, Innocenzo Rainero, Irene Rosas Allende, Jakub Hort, Janine Diehl-Schmid, Jasper Van Dongen, Jean-Sebastien Vidal, Jenni Lehtisalo, Jens Wiltfang, Jesper Qvist Thomassen, Johannes Kornhuber, Jonathan A. Haines, Jonathan Vogelgsang, Juan Pineda, Juan Fortea, Julius Popp, Juergen Deckert, Katharina Buerger, Kevin Morgan, Klaus Fliessbach, Kristel Sleegers, Laura Molina-Porcel, Lena Kilander, Leonie Weinhold, Lindsay Farrer, Li-San Wang, Luca Kleineidam, Lucia A. Farotti, Lucilla Parnetti, Lucio Tremolizzo, Lucrezia Hausner, Luisa Benussi, Lutz Froelich, M. Arfan Ikram, M. Candida Deniz-Naranjo, Magda Tsolaki, Maitee Rosende-Roca, Malin Lowenmark, Marc Hulsman, Marco Spallazzi, Margaret H. Pericak-Vance, Margaret Esiri, Maria Bernal Sanchez-Arjona, Maria Carolina Dalmasso, Maria Teresa T. Martinez-Larrad, Marina Arcaro, Markus Noethen, Marta Fernandez-Fuertes, Martin Dichgans, Martin Ingelsson, Martin Herrmann, Martin Scherer, Martin Vyhnalek, Mary M. Kosmidis, Mary M. Yannakoulia, Matthias Schmid, Michael J. Ewers, Michael T. Heneka, Michael Wagner, Michela Scamosci, Miia Kivipelto, Mikko Hiltunen, Miren Zulaica, Montserrat Alegret, Myriam Fornage, Natalia Roberto, Natasja van Schoor, Nazib Seidu, Nerisa Banaj, Nicola Armstrong, Nikolaos Scarmeas, Norbert A. Scherbaum, Oliver Goldhardt, Oliver Hanon, Oliver Peters, Olivia Anna Skrobot, Olivier Quenez, Ondrej Lerch, Paola Bossu, Paolo Caffarra, Paolo Dionigi Rossi, Paraskevi Sakka, Patrizia Mecocci, Per Hoffmann, Peter Holmans, Peter A. Fischer, Peter Riederer, Qiong Yang, Rachel Marshall, Rajesh N. Kalaria, Richard Mayeux, Rik Vandenberghe, Roberta Cecchetti, Roberta Ghidoni, Ruth Frikke-Schmidt, Sandro Sorbi, Sara Haegg, Sebastiaan Engelborghs, Seppo Helisalmi, Sigrid Botne Sando, Silke Kern, Silvana Archetti, Silvia Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Simon Mead, Simona Ciccone, Srdjan Djurovic, Stefanie Heilmann-Heimbach, Steffi Riedel-Heller, Teemu Kuulasmaa, Teodoro del Ser, Thibaud Lebouvier, Thomas Polak, Tiia Ngandu, Timo Grimmer, Valentina Bessi, Valentina Escott-Price, Vilmantas Giedraitis, Vincent Deramecourt, Wolfgang Maier, Xueqiu Jian, Yolande A. L. Pijnenburg, Patrick Gavin Kehoe, Guillermo Garcia-Ribas, Pascual Sanchez-Juan, Pau Pastor, Jordi Perez-Tur, Gerard Pinol-Ripoll, Adolfo Lopez De Munain, Jose Maria Garcia-Alberca, Maria J. Bullido, Victoria Alvarez, Alberto Lleo, Luis M. Real, Pablo Mir Miguel Medina, Philip Scheltens, Henne Holstege, Marta Marquie, Maria Eugenia Saez, Angel Carracedo, Philippe Amouyel, Gerard D. Schellenberg, Julie Williams, Sudha Seshadri, CorneliaM. Van Duijn, Karen A. Mather, Raquel Sanchez-Valle, Manuel Serrano-Rios, Adelina Orellana, Lluis Tarraga, Kaj Blennow, Ole A. Andreassen, Danielle Posthuma, Jordi Clarimon, Merce Boada, Wiesje M. Van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. Van der Lee, Agustin Ruiz

NATURE COMMUNICATIONS (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

APOE and vascular disease: Sequencing and genotyping in general population cohorts

Katrine L. Rasmussen, Jiao Luo, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt

Summary: The structural genetic variations in the APOE gene are associated with vascular diseases. APOE variants with high apoE, triglycerides, and remnant cholesterol are associated with peripheral arterial disease (PAD), while common APOE variants with high LDL cholesterol, triglycerides, and remnant cholesterol are associated with ischemic heart disease (IHD). APOE variants with low apoE are associated with increased risk of ischemic cerebrovascular disease (ICVD).

ATHEROSCLEROSIS (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Plasma TSH and cardiovascular disease in the general population: A Mendelian randomization study of 105,224 individuals

Nawar Dalila, Ruth Frikke-Schmidt, Borge G. Nordestgaard, Anne Tybjaerg-Hansen

Summary: This study found that low levels of thyroid stimulating hormone (TSH) are associated with increased risk of cardiovascular diseases (such as atrial fibrillation, myocardial infarction, stroke) both observationally and genetically. These findings suggest a potential causal relationship.

ATHEROSCLEROSIS (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals

Laerke Kristine Kyhl, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Sune Fallgaard Nielsen

Summary: High levels of plasma triglycerides, BMI, and waist circumference, individually and combined, are associated with an increased risk of clinically diagnosed non-alcoholic fatty liver disease. This study found that the risk of non-alcoholic fatty liver disease increased in individuals with higher plasma triglycerides, BMI, and waist circumference over a 9.2-year follow-up period.

ATHEROSCLEROSIS (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Genetic variation in solute carrier family 5 member 2 mimicking sodium-glucose co-transporter 2-inhibition and risk of cardiovascular disease and all-cause mortality: reduced risk not explained by lower plasma glucose

Louise E. Bechmann, Frida Emanuelsson, Borge G. Nordestgaard, Marianne Benn

Summary: A functional genetic variant in SLC5A2, mimicking SGLT2-inhibition, was associated with a lower risk of heart failure, myocardial infarction, ischaemic heart disease, and all-cause mortality. However, the effects were minimally mediated through lower plasma glucose.

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence

Maria Booth Nielsen, Yunus Colak, Marianne Benn, Amy Mason, Stephen Burgess, Borge Gronne Nordestgaard

Summary: Observational findings indicate that elevated plasma adiponectin levels are associated with an increased risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction. However, genetic evidence does not support the causality of these associations.

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹
Article Endocrinology & Metabolism

High Lipoprotein(a) May Explain One-Quarter of Clinical Familial Hypercholesterolemia Diagnoses in Danish Lipid Clinics

Berit Storgaard Hedegaard, Borge Gronne Nordestgaard, Helle Lynge Kanstrup, Kristian Korsgaard Thomsen, Jan Bech, Lia Evi Bang, Finn Lund Henriksen, Lars Juel Andersen, Thomas Gohr, Linnea Hornbech Larsen, Anne Merete Boas Soja, Frank-Peter Elpert, Tomas Joen Jakobsen, Anette Sjol, Albert Marni Joensen, Ib Christian Klausen, Erik Berg Schmidt, Christian Sorensen Bork

Summary: This study investigated the presence of lipoprotein(a) in individuals referred to Danish lipid clinics and found that elevated lipoprotein(a) played a role in a quarter of individuals who met the diagnosis criteria for clinical familial hypercholesterolemia (FH).

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

添加到收藏夹
Article Multidisciplinary Sciences

Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojasj, Thiago Peixoto Leal, Akinori Miyashita, Celine Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Kucukali, Seth D. Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, Maria J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stephanie Debette, Jean-Francois Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo Garcia-Ribas, Jose Maria Garcia-Alberca, Pablo Garcia-Gonzalez, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonca, Merce Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Borge G. Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A. L. Pijnenburg, Gerard Pinol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puertaj Jordi Perez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M. Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A. Ross, Jose Luis Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Raquel Sanchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhangc, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sanchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Todau, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje van der Fliere, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D. Greicius, Emmanuel Mignot

Summary: We analyzed the HLA associations in individuals with Parkinson's disease and Alzheimer's disease across different ancestry groups and found that these two diseases share a common protective association at the HLA locus. Fine-mapping showed that specific subtypes of HLA-DRB1*04 were responsible for this association, with HLA-DRB1*04:04 and HLA-DRB1*04:07 showing the strongest association. This protective effect was also associated with decreased neurofibrillary tangles in the brain and reduced levels of tau protein in cerebrospinal fluid.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

添加到收藏夹
Article Public, Environmental & Occupational Health

Health and wellbeing in refugee families from Syria resettled in Denmark

Nina Odgaard Nielsen, Eirikur Benedikz, Morten Dahl, Jeanette Praestegaard, Marianne Lindahl

Summary: The aim of this study was to evaluate the self-reported health status and wellbeing of refugee families from Syria 2-4 years after resettlement in Denmark, and compare it with a Danish reference population, to determine the need for specialized health care. The study involved 90 individuals from Syria aged 13-56 years, and found that the refugee families had poorer health and wellbeing compared to the Danish population. The findings highlight the importance of providing systematic and specialized health care services to resettled refugees.

JOURNAL OF MIGRATION AND HEALTH (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Neutrophil counts and cardiovascular disease

Jiao Luo, Jesper Qvist Thomassen, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt

Summary: This study investigated the associations between neutrophil counts and nine cardiovascular endpoints using observational and genetic approaches. The results showed that high neutrophil counts were associated with an increased risk of all cardiovascular outcomes. Genetic studies also supported this finding. No robust associations were found for other types of leukocytes in the two-sample MR analysis.

EUROPEAN HEART JOURNAL (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development

Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels

Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2024)

添加到收藏夹
Review Cardiac & Cardiovascular Systems

Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases

MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao

Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2024)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Classification of regulatory T cells and their role in myocardial ischemia-reperfusion injury

Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng

Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2024)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

β-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice

Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie

Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2024)

添加到收藏夹
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.