Article
Health Care Sciences & Services
Richard J. Roberts, Logan Hallee, Chi Keung Lam
Summary: Hsp90 is a key molecular chaperone that interacts with numerous disease pathways in cells, making it a potential therapeutic target. While small-molecule inhibition of Hsp90 activity may have cardiac toxicity, targeting Hsp90 through modulation of post-translational modifications (PTMs) could be a more attractive therapeutic strategy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Ferda Demir, Kyoji Urayama, Anais Audebrand, Ayca Toprak-Semiz, Marja Steenman, Hitoshi Kurose, Canan G. Nebigil
Summary: This study reveals that pressure overload-mediated PKR2 signaling in cardiomyocytes contributes to cardiac hypertrophy through autocrine signaling, and vascular rarefaction via cardiac cytokine-mediated cardiomyocyte-endothelial cell communications. Our results may contribute to the development of potential therapeutic targets for heart failure.
Article
Cell Biology
Michael W. Lero, Leslie M. Shaw
Summary: This review underscores the significance of the IR/IGF-1R signaling pathway in cancer and its potential as a therapeutic target. Understanding the pathway's role in normal mammary gland function provides insight into its aberrations in breast cancer. However, efforts to target this pathway for cancer treatment are hindered by a lack of biomarkers and adverse effects on normal metabolism.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Shuqin Sun, Shuo Yang, Nannan Zhang, Chunpeng Yu, Junjun Liu, Wenjing Feng, Wanqun Xu, Yongjun Mao
Summary: This study found that Astragalus polysaccharides (APS) can attenuate cardiac hypertrophy in diabetic cardiomyopathy (DCM) by inhibiting the activation of the bone morphogenetic protein 10 (BMP10) pathway. APS treatment reduced cardiomyocyte hypertrophy under high-glucose stimulation and improved cardiac function and hypertrophy in DCM rats. Therefore, APS could be a promising candidate for the treatment of DCM.
Article
Biotechnology & Applied Microbiology
Sakshi Khurana, Stefano Schivo, Jacqueline R. M. Plass, Nikolas Mersinis, Jetse Scholma, Johan Kerkhofs, Leilei Zhong, Jaco van de Pol, Rom Langerak, Liesbet Geris, Marcel Karperien, Janine N. Post
Summary: This study utilized computational models and software tools to analyze the mechanisms regulating the switch between permanent and transient cartilage, identifying potential therapeutic opportunities. Combinatorial treatments were tested and validated experimentally, showing both positive and negative effects on cartilage formation and growth, providing insights for interventions in normal cartilage development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Endocrinology & Metabolism
Thi Kim Chung Le, Xuan Dat Dao, Dang Vung Nguyen, Duc Huy Luu, Thi Minh Hanh Bui, Thi Huong Le, Huu Thang Nguyen, Tran Ngoan Le, Toshio Hosaka, Thi Thu Thao Nguyen
Summary: The discovery of insulin in 1921 sparked research on insulin activity and insulin resistance. This mini-review synthesizes updated discoveries in this field to uncover related mechanisms and inform the development of novel applications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
E. Dale Abel
Summary: Insulin receptors play a critical role in regulating cardiac growth, survival, substrate uptake, and mitochondrial metabolism. Altered insulin signaling in the heart can contribute to ventricular remodeling and heart failure progression. Understanding the role of insulin signaling in cardiac physiology and pathology may have therapeutic implications for conditions like obesity and diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biology
Ji-Sun Lee, Claire E. Tocheny, Leslie M. Shaw
Summary: This review provides an overview of the role of the IGF signaling pathway in breast cancer and discusses its potential as a therapeutic target. Dysregulation of IGF pathway components contributes to breast cancer risk and progression, and the pathway has also been implicated in resistance to current therapies. Unfortunately, targeting IGF signaling for breast cancer treatment has been unsuccessful so far due to adverse effects on normal glucose metabolism. However, recent discoveries offer hope for continued efforts in this area.
Article
Cardiac & Cardiovascular Systems
Moriah Gildart Turcotte, Hrishikesh Thakur, Michael S. Kapiloff, Kimberly L. Dodge-Kafka
Summary: Pathological cardiac myocyte hypertrophy, which is a condition characterized by the enlargement of heart cells, is regulated by the pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin. This study reveals that the scaffold protein muscle A-Kinase Anchoring Protein beta (mAKAP beta/AKAP6 beta) organizes perinuclear signalosomes, which are responsible for localized calcium transients and the subsequent activation of calcineurin-dependent NFATc nuclear localization, leading to myocyte hypertrophy upon beta-adrenergic receptor activation. These findings demonstrate the existence of a functionally independent calcium signaling compartment in cardiac myocytes that regulates hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Virology
Agata Jozefiak, Magdalena Larska, Malgorzata Pomorska-Mol, Jakub J. Ruszkowski
Summary: IGF-1 activates intracellular signaling pathways by binding to IGF-1R, including PI3K/AKT and MAPK pathways, to regulate cell proliferation and apoptosis. The IGF-1 signaling also promotes cell differentiation and proliferation through the Ras/MAPK pathway.
Article
Endocrinology & Metabolism
Peter Wolf, Khaoula Bouazizi, Nadjia Kachenoura, Celine Piedvache, Antonio Gallo, Sylvie Salenave, Luigi Maione, Jacques Young, Mikael Prigent, Anne-Lise Lecoq, Emmanuelle Kuhn, Helene Agostini, Severine Trabado, Alban Redheuil, Philippe Chanson, Peter Kamenicky
Summary: In this study, cardiac magnetic resonance imaging was used to investigate the cardiac morphology and function of patients with active acromegaly. The study found that these patients had increased left ventricular mass and end-diastolic volume compared to controls. Treatment was able to reduce these measures without significantly affecting extracellular mass.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Can Wei, Mengting Sun, Xiao Liang, Bingbing Che, Ningning Wang, Lili Shi, Ying Fan
Summary: Transcriptomic analysis of DCM myocardium before and after SPM treatment revealed 1,318 DEGs in DCM, with 174 DEGs potentially reversed by SPM, particularly those related to immune system and signal transduction pathways. This study provides insights into the protective mechanism of SPM against DCM by targeting abnormal immune response and signal transduction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Miyuki Suzawa, Michelle L. Bland
Summary: Nutrients alone are not enough for animal growth and development, as insulin and related hormones are also necessary for normal growth. These hormones communicate nutrient status between organs, allowing animals to coordinate growth and metabolism. Insulin signaling plays important roles in development and metabolism, and defects in insulin production and signaling can lead to diabetes.
Article
Nutrition & Dietetics
Diletta Arcidiacono, Alice Zaramella, Federico Fabris, Ricardo Sanchez-Rodriguez, Daniele Nucci, Matteo Fassan, Mariateresa Nardi, Clara Benna, Chiara Cristofori, Tiziana Morbin, Salvatore Pucciarelli, Alberto Fantin, Stefano Realdon
Summary: The study investigated the effect of moderate calorie and protein restriction on overweight or obese patients with Barrett's esophagus, finding that the intervention was effective in reducing obesity-related cancer risk factors. Patients in the program experienced significant reductions in body mass index, waist circumference, and IGF-1 levels.
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
