Article
Cardiac & Cardiovascular Systems
Chih-Hsin Hsu, Jun-Neng Roan, Shih-Yuan Fang, Meng-Hsuan Chiu, Tzu-Ting Cheng, Chien-Chi Huang, Ming-Wei Lin, Chen-Fuh Lam
Summary: This study found that transplantation of viable mitochondria can reverse vascular and cardiac structural and functional damage in rats with pulmonary hypertension. By improving the contractile ability of the pulmonary artery and inhibiting abnormal proliferation, mitochondrial transplantation may be a revolutionary approach for treating pulmonary hypertension.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Sasha Z. Prisco, Lynn Hartweck, Jennifer L. Keen, Neal Vogel, Felipe Kazmirczak, Megan Eklund, Anna R. Hemnes, Evan L. Brittain, Kurt W. Prins
Summary: Excessive protein glycation may aggravate right ventricular dysfunction in patients with pulmonary arterial hypertension by inhibiting fatty acid oxidation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Peerapat Kaveevorayan, Nithi Tokavanich, Veraprapas Kittipibul, Thana Lertsuttimetta, Seri Singhatanadgige, Pat Ongcharit, Supanee Sinphurmsukskul, Aekarach Ariyachaipanich, Sarawut Siwamogsatham, Kanokwan Thammanatsakul, Supaporn Sritangsirikul, Sarinya Puwanant
Summary: This study aimed to determine the prevalence, characteristics, and outcomes of primary isolated right ventricular failure (PI-RVF) after heart transplant (HTX). PI-RVF can be diagnosed within 24-72 hours after completion of heart transplantation. The study found that 59% of patients developed PI-RVF, with 48% meeting the criteria for PGD-RV. Severe RV failure was associated with increased rates of 30-day mortality and post-operative dialysis, while moderate RV failure was associated with post-operative dialysis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sijuan Sun, Hongbin Zhu, Shoubao Wang, Xiuxia Xu, Lincai Ye
Summary: This study established a postnatal right ventricular volume overload (VO) model in mice using a modified abdominal arteriovenous fistula. It was found that in VO mice, the right ventricular cavity increased in size with a thickened free wall, and the stroke volume increased by about 30%-40% within 2 months after surgery. Subsequently, the right ventricular systolic pressure increased, pulmonary valve regurgitation was observed, and small pulmonary artery remodeling appeared.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Wuwan Wang, Wei Chen, Xue Lin, Ligang Fang
Summary: This study aimed to investigate the influence of right ventricular (RV) dysfunction on the clinical outcomes of patients with LVNC through accurate and comprehensive measurements of RV function. The results showed that RV dysfunction is associated with the prognosis of patients with LVNC, and RV dysfunction and impaired RV global longitudinal strain are independent predictors of mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
F. T. Bekedam, M. J. Goumans, H. J. Bogaard, F. S. de Man, A. Llucia-Valldeperas
Summary: Right ventricular fibrosis is a stress response caused by activation of cardiac fibroblasts, leading to increased synthesis and remodeling of the extracellular matrix. While it provides structural protection in response to damage, it also contributes to increased myocardial stiffness and dysfunction. This review summarizes current knowledge and studies on the development of right ventricular fibrosis in response to pressure overload and its potential for improving cardiac function. (c) 2023 Published by Elsevier Inc.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Neurosciences
Aisling M. Burns, Aline Nixon, Joanne Mallinson, Sally M. Cordon, Francis B. Stephens, Paul L. Greenhaff
Summary: The study reveals that immobilisation leads to a significant reduction in forearm glucose uptake within a short period of time, while lipid uptake remains unchanged. This effect is specific to the immobilised limb, highlighting the impact of muscle disuse on metabolic dysregulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cardiac & Cardiovascular Systems
Rui Shi, Zhi-Gang Yang, Ying-Kun Guo, Wen-Lei Qian, Yue Gao, Xue-Ming Li, Li Jiang, Hua-Yan Xu, Yuan Li
Summary: This study investigated the difference in right ventricular (RV) structural and functional alteration in patients with diabetes mellitus (DM) with preserved left ventricular ejection fraction (LVEF), and the ventricular interdependence in these patients, using cardiac MR (CMR) feature tracking. The results showed that patients with DM had lower RVGLS and RVGCS compared to normal controls, with RVGRS showing no significant difference. The difference in RVGLS was fully mediated by LVGLS, while the difference in RVGCS was partly mediated by LVGLS and LVGCS.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Max Berrill, Eshan Ashcroft, David Fluck, Isaac John, Ian Beeton, Pankaj Sharma, Aigul Baltabaeva
Summary: This study aimed to assess the predictive value of echocardiographic parameters of left and right ventricular function on the long-term prognosis of acute heart failure (AHF). The results showed that several parameters of right ventricular function were predictive of the 2-year outcome, while left ventricular ejection fraction could not identify patients at risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Hao Yi-Dan, Zhao Ying-Xin, Yang Shi-Wei, Zhou Yu-Jie
Summary: This review discusses the role of high-energy phosphates in ischemic heart disease and the clinical evidence, highlighting the importance of exogenous creatine phosphate in cardioprotection. Although exogenous CrP has not been shown to improve long-term survival, it has beneficial effects on multiple secondary but important outcomes and short-term survival.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mahon L. Maguire, Debra J. McAndrew, Hannah A. Lake, Philip J. Ostrowski, Sevasti Zervou, Stefan Neubauer, Craig A. Lygate, Jurgen E. Schneider
Summary: This study developed an improved P-31-CMRS technique for evaluating myocardial energetics in mice. The results showed that overexpression of creatine and creatine kinase in the heart significantly increased the ratio of phosphocreatine to adenosine triphosphate, indicating an augmented energetic status.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Benes, Martin Kotrc, Peter Wohlfahrt, Katerina Kroupova, Marek Tupy, Josef Kautzner, Vojtech Melenovsky
Summary: Right ventricular (RV) function in heart failure patients with reduced ejection fraction (HFrEF) should be assessed by considering both RV function and size. RV size (measured as RV-basal diameter) was associated with poor outcomes, independent of RV dysfunction grade. A novel parameter, RV global dysfunction score (RVGDs), which combines RV size and function, had superior prognostic value compared to RV dysfunction grade alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Fernando Scudiero, Angelo Silverio, Iacopo Muraca, Vincenzo Russo, Marco Di Maio, Antonio Silvestro, Davide Personeni, Rodolfo Citro, Mario Enrico Canonico, Gennaro Galasso, Italo Porto, Guido Parodi
Summary: This study evaluated the long-term clinical outcomes of hospitalized patients with COVID-19, finding that right ventricular dysfunction is significantly associated with 1-year mortality. RV dysfunction is relatively common in COVID-19 patients and independently linked to an increased risk of mortality.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Physiology
Zuzanna Lewicka-Potocka, Anna Maria Kaleta-Duss, Ewa Lewicka, Marcin Kubik, Anna Faran, Pawel Szymeczko, Rafal Galaska, Grzegorz Raczak, Alicja Dabrowska-Kugacka
Summary: Moderate physical activity has a positive impact on health, although extreme forms of sport such as marathon running may trigger exercise-induced cardiac fatigue. This study analyzed the impact of running a marathon on right ventricular mechanics in amateur athletes using echocardiography. The findings showed increased RV volumes, decreased RV ejection fraction, and decreased RV radial shortening in amateur athletes after running a marathon, with these changes correlating with training volume and galactin-3 levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Multidisciplinary Sciences
Tetsuji A. Kitano, Yosuke A. Nabeshima, Yasufumi A. Nagata, Masaaki A. Takeuchi
Summary: The prognostic value of right ventricular ejection fraction (RVEF) assessed by three-dimensional echocardiography (3DE) was examined and compared to left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LVGLS). RVEF was found to have a higher predictive power than LVEF in certain populations and was similar to LVGLS in terms of prognostic value. Individual patient data analysis confirmed these findings.
Article
Genetics & Heredity
Adam Waring, Andrew Harper, Silvia Salatino, Christopher Kramer, Stefan Neubauer, Kate Thomson, Hugh Watkins, Martin Farrall
Summary: This study introduces methods for gene association and variant interpretation that detect clustering of rare missense variants in Mendelian disease genes, which can enhance disease-gene discovery. The statistical methods presented in this study are more powerful and computationally faster than alternative methods, and can effectively integrate ACMG criteria to provide strong evidence of pathogenicity for variants of uncertain significance.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Endocrinology & Metabolism
Zahra Raisi-Estabragh, Luca Biasiolli, Jackie Cooper, Nay Aung, Kenneth Fung, Jose M. Paiva, Mihir M. Sanghvi, Ross J. Thomson, Elizabeth Curtis, Julien Paccou, Jennifer J. Rayner, Konrad Werys, Henrike Puchta, Katharine E. Thomas, Aaron M. Lee, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Cyrus Cooper, Steffen E. Petersen, Nicholas C. Harvey
Summary: The study found a positive association between bone health and vascular health with consistent patterns in men and women. Blood biomarkers played an important role in mediating the association, with different directions of effect, but did not fully explain the observed effects.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew Apps, Ladislav Valkovic, Mark Peterzan, Justin Y. C. Lau, Moritz Hundertmark, William Clarke, Elizabeth M. Tunnicliffe, Jane Ellis, Damian J. Tyler, Stefan Neubauer, Oliver J. Rider, Christopher T. Rodgers, Albrecht Ingo Schmid
Summary: Phosphorus spectroscopy is an effective method for studying cardiac energetics and can provide valuable information about myocardial conditions through the calculation of different phosphorus compound ratios. This study introduces a method to accurately measure Pi by overcoming interference from 2,3-DPG signals, and demonstrates the stability of myocardial Pi/PCr and pH at rest and during stress.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Yan Xia, Le Zhang, Nishant Ravikumar, Rahman Attar, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen, Alejandro F. Frangi
Summary: A new robust approach called Image Imputation Generative Adversarial Network (I2-GAN) is proposed to learn and infer missing slices in cardiac magnetic resonance sequences, improving accuracy of cardiac volume measurements. Experimental results show significant improvements in missing slice imputation for CMR using this method.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Cole B. Hirschfeld, Maurizio Dondi, Thomas N. B. Pascual, Mathew Mercuri, Joao Vitola, Ganesan Karthikeyan, Nathan Better, John J. Mahmarian, Salah E. Bouyoucef, Henry Hee-Seung Bom, Vikram Lele, Vincent Peter C. Magboo, Erick Alexanderson, Adel H. Allam, Mouaz H. Al-Mallah, Albert Flotats, Scott Jerome, Philipp A. Kaufmann, Osnat Luxenburg, S. Richard Underwood, Madan M. Rehani, Jenia Vassileva, Diana Paez, Andrew J. Einstein
Summary: This study established worldwide and regional diagnostic reference levels and achievable administered activities for SPECT MPI, showing significant differences between regions and emphasizing the importance of standardized reporting methods for improving the validity and comparability of regional DRLs.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Genetics & Heredity
Andrew R. Harper, Anuj Goel, Christopher Grace, Kate L. Thomson, Steffen E. Petersen, Xiao Xu, Adam Waring, Elizabeth Ormondroyd, Christopher M. Kramer, Carolyn Y. Ho, Stefan Neubauer, Rafik Tadros, James S. Ware, Connie R. Bezzina, Martin Farrall, Hugh Watkins
Summary: The study identified 12 genome-wide significant susceptibility loci for HCM, showing a strong polygenic influence, especially for sarcomere-negative HCM. A genetic risk score influenced the odds of HCM and phenotypic severity in carriers of sarcomere variants. Mendelian randomization identified diastolic blood pressure as a key modifiable risk factor for sarcomere-negative HCM.
Article
Cardiac & Cardiovascular Systems
Andrew J. M. Lewis, Jennifer J. Rayner, Ines Abdesselam, Stefan Neubauer, Oliver J. Rider
Summary: The study found that obesity is associated with left ventricular hypertrophy even in the absence of other comorbidities, but the magnitude of this change is modest even in severe obesity. Therefore, left ventricular wall thickness exceeding a certain value cannot be simply attributed to obesity, and alternative diagnoses should be considered.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Samer Gawrieh, Katharine Roberts, Christopher J. Lisanti, Ryan B. Schwope, Katherine M. Cebe, Valerie Paradis, Pierre Bedossa, Jennifer M. Aldridge Whitehead, Aymeric Labourdette, Veronique Miette, Stefan Neubauer, Celine Fournier, Angelo H. Paredes, Naim Alkhouri
Summary: In a cohort of asymptomatic middle-aged Americans, the prevalence of NAFLD was 38%, NASH was 14%, and significant liver fibrosis was present in 6% of the participants.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zahra Raisi-Estabragh, Amine M'Charrak, Celeste McCracken, Luca Biasiolli, Maddalena Ardissino, Elizabeth M. Curtis, Nay Aung, Claudia K. Suemoto, Clare Mackay, Sana Suri, Thomas E. Nichols, Nicholas C. Harvey, Steffen E. Petersen, Stefan Neubauer
Summary: The study found that better cognitive performance was associated with certain cardiovascular magnetic resonance (CMR) measures in participants from the UK Biobank, suggesting a link between brain and cardiovascular health. These associations remained significant even after adjusting for various confounding factors.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Physiology
Sevasti Zervou, Debra J. McAndrew, Hannah J. Whittington, Hannah A. Lake, Kyung Chan Park, Kuan Minn Cha, Philip J. Ostrowski, Thomas R. Eykyn, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Summary: The study suggests that modest elevation of AK1 activity may improve functional recovery following ischemia/reperfusion injury, but has unexpected impacts on left ventricular weight, function, and metabolite levels under basal resting conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Afifah Mohamed, Maciej Marciniak, Wilby Williamson, Odaro J. Huckstep, Winok Lapidaire, Angus McCance, Stefan Neubauer, Paul Leeson, Adam J. Lewandowski
Summary: Preterm-born adults show altered left ventricular structure and function in response to systolic blood pressure elevation, indicating increased susceptibility to cardiac remodeling. Additional primary prevention strategies targeting cardiovascular risk reduction in this population may be necessary.
Article
Cardiac & Cardiovascular Systems
Moritz J. Hundertmark, Olorunsola F. Agbaje, Ruth Coleman, Jyothis T. George, Rolf Grempler, Rury R. Holman, Hanan Lamlum, Jisoo Lee, Joanne E. Milton, Heiko G. Niessen, Oliver Rider, Christopher T. Rodgers, Ladislav Valkovic, Eleanor Wicks, Masliza Mahmod, Stefan Neubauer
Summary: Empagliflozin has shown significant benefits in reducing HF hospitalization and cardiovascular mortality. The EMPA-VISION trial aims to study the effects of empagliflozin on cardiac energy metabolism using MRS and CMR, shedding light on its mechanistic action in HF patients.
Article
Computer Science, Artificial Intelligence
Yan Xia, Nishant Ravikumar, John P. Greenwood, Stefan Neubauer, Steffen E. Petersen, Alejandro F. Frangi
Summary: The study presents a novel super-resolution algorithm based on conditional generative adversarial networks for generating high-quality cardiac MR images, which benefits subsequent image analyses and demonstrates superior performance in experiments.
MEDICAL IMAGE ANALYSIS
(2021)
Review
Cardiac & Cardiovascular Systems
Zahra Raisi-Estabragh, Nicholas C. Harvey, Stefan Neubauer, Steffen E. Petersen
Summary: The UK Biobank is a valuable health research resource with a large sample size and comprehensive health tracking data. The incorporation of imaging studies enhances the dataset, providing more detailed information for interdisciplinary health research.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Geriatrics & Gerontology
Zahra Raisi-Estabragh, Celeste McCracken, Jackie Cooper, Kenneth Fung, Jose M. Paiva, Mohammed Y. Khanji, Elisa Rauseo, Luca Biasiolli, Betty Raman, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Nicholas C. Harvey, Steffen E. Petersen
Summary: The study found that individuals with adverse baseline cardiovascular magnetic resonance phenotypes had a higher likelihood of testing positive for COVID-19, independent of traditional cardiovascular risk factors. Therefore, observational reports of cardiovascular involvement after COVID-19 may partly reflect pre-existing cardiac conditions.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)